Marmoset Models Commonly Used in Biomedical Research
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~.. R---'------ : KASMERA: Vol
~.. r---'-------------- : KASMERA: Vol.. 9, No. 1 4,1981 Zulla. Maracaibo. Venezuela. PROTOZOOS DE VENEZUELA Carlos Diaz Ungrla· Tratamos con este trabajo de ofrecer una puesta al día de los protozoos estudiados en nuestro país. Con ello damos un anticipo de lo que será nuestra próxima obra, en la cual, además de actualizar los problemas taxonómicos, pensamos hacer énfasis en la ultraestructura, cuyo cono cimiento es básico hoy día para manejar los protozoos, comQ animales unicelulares que son. Igualmente tratamos de difundir en nuestro medio la clasificación ac tual, que difiere tanto de la que se sigue estudiando. y por último, tratamos de reunir en un solo trabajo toda la infor mación bibliográfica venezolana, ya que es sabido que nuestros autores se ven precisados a publicar en revistas foráneas, y esto se ha acentuado en los últimos diez (10) años. En nuestro trabajo presentaremos primero la lista alfabética de los protozoos venezolanos, después ofreceremos su clasificación, para terminar por distribuirlos de acuerdo a sus hospedadores . • Profesor de la Facultad de Ciencias Veterinarias de la Universidad del Zulia. Maracaibo-Venezuela. -147 Con la esperanza de que nuestro trabajo sea útil anuestros colegas. En Maracaibo, abril de mil novecientos ochenta. 1 LISTA ALF ABETICA DE LOS PROTOZOOS DE VENEZUELA Babesia (Babesia) bigemina, Smith y Kilbome, 1893. Seflalada en Bos taurus por Zieman (1902). Deutsch. Med. Wochens., 20 y 21. Babesia (Babesia) caballi Nuttall y Stricldand. 1910. En Equus cabal/uso Gallo y Vogelsang (1051). Rev. Med.Vet. y Par~. 10 (1-4); 3. Babesia (Babesia) canis. Piana y Galli Valerio, 1895. En Canis ¡ami/iaris. -
Plasmodium Scientific Classification
Plasmodium - Wikipedia https://en.wikipedia.org/wiki/Plasmodium From Wikipedia, the free encyclopedia Plasmodium is a genus of parasitic alveolates, many of which cause malaria in their hosts.[1] The parasite always has two hosts in its life Plasmodium cycle: a Dipteran insect host and a vertebrate host. Sexual reproduction always occurs in the insect, making it the definitive host.[2] The life-cycles of Plasmodium species involve several different stages both in the insect and the vertebrate host. These stages include sporozoites, which are injected by the insect vector into the vertebrate host's blood. Sporozoites infect the host liver, giving rise to merozoites and (in some species) hypnozoites. These move into the blood where they infect red blood cells. In the red blood cells, the parasites can either form more merozoites to infect more red blood cells, or produce gametocytes which are taken up by insects which feed on the vertebrate host. In the insect host, gametocytes merge to sexually reproduce. After sexual reproduction, parasites grow into new sporozoites, which move to the insect's salivary glands, from which they can infect a vertebrate False-colored electron micrograph of a [1] host bitten by the insect. Plasmodium sp. sporozoite. The genus Plasmodium was first described in 1885. It now contains Scientific classification about 200 species, which are spread across the world where both the (unranked): SAR insect and vertebrate hosts are present. Five species regularly infect humans, while many others infect birds, reptiles, -
Harnessing the Power of Bacteria in Advancing Cancer Treatment
International Journal of Molecular Sciences Review Microbes as Medicines: Harnessing the Power of Bacteria in Advancing Cancer Treatment Shruti S. Sawant, Suyash M. Patil, Vivek Gupta and Nitesh K. Kunda * Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Jamaica, NY 11439, USA; [email protected] (S.S.S.); [email protected] (S.M.P.); [email protected] (V.G.) * Correspondence: [email protected]; Tel.: +1-718-990-1632 Received: 20 September 2020; Accepted: 11 October 2020; Published: 14 October 2020 Abstract: Conventional anti-cancer therapy involves the use of chemical chemotherapeutics and radiation and are often non-specific in action. The development of drug resistance and the inability of the drug to penetrate the tumor cells has been a major pitfall in current treatment. This has led to the investigation of alternative anti-tumor therapeutics possessing greater specificity and efficacy. There is a significant interest in exploring the use of microbes as potential anti-cancer medicines. The inherent tropism of the bacteria for hypoxic tumor environment and its ability to be genetically engineered as a vector for gene and drug therapy has led to the development of bacteria as a potential weapon against cancer. In this review, we will introduce bacterial anti-cancer therapy with an emphasis on the various mechanisms involved in tumor targeting and tumor suppression. The bacteriotherapy approaches in conjunction with the conventional cancer therapy can be effective in designing novel cancer therapies. We focus on the current progress achieved in bacterial cancer therapies that show potential in advancing existing cancer treatment options and help attain positive clinical outcomes with minimal systemic side-effects. -
Molecular Analysis of Candidate Probiotic Effector Molecules of Lactobacillus Plantarum
Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum Daniela Maria Remus Thesis committee Promoter Prof. dr. Michiel Kleerebezem Professor of Bacterial Metagenomics Wageningen University Co-promoter Dr. Peter A. Bron Senior Scientist, NIZO food research BV, Ede Other members Prof. dr. Tjakko Abee, Wageningen University Prof. dr. Pascal Hols, University of Lovain (Lovain la Neuve), Belgium Dr. Philippe Langella, National Institute of Agricultural Research (INRA), Paris, France Prof. dr. Roland J. Siezen, Radboud University, Nijmegen This research was conducted under the auspices of the Graduate School VLAG (Advanced studies in Food Technology, Agrobiotechnology, Nutrition and Health Sciences). Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum Daniela Maria Remus Thesis submitted in fulfillment of the requirements for the degree of doctor at Wageningen University by the authority of the Rector Magnificus Prof. dr. M.J. Kropff, in the presence of the Thesis Committee appointed by the Academic Board to be defended in public on Tuesday 09 October 2012 at 4 p.m. in the Aula. Daniela Maria Remus Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum Ph.D. Thesis, Wageningen University, Wageningen, The Netherlands (2012) With references and summaries in English and Dutch. ISBN 978-94-6173-373-3 Summary Lactobacilli occupy diverse natural habitats, including dairy products and the mammalian gastrointestinal (GI) tract, and several Lactobacillus strains are marketed as probiotics that can interact with host cells in the GI tract by which they are proposed to beneficially influence the health status of their consumers. The discovery of probiotic effector molecules is instrumental to understand the exact modes of probiotic action, which is required for their controlled, safe, and purpose-directed application. -
Plantaricin KW30
The Molecular and Cellular Characterisation of the First Glycocin: Plantaricin KW30 Judith Stepper 2009 The Molecular and Cellular Characterisation of the First Glycocin: Plantaricin KW30 A thesis presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biochemistry at Massey University, Palmerston North, New Zealand Judith Stepper 2009 “What we know is a drop. What we don’t know is an ocean.” Isaac Newton (1643 – 1727) ABSTRACT Bacteriocins, typically secreted by Gram-positive and -negative bacteria, are ribosomally- synthesised antimicrobial peptides which inhibit the growth of competing bacteria. We have purified a 43 amino acid bacteriocin, plantaricin KW30 (PlnKW30) produced by Lactobacillus plantarum KW30, that has little amino acid sequence similarity to any other characterised bacteriocin. The gene encoding plnKW30 is in a cluster with the genes required for maturation and export of, and immunity to, the bacteriocin. This arrangement of genes is similar to the genomic context of bacteriocin genes in other lactic acid bacteria. The plnKW30 gene cluster comprises six genes encoding a glycosyltransferase, a proteolytic ABC-transporter, two putative thioredoxins, a response regulator and PlnKW30 itself. PlnKW30 was found to possess two unusual post-translational modifications: an O-glycosylated serine and an unprecedented S-glycosylation of the C-terminal cysteine. The modified serine is located on an eight residue loop that is tethered by a disulfide bridge. Both modifications have been identified as N-acetylglucosamines (GlcNAc), making PlnKW30 the first described class IV bacteriocin. A post-translational modification with S-linked GlcNAc is unprecedented in bacteriocins as well as in all genera. -
The Bacteriostatic Diglycocylated Bacteriocin Glycocin F Targets A
Copyright is owned by the Author of the thesis. Permission is given for a copy to be downloaded by an individual for the purpose of research and private study only. The thesis may not be reproduced elsewhere without the permission of the Author. The Bacteriostatic Diglycosylated Bacteriocin Glycocin F Targets a Sugar-Specific Transporter A thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Manawatu New Zealand Kelvin Ross Drower 2014 Dedicated to Nana and Pop Abstract The increasing prevalence of antibiotic-resistance bacteria is threatening to end the antibiotic era established following Alexander Fleming's discovery of penicillin in 1928. Over-prescription and misuse of broad-spectrum antibiotics has hastened the development and spread of antibiotic resistance. This, combined with a lack of research and development (R&D) of new antibiotics by major pharmaceutical companies, may lead to a widespread recurrence of 'incurable' bacterial diseases. However while commercial R&D of antibiotics has waned, much research has been carried out to characterise bacteriocins, ribosomally-synthesised antimicrobial polypeptides thought to be produced by virtually all prokaryotes. Although hundreds of bacteriocins have been identified and characterised, only a handful of their cognate receptors on susceptible cells have been identified. Glycocin F is a bacteriostatic diglycosylated 43-amino acid bacteriocin produced by the Gram-positive bacterium Lactobacillus plantarum KW30 that inhibits the growth of a broad range of bacteria. The mechanism of action of glycocin F is unknown, however evidence suggested that glycocin F binds to cells via a N-acetylglucosamine (GlcNAc) specific phosphoenolpyruvate:carbohydrate-phosphotransferase system (PTS) transporter, as had been shown for lactococcin A, lactococcin B and microcin E492 that target a mannose specific PTS transporter. -
UC Berkeley Electronic Theses and Dissertations
UC Berkeley UC Berkeley Electronic Theses and Dissertations Title Interactions of Microbes in Communities Permalink https://escholarship.org/uc/item/2hg5h7k6 Author Sczesnak, Andrew Publication Date 2018 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California Interactions of Microbes in Communities By Andrew Sczesnak A dissertation submitted in partial satisfaction of the requirements for the degree of Joint Doctor of Philosophy with University of California, San Francisco in Bioengineering in the Graduate Division of the University of California, Berkeley Committee in charge: Professor Adam P. Arkin, Chair Professor Matthew Traxler Professor Michael Fischbach Fall 2018 Abstract Interactions of Microbes in Communities By Andrew Sczesnak Joint Doctor of Philosophy with University of California, San Francisco in Bioengineering University of California, Berkeley Professor Adam P. Arkin, Chair Groups of microorganisms sharing an environment (microbial communities) are ubiquitous in nature. Microbial communities provide essential ecosystem services to other life on Earth by e.g., participating in global biogeochemical processes or interacting with a host’s immune system. Such microbes compete for scarce resources, modify an environment for their own purposes, actively war, and occasionally cooperate. Though numerous studies have surveyed the diversity of microbial life in different environments, few have determined the ways in which members of microbial communities interact with one another. Understanding the ways and means by which microbes interact is essential if we are to understand how microbial communities form, persist, and change over time. Knowledge of these processes will allow us to rationally design microbial communities to perform useful functions and predict how our actions might shift the balance of microbes in a community, and thus affect its function. -
Produced by Bacillus Amylo- Liquefaciens Isolated From
RESEARCH ARTICLE INTERNATIONAL MICROBIOLOGY (2006) 9:111-118 www.im.microbios.org Márcia P. Lisboa1 Characterization of a Diego Bonatto2 Delmar Bizani1 bacteriocin-like substance João A.P. Henriques3 produced by Bacillus amylo- Adriano Brandelli1* liquefaciens isolated from 1Department of Science Food, the Brazilian Atlantic forest ICTA, Federal University of Rio Grande do Sul, Porto Alegre, Brazil 2Biotechnology Institute, University of Caxias do Sul, Brazil 3Biotechnology Center, Federal University of Rio Grande do Sul, Summary. A Bacillus strain producing a bacteriocin-like substance was charac- Porto Alegre, Brazil terized by biochemical profiling and 16S rDNA sequencing. Phylogenetic analysis indicated that the strain has high sequence similarity with Bacillus amyloliquefa- ciens. The antimicrobial substance was inhibitory to pathogenic and food-spoilage bacteria, such as Listeria monocytogenes, Bacillus cereus, Serratia marcescens, and Pasteurella haemolytica. It was stable over a wide temperature range, but lost activity when the temperature reached 121°C/15 min. Maximum activity was observed at acidic and neutral pH values, but not at alkaline pH. The antimicrobial Received 18 February 2006 substance was sensitive to the proteolytic action of trypsin, papain, proteinase K, Accepted 17 May 2006 and pronase E. Except for iturins, other antimicrobial peptides have not been des- *Corresponding author: cribed for B. amyloliquefaciens. The identification of a bacteriocin-like inhibitory A. Brandelli substance active against L. monocytogenes addresses an important aspect of food ICTA-UFRGS protection. [Int Microbiol 2006; 9(2):111-118] Av. Bento Gonçalves 9500 91501-970 Porto Alegre, Brazil Tel. +55-5133166249 Fax +55-5133167048 Key words: Bacillus amyloliquefaciens · antimicrobial activity · bacteriocin · E-mail: [email protected] bioactive peptide many attempts are being made to incorporate bacteriocins Introduction into processes and products [25]. -
A Meta-Analysis of the Genus Alouatta
Chapter 17 Ecological and Anthropogenic Influences on Patterns of Parasitism in Free-Ranging Primates: A Meta-analysis of the Genus Alouatta Martin M. Kowalewski and Thomas R. Gillespie 17.1 Introduction Parasites play a central role in tropical ecosystems, affecting the ecology and evolution of species interactions, host population growth and regulation, and com- munity biodiversity (Esch and Fernandez 1993; Hudson, Dobson and Newborn 1998; Hochachka and Dhondt 2000; Hudson et al. 2002). Our understanding of how nat- ural and anthropogenic factors affect host-parasite dynamics in free-ranging pri- mate populations (Gillespie, Chapman and Greiner 2005a; Gillespie, Greiner and Chapman 2005b; Gillespie and Chapman 2006) and the relationship between wild primates and human health in rural or remote areas (McGrew et al. 1989; Stuart et al. 1990; Muller-Graf, Collins and Woolhouse 1997; Gillespie et al. 2005b; Pedersen et al. 2005) remain largely unexplored. The majority of emerging infec- tious diseases are zoonotic – easily transferred among humans, wildlife, and domes- ticated animals – (Nunn and Altizer 2006). For example, Taylor, Latham and Woolhouse (2001) found that 61% of human pathogens are shared with animal hosts. Identifying general principles governing parasite occurrence and prevalence is critical for planning animal conservation and protecting human health (Nunn et al. 2003). In this review, we examine how various ecological and anthropogenic factors affect patterns of parasitism in free-ranging howler monkeys (Genus Alouatta). 17.1.1 Evidence of the Relationships Between Howlers and Parasitic Diseases in South America The genus Alouatta is the most geographically widespread non-human primate in South America, with 8 of 10 Alouatta species ranging from Northern Colombia M.M. -
GRAS Notice 685, Lactobacillus Plantarum Strain 299V
GRAS Notice (GRN) No. 685 http://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/default.htm ORIGINAL SUBMISSION 1701 Pennsylvania Avenue, NW Attomeys at Law in Suite 700 Chicago Quoties/ Bmdy u.r Washington, District of Columbia 20006-5805 Indianapolis 202.372.9600 Madison Fax 202.372.9599 Milwaukee www.quarles.com Naples Phoenix Scottsdale Tampa Tucson Washington, D.C. Writer's Direct Dial: 202-372-9529 E-Mail: [email protected] December 20,2016 BY Hand Delivery United States Food and Drug Administration Center for Food Safety and Applied Nutrition Office ofFood Additive Safety HFS-200 5001 Campus Drive College Park, MD 20740 Re: GRAS Notification for Lactobacillus plantarum Strain 299v Dear Dr. Anderson: Enclosed is a copy of a GRAS notification submitted on behalfofProbi AB, of Lund, Sweden ("Probi") through its Agent Mark Yacura ofthe law firm Quarles & Brady LLP in accordance with the requirements of21 C.F.R. Part 170, Subpart E. If you have any questions or concerns regarding these minutes, please contact me at (202) 372-9529 or at [email protected]. Sincerely, (b) (6) fR1[E~[EG~[EfQJ DEC 2 1 2016 OFFICE OF FOOD ADDITIVE SAFETY Generally Recognized as Safe (GRAS) Determination for the Use of Lactobacillus plantarum Strain 299v in Conventional Foods Submitted by ProbiAB Lund, Sweden Submitted to United States Food and Drug Administration Center for Food Safety and Applied Nutrition Office of Food Additive Safety HFS-200 5001 Campus Drive College Park, MD 20740 Prepared by ProbiAB and JHeimbach LLC Port Royal, Virginia December 2016 GRAS Determination for 1 JHEJMBACH LLC Lactobacillus plantarum 299v Table of Contents Part 1 - Signed Statements and Certification............................................................................ -
Non-Canonical Functions of the Bacterial Sos Response
University of Pennsylvania ScholarlyCommons Publicly Accessible Penn Dissertations 2019 Non-Canonical Functions Of The aB cterial Sos Response Amanda Samuels University of Pennsylvania, [email protected] Follow this and additional works at: https://repository.upenn.edu/edissertations Part of the Microbiology Commons Recommended Citation Samuels, Amanda, "Non-Canonical Functions Of The aB cterial Sos Response" (2019). Publicly Accessible Penn Dissertations. 3253. https://repository.upenn.edu/edissertations/3253 This paper is posted at ScholarlyCommons. https://repository.upenn.edu/edissertations/3253 For more information, please contact [email protected]. Non-Canonical Functions Of The aB cterial Sos Response Abstract DNA damage is a pervasive environmental threat, as such, most bacteria encode a network of genes called the SOS response that is poised to combat genotoxic stress. In the absence of DNA damage, the SOS response is repressed by LexA, a repressor-protease. In the presence of DNA damage, LexA undergoes a self-cleavage reaction relieving repression of SOS-controlled effector genes that promote bacterial survival. However, depending on the bacterial species, the SOS response has an expanded role beyond DNA repair, regulating genes involved in mutagenesis, virulence, persistence, and inter-species competition. Despite a plethora of research describing the significant consequences of the SOS response, it remains unknown what physiologic environments induce and require the SOS response for bacterial survival. In Chapter 2, we utilize a commensal E. coli strain, MP1, and established that the SOS response is critical for sustained colonization of the murine gut. Significantly, in evaluating the origin of the genotoxic stress, we found that the SOS response was nonessential for successful colonization in the absence of the endogenous gut microbiome, suggesting that competing microbes might be the source of genotoxic stress. -
The Historical Ecology of Human and Wild Primate Malarias in the New World
Diversity 2010, 2, 256-280; doi:10.3390/d2020256 OPEN ACCESS diversity ISSN 1424-2818 www.mdpi.com/journal/diversity Article The Historical Ecology of Human and Wild Primate Malarias in the New World Loretta A. Cormier Department of History and Anthropology, University of Alabama at Birmingham, 1401 University Boulevard, Birmingham, AL 35294-115, USA; E-Mail: [email protected]; Tel.: +1-205-975-6526; Fax: +1-205-975-8360 Received: 15 December 2009 / Accepted: 22 February 2010 / Published: 24 February 2010 Abstract: The origin and subsequent proliferation of malarias capable of infecting humans in South America remain unclear, particularly with respect to the role of Neotropical monkeys in the infectious chain. The evidence to date will be reviewed for Pre-Columbian human malaria, introduction with colonization, zoonotic transfer from cebid monkeys, and anthroponotic transfer to monkeys. Cultural behaviors (primate hunting and pet-keeping) and ecological changes favorable to proliferation of mosquito vectors are also addressed. Keywords: Amazonia; malaria; Neotropical monkeys; historical ecology; ethnoprimatology 1. Introduction The importance of human cultural behaviors in the disease ecology of malaria has been clear at least since Livingstone‘s 1958 [1] groundbreaking study describing the interrelationships among iron tools, swidden horticulture, vector proliferation, and sickle cell trait in tropical Africa. In brief, he argued that the development of iron tools led to the widespread adoption of swidden (―slash and burn‖) agriculture. These cleared agricultural fields carved out a new breeding area for mosquito vectors in stagnant pools of water exposed to direct sunlight. The proliferation of mosquito vectors and the subsequent heavier malarial burden in human populations led to the genetic adaptation of increased frequency of sickle cell trait, which confers some resistance to malaria.