The Center for Technological Development in Health (CDTS)
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And Missions
Shared values The International and missions Network AFRICA ASIA - PACIFIC The Institut Pasteur International Network brings together 32 ins- Pasteur Center in Cameroon Institut Pasteur du Cambodge titutions, united by their Pasteurian values and missions, for the Institut Pasteur de Bangui Institut Pasteur of Shanghai, benefit of populations’ health. A unique model of cooperation Institut Pasteur de Côte d’Ivoire Chinese Academy of Sciences Institut Pasteur de Guinée Institut Pasteur Korea in the field of health, this network connects men and women on Institut Pasteur de Madagascar Institut Pasteur du Laos every continent, who contribute daily to gain ground in the fight CERMES Niger Hong Kong University - against infectious agents, through biomedical research, public Institut Pasteur de Dakar Pasteur Research Pole health activities, and training. The conjunction of these three mis- Institut Pasteur sions relies on a network of expert scientists and cutting-edge AMERICAS de Nouvelle-Calédonie technologies in order to address health issues on both the local INRS-Institut Armand-Frappier National Institute of and the international level. Oswaldo Cruz Foundation Hygiene and Epidemiology Institut Pasteur Institut Pasteur de la Guadeloupe in Ho Chi Minh City Institut Pasteur in Nha Trang Institut Pasteur de la Guyane ; Shutterstock. Institut Pasteur de Montevideo MAGHREB – MIDDLE EAST EUROPE Institut Pasteur d’Algérie Institut Pasteur in Iran Sciensano (Brussels) Institut Pasteur du Maroc Stephan Angeloff ; © Institut Pasteur Institute of -
New Test Can Diagnose 416 Viruses from Tropical Regions 1 December 2016
New test can diagnose 416 viruses from tropical regions 1 December 2016 Researchers from the University of São Paulo region and is transmitted mainly by midges of the (USP) at Ribeirão Preto in Brazil have developed a species Culicoides paraensis. platform that analyzes clinical samples from patients to diagnose infection by 416 viruses found "There are several other viruses that haven't yet in the world's tropical regions. caused problems in humans but may do so one day," Aquino said. "They're evolving all the time, According to its creators, the tool can be used by and with the degradation of natural environments reference laboratories such as Adolfo Lutz infectious agents once confined to natural niches Institute, Oswaldo Cruz Foundation (Fiocruz) and could spread farther afield." Evandro Chagas Institute in Brazil to assist epidemiological surveillance by detecting Although the platform is designed above all to pathogens with the potential to cause epidemics in detect pathogens transmitted by arthropods such humans. as mosquitoes and ticks, it can also diagnose infectious agents transmitted by small mammals, Results of the research project, which was like hantavirus. coordinated by Victor Hugo Aquino, a professor at the University of São Paulo's Ribeirão Preto Aquino explained that the selection encompasses Pharmaceutical School (FCFRP-USP), and all viruses occurring in tropical regions with DNA supported by FAPESP, have been published in sequences deposited in GenBank, a public PLoS Neglected Tropical Diseases. database maintained by the National Center for Biotechnology Information (NCBI), which is part of "The number of patients with suspected dengue, the United States National Library of Medicine Zika or chikungunya infection will increase when (NLM). -
Services Policy Review of Paraguay
UNITED NATIONS CONFERENCE ON TRADE AND DEVELOPMENT SERVICES POLICY REVIEW PARAGUAY UNITED NATIONS CONFERENCE ON TRADE AND DEVELOPMENT SERVICES POLICY REVIEW PARAGUAY ii SERVICES POLICY REVIEW OF PARAGUAY NOTE The symbols of United Nations documents are composed of capital letters combined with figures. Mention of such a symbol indicates a reference to a United Nations document. The views expressed in this volume are those of the authors and do not necessarily reflect the views of the United Nations Secretariat or of the government of Paraguay. The designations employed and the presentation of the material do not imply the expression of any opinion on the part of the United Nations concerning the legal status of any country, territory, city or area, or of authorities or concerning the delimitation of its frontiers or boundaries, or regarding its economic system or degree of development. Material in this publication may be freely quoted or reprinted, but acknowledgement is requested, together with a copy of the publication containing the quotation or reprint to be sent to the UNCTAD secretariat. This publication has been edited externally. For further information on the Trade Negotiations and Commercial Diplomacy Branch and its activities, please contact: Ms. Mina MASHAYEKHI Head Trade Negotiations and Commercial Diplomacy Branch Division of International Trade in Goods and Services, and Commodities Tel: +41 22 917 56 40 Fax: +41 22 917 00 44 www.unctad.org/tradenegotiations UNCTAD/DITC/TNCD/2014/2 © Copyright United Nations 2014 All rights reserved. Printed in Switzerland ACKNOWLEDGEMENTS iii ACKNOWLEDGEMENTS This publication presents the result of a Services Policy Review (SPR) undertaken by the government of Paraguay in collaboration with UNCTAD. -
Seasonal Variations in Phenological Traits: Leaf Shedding and Cambial Activity in Parkia Nitida Miq
Seasonal variations in phenological traits: leaf shedding and cambial activity in Parkia nitida Miq. and Parkia velutina Benoist (Fabaceae) in tropical rainforest Hélène Morel, Thomas Mangenet, Jacques Beauchêne, Julien Ruelle, Eric Nicolini, Patrick Heuret, Bernard Thibaut To cite this version: Hélène Morel, Thomas Mangenet, Jacques Beauchêne, Julien Ruelle, Eric Nicolini, et al.. Seasonal variations in phenological traits: leaf shedding and cambial activity in Parkia nitida Miq. and Parkia velutina Benoist (Fabaceae) in tropical rainforest. Trees - Structure and Function, Springer Verlag, 2015, 29 (4), pp.973-984. 10.1007/s00468-015-1177-4. hal-01135166 HAL Id: hal-01135166 https://hal.archives-ouvertes.fr/hal-01135166 Submitted on 25 May 2016 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. Seasonal variations in phenological traits: leaf shedding and cambial activity in Parkia nitida Miq. and Parkia velutina Benoist (Fabaceae) in tropical rainforest He´le`ne Morel • Thomas Mangenet • Jacques Beaucheˆne • Julien Ruelle • Eric Nicolini • Patrick Heuret • Bernard Thibaut Abstract the radial enlargement zone and wall-thickening zone. At Key message In French Guiana, the leaf and cambium the same time, we observed leaf shedding pattern in the phenologies should not be considered only as exoge- crown of the same trees. -
The Negro in France
University of Kentucky UKnowledge Black Studies Race, Ethnicity, and Post-Colonial Studies 1961 The Negro in France Shelby T. McCloy University of Kentucky Click here to let us know how access to this document benefits ou.y Thanks to the University of Kentucky Libraries and the University Press of Kentucky, this book is freely available to current faculty, students, and staff at the University of Kentucky. Find other University of Kentucky Books at uknowledge.uky.edu/upk. For more information, please contact UKnowledge at [email protected]. Recommended Citation McCloy, Shelby T., "The Negro in France" (1961). Black Studies. 2. https://uknowledge.uky.edu/upk_black_studies/2 THE NEGRO IN FRANCE This page intentionally left blank SHELBY T. McCLOY THE NEGRO IN FRANCE UNIVERSITY OF KENTUCKY PRESS Copyright© 1961 by the University of Kentucky Press Printed in the United States of America by the Division of Printing, University of Kentucky Library of Congress Catalog Card No. 61-6554 FOREWORD THE PURPOSE of this study is to present a history of the Negro who has come to France, the reasons for his coming, the record of his stay, and the reactions of the French to his presence. It is not a study of the Negro in the French colonies or of colonial conditions, for that is a different story. Occasion ally, however, reference to colonial happenings is brought in as necessary to set forth the background. The author has tried assiduously to restrict his attention to those of whose Negroid blood he could be certain, but whenever the distinction has been significant, he has considered as mulattoes all those having any mixture of Negro and white blood. -
Rich Fraction from Arrabidaea Chica Verlot (Bignoniaceae)
ORIGINAL RESEARCH published: 20 July 2021 doi: 10.3389/fphar.2021.703985 Antileishmanial Activity of Flavones- Rich Fraction From Arrabidaea chica Verlot (Bignoniaceae) João Victor Silva-Silva 1†, Carla Junqueira Moragas-Tellis 2†, Maria do Socorro dos Santos Chagas 2, Paulo Victor Ramos de Souza 2,3, Celeste da Silva Freitas de Souza 1, Daiana de Jesus Hardoim 1, Noemi Nosomi Taniwaki 4, Davyson de Lima Moreira 2, Maria Dutra Behrens 2†, Kátia da Silva Calabrese 1*† and Fernando Almeida-Souza 1,5† 1Laboratory of Immunomodulation and Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, 2Laboratory of Natural Products for Public Health, Pharmaceutical Techonology Institute – Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, 3Student on Postgraduate Program in Translational Research in Drugs and Medicines, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil, 4Electron Microscopy Nucleus, Adolfo Lutz Institute, São Edited by: Paulo, Brazil, 5Postgraduate in Animal Science, State University of Maranhão, São Luís, Brazil Pinarosa Avato, University of Bari Aldo Moro, Italy Reviewed by: Acknowledging the need of identifying new compounds for the treatment of leishmaniasis, Edson Roberto Silva, this study aimed to evaluate, from in vitro trials, the activity of flavones from Arrabidaea University of São Paulo, Brazil chica against L. amazonensis. The chromatographic profiles of the hydroethanolic extract Miriam Rolon, Centro para el Desarrollo de la and a flavone-rich fraction (ACFF) from A. chica were determined by high-performance Investigacion Cientifica, Paraguay liquid chromatography coupled with a diode-array UV-Vis detector (HPLC-DAD-UV) and *Correspondence: electrospray ionization mass spectrometry in tandem (LC-ESI-MS-MS). -
Priority, Invisibility and Eradication: the History of Smallpox and the Brazilian Public Health Agenda
Medical History, 2009, 53: 229–252 Priority, Invisibility and Eradication: The History of Smallpox and the Brazilian Public Health Agenda GILBERTO HOCHMAN* Introduction This article describes three periods in Brazil’s modern history when governmental action was (or was not) taken against smallpox: first, when smallpox control became a priority in the Brazilian sanitary agenda from the nineteenth century to the beginning of the twentieth century; second, when it was rendered politically invisible during decades when greater attention was given to yellow fever and malaria control; third, when it reappeared at the cen- tre of Brazilian health policy in the 1960s until its eventual eradication in 1973. Smallpox control in the latter two periods is suffused with paradox. For example, evidence suggests that the nearly fifty-year absence or lack of policies and agencies to deal with smallpox actually favoured the mobilization of local, national and international resources once the era- dication programme was launched in 1966; these new approaches were accelerated from 1969 until the completion of eradication in 1973. Equally paradoxical, it was during the spe- cific context of the military regime after 1964 that the Brazilian health system developed the capacity to mobilize existing but dispersed resources and flexibly to innovate, incorporate, and adapt new policies. Another important element in this period was institutional learning based on other vertical programmes such as the malaria eradication campaign. Although the Brazilian smallpox eradication programme was constrained by international agencies and by bilateral co-operation with the United States, the period after 1964 offered opportunities for the realization of a new and wide-ranging national health capacity including the creation of a national system of epidemiological surveillance and a national childhood immunization programme. -
COVID-19 Pandemic in Rio De Janeiro, Brazil: a Social Inequality Report
medicina Communication COVID-19 Pandemic in Rio de Janeiro, Brazil: A Social Inequality Report Yago Bernardo 1,2 , Denes do Rosario 1,3 and Carlos Conte-Junior 1,2,3,4,* 1 COVID Research Group, Center for Food Analysis (NAL), Technological Development Support Laboratory (LADETEC), Cidade Universitária, Rio de Janeiro 21941-598, RJ, Brazil; [email protected] (Y.B.); [email protected] (D.d.R.) 2 Graduate Program in Veterinary Hygiene (PPGHV), Faculty of Veterinary Medicine, Fluminense Federal University (UFF), Vital Brazil Filho, Niterói 24230-340, RJ, Brazil 3 Graduate Program in Food Science (PPGCAL), Institute of Chemistry (IQ), Federal University of Rio de Janeiro (UFRJ), Cidade Universitária, Rio de Janeiro 21941-909, RJ, Brazil 4 Graduate Program in Sanitary Surveillance, National Institute of Health Quality Control (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil * Correspondence: [email protected]; Tel.: +55-21-3938-7825 Abstract: Background and Objectives: To perform a retrospective report on the lethality of COVID-19 in different realities in the city of Rio de Janeiro (RJ). Materials and Methods: We accomplished an observational study by collecting the data about total confirmed cases and deaths due to COVID-19 in the top 10 high social developed neighborhoods and top 10 most populous favelas in RJ to determine the case-fatality rate (CFR) and compare these two different realities. Results: CFR was significatively higher in poverty areas of RJ, reaching a mean of 9.08% in the most populous favelas and a mean of 4.87% in the socially developed neighborhoods. Conclusions: The social mitigation measures adopted in RJ have benefited only smaller portions of the population, excluding needy communities. -
Acceptability of Long-Acting Injectable Cabotegravir (CAB LA) in HIV
AIDS and Behavior https://doi.org/10.1007/s10461-020-02808-2 ORIGINAL PAPER Acceptability of Long‑Acting Injectable Cabotegravir (CAB LA) in HIV‑Uninfected Individuals: HPTN 077 Elizabeth E. Tolley1 · Sahar Z. Zangeneh2 · Gordon Chau2 · Joe Eron3 · Beatriz Grinsztejn4 · Hilton Humphries5 · Albert Liu6 · Marc Siegel7 · Maseko Bertha8 · Ravindre Panchia9 · Sue Li2 · Leslie Cottle2 · Alex Rinehart10 · David Margolis10 · Andrea Jennings11 · Marybeth McCauley12 · Raphael J. Landovitz13 © The Author(s) 2020 Abstract Long-acting injectable PrEP could ofer an alternative to daily oral PrEP, improve adherence and protection, if found acceptable, safe and efective. HPTN 077 evaluated injectable cabotegravir safety, tolerability and pharmacokinetics among HIV-uninfected males and females in sequentially-enrolled cohorts of two dosing strategies. We compared acceptability of product attributes, prevention preferences and future interest in injectable PrEP (FIIP) by region, sex-at-birth, arm and cohort and used multivariable analysis to identify FIIP determinants. Baseline injectable PrEP preferences were higher in non-U.S. sites and increased in both regions over time. In multivariable models, FIIP was most strongly associated with acceptability of product attributes, was higher in non-U.S. sites and more altruistic participants. Treatment arm and report of pain were not associated with FIIP. Injectable acceptability was highest in non-U.S. sites. Preferences for injectable versus other PrEP methods were higher among U.S. males than females, but higher -
Annex 1 Recommendationsa for the Production and Quality Control of Smallpox Vaccine, Revised 2003
© World Health Organization WHO Technical Report Series, No. 926, 2004 Annex 1 Recommendationsa for the production and quality control of smallpox vaccine, revised 2003 Recommendations published by WHO are intended to be scientific and advisory. Each of the following sections constitutes guidance for national regulatory authorities and for the manufacturers of biological products. If a national regulatory authority so desires, these Recommendations may be adopted as definitive national requirements, or modifications may be justified and made by a national regulatory authority. It is recommended that modifications to these Recommendations be made only on condition that the modifications ensure that the vaccine is at least as safe and efficacious as that prepared in accordance with the Rec- ommendations set out below. The parts of each section printed in small type are comments for additional guidance intended for manufacturers and national regulatory authori- ties, which may benefit from those details. In these Recommendations, Part A describes the general provisions for the production and quality control of small- pox vaccine and is applicable to production of vaccine in all permissible substrates, including the use of a cell bank. Part B describes national control requirements. The terms “national regulatory authority” and “national control labo- ratory”, as used in these Recommendations, always refer to the country in which the vaccine is manufactured. a Previously called Requirements for Smallpox vaccine. 27 Introduction 28 General considerations 29 Part A. Manufacturing recommendations 32 A.1 Definitions 32 A.2 General manufacturing recommendations 34 A.3 Production control 35 A.3.1 Control of source materials 35 A.3.2 Control of vaccine production 42 A.3.3 Control of bulk suspensions 51 A.3.4 Final bulk 53 A.4 Filling and containers 56 A.5 Control tests on final product 56 A.6 Records 58 A.7 Samples 58 A.8 Labelling 58 A.9 Distribution and shipping 59 A.10 Storage and expiry data 59 Part B. -
Brazil Pdf Icon[858 KB, 3 Pages]
Brazil • Capital: Brasilia • Infant Mortality Rate: Total: 20.5 deaths/1,000 live • Area: 8,514,877 sq km births; male: 23.9 deaths/1,000 live births; female: 16.93 • Population: 205,716,890 (July 2012 est.) deaths/1,000 live births (2012 est.) • Age Structure: 0-14 years: 26.2% (male 27,219,651/female • Literacy Rate: Total population: 88.6%; male: 88.4%; 26,180,040); 15-64 years: 67% (male 67,524,642/female female: 88.8% (2004 est.) 68,809,357); 65 years and over: 6.7% (male 5,796,433/ • GDP: $2.282 trillion (2011 est.) female 7,899,650) (2011 est.) • GDP per Capita: $11,600 (2011 est.) • Life Expectancy at Birth: Total population: 72.79 years; male: 68.24 years; female: 76.53 years (2012 est.) U.S. CDC Direct Country Support Brazil launched its national influenza surveillance system in 2000. After the pandemic, there was a need to adapt the strategy of influenza surveillance in Brazil and obtain a better understanding of the clinical, epidemiological and etiological cases of severe acute respiratory infection (SARI) since a variety of agents, beyond influenza are responsible for most of these cases and occurrence may occur in clusters of cases that deserve specific and timely interventions. Given the need to structure influenza surveillance in Brazil to improve prevention and control activities and identify unusual or new human influenza subtypes, the Ministry of Health (MOH) issued ordinance Official n. 2,693 in 2011. This promotes the strengthening of epidemiological surveillance for influenza in 72 priority municipalities. -
ACHR29 93 6.Pdf (1.199Mb)
ACHR 29/93.6 Original: English Revt REGIONAL SYSTEM OF VACCINES FOR LATIN AMERICA AND THE CARIBBEAN (SIREVA) i ,> Division of Health and Development k- f Program of Research and Technological Development in Health July 1993 The issue of this document does not constitute formal publication. It should not be reviewed, abstracted or quoted without the agreement of the Pan American Health Organization (PAHO). Authors alone are responsible for views expressed in signed articles. TABLE OF CONTENTS I. INTRODUCTION ........................................ 1 II. ACTIVITIES FOR EXPANSION OF SIREVA A. TECHNICAL AND SCIENTIFIC SUPPORT .................. 2 B. DISSEMINATION OF THE SIREVA PROPOSAL .............. 3 C. FINANCIAL SUPPORT OF SIREVA ........................ 3 D. POLITICAL SUPPORT OF SIREVA ................. 3....... á HIII. DEVELOPMENT OF MASTER PLAN ....................... 4 A. MATER PLAN FOR DEVELOPMENT OF S. PNEUMONIAE VACCINE ............................... 5 - Proposed research activity ............................ 6 - Implementation of master plan ........................ 8 B. MASTER PLAN FOR DEVELOPMENT OF TYPHOID FEVER VACCINE ..................................... 8 J - Research proposal for improved vaccine .................. 9 - Implementation of master plan: Joint development -- Mexico and Brazil ................................... 10 C. MASTER PLAN FOR THE DEVELOPMENT OF IMPROVED N. MENINGIDITIS, SEROGROUP B VACCINE ........................................... 11 - Proposed research activity ............................ 13 - Design