HERE AND Report to the Community | 2017 NOW LEADERSHIP CONTENTS MESSAGE

Leadership Message 1 crucial neighborhood caregivers. When added Patient Care 2 to our longstanding partnerships with local schools, homeless shelters and other community Research 16 organizations, we are doing more than ever to It all began with the spark of an idea. In aid all those who need quality healthcare. Community 1902, a growing Los Angeles community was Outreach 30 struggling to get quality healthcare, so a group Meanwhile, locally and throughout the nation, of civic leaders came together to create the consumers, payers and employers are asking for Education 38 the forerunner of Cedars-Sinai, the 12-bed better coordination of care to help people get Kaspare Cohn Hospital in the Angelino Heights and stay healthy, ensure that patients always The Campaign neighborhood east of downtown Los Angeles. get the right amount of care and help keep for Cedars-Sinai 44 healthcare affordable for all. You will see many Much has changed in medicine and healthcare examples in this report of how Cedars-Sinai is The Numbers 52 over the past 115 years, yet Cedars-Sinai is still pioneering new ways to provide healthcare that driven every day by the same fundamental is not only of the highest quality, but also has Where We Are 54 question: “What does the community need?” the value and efficiency that the public wants.

Leadership 2016 56 One of our top priorities today is to respond Throughout these pages, you also will see to the demand for more accessible, convenient how our pioneering biomedical research and healthcare. As a result, we have been expanding education programs are training the healthcare our geographic reach in a variety of ways — professionals of tomorrow. And you will learn establishing new Cedars-Sinai outpatient how the support of community donors is facilities closer to where people live and work; essential to our ability to continue meeting our acquiring and affiliating with outstanding region’s needs for years to come. physician groups, community hospitals and outpatient surgical centers; and developing With your help, Cedars-Sinai continues innovative partnerships with other organizations. to evolve as we address the complex and changing healthcare needs of one of the most We also are meeting community needs by helping diverse regions in the nation. We are grateful to improve the health of our region’s underserved. have the support of people and organizations Cedars-Sinai’s Community Clinics Initiative, for who share our longstanding dedication to the example, expands our partnerships with these people of Los Angeles.

VERA GUERIN THOMAS M. PRISELAC Chair, Board of Directors President and CEO

CEDARS-SINAI 1 PATIENT CARE HERE: Physicians, nurses and thousands of other healthcare professionals are committed to providing the best care to every patient, from primary to specialized care for complex and advanced diseases.

NOW: 886 LICENSED BEDS 254,668 PATIENT DAYS 242,112 PATIENTS CARED FOR BY CEDARS‑SINAI MEDICAL NETWORK 2,758 NURSES 2,156 MEDICAL STAFF

CEDARS-SINAI 3

REDUCED MEDICATION PRESIDENTIAL PREPARED PATIENT CARE READMISSIONS LITERACY ZERO TOLERANCE TOP EMPLOYER EQUITABLE CARE PRECISION FOR EBOLA

By strengthening Cedars-Sinai is Using a systematic Forbes ranked The Human Rights Cedars-Sinai The U.S. Department Cedars-Sinai clinical support for enhancing patient method of strict Cedars-Sinai as Campaign Foundation was among 40 of Health and Human vulnerable patients safety after discharge adherence to a one of the nation’s recognized Cedars- organizations selected Services tapped has expanded during and after by using a novel set of evidence-based best places to Sinai as a leader in by the White House Cedars-Sinai to transitions to skilled method to assess the protocols, Cedars- work, garnering the LGBT healthcare to participate in a become part of a services across nursing facilities, medication literacy of Sinai surgical teams institution a top spot equality. The Precision Medicine network of 10 regional the Cedars-Sinai vulnerable patients. developed best on the magazine’s foundation is the Initiative Summit in centers prepared multiple Enhanced Care Patients leaving the practices covering the 2016 list of America’s educational arm of Washington, D.C. The to treat Ebola. The Program significantly hospital with new entire care process Best Employers. the Human Rights event brought together designation means locations, reduced the rate of prescriptions may for every hip- and The health system Campaign, the medical researchers, Cedars-Sinai will hospital readmissions. not fully understand knee-replacement also earned the 2016 country’s largest clinicians, community play a critical role making it The program plays how to take their surgery. Surgical-site Workplace of the lesbian, gay, bisexual advocates and others in bolstering the a critical role in safe medications, and the infections in bones or Year Award from and transgender from around the nation’s front-line easier for more care transitions, with risk of drug-related joints after orthopedic The Advisory Board (LGBT) civil rights country to mark the defenses against nurse practitioners problems rises during surgeries can lead Company. On the organization. The one-year anniversary highly communicable people to access closely monitoring such transitions in to readmissions, Forbes list, Cedars- findings were part of the initiative’s diseases. As a patients through care. Nurses follow up longer hospital stays, Sinai ranked 87th of the foundation’s launch. It featured designated Ebola coordinated, regularly scheduled post-discharge with prolonged antibiotic among institutions Healthcare Equality remarks from President assessment hospital, rounds in skilled the patients at highest therapy, reduced with more than 5,000 Index 2016, an Barack Obama, patient Cedars-Sinai is quality care nursing facilities. These risk to make sure they mobility, intensive employees, based annual survey that stories, and roundtable committed to nurses serve as an are taking the right rehabilitation and on an independent encourages equal care discussions to build maintaining its “always close to home. extra layer of support medication at the right higher healthcare survey of 30,000 U.S. for LGBT Americans momentum and ready” status, and for patients as well as dose at the right time. costs. Although the employees who work by evaluating inclusive collaborations around held an extensive drill liaisons between the In addition, Cedars- incidence of such for large companies policies and practices precision medicine to prepare medical facility, physicians and Sinai pharmacists infections at Cedars- and institutions, for patients, visitors efforts. Cedars-Sinai staff to receive family members. They review medication lists Sinai already meets including U.S. divisions and employees. Precision Health, suspected Ebola focus on enhancing for high-risk patients national benchmarks, of international firms. Cedars-Sinai earned a partnership of patients. Cedars-Sinai coordination of and call them within the medical center The Advisory Board top marks in meeting scientists, clinicians constantly updates its care and preventing 72 hours. The pilot aimed to reduce the Company award nondiscrimination and industry, launched readiness protocols medical complications. phase was so effective rate to zero — and keep recognizes top- and training criteria in September 2016. by learning from other In addition, dedicated that the method it there. The Orthopedic performing hospitals that demonstrate The goal of the regional centers and pharmacists ensure is being expanded Surgical-Site Infection and health systems its commitment to partnership is to drive with data received patients leave the to reach high-risk Bundle includes nationwide for equitable care for development of the from the few hospitals hospital with clear and patients throughout steps such as testing outstanding employee LGBT patients and newest technology that already have updated medication the medical center. for the common engagement, their families. and best research, treated Ebola patients. lists. The Enhanced infectious bacterium and Cedars-Sinai coupled with the finest Care Program has Staphylococcus was among just clinical practice, to drawn national aureus and measures 20 organizations rapidly deliver precise Cedars-Sinai now operates attention for its to maintain a receiving the honor. and personalized primary and urgent care innovative care model. sterile environment healthcare solutions to locations in Culver City, as well throughout surgery. Cedars-Sinai patients. as Marina Del Rey Hospital.

4 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 5

NEW HEART CALIFORNIA TRANSPLANT ORTHOPEDIC ANTIBIOTIC REHABILITATION CULTURAL PATIENT CARE MARINA MEDICINE RECORD STRETCHES BEST PRACTICES INSTITUTE OPENS HONOR ROLL COMPETENCE

Cedars-Sinai With 132 adult heart Formerly a section To enhance patient Cedars-Sinai, U.S. News & World The Institute for Cedars-Sinai operates Marina transplants performed of the Department of safety, improve UCLA Health and Report’s Best Diversity in Health Del Rey Hospital as in 2015, the Cedars- Surgery, orthopedics outcomes and combat Select Medical Hospitals 2016 – 17 Management named performed the part of a continuing Sinai Heart Institute at Cedars-Sinai has the global threat partnered to open named Cedars-Sinai Cedars-Sinai an Equity commitment to topped its own record achieved record clinical of drug-resistant the largest acute to its Honor Roll and of Care Champion most adult increasing access to for the most such and academic growth infections, Cedars- inpatient rehabilitation ranked the medical and ranked it as one coordinated, quality procedures in the U.S. over the past several Sinai is promoting hospital on the West center nationally in of 20 top-performing heart transplants care throughout for the third straight years, prompting the extra measures for Coast, located in the 11 adult specialties: hospitals nationally. Southern California. year, while continuing establishment of a the effective use of Century City area of cardiology and heart The institute’s in the U.S. for The 145-bed hospital, to set new standards new Department of antibiotics. As part of Los Angeles, less than surgery; diabetes 2015 Diversity which features a in care. Cedars-Sinai’s Orthopaedics in 2016. its “Get Smart About three miles from the and endocrinology; and Disparities the third 24-hour emergency development and Its board-certified Antibiotics” program, main Cedars-Sinai ear, nose and throat; Benchmarking Survey room, is now a use of antirejection physicians provide the Antimicrobial campus. The new, gastroenterology tracked more than straight year. distinct community therapies, such as new comprehensive Stewardship team 138-bed California and gastrointestinal 1,000 hospitals’ affiliate of Cedars- medicines and blood- orthopedic care, implemented best Rehabilitation Institute surgery; geriatrics; measures to tackle Sinai. In addition to cleansing procedures, including the surgical practice alerts in the greatly expands gynecology; healthcare disparities. general acute-care have contributed to and nonsurgical electronic health records the area’s acute nephrology; neurology Cedars-Sinai garnered medical services and high success rates: treatment of the spine, of patients who receive rehabilitation services. and neurosurgery; acclaim for its cultural emergency care, The national average hand, shoulder and certain antibiotics for It offers a broad range orthopedics; competency efforts Marina Del Rey Hospital rejection rate is upper extremities, three or more days. The of highly specialized pulmonology; and that train staff to focus offers expertise around 25 percent, hip and knee — from alert allows physicians care and treatment urology. The report on the needs of diverse in a wide range of while the rate at the reconstruction to total to reassess the for patients with also ranked Cedars- patient populations, specialties, including Heart Institute is joint replacement — antibiotic prescription spinal cord and brain Sinai as “high- including non-native spine, weight loss less than 15 percent. foot and ankle disorders and evaluate further injuries, neurological performing” in nine English speakers. The surgery, orthopedics, The United Network and injuries, and treatment needs. disorders, strokes, adult procedures and survey also tracked minimally invasive for Organ Sharing, trauma and fractures, Antibiotic-resistant amputations and other conditions. Overall, the how hospitals provide surgery, women’s which manages the plus arthroscopic infections spread acute conditions. The medical center ranked employee orientation health and internal nation’s transplant surgery, sports quickly among patients hospital’s physician- among the top 20 and continuing medicine. As part system, compiles these medicine and pediatric with compromised led team includes hospitals nationwide, education to address of the Cedars-Sinai statistics annually. orthopedics. Its immune systems. physical therapists, fourth in California varying patient family with nonprofit leading-edge imaging Incorrect use of occupational therapists, and second in the beliefs and religious status, Marina Del Rey techniques allow antibiotics increases speech therapists Los Angeles metro views that may Hospital’s mission clinicians to see bones hospitalizations, lengths and specialized area. Cedars-Sinai affect treatment. In Retired Marine Corps Staff will focus even more and joints in detail. of stay and risks of nursing staff. also scored high in addition to educating Sergeant and educator Larry thoroughly on meeting Cedars-Sinai has long death. Cedars-Sinai patient safety. employees about such Lewis received a lifesaving heart the needs of the local been recognized as healthcare providers sensitivities, Cedars- transplant at Cedars-Sinai. community, including one of the nation’s top strive to prescribe Sinai encourages provision of community orthopedic centers the right antibiotic at diversity in its medical, benefit programs. by U.S. News & World the right dose at the nursing, and other Report. right time and better clinical residencies and educate patients. fellowship programs.

6 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 7

HEALING GARDENS SUPERIOR RADIATION TOPS IN PATIENT PRENATAL INNOVATION PATIENT CARE IN BLOOM SURGERIES PAIR EXCHANGE ON POINT SATISFACTION DESTINATION CHALLENGE

A beautification The medical center The Cedars-Sinai With the recently Cedars-Sinai Health Cedars-Sinai is More than 20 teams “Innovation at project has is participating in Kidney Transplant installed TrueBeam System® received top primed to become of registered nurses transformed the a leading effort to Program performed Radiotherapy System, scores in the national a destination for and physicians tested Cedars-Sinai outdoor Cedars- improve the quality of its third successful radiation oncologists Hospital Consumer pregnant women in their competitive and Sinai Plaza Level surgical care. Cedars- paired exchange, with at the Cedars-Sinai Assessment of California who are entrepreneurial skills is not limited into a lush garden Sinai is collecting teams in six operating Samuel Oschin Healthcare Providers seeking sophisticated to improve the patient refuge, bringing clinical, risk-adjusted rooms simultaneously Comprehensive Cancer and Systems hospital prenatal screening. experience at Cedars- to a select few; water features, outcomes data for a performing three Institute can deliver survey. Developed by The Cedars-Sinai Sinai in the MD/RN shaded seating, national database as laparoscopic treatments twice as National Research Corp. Cytogenetics Patient Experience it’s happening improved lighting part of the American nephrectomies on fast as previously and adopted by the Laboratory became the Innovation Challenge. and other tranquil College of Surgeons donors and three possible. The system Centers for Medicare first to gain approval The nurse/physician every day in all features to four areas National Surgical transplantations integrates imaging, & Medicaid Services, from the California teams pitched their around the north Quality Improvement in patients. Paired beam delivery and the survey provides the Department of Public ideas to a panel of of our units.” and south towers. Program. Using exchange programs motion management public with information Health for administering executive judges after The redesigned anonymous clinical allow donor-recipient to provide precise on inpatient and chromosomal brainstorming and — Dr. Christopher Ng, co-chair exteriors provide a data gathered from duos to swap living- control for targeting outpatient care microarray (CMA) creating prototypes. of the MD/RN Patient Experience green sanctuary for patients’ medical donor kidneys with even the tiniest of from the patient’s testing to women The winning team Innovation Challenge patients and visitors, charts — rather than others in need, tumors. TrueBeam is perspective. In overall participating in the designed an app that serene landscape administrative data — providing a vital the most advanced inpatient satisfaction, state’s Prenatal allows tracheostomy views from patient means complications option for patients linear accelerator 83.7 percent of patients Screening Program, or intubated patients rooms, and spaces for are more likely to be who are incompatible in the field. The rated Cedars-Sinai a which includes some to communicate physicians and staff noticed. Results are with the friends or accelerator — which 9 or 10 on a 10-point 400,000 prospective more easily in a to recharge. Each of compared to those family members who particularly is suited scale (with 10 being mothers annually. CMA variety of languages. the four gardens has of other hospitals, are willing to be their for treating tumors of the “best hospital testing, a DNA-based The idea will be a unique design and similar in size and type. donors. To enable the lung, abdomen, possible”), while 94.3 method of genetic implemented and includes specially Tracking 30-day transplantation in breast, prostate, head percent of patients analysis that can tested system-wide. selected foliage such outcomes helps patients who are and neck — allows rated Cedars-Sinai catch abnormalities as bamboo, fruitless identify complications highly sensitized patients to receive a 9 or 10 for overall overlooked by olive trees, lavender such as surgical-site against antigens briefer, more intense, outpatient satisfaction. traditional cytogenetic and aloe. The project infections, urinary that cause organ yet safer treatments in In the medical group testing, is the gold also includes built- tract infections and rejection, Cedars- fewer sessions, while patient satisfaction standard for detection in concrete pads for pneumonia. On Sinai participates in minimizing the impact ratings, 80 percent of of alterations in the future art installations. average, participating numerous registries, on surrounding tissues. Cedars-Sinai patients submicroscopic The Healing Gardens hospitals have including the National said their doctor chromosome that project is part of prevented 250 to Kidney Registry and listens carefully and flag for potential birth Bhargavi Simhadri, RN, Lauren a comprehensive 500 complications the United Network provides explanations defects, developmental Smith, RN, and Dr. Kuang-Yuh effort to beautify the and saved two to for Organ Sharing, in that are easy to delays and genetic Chyu, won the MD/RN Patient campus and improve three dozen lives and addition to employing understand, and 80 disorders. Cedars- Experience Innovation Challenge exterior wayfinding for millions of dollars desensitization percent said the office Sinai has offered CMA for their app that allows intubated a more positive patient each year. strategies. staff is respectful. testing to private patients to communicate more easily. experience. patients since 2010.

8 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 9

NAVIGATORS THE PEOPLE’S ADVANCED CARE PATIENT CARE CHART COURSE TYPING TEST CHOICE LABOR DAY READY HEART ALERT SMART IV PUMPS CONSIDERATIONS

Cedars-Sinai clinical A new technique at For the 20th year in a Changes in the Cedars-Sinai is the first It was long standard Patients with Clinical trial trial navigators are Cedars-Sinai called row, Cedars-Sinai won childbirth education hospital in the nation procedure for nurses progressive conditions essential to the extended blood the National Research program at Cedars- to use electronic to manually program sometimes receive navigators continued success of matching goes beyond Corp.’s (NRC) Sinai are helping health records to IV pumps for aggressive treatments the nearly 500 clinical the standard typing of Consumer Choice expectant mothers identify patients at medication infusions, near the end of life serve as a trials underway in A, B, O and AB, and Award for providing feel even closer to the risk for congestive punching in numbers that offer little or no FY2016. The trials have positive or negative Rh the highest-quality nurses who care for heart failure. The such as the correct benefit — and can connection led to groundbreaking factor, to match donor medical care in the them. The same nurses CS-Link™ system dose, concentration even cause harm. A discoveries for and recipient blood Los Angeles region who will be with the automatically alerts and infusion rate. Cedars-Sinai initiative between conditions from types precisely for based on a survey of mother as she delivers an interdisciplinary Each press of a button is sparking cultural heart disease to transfusions. Cedars- area households. Every now are teaching healthcare team to represents a risk of changes in such patients and inflammatory bowel Sinai is a pioneer in year NRC conducts an the classes that help address a patient’s error that could cause treatment to ensure disease. Among their testing for genetically independent survey parents-to-be prepare specific heart- harm. Automated, that patients’ wishes scientists. wide range of duties, based variations about hospitals. for labor and birth. The health needs. When standardized are honored. Steps navigators help recruit in antigens — the Cedars-Sinai has courses are evidence- information signaling procedures for include appropriate patients and sort proteins and sugars ranked No. 1 in best based, realistic and the potential for administering IV drugs use of feeding tubes through calls and that reside on red overall quality of family-centered, with heart failure is now are used in 42 in patients with emails to find the right blood cells. Blood healthcare and has content drawn from activated through inpatient units to make advanced dementia, volunteers for these types A and B and the been awarded the a variety of methods CS-Link, the patient medication infusions early palliative vital studies. They Rh factor are the only NRC’s prestigious and approaches. The receives education on safer at Cedars-Sinai. care consultations also help guide the antigens most hospital Consumer Choice classes welcome all improving heart health, Smart IV pumps for patients with participants through transfusion services Award every year pregnant women a dietary consultation replaced 1,300 infusion high-mortality rate the ins and outs of test for. But additional since 1996, when the and their partners, and medication devices and were cancers and reduction the process and serve antigens can trigger rankings began. NRC’s but parents who reconciliation. Patients integrated to the CS- of ineffective as coordinators for an immune reaction in surveys are considered plan to have their receive scales to weigh Link™ electronic health chemotherapy in the patients, researchers the recipient. Patients the gold standard in babies delivered at themselves daily at record to standardize last two weeks of life. and staff. receiving multiple healthcare information. Cedars-Sinai gain the home and have a nursing practice to The push for advance transfusions, or who In 2015 – 16, Cedars- additional benefit post-discharge follow- reduce the potential care planning also Tracey Early, patient care have conditions such Sinai was the only of forging a care up appointment. for programming is expanding, with a coordinator for the Regenerative as sickle cell disease, medical center in the relationship with Optimizing electronic errors at the bedside. targeted approach Medicine Clinic at the Cedars- are at highest risk. The Los Angeles area to the medical center’s health records in this focusing on patients in Sinai Heart Institute, and Jaime Cedars-Sinai blood win the Consumer caregivers that way helps prevent the advanced stages Richardson, the cancer clinical bank now can identify Choice Award. continues through the readmissions, improves of serious, progressive trial navigator at the Cedars-Sinai 32 antigens with a postpartum period. outcomes and ensures illnesses. Cedars- Samuel Oschin Comprehensive single blood test. that patients have the Sinai’s approach to Cancer Institute necessary tools to be the challenges of discharged safely. end-of-life care is so comprehensive that other hospitals are using it as a model.

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MOVEMENT PREGNANCY CARDIAC AGAINST INTERNATIONAL A BETTER PATIENT PROBLEMS PRESCRIPTION MONITORING PATIENT CARE SCORE! PARKINSON’S EFFORT EXPERIENCE PINPOINTED FOR BETTER CARE EXPANDS

For three years, An innovative Recognizing how Cedars-Sinai has A faster, more accurate Inpatients now can The Centralized The Outpatient teams across Cedars- tool resembling a difficult it can be for recommitted to and less invasive have their discharge Monitoring Center, Sinai have engaged wristwatch could patients to come from putting its patients test to help detect prescriptions delivered which continuously Pharmacy caregivers around the improve quality of other countries to and their needs first premature rupture of to their bedside checks inpatient concept of “Safe Care life for Parkinson’s the U.S. for medical with a program to membranes during before going home. cardiac activity delivers in the OR. Every disease patients and care, Cedars-Sinai foster teamwork and pregnancy was Caregivers request the across Cedars-Sinai, time” (SCORE). better inform the is committed to continually ensure launched at Cedars- medications through recently moved to a prescriptions Led by surgeons, neurologists who making this transition exceptional service. Sinai in May. Standard the Cedars-Sinai larger space, adding anesthesiologists, treat them. A team as easy as possible That ever-expanding diagnostic methods, Outpatient Pharmacy the capacity to to patients at nurses and technicians, in the Movement with its Center for effort now includes including ultrasound, prior to patient cover an additional in partnership Disorders Program International Health. a dedicated patient- are often not sufficient discharge. Outpatient 66 patients. Other bedside before with administrative in the Cedars-Sinai Through computerized experience team to or accurate when pharmacists review the enhancements include leadership, SCORE’s Department of telemedicine links, coordinate formal diagnosing pregnant patient’s medication eight new monitoring discharge unit-based Neurology is one of doctors and their training programs patients suspected lists and reconcile stations, software interdisciplinary the first in the nation patients may exchange for all Cedars-Sinai of having ruptured them with discharge upgrades allowing to support teams emphasize to test a device medical information employees. Enhanced membranes. By orders to ensure greater access to the surgical quality and that tracks patient and advice with service can have a identifying a protein that all prescriptions information needed to continuity of care. improvements in movements every experts at Cedars- powerful effect on called placental alpha are complete, safe make critical decisions, patient safety. SCORE two minutes over six Sinai within minutes patient satisfaction microglobulin-1 in and appropriate. better clinical support is changing more than to 10 days, showing from anywhere in the and overall health vaginal fluids, the Pharmacists work tools, stronger processes; it’s also symptom fluctuations world. The multilingual outcomes. new test can help closely with technology security promoting a culture throughout the day. International Health determine whether a prescribers to resolve and faster hardware. in which people feel The device — the size, Services team assists rupture has occurred. any identified issues In addition, 10 clinical comfortable speaking weight and shape of a in coordinating The test also detects and recommend partners are being up about issues and wristwatch — vibrates arrangements, housing related complications, affordable alternatives added to the center’s getting constructive to remind patients during treatment which can include to any coverage issues. roster. Since it was feedback from to press a button and itineraries for infection, umbilical Patients pay the same established in 2011, the colleagues. Teams indicating that they families traveling with prolapse, placental prescription copay for center has improved have worked with have taken medication the patient. abruption and risk of delivery to the bedside patient safety by the Performance prescribed to reduce preterm delivery. as at a retail pharmacy. implementing Improvement body movements. The service supports telemetry monitoring Department’s Lean Six The gadget provides continuity of care, on individual units, Sigma management a quantitative way to improves medication which enables nurses tools to develop monitor patients in adherence, enhances and clinicians to watch projects such as the between physician the patient experience for life-threatening Nazeli Bairamian, PharmD, is OR Sweep, which visits to optimize and potentially arrhythmias specific to among the Cedars-Sinai pharmacists removes all previous care and more reduces drug-related each patient’s diagnosis delivering discharge medications patient identifiers fully understand readmissions. rather than keeping to patients at the bedside. from the operating the disease. all patients in cardiac room, helping avoid observation units. mislabeled specimens.

12 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 13 BETTER GO WEST, ARTHRITIS HEALTHCARE ACCURATE PATIENT CARE YOUNG MAN BEST IN SHOW GAME-CHANGER DETECTIVE STORY BY DESIGN LABELING NOT JUST FOR KIDS

As part of an effort The Barbara Cowen A groundbreaking Cedars-Sinai An esteemed Mislabeled laboratory The need to stay up Dogs and their to bring high-quality Pets Offering procedure developed neurologists and group of healthcare specimens can result to date with vaccines care closer to where Ongoing Care and by Cedars-Sinai rheumatologists are organizations has in mistaken diagnoses, does not end at age 18. owners in people live and work, Healing (POOCH) physicians can bring teaming up to better formed the Innovation delayed treatment Although many people Cedars-Sinai is Volunteer Program relief and mobility to detect a rare variant Learning Network and unnecessary believe that their the Barbara extending its reach in at Cedars-Sinai, patients who have of multiple sclerosis to offer insights and procedures, and childhood vaccines will Southern California which brings gentle damaged finger joints called neuromyelitis methodologies for put the safety of continue protecting Cowen POOCH with the opening of and affectionate or severe arthritis optica (NMO). The problem solving blood transfusions them, adults actually medical offices in the dogs to Cedars- in their hands and two departments have while encouraging at risk. Cedars-Sinai need new vaccines Volunteer fast-growing Playa Sinai for patient wrists. The technique been working together companies to share is combining the and boosters to Vista community — visits, was honored uses the meniscus because multiple best practices. The Six Sigma strategy maintain immunity Program a key hub in the with a Health and from a cadaver knee sclerosis shares network includes of performance from a variety of region’s technology Safety Recognition to reconstruct joints, similar symptoms Cedars-Sinai and other improvement with diseases. The Injection provide comfort industry that boasts Award from the alleviating pain and with lupus, which is select healthcare nurses’ bedside Center at Cedars-Sinai offices for Facebook, city of Beverly Hills’ allowing patients usually treated by systems, health observations to reduce educates patients and support Google and YouTube. Health and Safety to recapture critical rheumatologists. foundations, safety-net these critical errors. The and providers about The new facility will Commission. The mobility. It improves Because of symptom providers, design and effort has led to such vaccines for adults, throughout accommodate some award celebrates on the traditional similarity, many innovation firms, and changes as eliminating while the Cedars- 500 patients per day groups and individuals approach of inserting NMO patients see tech companies with a manual entry of patient Sinai Travel Clinic Cedars-Sinai. and be staffed by two that demonstrate a hard silicone implant, rheumatologists common goal: to make IDs for lab test labels recommends specific dozen physicians, leadership and which can become before they are healthcare better and requiring two vaccines for those whose expertise creativity in promoting infected or break over referred to a through good design. barcodes — one for planning global travel. encompasses primary health and safety in time. The meniscus, neurologist. NMO is By participating medications and one Based on the patient’s care, urgent care and the city. Volunteers a spongy cartilage very difficult to detect, in twice-monthly for lab tests — to be itinerary, pharmacists specialties such as whose dogs have that prevents joints but it’s a manageable webinars and periodic printed on patient provide vaccines internal medicine, passed the rigorous from rubbing against and treatable in-person meetings, ID bands. A solution against diseases dermatology, and POOCH screening one another, is far condition. Awareness members connect, implemented in such as hepatitis A, obstetrics and process bring their more resilient and and diagnostic share knowledge and medical and surgical typhoid and yellow gynecology. Set to pets to the medical durable than silicone. testing are the key to gain inspiration. units requires that fever. They also offer open in summer 2017, center to offer a Its malleability also knowing how to treat two caregivers verify antibiotics for treating the expansion will special source of ensures a neat fit into NMO patients. In the patient identifiers travelers’ diarrhea serve Culver City, Mar comfort and support the joint. A Cedars- past two years, this during the specimen- and prescriptions Vista, Marina del Rey, to pet-loving patients, Sinai study of patients collaborative effort labeling process. These to prevent altitude Playa del Rey and families and staff. who underwent the led to the diagnosis and other advanced sickness and malaria. Westchester. meniscus repair found of patients whose techniques are being that none experienced disease could have shared with hospitals postoperative gone unrecognized or nationwide through Tucker, a POOCH volunteer, complications or who could have ended scientific publications passed the rigorous screening required follow-up up having unnecessary and presentations process to offer a special source surgeries. and invasive brain at national quality of support to pet-loving patients, biopsies. meetings. families and staff.

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RESEARCH HERE: Investigators in the Van Eyk Laboratory study the molecular basis behind a variety of cardiovascular disorders, with projects ranging from basic discovery research to clinically relevant analytical studies.

NOW: 482 ACTIVE CLINICAL TRIALS 1,519 RESEARCH PROJECTS $30,500,000 TECHNOLOGY TRANSFER ROYALTY INCOME REINVESTED IN RESEARCH

OVER 1,400 PUBLICATIONS

MORE THAN 200 PRINCIPAL INVESTIGATORS

CEDARS-SINAI 17

PROSTATE RESEARCH SHAPESHIFTING RESEARCH STORM CHASERS TO BE PRECISE PROGNOSIS RENOWN IT’S COMPLICATED TUMOR CELLS ALS INSIGHTS

Predicting sudden Through the Cedars- A Cedars-Sinai Among the nation’s Inflammation A novel genetic Brain immune cells Investigators cardiac arrest — which Sinai Precision Health scientist is leading hospitals not affiliated may be a culprit biomarker that drives play a direct role in is fatal to 90 percent partnership, scientists, a multi-institutional with universities, driving increased the progression of the development of found that more of its victims within clinicians and industry effort to investigate Cedars-Sinai rose to prostate cancer many breast and amyotrophic lateral 10 minutes — has experts are leveraging how prostate a ninth-place ranking, risk that results prostate cancers sclerosis (ALS). Mouse than half of all been as perplexing emerging knowledge cancer spreads to with a total of nearly from obesity. To has been identified models provided to cardiologists about the human bone with the aim $140 million in unravel this complex by Cedars-Sinai insights into how faulty sudden cardiac as forecasting the genome, insights into of finding where extramural research relationship, Cedars- scientists. The cellular components perfect storm is to the body’s complex in the treatment support and Sinai investigators discovery could may cause the fatal arrest patients meteorologists. Now, chemical activity process lifesaving $56 million in are performing replace standardized disorder, which Cedars-Sinai Heart (metabolomics), chemotherapies could federal grant awards in-depth analysis treatments by gradually destroys experience Institute investigators protein function and be used. A five-year, from the National of inflammatory identifying patients nerve cells that have demonstrated structure (proteomics), $8.2 million grant Institutes of Health. tissue markers, who will respond control muscle advance warning that more than half of and billions of from the National Royalty revenues which enables positively to function. This Cedars- all patients experience microorganisms (the Cancer Institute topped $23 million, characterization chemotherapies. Sinai research also symptoms for advance warning microbiome). With will help fund the with 90 invention of the specific The biomarker is suggests how these symptoms for up to a the help of ever- project, which focuses disclosures, seven inflammatory cell part of a protein- faulty components up to a month. month. Their landmark faster computing, on interactions license agreements types present in the interaction process might be repaired. study, published in the immense data between the tumor and 16 patents prostates of men with that makes cells rigid. The investigators the Annals of Internal generated by these microenvironment issued. Cedars- and without prostate The investigation developed two genetic Medicine, outlines discoveries can be and prostate epithelial Sinai investigators cancer. They also are found that, when strains of mice that the most common combined into a tissue, the site of also shared their exploring whether this biomarker is lacked a gene known signs, including comprehensive profile prostate cancer discoveries with race modifies this risk, lost or lowered, cells as C9orf72, which their intermittent chest of an individual’s total development. The other scientists given that African- become “deformable,” previous work showed pain and pressure, biology that allows disease affects one around the world, American men have squeezing through was important for shortness of breath, the rapid delivery in seven men in the publishing more a 67 percent higher tissue spaces and brain immune function. palpitations, and of personalized United States, most than 1,400 articles in prostate cancer risk enabling the cancer Instead of developing ongoing influenza- healthcare solutions older than 65. While medical journals and than white men — to grow. Investigators ALS, mice lacking the like indicators such to each patient. With the prognosis for most welcoming more than and more than twice can utilize this gene unexpectedly as nausea and mobile applications patients is excellent, 120 visiting scientists the mortality risk. knowledge to identify suffered immune abdominal and back and sensors, patients with a five-year to conduct and Identifying the roles patients who will system abnormalities. pain. Approximately at home can generate relative survival rate observe research. of socioeconomics, respond to a class of Structures within 350,000 people in their own data, such of nearly 100 percent, lifestyle, genetics and chemotherapy drugs brain immune cells — the U.S. die each year as heart rates and that figure drops other factors may that damage cancer known as lysosomes — from sudden cardiac blood-glucose levels, to only 28 percent lead to solutions cell protein structures. that normally dispose arrest — accounting for transmittal to when prostate cancer for alleviating The study is the first of unwanted cellular for 50 percent of all their physicians — metastasizes to bone increased risk. to devise a targeting material stopped cardiovascular deaths an advance known and other sites. strategy for tumor functioning properly nationally. as “near-patient cells that exhibit without the C9orf72 technologies.” amoeboid shape- gene. altering properties.

18 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 19

IBD TREATMENT YOU GO HIGH, TARGET: BREAST RESEARCH MAP WEIGHT GOES LOW GOOD TO THE BONE CANCER IDEAL MATCH SUDDEN IMPACT BIOBANK DEPOSITS

A study co-authored Investigations led Studies at Cedars- A project led by Thanks to a African Americans A biobank that can Cedars-Sinai’s by a Cedars-Sinai by the Cedars- Sinai are opening the Cedars-Sinai transatlantic are twice as likely as store millions of tissue physician explores Sinai Diabetes and up new possibilities Samuel Oschin collaboration whites to die from and blood samples, Biobank can the role of genetic Obesity Research for regenerative Comprehensive between Cedars- sudden cardiac arrest, analyze them and variations in patients Institute suggest the treatments of Cancer Institute Sinai and Saint-Louis and they tend to generate an array store millions with inflammatory higher your home, osteoporosis, a assembled a new Hospital in Paris, be younger when it of digital images to bowel disease (IBD) the healthier your chronic condition nanoparticle aimed physicians soon could occurs, according to advance scientific of tissue and and could provide weight. The study of lost bone at revealing and then determine whether Cedars-Sinai Heart discovery has opened a map for more analyzed data from mass that leaves eliminating breast a transplanted organ Institute investigators. at Cedars-Sinai. The blood samples. effective treatments. 31,549 adults in Peru. people vulnerable cancer tumors. The will be rejected before The findings arose nearly 7,000-square- The international The prevalence of to fractures. In a scientists assembled the procedure even from a comprehensive, foot facility, built with investigation — the obesity among men landmark study, the nanoparticle, begins. The protein 16-hospital, multiyear support from the largest of its kind — residing at elevations scientists showed HerMn, by attaching a human leukocyte assessment of National Institutes examined the records of at least 9,843 feet that a combination genetically engineered antigen (HLA) is cardiac deaths of Health, is divided of 35,000 patients was 50 percent less of adult stem cells protein to a synthetic essential to matching among the million into three units that with the two most than in those living and a specific compound that organ donors to people of Portland’s connect aspects of common forms of no higher than 1,640 hormone may speed enhances contrast transplant patients. metropolitan area. discovery into one the illness, Crohn’s feet. These men also up the rate at which in MRI. Previously But rejection of Led by scientists at seamless process. disease and ulcerative had less abdominal osteoporosis-caused developed at the the transplanted the Cedars-Sinai Heart The first unit is colitis. The genetic obesity, which is fractures mend. The institute, the protein organ still may Institute, the team devoted to collecting information provided strongly associated investigators helped targets and penetrates occur because of reviewed medical and preserving new insights into with cardiovascular repair spinal fractures HER2+ tumors, a donor-specific HLA records of 126 African biospecimens, the IBD progression and disease. Women, in animal models by highly aggressive antibodies, which Americans and 1,262 second to pathology the rate at which the however, injecting parathyroid type of breast cancer some patients have in whites with sudden testing and the third disease develops demonstrated hormone, along with resistant to standard their systems due to cardiac arrest over a to digital image and damages the no measurable injections of stem chemotherapy. In previous transplants 10-year period. The analysis. Operated gastrointestinal difference. Obesity cells. The combination animal models, the or exposure to blood effort represents by the Biobank and tract. The findings, is a global epidemic significantly enhanced resulting nanoparticle products. The findings the first scientific Translational Research published in The carrying increased stem cell migration enhanced MRIs of could help safeguard analysis to compare Core, the complex will Lancet, show that risks of diabetes, to bone fractures and breast tumors and transplanted the detailed medical enable Cedars-Sinai Dr. Ayesha Sherzai, co-director IBD actually may be cardiovascular increased formation of destroyed the cancer organs by enabling histories of patients patients to become of the Alzheimer’s Prevention a wider spectrum of disease, hypertension new, healthy bone. cells. If successful in doctors to plan of different races who part of a living Program, in the Cedars-Sinai bowel disorders than and several types of humans, this two- appropriate clinical were stricken by the laboratory, benefiting Biobank and Translational previously thought cancer. The World pronged attack could interventions. This fatal condition, which themselves and future Research Core complex and that genetic Health Organization produce positive approach also could kills about 350,000 generations. analysis might identify estimates that results with less avoid using costly Americans annually. patients who could 500 million adults damage to healthy immunotherapy to The study has benefit from earlier are obese. tissue than current suppress what might expanded to include interventions with therapies. be largely benign HLA Southern California. more aggressive antibodies. treatments.

20 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 21

A BOOST FOR SHALOM MEMORIES ARE RESEARCH WAIT STAPH LUNG RESEARCH SAFE CARE STEM CELLS HEART STRONG VISIONARY EDITING MADE OF THIS

Commonly The National Cedars-Sinai A major agreement The Cedars-Sinai Heart Using a revolutionary Memories are essential Investigators seek prescribed beta- Institutes of Health nurses will study advancing U.S.–Israeli Institute and Women’s gene-editing to our decisionmaking lactam antibiotics for has awarded a grant the transition of collaboration on stem Ischemia Syndrome technique called abilities, but why are to understand methicillin-resistant to Cedars-Sinai’s older adults from cell research was Evaluation (WISE) CRISPR/Cas9, Cedars- we so sure they are Staphylococcus Women’s Guild Lung the hospital to the signed at a Cedars- study are targeting Sinai scientists accurate? Seeking an the underlying aureus (MRSA) may Institute to investigate home with a grant Sinai event. The heart failure with removed the genetic answer, Cedars-Sinai worsen the condition, mechanisms driving from UniHealth pact, between the preserved ejection mutation that causes investigators have mechanisms that according to findings pulmonary fibrosis, Foundation. The California Institute for fraction (HFpEF), retinitis pigmentosa, identified a unique by Cedars-Sinai a poorly understood Systems Addressing Regenerative Medicine an all-too-common an inherited eye set of neurons in the cause various scientists. These disorder. The effort Frail Elders (SAFE) and Israel’s Ministry of condition that leads to disease that can lead medial temporal lobe, findings pose a aims to improve Care study is a nurse- Science, Technology extreme fatigue and to blindness. This the brain’s memory- lung diseases, potential dilemma understanding of led, interprofessional and Space, provides breathing difficulties. condition currently processing plant for for physicians the role that beta- initiative that rapidly a new framework HFpEF predominantly has no known cure facts and events. The and ultimately because the overall arrestin proteins identifies and provides to foster global affects women but and affects some study, published in effectiveness of beta- play in regulating inpatient care to partnerships and joint also occurs in men 80,000 people in the Nature Neuroscience, translate those lactam treatments lung inflammation high-risk older adults funding opportunities with diabetes, obesity U.S. Animal models recorded electrical frequently makes and scarring. The and helps support in regenerative and hypertension. The were engineered signals of 1,049 findings to these antibiotics the project could help their successful medicine. The institute, Heart Institute showed to exhibit inherited individual neurons first line of defense scientists turn beta- transition back into created by a 2004 that, weeks after blindness, and when in each of 28 improve patient when severe bacterial arrestins into targets the community. The statewide voter experimental infusions the mutated gene study volunteers infections are of for experimental 4-year-old program initiative, has provided of cardiac stem cells, causing blindness to reveal which health. unknown origin. therapies to treat has proven to reduce millions of dollars the heart-pumping was excised, retinal cells corresponded Further, culturing the lung-scarring lengths of stay to Cedars-Sinai and function of those degeneration was to memories, the MRSA can take a disease, for which as well as patient other institutions to with hypertension hindered and vision accuracy of memory day or more, making no cure currently complications. The develop new therapies and HFpEF returned improved. This retrieval and which early diagnosis exists. The work funding enables for deadly diseases to normal. The U.S. technique may lead to cells reported visual difficult. MRSA is builds upon previous Cedars-Sinai and disorders. Cedars- Food and Drug treating patients with information but were a virulent form of Lung Institute Nursing Research to Sinai’s selection as Administration has retinitis pigmentosa not influenced by staphylococcal discoveries that implement SAFE Care host for the signing awarded Cedars-Sinai and other genetic memory. While no infection that causes lack of beta-arrestin in three partnering affirms its role as clearance to apply for disorders. treatments for failing more than 11,000 genes demonstrated Magnet hospitals a key player in the technique’s use memory currently deaths per year. decreased lung throughout Los experimental stem in patients. WISE also exist, distinguishing fibrosis. An estimated Angeles County. The cell technology, which has begun a five-year these two types 140,000 Americans collaborations involve has shown promise clinical study of 120 of cells could help have pulmonary training nurses and in regenerating tissue women at risk for the future therapies fibrosis, which affects executives with the in bone fractures, condition, monitoring target the correct mainly middle-aged goal of sustaining and reversing heart them with cardiac MRI neurons for maximum and older people, and expanding the model attack damage and and a high-technology effectiveness. patients only survive to yet more hospitals. stimulating other types catheter that measures Dr. Victor Tapson, a pulmonary for three to five years of healing once limited pumping and resting medicine specialist, examines a patient. after diagnosis. to the imagination. heart functions.

22 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 23

BLADDER MATRIX MYSTERY MEDICAL A CLOSER LOOK COGNITION RESEARCH #SIDEEFFECTS BIOMARKERS GUT FEELINGS SOLVED CROSSOVERS AT EYE DISEASE CONSERVATION

The first-ever study A grant from the A disposable A study co-authored Even 10 years ago, A gene controlling Cedars-Sinai scientists Cedars-Sinai analyzing social U.S. Department of biosensor, developed by a Cedars-Sinai a gut physician and development of successfully tested media for data about Defense is helping at Cedars-Sinai to help lung expert revealed a joint specialist human macula has a new method for specialists gastrointestinal side a multidisciplinary doctors predict which how certain infectious might not have found been discovered in preserving cognition effects from narcotics Cedars-Sinai team abdominal surgery bacteria resist common ground investigations led in experimental collaborate was spearheaded develop biomarkers patients will experience antibiotic therapy. The beyond their shared by a retina specialist models of Alzheimer’s by the Cedars-Sinai for interstitial cystitis, postoperative results could open up drive to improve at the Cedars-Sinai disease using bone to distinguish Center for Outcomes also known as painful complications, has new approaches to health. Now, with Board of Governors marrow-derived Research and Education. bladder syndrome, a received approval from combating chronic the understanding Regenerative Medicine white blood cells. between Investigators reviewed condition affecting the FDA. This acoustic infections, especially that many immune- Institute. The macula, Immune cells are a vast collection of millions of people in gastrointestinal in patients with cystic mediated diseases the central portion of critical for healthy two diseases patient entries on the U.S. Interstitial surveillance biosensor fibrosis. The study share a genetic the retina, is needed brain function, but as Twitter and other cystitis patients monitors and assesses examined formation of architecture, Cedars- for normal vision. The Alzheimer’s disease with similar forums as well as typically experience intestinal activity biofilms, communities Sinai investigators findings represent progresses, they postings on health- serious pelvic pain to provide real- of bacteria encased in these areas are the culmination become defective. symptoms. related websites. They plus an urgent need time information in matrixes of combining their of more than two The study found examined millions of to urinate as often for better-informed organic compounds expertise to address decades of work and that the number of tweets and hundreds as 30 times during feeding decisions. known as polymers. both Crohn’s ultimately required immune cells passing of thousands of posts the day and 20 Scientists found Experiments showed disease — a form an international team through the blood with keywords such as times at night. The that the biosensor that the viruses piece of inflammatory of 20 investigators, and brain increased “pain meds,” “bloating” team is comparing predicted the together polymers bowel disease — and who used data from and that immune and “nausea.” They urine samples of abdominal condition into highly ordered, ankylosing spondylitis, the Human Genome cells infiltrating the also searched for interstitial cystitis with more than 80 liquid crystals to an inflammatory spine Project and computer brain from the blood references to several patients treated at percent accuracy, shelter them from disorder. The scientists analysis to identify resisted abnormalities pain-controlling the Cedars-Sinai allowing physicians to antibiotic attacks. have found that some mutations that associated with narcotics. Analysis Center for Women’s confidently delay food This way, infectious Crohn’s patients have cause North Carolina Alzheimer’s, providing of these unfiltered Continence and Pelvic intake when necessary. bacteria can survive genetics closer to macular dystrophy, an encouraging step sentiments revealed Health with control Patients not at risk for to produce lingering people with ankylosing which prevents toward human trials that many people group samples. The digestive difficulties infections, and even spondylitis than are macular formation. to further test these using narcotics investigators are can begin eating, cling to catheters and found in others with Understanding how treatment strategies. for pain relief are seeking biomarkers which promotes other medical devices the same disease — the gene works not warned about to improve diagnosis, faster wound healing. to spread disease to and vice versa. The could put improved potential side effects. predict chances of Previously, no reliable other patients. team is exploring treatments for Dr. Nancy Sicotte, director of the Some patients also symptom recurrence means existed treatments that can macular diseases Multiple Sclerosis Program, and turn to over-the- and identify for prospectively benefit both groups of within sight. Dr. Michael Weisman, director of counter remedies therapeutic targets for diagnosing patients. Importantly, the Division of Rheumatology or other solutions future clinical trials. postoperative the physicians also of unproven value abdominal are finding out which without first complications. therapies should be consulting physicians. avoided in treating certain patients.

24 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 25

SMOKING GUN FOR PANCREATIC BIOINFORMATICS NANODRUG’S BIRTH OF RESEARCH CANCER BOUNTY MODEL BEHAVIOR BIG POTENTIAL HEART DISEASE BETTER WITH AGE MAP OF THE BACK

Cigarette smoking As part of the Historically, patients A grant from the Preterm delivery Stem cell models A major, longstanding Investigators can cause pancreatic International with glioblastoma National Cancer and other adverse used for studying challenge in cancer, and a multi- Cancer Genome multiforme — the Institute will facilitate pregnancy outcomes amyotrophic lateral diagnosing back have found that center study led by Consortium, the most aggressive type development of significantly increase sclerosis (ALS) may disorders has been Cedars-Sinai scientists Cedars-Sinai Center of brain tumor — new generations the potential be improved by aging pinpointing the immune cells demonstrates for Bioinformatics and have a survival rate of nanomedicines for women’s motor neurons to exact disc causing a how. The study Functional Genomics of just 14 – 15 months that reduce harmful cardiovascular show how the disease patient’s pain. Now in the brain also uncovered a is participating in the after diagnosis. Now, side effects of anti- disease. Cedars- damages cells later an advanced imaging potential treatment largest-ever effort to scientists in the cancer drugs. Such Sinai researchers are in life. Cedars-Sinai technique and the play a direct for the lethal disease. systematically analyze Cedars-Sinai Center submicroscopic examining how these scientists are building power of precision The investigators cancerous tumors. for Neurosurgical therapies attack the outcomes can be used an enhanced model medicine are giving role in the developed mouse The project leverages Outcomes Research cancer cells directly, to identify women at of ALS by creating doctors a detailed models that showed secure, cloud-based are harnessing big leaving surrounding risk so that appropriate induced pluripotent roadmap to spinal development development services to analyze data and virtual non-tumor cells intact. prevention strategies stem cells (iPSCs) symptoms. The of pancreatic vast quantities of modeling to create a Cedars-Sinai scientists can be implemented. derived from patients’ approach, developed of ALS. adenocarcinoma genetic data. The comprehensive profile are focusing on forms For new mothers skin cells. For ALS, at Cedars-Sinai, precursors. When center also ensures of each individual’s of the disease that who deliver early the process is used employs a biomarker exposed to cigarette optimal computing cancer, furthering the have a poor prognosis and agree to join the to grow and examine associated with disc smoke, cancerous cells speed by running quest for personalized or against which study, blood is drawn iPSC-derived motor degeneration that grew and multiplied. different sections treatments of this current therapies are and vascular testing neurons. To help is tracked with a Fortunately, a drug, of the genome pernicious disease. mostly ineffective. performed. Additional age the cells, the sophisticated MRI suberoylanilide across hundreds of The process starts Nanodrugs have been tests are conducted group identified a imaging platform. hydroxamic acid, computer servers at with a biopsy to shown to successfully six months later. series of genetic With a precision can counter this once. Maximizing new obtain cells from the treat tumors that Using leading-edge markers to assess medicine approach, destructive process. technologies allows brain tumor that are originate in the brain technology, scientists cell maturity. No investigators use When administered to Cedars-Sinai experts grown and used to as well as certain are searching for treatment currently induced pluripotent experimental animals, to investigate changes build a mathematical metastatic breast biochemical markers exists for ALS, and stem cells derived the drug reversed across thousands model of the tumor. cancers. Nanoimaging as well as examining most patients suffer from a patient’s own effects of smoking of cells within an By running the MRI diagnostic blood pressure and paralysis and usually skin to engineer and suppressed affected tissue — virtual tumor through agents engineered cholesterol levels. The succumb to the skeletal tissue repair, development of or across thousands genomic sequencing, at Cedars-Sinai carry project also accurately disease within five and are assessing this pancreatic cancer. of people. the scientists can test the potential to assesses blood-vessel years of diagnosis. method as a back for millions of genetic replace invasive tissue health noninvasively. pain therapy. mutations. Once the biopsies — particularly Data generated by this Dr. Robert Baloh, director of cellular culprits are in patients with National Institutes of Neuromuscular Medicine in the discovered, the team multiple brain lesions. Health-funded study Department of Neurology and the can devise treatments will help create a multidisciplinary ALS Program that target only the heart disease risk- abnormal proteins stratification system driving the cancer. for women of childbearing age.

26 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 27 ANTI- INFLAMMATORY HEALTHCARE SURVIVAL MATERNAL DOUBLE DOWN ON BANANAS ABOUT RESEARCH ACCELERATOR STRATEGY INSTINCT DAMAGE CONTROL HEART STEM CELLS A PROTEIN HOPE AGAINST DMD

The health system Cedars-Sinai Each year, A rheumatoid arthritis Through technologies A banana-shaped Scientists at the The Cedars-Sinai launched an extremely investigators have approximately 50,000 drug may prevent previously developed molecule discovered Cedars-Sinai Heart successful startup discovered an anti- American women artery damage at the Cedars-Sinai by investigators at Institute have devised Accelerator, incubator program inflammatory survival experience pregnancy from Kawasaki Heart Institute, the Cedars-Sinai a novel therapeutic in collaboration with strategy employed complications — disease, the most investigators Heart Institute may approach that might powered by the global company by bacteria that including hypertension, commonly acquired have shown that hold the key to slow or even reverse Techstars to foster could potentially be sepsis and cardiac disorder in therapeutic stem- predicting heart the muscle-destroying Techstars, innovations to improve applied to treating hemorrhaging — that children in the U.S., cell-based tissue failure. Dubbed the process of Duchenne patient outcomes. inflammatory diseases put mother and baby affecting nearly regeneration is “banana protein” but muscular dystrophy fosters startup Cedars-Sinai medical in people. In Cell at risk for serious 4,000 children each effective. Two clinical scientifically known (DMD). DMD primarily and scientific Host & Microbe, illness and even year. Cedars-Sinai trials are underway as BIN1, the molecule affects males, robbing companies and experts mentored they explain that death. Cedars-Sinai investigators found to examine the use plays a significant them of their ability young companies invading bacteria face led a study of women that administering of cardiac-derived role in disease and to walk and leaving innovations in whose ideas have many of the same suffering from the anakinra — a drug stem cells to repair in the strength of them with an average the potential to challenges as humans most severe maternal for rheumatoid or reverse damage to contraction during life expectancy of patient care. transform health and with inflammatory illnesses and found that arthritis — reduced cardiovascular tissue. a heartbeat. BIN1 just 25 years. Most healthcare delivery. diseases do. The 41 percent of these coronary artery One trial infuses can be detected in DMD studies focus Faculty members findings represent an mothers deliver early, inflammation and stem cells into heart the bloodstream, so on skeletal muscle and executives important step toward and, of the women who injury and abdominal attack patients to scientists developed deterioration, worked closely with developing effective experienced placental aortic aneurysms in assess whether the a test to use it to but the disease entrepreneurs at treatments for hemorrhaging, animal models. The treatment decreases identify cardiac inexorably weakens the 10,000-square- inflammatory diseases 63 percent had cause of Kawasaki heart muscle damage disease. The Heart cardiac muscle, foot Cedars-Sinai such as diabetes, previously given birth disease is unknown, and improves Institute team aims culminating in heart Innovation Space. rheumatoid arthritis via cesarean section and the disorder cardiac function. to obtain Food and failure. Investigators Selected companies and pulmonary and experienced typically is preceded The other study Drug Administration discovered that began mentorships in emphysema that a higher rate of by fever and produces investigates whether approval for the blood mice with muscular March and presented affect millions placental abnormality, inflammation and cardiac-derived test so physicians dystrophy benefit to potential investors worldwide. Current suggesting that injury of blood vessels. stem cells can be can use it to help strikingly from and the public during treatments for Crohn’s placental hemorrhage Life-threatening used to treat dilated determine heart treatment with cardiac a demonstration day disease, hepatitis and strongly correlates with complications may cardiomyopathy, a health and forecast stem cells. This work in June. Selected other inflammatory early births. Results occur, including condition in which patient outcomes. at Cedars-Sinai from nearly 500 conditions are of the study suggest aneurysms that can the heart’s pumping The investigators also forms the basis for applicants worldwide, aimed at diminishing avoiding unnecessary lead to thrombosis ability is compromised are studying methods a clinical trial — Halt the inaugural class symptoms but may cesarean section (blood clots), stenosis as the left ventricle to restore or replace cardiomyOPathy featured 11 startup not address the root delivery and ensuring (artery narrowing) or is enlarged and BIN1 as a potential progrEssion (HOPE) Dr. Brennan Spiegel, director companies, all of which cause or prompt quality hospital care for aortic rupture. weakened. treatment for Duchenne — that is of Health Services Research at signed commercial inflammation to symptomatic mothers heart failure. the first to examine Cedars-Sinai, is leading studies into agreements with subside. to manage their health whether cardiac stem whether virtual reality goggles can Cedars-Sinai. and that of their cell therapy can reverse ease patients’ stress. premature babies. heart muscle damage from the disease.

28 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 29

COMMUNITY OUTREACH HERE: Students at Arlington Heights Elementary have fun learning about healthy food choices with Cedars-Sinai Healthy Habits Coordinator Angela Armijo.

NOW: $695,634,000 CONTRIBUTION FOR COMMUNITY BENEFIT 33 PARTNERSHIPS WITH COMMUNITY CLINICS $5,000,000 TO LOS ANGELES NONPROFITS TO IMPROVE COMMUNITY CLINICS AND MENTAL HEALTHCARE >25,000 ADULT AND SENIOR ENCOUNTERS IN COMMUNITY EDUCATION SCREENING/ IMMUNIZATION PROGRAMS AND HEALTH FAIRS

CEDARS-SINAI 31

STRENGTHENING COMMUNITY GRANTS AID STOP DOMESTIC TRAUMA SUPPORT L.A.’S HEALTH SUPERMARKET NO LANGUAGE OUTREACH L.A.’S HOMELESS VIOLENCE TO SCHOOLS SAFETY NET SWEEP SWIM COACH-ING BARRIER TO CARE

While Los Angeles A grant from Cedars- Students at 28 Cedars-Sinai Choose the most To help celebrate Hypertension, “Our goal is to grapples with a Sinai enables the elementary, middle and has launched colorful fruits and the newly reopened diabetes and heart growing homelessness Los Angeles LGBT high schools in the a multifaceted vegetables. Resist 109th Street Pool disease are among the give more kids crisis, Cedars-Sinai Center to meet the Los Angeles Unified initiative to help high-sugar impulse in Watts, a team major health issues is providing financial complex needs of School District L.A.’s community buys. Read food labels from Cedars-Sinai facing older Korean access to public support to a number domestic violence received essential, clinics better serve carefully and go for COACH for Kids® — Americans. A team of of local nonprofit survivors. The funding on-site support from those in greatest the products with the a program of the Cedars-Sinai nurses, pools so they organizations that bolsters the center’s the Cedars-Sinai Share need and alleviate fewest ingredients. Maxine Dunitz doctors and support address the health comprehensive STOP and Care program, health disparities These are some of Children’s Health staff provided free can increase needs of homeless Partner Abuse/ care that teachers are across Los Angeles. the tips South Los Center — distributed health screenings individuals. Among Violence Program. not trained to deliver. The Community Angeles residents hundreds of free and flu shots in their physical recipients of 2016 Cedars-Sinai’s support The rising demand Clinic Initiative: took home from a swimsuits in Koreatown, breaking grants totaling nearly comes at a time when for psychological Strengthening L.A.’s grocery store tour at partnership with the down a language activity.” $400,000 were state and federal aid services for students Safety Net focuses a Ralphs supermarket, Children’s Health barrier that often Step Up on Second, for domestic violence coincides with a steep on major projects to offered by the Fund. COACH health prevents residents — Michele Rigsby Pauley, RN, a multisite housing programs — which decline in state funding enhance leadership Cedars-Sinai Healthy educators also from receiving the MSN, CPNP, program director agency that provides has never been for school-based and effectiveness in Habits program in provided children healthcare they need. of Cedars-Sinai COACH for Kids street-based health substantial for the counseling. Cedars- Federally Qualified collaboration with the with sunscreen and Korean-speaking services to individuals LGBT community — Sinai counselors teach Health Centers and Los Angeles Urban shared information Cedars-Sinai staff experiencing chronic has declined anger management “lookalike” clinics. League. About 18 with families about put community homelessness; United precipitously. Among and social skills, and Cedars-Sinai provided women participated in sun and pool safety. members at ease, Way, to support those assisted were a use art therapy and $2.28 million in the two-part program, The event was just answering questions the organization’s transgender woman other methods to help funding to help which began with a one of numerous and providing blood comprehensive efforts who has since parents and students enhance local clinics’ classroom session summer gatherings pressure, cholesterol to move the chronically escaped her abusive cope with issues such capabilities with at Sunnyside Baptist and health fairs in low- and blood glucose homeless into partner, holds a as bullying, divorce and yearlong programs Church and concluded income Los Angeles tests to the 212 people permanent housing; steady job and plans incarcerated parents. in three key areas: with hands-on neighborhoods at who took advantage New Directions for to attend college. The The free services quality improvement, education at Ralphs, which COACH gave of the event, which Veterans, for mental LGBT Center is one are an extension leadership and learning how to read away thousands was sponsored by health services for of nearly two dozen of Cedars-Sinai’s financial strength. food labels and make of swimsuits while the Los Angeles homeless veterans nonprofit community decades-old Share and Community clinics healthy choices on offering tips on how Koreatown Senior or those at risk of organizations across Care program, which in L.A. County care a budget. to enjoy fun in the and Community homelessness; and Los Angeles receiving provides numerous for about 1.4 million sun safely. COACH Center, Cedars-Sinai JWCH Institute, to Cedars-Sinai grants to services to district patients who are provides no-cost and the Los Angeles support expansion of expand free or low- schools, including a among our most services to thousands Department of Aging. a new clinic in an area cost mental health new effort to retain vulnerable residents. of families living where the need for services. teachers who may without access to Kids celebrate the newly reopened homeless healthcare suffer burnout during essential medical 109th Street Pool in Watts with services far exceeds their first two years care and basic social free swimsuits distributed by capacity. on the job. services throughout Cedars-Sinai COACH for Kids. Los Angeles County.

32 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 33

BRAINWORKS COMMUNITY LATINO HEALTH GOALS FOR COLON CANCER HEALTHCARE INSPIRES YOUNG SURGERY OUTREACH IN FOCUS FINANCIAL AID END OF LIFE EDUCATION CAREERS UP CLOSE SCIENTISTS SIMULATION

Nearly 500 Cedars- As a not-for-profit “Who Shall Live and The American Cancer The Cedars-Sinai Nearly 200 middle The 10,000-square- Cedars-Sinai Sinai physicians, academic health Who Shall Die and Society estimates that Youth Employment school students foot Women’s Guild nurses, dietitians, system, Cedars- Who Decides?” That 17,240 new cases of and Development experienced up-close Simulation Center and the pharmacists, Sinai is committed was the subject of a colorectal cancer will (YED) program science opportunities for Advanced Clinical podiatrists and to providing Yom Kippur discussion be diagnosed among welcomed 45 Fairfax at Cedars-Sinai’s 18th Skills regularly gives Los Angeles educators staffed compassionate, at Temple Emanuel African Americans High School students, annual Brainworks students from Los Telemundo 52– quality healthcare of Beverly Hills, in 2016. In fact, this the latest high school program. The event Angeles-area schools Rams host KVEA’s 12th annual to everyone in the just one of the Los population is more juniors and seniors featured numerous a chance to experience Health and Wellness community, regardless Angeles community likely to die from whom YED has learning stations, something more events that Fair at the Los of their ability to pay. organizations colorectal cancer helped prepare for including virtual challenging than Angeles Convention Cedars-Sinai offers that Cedars-Sinai than any other ethnic college and careers surgery with 3-D dissecting frogs in encourage Center. Cedars-Sinai financial assistance collaborates with to group, due largely to in healthcare over imaging, microscopes biology class. Among provided 6,400 health to eligible community make advance care the lack of access to the past 23 years. and a phantom those taking advantage young fans to screenings at the fair, members who cannot planning a standard care and the stigma Participating students skull; surgical of the opportunity the largest of the afford to pay for their part of healthcare. associated with earn money while job- instrumentation; was a group of some be active for many community care, including the Such forums are an screening. Cedars- shadowing Cedars- neuropathology 45 students from events Cedars- uninsured and those opportunity for the Sinai is attacking Sinai employees in with microscope Francisco Bravo at least 60 Sinai participates in with limited means. public to learn about the disease with departments across slides of various Medical Magnet throughout the year. The unreimbursed tough but important education. Experts the medical center tumors; rehabilitation, High School in Boyle minutes a day. Cedars-Sinai COACH cost of providing end-of-life discussions from the medical as part of the two- where students Heights, who got for Kids® — a program direct medical care and how to complete center visited Temple year program, a learned therapeutic a firsthand look at of the Maxine Dunitz for the poor and advance healthcare Church of God in collaboration of applications for brain how surgical teams Children’s Health underserved in directives. Community Christ and other Cedars-Sinai, Fairfax tumor patients; brain troubleshoot in the Center — offered FY2016 exceeded members also heard African-American High, Los Angeles and spine surgical operating room. The immunizations, $93.5 million. about the challenges institutions across Unified School instruments; and teenagers — who were weighed and and responsibilities Los Angeles to deliver District and the advanced research, assigned the roles of measured children, physicians face the message that the Regional Occupational where students surgeons, nurses and and provided nutrition in caring for the disease is preventable Program. Some learned about sheep anesthesiologists in the education. Blood terminally ill. The and that screening is 70 percent of YED brains. For the first simulated operating Donor Services and effort by Cedars-Sinai harmless and can students graduate time, Brainworks also room — had to figure the Breast Cancer Risk physicians and local save lives. from college and used the Women’s out quickly why a Reduction Program religious leaders was pursue careers in Guild Simulation baby’s oxygen level also took part, as inspired by stories healthcare, with Center for Advanced suddenly dropped. did Cedars-Sinai out of La Crosse, many landing jobs at Clinical Skills, where They also practiced researchers, who Wisconsin, where Cedars-Sinai. students practiced surgery on virtual Six hundred participants from surveyed attendees some 96 percent medicine on a reality simulators, Cienega Elementary School on their healthcare of residents have “patient” with real- learned CPR and in Los Angeles helped kick off decisionmaking put their end-of-life life features such as interacted with a the inaugural Play 60 Challenge process. wishes in writing. breathing and blinking. mannequin that talks, Assembly Program, sponsored breathes and bleeds. by Cedars-Sinai and the Los Angeles Rams.

34 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 35

COMMUNITY CALMER ONE-STOP SERVICE RAMS JOIN TEEN RESEARCH PLAN AHEAD OUTREACH CLASSROOMS SCREEN SAVER FOR OLDER ADULTS THE TEAM SCENE FOR SAFETY A GOOD FIT

Tibetan singing More than 115 people Older adults received The Los Angeles Nineteen high school How do you stay safe Los Angeles Head and neck bowls. Native received free head free blood pressure, Rams have become students from during an earthquake elementary school American talking and neck cancer cholesterol and official partners throughout Southern or other disaster? teachers learned cancers can sticks. Feathers and screenings performed blood glucose with Cedars-Sinai California participated And how do you how to make fitness beads. These are the by physicians from the screenings from a in promoting health in the fourth annual create an emergency more fun for students be symptom- rather unusual tools Cedars-Sinai Samuel team of 35 Cedars- and wellness in local Research Week, kit that takes into during a free, daylong the team from the Oschin Comprehensive Sinai healthcare communities. The a program of the account your health seminar on physical free, so doctors Cedars-Sinai Share Cancer Institute and professionals during partnership includes Cedars-Sinai Board needs? These are the education training and Care program the Department of the 14th annual community outreach of Governors questions members of provided by Cedars- recommend takes to stress- Surgery as well as West Hollywood programs highlighting Regenerative Medicine Disaster Preparedness Sinai. About 75 reduction workshops the medical center’s Senior Health Fair the importance of Institute that gives and Response at educators participated regular screenings. for new Los Angeles dental residents. at Plummer Park exercise, healthy young scholars hands- Cedars-Sinai and in the training, Unified School Medical professionals Community Center. eating, preventive on exposure to stem the medical center’s led by a facilitator Cedars-Sinai District teachers. recommend that Cedars-Sinai also healthcare and health cell research. More Environmental from Coordinated The workshops — adults undergo provided podiatry education for school- than 40 students from Health and Safety Approach to physicians part of three regular screenings screenings, nutrition age children as well 16 schools applied department helped Child Health, weeklong summer for head and neck counseling and as adults. The Rams for the program, answer at health fairs an organization performed free training events for cancers, which occur education on stroke and Cedars-Sinai also the culmination of a around L.A. They dedicated to teachers — were in more than 50,000 prevention. The are co-hosting events yearlong outreach provided information preventing childhood examinations spun out of the Share Americans annually. event is a vital link as part of Play 60, effort. Participants, about how long obesity. The teachers and Care art therapy The most common to health services for the NFL’s national who were chosen medications last came primarily from for more than program offered by types are throat, older adults who are youth health and by Cedars-Sinai without refrigeration, the 15 Mid-City Cedars-Sinai at 28 larynx, tongue and underinsured and face fitness campaign that Volunteer Services how to control elementary schools 115 people. Los Angeles schools. thyroid cancers, but other challenges that focuses on increasing and the Cedars-Sinai diabetes through diet that the Cedars-Sinai Participants learned malignancies also limit access to care. the wellness of young Youth Employment if medications run Healthy Habits program tips such as getting can occur in the nasal fans by encouraging and Development out and how to plan partners with to enough rest and cavities, sinuses, lips, them to be active for program, conducted ahead for alternative provide workshops confiding in a friend mouth and salivary at least 60 minutes a experiments using places to receive on nutrition and when the going gets glands. While many day. In addition, at all state-of-the art dialysis. fitness. The training, tough. Teachers cases are without Rams home games, equipment, attended which included a also learned how to symptoms, others can Cedars-Sinai sponsors scientific lectures and rigorous workout use unconventional include a neck lump, the Kids Zone, an presented the results for the teachers tools to create a persistent sore throat, interactive play area of their investigations. themselves, also calm classroom hoarseness, pain just outside the Los inspired participants atmosphere, which when swallowing Angeles Memorial to find their own ways has the potential or unexplained Coliseum. of engaging kids in to reduce stress weight loss. indoor and outdoor Dr. Allen Ho, director of the for students and physical activities Head and Neck Cancer Program, staff alike. at school. performs a free head and neck cancer screening.

36 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 37

EDUCATION HERE: Medical residents gain valuable experience through rotations at free clinics throughout Los Angeles, including the Saban Community Clinic.

NOW: 15 RESIDENCY PROGRAMS 74 FELLOWSHIP PROGRAMS 944 MEDICAL STUDENTS ON ROTATIONS IN 11 DEPARTMENTS 125 NURSING RESIDENTS TRAINED

CEDARS-SINAI 39

STRENGTH IN DEGREES OF SCHOLARLY OPERATION UNDER EDUCATION NUMBERS GROWTH EXPANDED SCOPE ASK A LIBRARIAN PURSUITS LEADERSHIP ADVISEMENT

Educating future Cedars-Sinai’s By nearly every A pilot project with Residents, fellows and The Cedars-Sinai Key Cedars-Sinai This year’s clinicians and medical dynamic graduate metric, the third Inter- the departments of young faculty who Medical Staff personnel are taking scientists is a vital school, which trains Institutional Graduate Internal Medicine and are transitioning to Leadership part in the Advisory Graduate part of Cedars- scientists to pursue Research Symposium Surgery embedded clinical science receive Development Board Fellowship, an Sinai’s mission as an discoveries that shed at Cedars-Sinai was a librarian from two years of valuable Program welcomed 18-month, MBA-style Symposium was academic medical light on diseases and the best yet. The the Cedars-Sinai training through the 28 participants. The program aimed at center. Medical inspire new therapies, all-day symposium, Medical Library Cedars-Sinai Clinical program introduces helping healthcare the largest yet, students completed added a master’s sponsored by the into a patient care Scholars Program, participants to leaders stay ready nearly 950 rotations in program in Biomedical Cedars-Sinai Graduate team. The librarian which welcomed practical insights to confront the drawing 100 11 departments during Science and Program in Biomedical reviewed current its largest incoming provided by challenges posed by FY2016, while more Translational Medicine. Science and literature to provide class in three years. department chairs, a rapidly changing participants than 400 residents The two-year degree Translational Medicine, the healthcare team The program offers members of the medical landscape. and fellows joined allows participants to drew 100 participants, with relevant studies career guidance, Medical Executive Topics addressed from 10 higher- Cedars-Sinai’s highly continue working full who had opportunities to support evidence- skills acquisition, Committee and include improving competitive training time while pursuing to network with based medicine. In and a curriculum in medical staff care while reducing learning programs that span in their studies. In their speakers, share ideas addition, the library translational medicine leadership. The hospital stays and excess of 50 specialty first year, master’s and research, and offered classes on and clinical research. curriculum, delivered enhancing the institutions. and subspecialty and doctoral students collect career advice. preparing to publish, This year, it added a through monthly synergy of office- areas. These future take the same In addition to two research analysis, new course of study lectures, emphasizes support functions. The physicians and courses, learning keynote speeches, and citation retrieval in health services the basics of Cedars- fellowships are offered investigators gain the fundamentals of the agenda included and management. research, a scientific Sinai medical staff though The Advisory exposure to a wide biomedical research expert panels, two The library continues discipline devoted to governance and Board Company, range of procedures, and how to translate poster sessions to expand its digital improving efficiency understanding of which combines patient populations, that work into tangible and several student holdings to meet the in healthcare delivery. the organizational research, technology state-of-the-art therapeutics. During presentations. needs of clinicians, Participants submit structure and and consulting equipment and novel the second year, Awards were given researchers and a funding proposal operations of the services to improve research protocols working with mentors, for the best student educators throughout for a research medical center. The the performance as well as academic both groups choose research. Students Cedars-Sinai, now project, which is program also discusses of healthcare faculty who provide research projects were urged to eschew providing access to then supervised by how Cedars-Sinai organizations around both mentorship and to satisfy degree “easy, facile” online more than 23,465 a mentor. Recent can best prepare for the world. Cedars- leadership. Cedars- requirements. But data searches and e-journals and nearly projects included changes in healthcare. Sinai is currently one Sinai also offers an while PhD candidates instead seek out 20,000 e-books. studies that sought Participants manage of the more than innovative Clinical have several years original studies. Ten It also supports to make radiation a project that allows 5,200 organizations Scholars Program that to complete their California institutions clinicians with more effective against them to apply the partnering with Cedars-Sinai graduate student supports residents, projects, master’s of higher learning mobile apps that cancer, prevent tools and concepts the firm to improve Hannah Park at the third fellows and young students have just took part in the event, improve access to organ rejection in learned in the program. healthcare services, Inter-Institutional Graduate faculty who aspire one, so their projects which is expected library content at transplants, measure They’re also offered value and efficiency. Research Symposium to become clinical are more modest in to expand in scope the point-of-care risk for cardiovascular continuing medical scientists. scope while remaining and participation in decisionmaking disease and treat education credits and rigorous. subsequent years. process. angina. significant networking opportunities.

40 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 41

PRIMARY CARE MULTINATIONAL GREAT PERIOPERATIVE SMELLS LIKE LEAN INTO SIMULATED EDUCATION PATHWAY COOPERATION EXPECTATIONS PREPARATION TEAM SPIRIT HEALTHCARE SCENARIOS

The Internal Medicine Biomedical research Seven students In perioperative A 10-week, 30-shift More than 200 The Women’s Guild New interns, Residency offers a has gone global, received doctorates care, the nurse’s role Pediatric Intensive Cedars-Sinai Simulation Center primary care pathway with multinational at the fourth begins at admission, Care Unit (PICU) employees enrolled in for Advanced Clinical residents designed to teach teams cooperating on commencement of includes preparing training class included Lean for Healthcare Skills enables new the unique aspects of large-scale studies. the Cedars-Sinai the patient physically five additional nurses courses to enhance interns, residents and and nursing outpatient medicine To keep ahead of Graduate Program in and emotionally for from Cedars-Sinai their ability to identify, nursing graduates to and population health the curve, Cedars- Biomedical Science surgery, extends who were chosen for quantify and eliminate practice their clinical graduates that are essential Sinai built a research and Translational through the procedure their positive team wasteful workplace and communications in the dramatically consortium that Medicine. Powerful and lasts until the spirit and desire for practices — and skills before working practice their evolving healthcare reaches throughout messages delivered patient is ready to continuous learning. benefit patients. with real patients. A system. Residents Central and Eastern during the ceremony return home. The The class requires an Based on the Toyota two-day experience clinical and choose among a Europe. Known reminded graduates aim is to help ensure 18-month commitment Production System teaches newly community-based as the Regional to shun shoddy a positive patient to working in the and increasingly minted doctors to communications indigent patient clinic, Cooperation for science, cast skeptical experience at every PICU. The unit adopted by healthcare use resuscitation a full-service Veterans Health, Science and eyes on published stage, resulting in provides an ideal providers to improve equipment, work skills before Administration Technology (RECOOP research and embrace optimal outcomes. training ground, as it efficiency and with needles, drill outpatient clinic or a HST) Association, the unexpected. Cedars-Sinai is a cares for more than effectiveness, the into bone, monitor working with large, multispecialty the partnership The students were leader in perioperative 400 infants, children classes are aimed at simulated patients medical group to includes 15 higher reminded that training, and, this and adolescents each leaders and staff — in cardiac distress real patients. serve as home base, education, healthcare medicine is a high past year, the medical year. Nurses gain from nurses to lab and manage sepsis. where they receive and research calling, that serious center partnered experience in aiding techs — who work The opportunity to ongoing mentorship. organizations in eight laboratory research with California State patients who are directly or indirectly train in a risk-free All Cedars-Sinai countries: Croatia, is tremendously University, Los undergoing treatment with patients. Trainees environment helps primary care Czech Republic, demanding and that Angeles, to offer two for conditions ranging learn how to break doctors and nurses residents have the Denmark, Hungary, they should not lose 10-week electives from asthma to complex tasks into build the confidence opportunity to train Poland, Romania, sight of scientific focusing on both cancer. The PICU manageable segments, to deal with actual at multiple sites to Slovak Republic and principles. The didactic and clinical is accredited by collect and analyze patients — and experience different Ukraine. This year, the graduate program practice, sponsored California Children’s data, and propose can result in lower patient populations association welcomed combines extensive by Cedars-Sinai’s Services, and Cedars- solutions based on stress when real-life and systems of its first administrative classroom learning Geri and Richard Sinai is designated the results. They “walk emergencies unfold. practice. They also fellow. RECOOP HST with long, rigorous Brawerman Nursing as a Pediatric Critical in patients’ shoes,” It also reinforces are introduced to investigators tackle hours of laboratory Institute. The first 10 Care Center by the prioritizing activities the collaborative extensivist medicine, a disorders such as work. It is accredited students graduated California Department of greatest value to spirit needed to newly defined field in prenatal health issues by the Western from the program in of Health. those the medical deliver effective care, internal medicine that and their effects on Association of Schools June 2016, with 20 center serves. Benefits including appreciating focuses on providing child health; obesity; and Colleges. more enrolling in include reduced nursing skills, as comprehensive and and metabolic, the fall. wait times for test nurses often serve as coordinated care to cardiovascular and results, elimination instructors during the patients with multiple neurodegenerative of unnecessary simulations. Dr. Deven Patel, a surgical resident, complex medical diseases. administrative steps in the Women’s Guild Simulation conditions. and improved safety. Center for Advanced Clinical Skills

42 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 43 THE CAMPAIGN FOR CEDARS-SINAI HERE: Generous donors to the Campaign for Cedars-Sinai provide the funding that sparks innovation and boosts Cedars-Sinai’s ability to improve the health of its community, from one generation to the next.

NOW: $600,000,000 CAMPAIGN GOAL BY 2018, THE BIGGEST FUNDRAISING EFFORT IN CEDARS-SINAI'S HISTORY 5,245 NEW DONORS 8,411 GRATEFUL PATIENTS

CEDARS-SINAI 45

THE CAMPAIGN FOR CEDARS-SINAI OVERVIEW

Disease Prevention and Control Innovations in Healthcare and Technology Leading-edge, next-generation research Cedars-Sinai’s scientific mission is built on two Cedars-Sinai is pushing the frontiers of goals: finding cures and preventing disease. medicine, developing new technologies and leads to extraordinary patient care. The institution is committed to making innovations that change the way disease discoveries that quickly benefit people with is diagnosed and treated. Top scientists diabetes, cancer, heart disease and other in cardiology, cancer, neurosciences, The Campaign for Cedars-Sinai is ambitious — with the objective of illnesses. Its investigators and physicians work gastrointestinal disease, metabolic disease hard day after day to provide real solutions for and regenerative medicine routinely raising $600 million — but is built on a tradition of excellence. It’s a people confronting disease right now, while work together at Cedars-Sinai with the searching for ways to eliminate and prevent understanding that a breakthrough against legacy honored and cultivated each day throughout the medical center, these ailments in the future. one condition also may apply to many others. Nanotechnology, biomedical imaging, the community and, more and more frequently, the world. Research and Precision Health and Targeted Therapies reconstructing model organs from stem cells Health conditions often are referred to by a and precision approaches are among the unique discovery are central to this legacy. Leading-edge innovation expands single name, but the more science reveals about collaborations that transcend specific medical how diseases work and how they affect our specialties. Cedars-Sinai’s ability to provide excellent patient care that extends and bodies, the more clear it becomes that what is considered one disease may actually be Education and Training improves lives. dozens. Precision health at Cedars-Sinai is an Funding for education is essential to providing important tool to fight the many manifestations patient care that is based on the most current of cancer and other illnesses. The institution’s medical advances. More than 400 residents and As both a global leader and a community hospital, Cedars-Sinai investigators use genetics, new and developing fellows work and learn in over 35 accredited technologies, and data in innovative ways to training programs at Cedars-Sinai, and partners with dedicated supporters. Every breakthrough, every match the right treatment to the right patient at scientists in the PhD and master’s programs the right time for the best outcomes. are trained in the field of translational research, discovery, every improvement ultimately begins with donors. With taking discoveries from the laboratory bench Aging and Longevity to the patient bedside. These investigators support for key areas, clinicians and scientists can continue to pursue Treatments for cancer, diabetes and other will produce the insights and make the illnesses are becoming so effective that they are breakthroughs that will define the future of new treatments and technologies that shape the future of medicine. transforming what were once life-threatening medicine. diseases into chronic conditions. Still, while we The Campaign for Cedars-Sinai is a commitment to uphold and advance are living longer than ever, these added years can come with significant health challenges. the institution’s rich legacy of research, and honor the compassion and Cedars-Sinai is dedicated to making discoveries that will ensure that we live healthier, not just generosity of its donors. longer, lives. The institution’s vibrant scientific programs also are examining ailments that affect us as we age, including Alzheimer’s and cardiovascular disease.

46 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 47

THE CAMPAIGN FOR DISEASE PREVENTION PRECISION HEALTH AND FY2016 FUNDRAISING HIGHLIGHTS CEDARS-SINAI AND CONTROL TARGETED THERAPIES (July 1, 2015 – June 30, 2016)

Andrew and Patricia McIntyre Esper A. Petersen Foundation Andrew and Patricia McIntyre are longtime As therapists and philanthropists, husband and Giving back: Every gift counts: supporters of research into pediatric infectious wife Leslie Pam, PhD, and Ann Christie Petersen, 74 percent of donors 81 percent of donors diseases at Cedars-Sinai, and the work of PhD, have spent a lifetime fostering health in Moshe Arditi, MD, director of the Infectious and body and spirit. In gratitude for receiving “the are grateful patients. gave less than $250. Immunological Diseases Research Center and most amazing care,” when Pam was diagnosed the Division of Pediatric Infectious Diseases. with stage 4 lymphoma and with an eye toward His laboratory investigates innate immunity the future, the couple now supports research and host-pathogen interactions as they relate at Cedars-Sinai through the Esper A. Petersen to inflammatory diseases, with particular focus Foundation — named after Petersen’s father — as on the lungs and the cardiovascular system. well as annual gifts to cancer research. Their most Arditi’s research program has been at the recent gift went to health services research in cutting edge of advancing our knowledge of the rheumatology. The gift supports the development <$250 >$250 mechanisms behind infection-induced asthma, of a smartphone app for rheumatic disease pulmonary infections, atherosclerosis and patients and will help foster understanding of Kawasaki disease, the leading cause of acquired how mobile technology can empower patients heart disease among children in the U.S. and to better manage their symptoms, enhance developed countries. With support from donors their relationship with their healthcare provider, like the McIntyres, Cedars-Sinai aims to improve improve early detection of serious disease and the lives of countless children and give hope to positively influence health outcomes. millions of families worldwide. The Maurice Amado Foundation Revenue by source: Robert and Elaine Falk When Micah Amado was diagnosed with kidney (July 1, 2015 – June 30, 2016) For decades, Robert and Elaine Falk served as failure, his mother, Honey, helped Cedars-Sinai unofficial healthcare advocates for their family rescue him by donating her own kidney. Through Total raised in FY2016: $65,402,185 and friends, caring for them in times of need the Maurice Amado Foundation, Honey and her Total number of donors: 11,849 and helping them navigate medical institutions. late husband, Ralph, directed a gift to Cedars- The Falks recently took this caregiving to a Sinai to support kidney research. Honey directed new level by supporting research into heart a second gift for research, the Maurice Amado ■ INDIVIDUALS: 61% disease, stem cells and gastroenterology. They Foundation Kidney Transplant Research Fund in cite several reasons for investing, including Memory of Ralph Albert Amado. Both gifts have their personal connections to the institution, supported the work of Stanley C. Jordan, MD, the quality of care provided and the medical director of the Division of Nephrology, medical ■ FOUNDATIONS: 22% center’s acceptance of people from all director of the Kidney Transplant Program, backgrounds. Robert was treated at Cedars- and medical director of the Human Leukocyte Sinai following a heart attack, and Elaine’s Antigen and Transplant Immunology Laboratory. ■ ESTATES AND TRUSTS: 10% grandfather was a cantor at Cedars of Lebanon. Jordan is studying intravenous immunoglobulin “Cedars-Sinai is like the family who cares for therapy, a process that prevents the body from you and keeps you healthy, just like we’ve done attacking a newly transplanted kidney in highly ■ CORPORATIONS: 7% in our family,” Elaine says. sensitized patients, who comprise approximately 40 percent of all kidney-transplant recipients.

48 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 49

THE CAMPAIGN MILESTONE GIFTS FOR INNOVATIONS IN HEALTHCARE TO CEDARS‑SINAI CEDARS-SINAI AGING AND LONGEVITY AND TECHNOLOGY EDUCATION AND TRAINING (July 1, 2015 – June 30, 2016)

Joseph Drown Foundation Barbara Herman The Fleischaker Family Foundation Luke Wu-Jei Chang* The Joseph Drown Foundation, a longtime Longtime supporter Barbara Herman witnessed After receiving heart and kidney transplants at supporter of Cedars-Sinai, recently helped Cedars of Lebanon’s merger with Mt. Sinai Cedars-Sinai, Pam Fleischaker worked with her Patricia S. Gordon, MD, and Leonard F. Hill* fund Parkinson’s disease research at the Hospital and its subsequent growth into the loved ones to support the Fleischaker Family Board of Governors Regenerative Medicine world-renowned medical center known as Foundation Fellow in Heart Transplantation. Institute. Cedars-Sinai investigators study a Cedars-Sinai. More recently, she provided the Fleischaker had lived a productive life with Loretta and Victor Kaufman variety of neurological diseases using stem cell seeds for even more growth with a gift that a genetic condition that causes the walls of technology as their primary research tool. “We kicked off the campaign to raise $10 million the heart to thicken, restricting blood flow. Lippman Family Foundation are excited about the promise of regenerative for the Women’s Guild Simulation Center for At age 62, she had her first heart transplant medicine, and we recognize that Cedars-Sinai is Advanced Clinical Skills. Dedicated to training but never felt well. Six years later, she needed Vicki Reynolds Pepper and Murray Pepper particularly nimble in bringing new discoveries medical professionals with the newest tools and another heart as well as a kidney. That’s when to life in ways that offer maximum benefit to technology, the simulation center features fully she was referred to Cedars-Sinai. Speaking of Sheri and Marc Rapaport patients,” Joseph Drown Foundation President functioning operating rooms, an intensive care her family’s decision to support this fellowship, Wendy Wachtell says. Parkinson’s disease unit and a trauma treatment area populated she says: “We wanted to help other people and research stands to benefit greatly from stem by high-tech, lifelike mannequins that act as other families. It’s extraordinary what they do John F. Whelan cell technology, and, with philanthropic support, patients. In this realistic and rigorous training at Cedars-Sinai — and they do it really well and Cedars-Sinai scientists can make a major impact environment, more than 2,000 surgeons, with great care.” The Shuangwang Zhang Family on how the condition is diagnosed and treated. physicians, nurses and allied healthcare professionals receive training every month to Selkowitz Family Foundation * Deceased Vicki Reynolds Pepper and Murray Pepper master advanced skills. Diagnosed with lupus at age 16, Adam Selkowitz To help build a healthier future, Vicki Reynolds is committed to helping spare others from the Pepper and Murray Pepper established the Robert Wood Johnson Foundation effects of this chronic disease, in which the Vicki Reynolds Pepper and Murray Pepper As part of its efforts to build a culture of health, body’s immune system attacks normal, healthy Endowed Fund in Regenerative Medicine in the Robert Wood Johnson Foundation provided tissue. In 2000, working with Daniel J. Wallace, MD, honor of Simon and Rose Pepper. The fund a grant to Cedars-Sinai to explore how data associate director of the Cedars-Sinai supports the research of Clive Svendsen, PhD, generated in real time and in the real world can Rheumatology Fellowship Program, Selkowitz director of the Board of Governors Regenerative transform how we think about and experience launched the nonprofit Lupus LA, which Medicine Institute, and the Kerry and Simone health and healthcare. The grant supports the funds the work of the Cedars-Sinai Division of Vickar Family Foundation Distinguished Chair work of Brennan M. Spiegel, MD, director of Rheumatology. Recently, the Selkowitz Family in Regenerative Medicine at Cedars-Sinai. Health Services Research in Academic Affairs Foundation also made a leadership gift to Regarding what his mother and father would and Clinical Transformation, who is examining recruit lupus investigator Caroline Jefferies, think about the breakthroughs that will be whether the language people use in tweets to PhD, to Cedars-Sinai. “Lupus is a tricky disease, accomplished in their names, Pepper says: describe their health could provide clinically with many variations, and it can be an underdog “My parents always were interested in meaningful insights into a patient’s quality when it comes to funding,” Selkowitz explains. Cedars-Sinai but never really had enough of life. This innovation could ultimately help “What spoke to us about Cedars-Sinai was money during their lifetime to make a caregivers understand, in a cost-effective that it could have a local impact, and then meaningful gift. So I wanted to make this gift and timely manner, the comparative value grow into something else, something global.” in their name. They would be very pleased, of prescribed therapies and ensure patients Visit us online at giving.cedars-sinai.edu I’m sure.” receive the treatments most appropriate for to learn how you can partner with their individual needs. Cedars‑Sinai to improve patients’ lives.

50 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 51

THE NUMBERS FINANCIAL SNAPSHOT

JULY 1, 2015 – JUNE 30, 2016 INCOME AND EXPENSES 886 1,519 Revenue from patient care and other sources $ 3,262,577,000 LICENSED BEDS RESEARCH PROJECTS Expenses $ 2,879,764,000 Operating income $ 382,813,000 Gain on extinguishment of debt $ 6,144,000 Investment income $ (87,518,000) 254,668 12,057 Net income to reinvest in Cedars-Sinai’s mission $ 301,439,000 PATIENT DAYS FULL-TIME EMPLOYEES (approximately 698 per day) USES OF NET INCOME Long-term debt to be repaid $ 980,067,000 Capital expenditures for facilities, renovation, technology and other $ 164,570,000 751,920 2,156 This year’s payment on long-term debt $ 48,135,000 OUTPATIENT VISITS PHYSICIANS ON (approximately 2,060 per day) MEDICAL STAFF COMMUNITY BENEFIT CONTRIBUTION Unreimbursed cost of direct medical care for the poor and underserved$ 95,344,000 (excludes the unreimbursed cost of caring for Medicare patients) 49,690 473 Charity care ($14,779,000) ADMISSIONS ENROLLED RESIDENT Unreimbursed cost of caring for Medi-Cal patients ($78,937,000) AND FELLOW POSITIONS Unreimbursed cost of caring for patients in specialty government programs ($1,628,000) Unreimbursed cost of direct medical care for Medicare patients $ 315,627,000 Community benefit programs, charitable contributions, 89,371 2,843 and education and training for physicians and other health professionals $ 106,558,000 EMERGENCY VISITS VOLUNTEERS (includes hundreds of free community education and medical screening/immunization programs offered at the medical center and in local schools, homeless shelters and community centers) 173,425 Research programs (includes translational and clinical research and studies on healthcare delivery) VOLUNTEER HOURS Total cost of research $ 178,105,000 Research funding from grants ($102,003,000) 242,112 $695,634,000 Research net of funding from grants ($76,102,000) PATIENTS CARED FOR CONTRIBUTION FOR BY CEDARS‑SINAI COMMUNITY BENEFIT MEDICAL NETWORK Total quantifiable community benefit $ 695,634,000

52 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 53 5 39

210

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39 COMMUNITY OUTREACH WHERE PATIENT CARE EDUCATION Health and Education

WE ARE Locations and Affiliates Residents and Fellows Programs 27

Thousand 1 Cedars-Sinai Medical Center 1 Cedars-Sinai Medical Center CC Community Clinic Initiative 9 405 170 5 9 Oaks 10 Lancaster (50+ partners and 13 Palmdale 2 Marina Del Rey Hospital 9 Kerlan-Jobe 210 grantees) Orthopaedic Clinic BURBANK 3 California Rehabilitation CO Cedars-Sinai COACH 13 159 Institute 14 Children’s Dental Center for Kids (51 sites) 101 13 of Greater Los Angeles 9 4 Urgent Care (Beverly Hills PASADENA HH Cedars-Sinai Healthy Habits 134 and Culver City) 15 Eisner Pediatric Family (30 sites) GLENDALE 39 Medical Center 5 Cedars-Sinai Medical Group SC Cedars-Sinai Share and Care 101 210 and Cedars-Sinai 16 The KHEIR Center 2 (28 sites) Health Associates 210 30 17 Los Angeles Christian 27 (multiple locations) CH Cedars-Sinai Community Health Centers 66 Health and Education HOLLYWOOD 6 Primary Care, Culver City 5 ALHAMBRA 19 18 Planned Parenthood (17 sites) 1 10 110 7 The Angeles Clinic and Los Angeles 10 YE Cedars-Sinai Youth 3 12 4|5|8 10 Research Institute 10 19 Saban Community Clinic Employment and 9 10 (2 locations) 7 5 Upland (2 locations) Development (1 site) 10 Riverside 10 San Bernardino 605 8 California Heart Center 1 20 Venice Family Clinic plus dozens of other health 5|7|11 101 57 10 83 60 9 Kerlan-Jobe and education programs 4|6 CULVER CITY 60 SANTA Orthopaedic Clinic MONICA MONTEBELLO 710 19

(6 locations) VERNON CARE PATIENT

72 110 10 Los Angeles Cardiology 2|5 60 90 405 Associates (8 locations) 9 HUNTINGTON PARK 71

11 Santa Monica Orthopaedic INGLEWOOD & Sports Medicine Group 42

12 Tower Hematology 142 Oncology Medical Group DOWNEY

13 Valley Internal Medicine EL SEGUNDO 5 105 19 (3 locations) 39 COMPTON 39 90 GARDENA 1 91

91

57 405 605 Orange 107 TORRANCE County 91 47 9

110 710

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103 405 22 213 47 241 110 1 261

55

39

405

5

133 1

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1 5 5 39

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39 COMMUNITY OUTREACH WHERE PATIENT CARE EDUCATION Health and Education

WE ARE Locations and Affiliates Residents and Fellows Programs 27

1 Cedars-Sinai Medical Center 1 Cedars-Sinai Medical Center CC Community Clinic Initiative 405 170 5 (50+ partners and 2 Marina Del Rey Hospital 9 Kerlan-Jobe 210 grantees) Orthopaedic Clinic BURBANK 3 California Rehabilitation CO Cedars-Sinai COACH 159 Institute 14 Children’s Dental Center for Kids (51 sites) 101 of Greater Los Angeles 4 Urgent Care (Beverly Hills PASADENA HH Cedars-Sinai Healthy Habits 134 and Culver City) 15 Eisner Pediatric Family (30 sites) GLENDALE 39 Medical Center 5 Cedars-Sinai Medical Group SC Cedars-Sinai Share and Care 101 210 and Cedars-Sinai 16 The KHEIR Center 2 (28 sites) Health Associates 210 30 17 Los Angeles Christian 27 (multiple locations) CH Cedars-Sinai Community Health Centers 66 Health and Education 18 HOLLYWOOD 6 Primary Care, Culver City 19 ALHAMBRA 19 18 Planned Parenthood (17 sites) 19 110 7 The Angeles Clinic and Los Angeles 16 10 YE Cedars-Sinai Youth EDUCATION Research Institute 19 Saban Community Clinic Employment and 10 (2 locations) 17 5 (2 locations) Development (1 site) 10 15 605 8 California Heart Center 1 20 Venice Family Clinic plus dozens of other health 101 57 10 83 60 9 Kerlan-Jobe and education programs CULVER CITY 60 SANTA Orthopaedic Clinic MONICA MONTEBELLO 710 19 (6 locations) 20 VERNON

72 110 10 Los Angeles Cardiology 60 90 405 Associates (8 locations) HUNTINGTON PARK 71 11 Santa Monica Orthopaedic INGLEWOOD14 & Sports Medicine Group 42

12 Tower Hematology 142 Oncology Medical Group DOWNEY

13 Valley Internal Medicine EL SEGUNDO 5 105 19 (3 locations) 39 COMPTON 39 90 GARDENA 1 91

91

57 405 605 107 TORRANCE 91 47

110 710

54 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 55 1 5

103 405 22 213 47 241 110 1 261

55

39

405

5

133 1

73

74

1 5 5 39

210

118

39 COMMUNITY OUTREACH WHERE PATIENT CARE EDUCATION Health and Education

WE ARE Locations and Affiliates Residents and Fellows Programs 27

1 Cedars-Sinai Medical Center 1 Cedars-Sinai Medical Center CC Community Clinic Initiative 405 170 5 (50+ partners and 2 Marina Del Rey Hospital 9 Kerlan-Jobe 210 grantees) Orthopaedic Clinic SC BURBANK 3 California Rehabilitation CO Cedars-Sinai COACH 159 Institute 14 Children’s Dental Center for Kids (51 sites) 101 of Greater Los Angeles 4 Urgent Care (Beverly Hills PASADENA HH Cedars-Sinai Healthy Habits 134 and Culver City) 15 Eisner Pediatric Family CC SC (30 sites) GLENDALE 39 Medical Center 5 Cedars-Sinai Medical Group Cedars-Sinai Share and Care 101 CC CC 210 SC 2 and Cedars-Sinai 16 The KHEIR Center CC OUTREACH COMMUNITY (28 sites) CC Health Associates SC 210 30 17 Los Angeles Christian 27 SC CC CO CC (multiple locations) CH Cedars-Sinai Community CC Health Centers CH CH 66 Health and Education CCCH HOLLYWOODSC ALHAMBRA 6 Primary Care, Culver City SC CC 19 18 Planned Parenthood (17 sites) CHCC CC CH CC 110 7 The Angeles Clinic and Los Angeles SC CC 10 YE Cedars-Sinai Youth SC HH CC CC Research Institute CHCHCHCH HH CO CC 19 Saban Community Clinic Employment and HHHH HHCHCO CC CH 10 (2 locations) HH HH CC CO 5 SC HH CCCO CC 10 (2 locations) Development (1 site) COHHSCHHHH|SC COCC|CC CH HH HH HH|SC HHHH CC CO 605 8 California Heart Center 1 HHHH CC CC 20 Venice Family Clinic plus dozens of other health CO HH HH HHHH CC 101 57 CC HHCC10 HH 83 CC CC 60 9 Kerlan-Jobe and education programs CULVER CC CC CC CITY CO 60 SANTACC CC CC Orthopaedic Clinic MONICA CO MONTEBELLO SC CC CO|CC 710 19 CC (6 locations) CCSC CHCC VERNON CC CCCH CO HH CC 72 Los Angeles Cardiology CC 110 10 405 CC 60 90 CO CO CO CO Associates (8 locations) CC HUNTINGTONCO CO PARK 71 CC CO 11 Santa Monica Orthopaedic SC CH COCO CO COINGLEWOODCC SC SCCO 42 CO & Sports Medicine Group COCO|SCCOCO CO CO|CC COCC CO CO SCSC COCO|COSCCO|SC 12 Tower Hematology COSC CO|CO 142 CC CC|CO Oncology Medical Group CC SCCO CO DOWNEY

EL SEGUNDO CC 13 Valley Internal Medicine 5 CO CO 105 19 (3 locations) CO CC 39 COMPTON CC 39 90 GARDENA 1 91

91

57 405 605 107 TORRANCE 91 CC 47

110 710

54 REPORT TO THE COMMUNITY 2016 CEDARS-SINAI 55 1 5

103 405 22 213 47 241 110 1 261

55

39

405

5

133 1

73

74

1 5

LEADERSHIP BOARD OF LIFE EXECUTIVE 2016 DIRECTORS TRUSTEES MANAGEMENT OUR MISSION

Vera Guerin Michael Alexander, MD Bernard Briskin Peter E. Braveman, Esq. Cedars‑Sinai Health System, a nonprofit, Chair, Board of Directors Robert K. Barth Steven D. Broidy* Senior Vice President, Legal Affairs independent healthcare organization, is Thomas M. Priselac John Bendheim Norman R. Brokaw**** Darren Dworkin committed to: President and CEO Laura W. Brill Judy Carroll Senior Vice President, Enterprise Information Systems, • Leadership and excellence in delivering Marc H. Rapaport Ilana Cass, MD Maxine N. Dunitz and Chief Information Officer quality healthcare services Vice Chair, Board of Directors Dale Cochran Robert M. Eller Mark Gavens Steven Romick John Coleman Aaron R. Eshman • Expanding the horizons of medical Executive Vice President, Secretary, Board of Directors Robert C. Davidson Lawrence N. Field** knowledge through biomedical research Health System Hospital Operations, Ari Engelberg Chester Firestein and Chief Operating Officer, • Educating and training physicians and Deborah Freund, PhD Michael R. Forman Cedars-Sinai Medical Center other healthcare professionals Russell Goldsmith Marilyn Gilfenbain Richard B. Jacobs Mark S. Greenfield Bram Goldsmith**** Executive Vice President • Striving to improve the health status of Andy Heyward Philip E. Hixon and Chief Strategy Officer our community David B. Kaplan Sue Neuman Hochberg John Jenrette, MD Scott Karlan, MD Irwin Hoffman, MD Executive Vice President, Quality patient care is our priority. Providing excellent clinical and service Jeffrey Katzenberg Sally Kurtzman Medical Network quality, offering compassionate care, Michael L. Langberg, MD Steven Koh Marion Laurie and supporting research and medical Senior Vice President, Medical Affairs, Stewart Kwoh John C. Law* education are essential to our mission. and Chief Medical Officer Thomas J. Leanse Don S. Levin** Shlomo Melmed, MD José de Jesús Legaspi John W. Mack This mission is founded in the ethical and Executive Vice President, James M. Lippman Edward Meltzer cultural precepts of the Judaic tradition, Academic Affairs, which inspires devotion to the art and Joshua Lobel Walter Mirisch and Dean of the Faculty science of healing, and to the care we Philomena McAndrew, MD Todd M. Morgan Arthur J. Ochoa, JD give our patients and staff. Peggy Miles, MD*** Steven Nichols Senior Vice President, James A. Nathan Luis Nogales Community Relations and Development, Christopher Ng, MD Lynda Oschin and Chief Development Officer Lawrence B. Platt* Bruce W. Rabin Andrew Ortiz Antony P. Ressler David I. Saperstein Senior Vice President, Richard Riggs, MD Milton Slotkin Human Resources and Organization Development Mark S. Siegel* Barbra Streisand Steven Spielberg Sanford B. Weiss Edward M. Prunchunas Executive Vice President Leslie Spivak Walter Zifkin * Past Chair of the Board and Chief Financial Officer Leslie Vermut ** Honorary Life Trustee Scott Weingarten, MD Clement Yang, MD *** Chief of Staff Senior Vice President and **** Deceased Chief Clinical Transformation Officer

56 REPORT TO THE COMMUNITY 2016

8700 Beverly Boulevard Los Angeles, California 90048

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