The Robert Koch Institute: an Historical Overview
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The Rat from an Aircraft: Investigations for Multiple Pathogen Detection
Poster Presentations New and Re-Emerging Zoonotic Diseases N19 The rat from an aircraft: Investigations for multiple pathogen detection Elisa Heusera, Arnt Ebingerb, Silva Holtfreterc, Andreas Zautnerd, René Rylla, Stephan Drewesa, Beate Matzkeita, Bernd Hoffmannb, Dirk Höperb, Markus Kellera, Allison Grosethf, Gottfried Wilharme, Daniel Mrochenc, Anna Obiegalag, Frank Dossh, Tobias Eisenbergi, Sandra Niendorfj, Sindy Böttcherk, Michael H. Kohnl, Charlotte Schröderm, Joachim Reetzn, Kati Franzkeo, Eric Ehrke-Schulzp, Martin Pfefferg, Katja Schmidtq, Martin Beerb, Rainer G. Ulricha,r,* a Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Novel and Emerging Infectious Diseases, Südufer 10, 17493 Greifswald-Insel Riems, Germany b Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Diagnostic Virology, Südufer 10, 17493 Greifswald-Insel Riems, Germany c Department of Immunology, University Medicine Greifswald, 17475 Greifswald, Germany d Institute of Medical Microbiology, University Medicine Göttingen, Kreuzbergring 57, 37075 Göttingen, Germany e Robert Koch Institute, Wernigerode Branch, Burgstr. 37, 38855 Wernigerode, Germany Friedrich-Loeffler- f Institut, Federal Research Institute for Animal Health, Group – Arenavirus Biology, Südufer 10, 17493 Greifswald-Insel Riems, Germany g Institute of Animal Hygiene and Veterinary Public Health, University of Leipzig, An den Tierkliniken 1, 04103 Leipzig, Germany h Clean Frank Doss GmbH, Kampstraße 27, 16792 Zehdenick, Germany i Hessian State Laborytory, Schubertstraße 60 - Haus 13, 35392 Gießen, Germany j Robert Koch-Institute, Department of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Seestraße 10, 13353 Berlin, Germany k Robert Koch-Institute, Regional Reference Laboratory of the WHO/Europe for Poliomyelitis, Seestraße 10, 13353 Berlin, Germany l Rice University, BioSciences, Houston, TX BioSciences MS-170, Rice University, 130 Anderson Biology, P.O. -
October 24–26, 2021 2
SCIENCE · INNOVATION · POLICIES WORLD HEALTH SUMMIT BERLIN, GERMANY & DIGITAL OCTOBER 24–26, 2021 2 “No-one is safe from COVID-19; “All countries have signed up to Universal no-one is safe until we are all Health Coverage by 2030. But we cannot safe from it. Even those who wait ten years. We need health systems conquer the virus within their that work, before we face an outbreak own borders remain prisoners of something more contagious than within these borders until it is COVID-19; more deadly; or both.” conquered everywhere.” ANTÓNIO GUTERRES Secretary-General, United Nations FRANK-WALTER STEINMEIER Federal President, Germany “We firmly believe that the “All pulling together—this must rights of women and girls be the hallmark of the European are not negotiable.” Health Union. I believe this can NATALIA KANEM be a test case for true global Executive Director, United Nations Population Fund (UNFPA) health compact. The need for leadership is clear and I believe the European Union must as- sume this responsibility.” “The lesson is clear: a strong health URSULA VON DER LEYEN system is a resilient health system. Health President, European Commission systems and preparedness are not only “Governments of countries an investment in the future, they are the that are doing well during foundation of our response today.” the pandemic have not TEDROS ADHANOM GHEBREYESUS Director-General, World Health Organization (WHO) only shown political leader- ship, but also have listened “If we don’t address the concerns and to scientists and followed fears we will not do ourselves a favor. their recommendations.” In the end, it is about how technology SOUMYA SWAMINATHAN Chief Scientist, World Health can be advanced as well as how Organization (WHO) we can make healthcare more human.” BERND MONTAG President and CEO, Siemens Healthineers AG, Germany “The pandemic has brought to light the “Academic collabo ration is importance of digital technologies and in place and is really a how it can radically bridging partnership. -
Annual Status Update on Measles and Rubella Elimination Germany
Annual Status Update on Measles and Rubella Elimination Germany 1 Dear NVC and national technical counterparts, dear colleagues, We kindly ask you to follow the definitions (please see Annex 1.1) and instructions provided in this form, and to enter numbers or text as required in each segment (table, text box, other). If you are using your own definitions and indicators, please provide an explanation and clarification why and how these could be considered equivalent to or as an adequate replacement for the WHO definitions and indicators. If the NVC would like to provide additional data and information to the RVC, please submit them as separate document(s). In 2020, the World Health Organization reformed its IT systems and internet platforms for data submission and exchange in 2020 to increase security, and a new SharePoint for the European Regional Verification Commission for Measles and Rubella Elimination was created. However, due to shifting of resources and time constrains in countries and at the WHO Regional Office related to the COVID-19 pandemic response, it was not possible to prepare instructions and conduct training for NVCs and national colleagues. Therefore, we kindly request you to submit your ASU and all relevant additional documents as attachments to an e-mail to RVC Secretariat, using address [email protected]. You may also copy any of VPI technical officers cooperating with you in preparation of the ASU and verification process. Please follow up with us to confirm that we received your ASU and any other issue that may need our support or attention. This update is to be submitted to the WHO Regional Office for Europe by 1 May 2021. -
Sir Charles Sherrington'sthe Integrative Action of the Nervous System: a Centenary Appreciation
doi:10.1093/brain/awm022 Brain (2007), 130, 887^894 OCCASIONAL PAPER Sir Charles Sherrington’sThe integrative action of the nervous system: a centenary appreciation Robert E. Burke Formerly Chief of the Laboratory of Neural Control, National Institute of Neurological Disorders, National Institutes of Health, Bethesda, MD, USA Present address: P.O. Box 1722, El Prado, NM 87529,USA E-mail: [email protected] In 1906 Sir Charles Sherrington published The Integrative Action of the Nervous System, which was a collection of ten lectures delivered two years before at Yale University in the United States. In this monograph Sherrington summarized two decades of painstaking experimental observations and his incisive interpretation of them. It settled the then-current debate between the ‘‘Reticular Theory’’ versus ‘‘Neuron Doctrine’’ ideas about the fundamental nature of the nervous system in mammals in favor of the latter, and it changed forever the way in which subsequent generations have viewed the organization of the central nervous system. Sherrington’s magnum opus contains basic concepts and even terminology that are now second nature to every student of the subject. This brief article reviews the historical context in which the book was written, summarizes its content, and considers its impact on Neurology and Neuroscience. Keywords: Neuron Doctrine; spinal reflexes; reflex coordination; control of movement; nervous system organization Introduction The first decade of the 20th century saw two momentous The Silliman lectures events for science. The year 1905 was Albert Einstein’s Sherrington’s 1906 monograph, published simultaneously in ‘miraculous year’ during which three of his most celebrated London, New Haven and New York, was based on a series papers in theoretical physics appeared. -
Journal of Health Monitoring | S3/2020 | EBPH-Workshop
JUNE 2020 FEDERAL HEALTH REPORTING SPECIAL ISSUE 3 JOINT SERVICE BY RKI AND DESTATIS Journal of Health Monitoring Evidence-based Public Health for Public Health Action – Proceedings of an international workshop at the Robert Koch Institute Berlin, Germany, 14 December 2018 1 Journal of Health Monitoring Index 3 Editorial Providing actionable evidence in Public 23 Proceedings Summary of World Café Discussions Health – The 2018 international workshop on Table 3: Dissemination evidence-based public health at the Robert Koch Institute, Berlin 7 Proceedings Emerging challenges in evidence-based public health and how to address them 9 Proceedings Conceptual issues in relation to the design, implementation and evaluation of interven- tions 11 Proceedings Taking stock of existing evidence and closing evidence gaps – Reflections from the National Institute for Health and Care Excellence (NICE) 13 Proceedings Novel methods for health intervention research 15 Proceedings Systematic reviews in public health: Exploring challenges and potential solutions 17 Proceedings Evidence-based public health (EBPH) health policy advising and information of the public 19 Proceedings Experiences from the Department of Infectious Disease Epidemiology at Robert Koch Institute 21 Proceedings Summary of World Café Discussions Table 1: Assessment 22 Proceedings Summary of World Café Discussions Table 2: Evaluation JournalJournal of of Health Health Monitoring Monitoring 2018 2020 3(XXX) 5(S3) 2 Journal of Health Monitoring Evidence-based Public Health for Public Health -
Can the New Type of Coronavirus Be Transmitted Via Food and Objects?
www.bfr.bund.de Can the new type of coronavirus be transmitted via food and objects? Updated BfR FAQ dated 30 March 2020 After the outbreak of the respiratory tract disorder COVID-19 caused by an infection with the new type of coronavirus (SARS-CoV-2), and the subsequent epidemic in various regions of China, the virus is now also spreading in Germany and Europe. Disconcerted consumers have asked the German Federal Institute for Risk Assessment (BfR) whether the virus can also be transmitted to humans via food and imported products such as children’s toys, mo- bile telephones, articles such as door handles, tools, etc., as well as dishes and cutlery. Against this background, the BfR has summarised the most important questions and an- swers on the topic. What do we know so far about the new type of virus-related respiratory tract disorder? The new type of respiratory tract disorder COVID-19 is based on an infection with the new type of coronavirus (SARS-CoV-2), according to the current state of knowledge. Knowledge about the exact transmission methods of this coronavirus is still limited. However, the trans- mission method of other closely related coronaviruses are well known. Different types of coronavirus typically trigger conventional colds in humans. Moreover, other coronaviruses, such as the SARS and MERS coronaviruses, have occurred in the past which have led to severe respiratory tract disorders. The main target organs of the coronavirus in humans are the respiratory tract organs. The most important transmission method is a ‘droplet infection’, where coronaviruses are emitted by humans or animals into the air via droplets, and then inhaled. -
Spread of a SARS-Cov-2 Variant Through Europe in the Summer of 2020
Article Spread of a SARS-CoV-2 variant through Europe in the summer of 2020 https://doi.org/10.1038/s41586-021-03677-y Emma B. Hodcroft1,2,3 ✉, Moira Zuber1, Sarah Nadeau2,4, Timothy G. Vaughan2,4, Katharine H. D. Crawford5,6,7, Christian L. Althaus3, Martina L. Reichmuth3, John E. Bowen8, Received: 25 November 2020 Alexandra C. Walls8, Davide Corti9, Jesse D. Bloom5,6,10, David Veesler8, David Mateo11, Accepted: 28 May 2021 Alberto Hernando11, Iñaki Comas12,13, Fernando González-Candelas13,14, SeqCOVID-SPAIN consortium*, Tanja Stadler2,4,92 & Richard A. Neher1,2,92 ✉ Published online: 7 June 2021 Check for updates Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identifed in Spain in early summer 2020 and subsequently spread across Europe. We fnd no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of efective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local eforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. -
Metchnikoff and the Phagocytosis Theory
PERSPECTIVES TIMELINE Metchnikoff and the phagocytosis theory Alfred I. Tauber Metchnikoff’s phagocytosis theory was less century. Indeed, the clonal selection theory and an explanation of host defence than a the elucidation of the molecular biology of the proposal that might account for establishing immune response count among the great and maintaining organismal ‘harmony’. By advances in biology during our own era5. tracing the phagocyte’s various functions Metchnikoff has been assigned to the wine cel- Figure 1 | Ilya Metchnikoff, at ~45 years of through phylogeny, he recognized that eating lar of history, to be pulled out on occasion and age. This figure is reproduced from REF. 14. the tadpole’s tail and killing bacteria was the celebrated as an old hero. same fundamental process: preserving the However, to cite Metchnikoff only as a con- integrity, and, in some cases, defining the tributor to early immunology distorts his sem- launched him into the turbulent waters of evo- identity of the organism. inal contributions to a much wider domain. lutionary biology. He wrote his dissertation on He recognized that the development and func- the development of invertebrate germ layers, I first encountered the work of Ilya tion of the individual organism required an for which he shared the prestigious van Baer Metchnikoff (1845–1916; FIG. 1) in Paul de understanding of physiology in an evolution- Prize with Alexander Kovalevski. By the age of Kruif’s classic, The Microbe Hunters 1.Who ary context. The crucial precept: the organism 22 years, he was appointed to the position of would not be struck by the description of this was composed of various elements, each vying docent at the new University of Odessa, where, fiery Russian championing his theory of for dominance. -
Vaccination Recommendations for Germany Miriam Wiese-Posselt, Christine Tertilt, and Fred Zepp
MEDICINE CONTINUING MEDICAL EDUCATION Vaccination Recommendations for Germany Miriam Wiese-Posselt, Christine Tertilt, and Fred Zepp SUMMARY accination is an effective means of preventing V infectious diseases (e1). The primary goal of vac- Background: Vaccination is an effective means of preventing cination is to protect the vaccinated person against the infectious diseases. In Germany, the Standing Vaccination disease in question (individual immunity). If a large Committee at the Robert Koch Institute (Ständige Impfkom- enough percentage of the population is vaccinated, then mission, STIKO) issues recommendations on vaccination to the spread of the pathogenic organism will be reduced prevent the occurrence and spread of infectious diseases in to such an extent that non-vaccinated persons are pro- the nation’s population. tected as well (herd immunity) (e2). Sustained vacci- Methods: Selective literature review, including consideration nation of a high percentage of the population against a of the current STIKO recommendations. pathogen for which man is the only reservoir can result Results: The annually updated vaccination calendar currently in its regional or even, in the ideal case, global elimi - includes recommendations for vaccination against diphtheria, nation (1). The total elimination of smallpox and the tetanus, pertussis, type b Haemophilus influenzae, hepatitis marked reduction of the incidence of poliomyelitis B, poliomyelitis, and pneumococci, beginning at the age of worldwide are impressive examples of the benefits of eight weeks. From the age of twelve months onward, immunization (Figure 1) (e3). children should be vaccinated against measles, mumps, rubella, varicella, and serogroup C meningococci. In later Methods childhood and adolescence, booster vaccinations are recom- In Germany, the Standing Vaccination Committee mended, in addition to the provision of any vaccina tions that (Ständige Impfkommission, STIKO) at the Robert Koch may have been missed. -
Annual Status Update on Measles and Rubella Elimination for 2016
ANNUAL STATUS UPDATE ON MEASLES AND RUBELLA ELIMINATION FOR 2016 Annual Status Update on Measles and Rubella Elimination for 2016 Germany 0 | P a g e ANNUAL STATUS UPDATE ON MEASLES AND RUBELLA ELIMINATION FOR 2016 This update is to be submitted to the WHO Regional Office by 15 April 2017. Please upload an electronic version of the update and a copy of page 5 signed by the NVC members to the RVC SharePoint: http://workspace.who.int/sites/EURORVC How to upload the report: 1. Make a copy of your report and any supporting documents and supplementary data in original (Microsoft Word) format. PLEASE DO NOT CONVERT THIS FILE INTO PDF FORMAT! 2. Login at “http://workspace.who.int/sites/EURORVC“ using the password provided by the WHO Secretariat to the NVC chairperson and EPI manager. You are at RVC SharePoint. 3. Click on “Country Annual Status Reports”. 4. Select and click on your country folder. 5. Open the folder for year of reporting (2016). 6. Click on “Upload” or drag the file to folder and it will be copied. 7. Click on “Browse…” or “Upload Multiple Files…” to select a single or multiple files from your PC or MAC to upload. 8. Select your file(s) and click on “OK”. 9. Double check that the files are uploaded under the Country Annual Status Reports/Your country name. Should you have any problems with access to the RVC SharePoint or uploading the report, please contact the WHO Secretariat by e-mail ([email protected]). This update report consists of three sections: Section 1: National Verification Committee (NVC) Section 2: Country measles and rubella profile Section 3: Update of general programme activities by components We would kindly ask you to follow the instructions provided in the form and enter numbers or text as required in each particular table. -
Emil Von Behring (1854–1917) the German Bacteriologist
Emil von Behring (1854–1917) The German bacteriologist and Nobel Prize winner Emil von Behring ranks among the most important medical scientists. Behring was born in Hansdorff, West Prussia, as the son of a teacher in 1854. He grew up in narrow circumstances among eleven brothers and sisters. His desire to study medicine could only be realized by fulfilling the obligation to work as an military doctor for a longer period of time. Between 1874 and 1878 he studied medicine at the Akademie für das militärärztliche Bildungswesen in Berlin. In 1890, after having published his paper Ueber das Zustandekommen der Diphtherie- Immunität und der Tetanus-Immunität bei Thieren, he captured his scientific breakthrough. While having worked as Robert Koch’s scientific assistant at the Berlin Hygienic Institute he had been able to show – together with his Japanese colleague Shibasaburo Kitasato (1852–1931) – via experimentation on animal that it was possible to neutralize pathogenic germs by giving „antitoxins“. Behring demonstrated that the antitoxic qualities of blood are not seated in cells, but in the cell-free serum. Antitoxins recovered of human convalenscents or laboratorty animals, prove themselves as life-saving when being applied to diseased humans. At last – due to Behring’s discovery of the body’s own immune defence and due to his development of serotherapy against diphtheria and tetanus – a remedy existed which was able to combat via antitoxin those infectious diseases which had already broken out. Having developped a serum therapy against diphtheria and tetanus Behring won the first Nobel Prize in Medicine in 1901. Six years before, in 1895, he had become professor of Hygienics within the Faculty of Medicine at the University of Marburg, a position he would hold for the rest of his life. -
(COVID-19) Daily Situation Report of the Robert Koch Institute
Coronavirus Disease 2019 (COVID-19) WeeklyDaily SituationSituation Report fromof the the Robert Robert Koch Koch Institute Institute CALENDAR08/01/202116/01/2021 WEEK 26/202 - UPDATED1 - CURRENT STATUS STATUS FOR GERMANY FOR GERMANY Since 6 March 2021, the Robert Koch Institute (RKI) has been publishing the English version of the COVID-19 situation reports for Germany on a weekly basis. Information on the daily epidemiological situation is available on the RKI’s online COVID-19 dashboard. In addition, the RKI’s website provides daily situation reports in German, information on vaccination data and from the intensive care registry, as well as other regularly uploaded data. [Information sources are provided at the end of this report]. The following information is provided in this situation report: Overview on the epidemiological situation, demographic distribution of cases, surveys on laboratory tests of SARS-CoV-2 in Germany, and information from additional RKI-based surveillance systems. – Changes since the last report are marked blue in the text – The current epidemiological situation in Germany As of 01 July 2021 Vaccination DIVI-Intensive care Confirmed cases 7-day incidence (7-di) monitoring register No. of districts Change to previous No. of vaccinations Total1 Active cases2 Total population with 7-di day for no. of cases reported in last 24h > 50/100,000 pop currently in ICU +892 -600 5.1 ±0 1st vaccin. + 443,036 -24 (3,729,033) [ca. 12,400] cases/100,000 pop. [0/412] 2nd vaccin. + 533,491 [590] Total no. of people No. of districts vaccinated with No. of deaths in 60-79 80+ Recovered3 Deaths with 7-di one/two vaccine ICU compared to years years > 100/100,000 pop dose/s and share of the previous day population +1,400 +63 1.9 1.4 ±0 N1: 45,817,029 (55.1%)4 + 51 (ca.