Rodent Blood-Stage Plasmodium Survive in Dendritic Cells That Infect Naive Mice
Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice Michelle N. Wykesa,1, Jason G. Kayb,2,3, Anthony Mandersonb,2,4, Xue Q. Liua,2,5, Darren L. Brownb,2, Derek J. Richarda,2,6, Jiraprapa Wipasac, Suhua H. Jianga,d,e, Malcolm K. Jonesa,f, Chris J. Janseg, Andrew P. Watersh, Susan K. Piercei, Louis H. Millerj,1, Jennifer L. Stowb, and Michael F. Gooda,1,5 aQueensland Institute of Medical Research, Brisbane, Queensland, Australia 4029; bInstitute for Molecular Bioscience, and fSchool of Veterinary Science, University of Queensland, Brisbane, Queensland, Australia 4072; cUniversity of Chiang Mai Research Institute for Health Sciences, Chiang Mai 50200, Thailand; dDepartment of Immunology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan City, Hubei, People’s Republic of China 430030; eDepartment of Pathogenic Biology and Immunology, Shihezi University School of Medicine, Shihezi City, Xinjiang, People’s Republic of China 832002; gDepartment of Parasitology, Center of Infectious Diseases, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands; hWellcome Centre for Molecular Parasitology and Faculty of Biomedical Life Sciences, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow G12 8TA, Scotland, United Kingdom; and iLaboratory of Immunogenetics, and jHead, Malaria Cell Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 Contributed by Louis H. Miller, June 2, 2011 (sent for review January 28, 2011) Plasmodium spp. parasites cause malaria in 300 to 500 million indi- RBC, but it has long been suspected that they may also have an- viduals each year. Disease occurs during the blood-stage of the other survival strategy.
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