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To Address a Proposed Federal Radiation Research Agenda Proceedings of the Public Meeting March 10-11, 1980 To Address a Proposed Federal Radiation Research Agenda Volume 2 Science Projection Papers Interagency Radiation Research Committee (Successor to the Committee on Federal Research into the Biological Effects of Ionizing Radiation) This book w« preowed at an account D' wwV tuonwed by an agency of irx United Slates GtvornTiefti Neither the United Stare* Government not any agency thereof. nc any ol Ihcn fmpIovHK mak« anv wefuinew of any informtiio'). apparatus P'Muct w cocn} :a<5ctnu(). ' recretenii that <tt uie «XJ><J not infringe prruateN awn«d (iflMs. n«tFr«fYe herein to my werif corrtfT'Mciai product, procett, or «<VK* by Itade name. irao>fra't. manufacturef. o> OtfWiVue do not neceuarilv ronititute O* imply fts enrJorK'nerif., reco*nrntntlftiQr*. en t&voting bii t^e Un''£ c» any agency lhereof. The view* and opin-on* of authori «n(»i>neO iwrcm da ru e'leel thow of the U"itsd Slate* Government or any agc^y thereo* These Proceedings have been published by the Interagency Radiation Research Committee. The Radiation Research Planning Group, Office of the Director, National Cancer Institute (NCI), has prepared the materials in collaboration with the Office of the Director, National Institutes of Health (NIH). Dr. Donald S. Fredrickson, Director, National Institutes of Health Dr. Vincent T. DeVita, Jr., Director, National Cancer Institute Dr. Oddvar F. Nygaard, Special Assistant to the Director, NCI Dr. Charles U. Lowe, Special Assistant to the Director, NIH Dr. Elliott H. Stonehill, Research Planning Officer, NCI Dr. Victor H. Zeve, Special Assistant to the Deputy Director, NCI Staff Assistants: Ms. Mary Purcell, Miss Patricia Wathen, Mrs. Violet Zitomer Interagency Radiation Research Committee SUBCOMMITTEE TO DEVELOP A FEDERAL STRATEGY FOR RESEARCH INTO THE BIOLOGICAL EFFECTS OF IONIZING RADIATION Co-Chairmen: Dr. Donald S. Fredrickson, National Institutes of Health Mr. Frank Arsenault, Nuclear Regulatory Commission Executive Secretary: Dr. Elliott H. Stonehill, NCI Dr. Charles M. Barnes Dr. William A. Mills National Aeronautics and Environmental Protection Agency Space Administration Dr. Oddvar F. Nygaard Dr. Monte Blau National Cancer Institute Veterans Administration Dr. Philip Schambra Dr. Randall S. Caswell National Institute of Environmental National Bureau of Standards Health Sciences Dr. Charles W. Edington Dr. Charlotte Silverman Department of Energy Bureau of Radiological Health, Dr. Clark W. Heath Food and Drug Administration Centers for Disease Control Dr. Edwin T. Still Dr. Charles U. Lowe Department of Defense National Institutes of Health Dr. Paul Strudler Mr. Samuel C. Marcus National Institute for Occupational National Center for Health Safety and Health, Statistics Centers for Disease Control This project has been supported in part with funds from the Department of Health and Human Services contracts N01-C0-75390 and 263-79C-0021. The contents of this publication do not necessarily reflect the views or policies of the Department, nor does mention of names, products, or organizations imply endorsement or criticism by the U. S. Government. Contents, Volume 2 Preface vii Program for Tuesday, March 11, 1980. x Science Projection Paper A: Diagnostic Procedures. Elliott Lasser 1 Cluster "A" Report, November 7,1979 45 Discussion following the presentation 47 Document submitted by James E. Youker, M.D., American College of Radiology 49 Document submitted by Donald K. Mitchell, The Washington Management Group, Inc 58 Science Projection Paper B: Technology Development. Warren K. Sinclair, Ph.D 59 Cluster "B" Report, November 7,1979 81 Discussion following the presentation 85 Document submitted by F. S. Goulding, Lawrence Berkeley Laboratory 89 Science Projection Paper C: Therapy. David A. Pistenma, M.D 91 Cluster "C" Report, November 7,1979 113 Discussion following the presentation 115 Science Projection Paper D: Pathways to Man. John H. Harley, Ph.D 117 Cluster "D" Report, November 7,1979 139 Discussion following the presentation 143 Document submitted by Carl J. Johnson, M.D., M.P.H., Jefferson County Health Department 145 Document submitted by Mary B. Thorman, Convener, Clearwater Chapter Sunshine Action Group 151 Science Projection Paper E: Ecosystems and Environment. Philip Gustafson, Ph.D 155 Cluster "E" Report, November 7, 1979 171 Discussion following the presentation 173 Science Projection Paper F: Physics. Mitio Inokuti, Ph.D 175 Cluster "F" Report, November 7, 1979 203 Discussion following the presentation 207 Science Projection Paper G: Chemistry. Michael G. Simic, Ph.D 213 Cluster "G" Report, November 7,1979 227 Discussion following the presentation 229 Science Projection Paper H: Molecular Effects: Interactions with Chemicalsand Viruses. Philip C. Hanawalt, Ph.D 233 Cluster "H" Report, November 7,1979 253 Discussion following the presentation 255 Science Projection Paper I: Mutagenesis, Transformation, Cell-Killing. Paul Todd, Ph.D 257 Cluster "I" Report, November 7, 1979 267 Discussion following the presentation 269 Contents, Volume 2 (Continued) Science Projection Paper J: Somatic Effects - Cancer. Fredric J. Burns, Ph.D 273 Cluster "J" Report, November 7, 1979 287 Discussion following the presentation 289 Document submitted by R. J. Michael Fry, Ph.D., Oak Ridge National Laboratory 291 Document submitted by Warren K. Sinclair, Ph.D., National Council on Radiation Protection and Measurements 295 Science Projection Paper K: Somatic Effects - Non-Cancer. Victor P. Bond, M.D., Ph.D 299 Cluster "K" Report, November 7,1979 307 Document submitted by Robert L. Brent, M.D., Ph.D., Thomas Jefferson University 311 Science Projection Paper L: Genetics. Douglas Grahn 361 Cluster "L" Report, November 7, 1979 383 Discussion following the presentation 385 Science Projection Paper M: Epidemiology. Genevieve Matanoski, M.D., Dr.P.H 389 Cluster "M" Report, November 7, 1979 415 Discussion following the presentation 419 Document submitted by Jeffrey V. Sutherland, The Rocky Flats Monitoring Committee 423 Science Projection Paper N: Space Radiobiology. S. P. Vinograd, M.D 433 Cluster "N" Report, November 29,1979 ? 457 Discussion following the presentation 463 Appendix: Index of Cluster Participants at the November 1979 Meetings 467 Author Index 479 Contents, Volume 1 Preface vii Program for Monday, March 10, 1980 , ix Donald S. Fredrickson, M.D.: Welcome and Introductory Remarks 1 Arthur C. Upton, M.D.: Background and Significance of Current Ionizing Radiation Research Effort 5 Issue Paper No. 1. Gilbert W. Beebe, Ph.D. What knowledge is considered certain regarding human somatic effects of ionizing radiation? 9 Discussion following the presentation 27 Document submitted by Rosalie Bertell, Ph.D., Ministry of Concern for Public Health, Buffalo, N. Y 29 Document submitted by Sally Wurtz, Ph.D.; Citizens' Hearings for Radiation Victims 67 Issue Paper No. 2. James V. Neel, M.D. What knowledge is considered certain regarding human genetic effects of ionizing radiation? 81 Discussion following the presentation 107 Issue Paper No. 3. R. J. Michael Fry, M.D. What are the limits of extrapolation in applying results from experimental radiation studies on cellular and animal systems to human populations? Ill Discussion following the presentation 135 Issue Paper No. 4. Eric J. Hall, D.Sc. What is the current knowledge about the effects of differences in schedules of delivery of a given dose of ionizing radiation (dose rate, fractionation) and "quality" of radiation (LET) on biological systems and how can this information be used to predict the effects of low doses of radiation in man? 137 Discussion following 'he presentation 153 Document submitted by Irwin D. J. Bross, Ph.D.; Roswell Park Memorial Institute : 159 Issue Paper No. 5. Mortimer M. Elkind, Ph.D. What is our current knowledge from animal and cellular systems about the combined effects of ionizing radiation and exposure to other agents (chemical, pharmacological, physical, viral, etc.) and is this knowledge adequate to predict human responses? 171 Discussion following the presentation 185 Document submitted by Byron S. Berlin, M.D., State of Michigan Department of Public Health, Lansing, Michigan 187 Document submitted by Professor Howard S. Ducoff, University of Illinois 189 Issue Paper No. 6. Harvey M. Patt, Ph.D. What is the state of knowledge about differences in response to ionizing radiation as a result of biological factors such as age, sex, and genetically determined variations? 191 Discussion following the presentation 207 Contents, Volume 1 (Continued) Issue Paper No. 7. John Rundo, Ph.D. What is the potential for significant exposure to internal radiation from environmentally dispersed radionuclides and what research is needed to reduce the effects of such exposure? 211 Discussion following the presentation 229 Issue Paper No. 8. Abraham Lilienfeld, M.D. What are the opportunities and limits in applying epidemiological methods to determine the effects of ionizing radiation on humans? 233 Discussion following the presentation 247 Document submitted by Carol Winston, City of Broomfield, Colorado 251 Document submitted by Allen Brodsky, Sc.D.; CRC Press, Inc 253 Issue Paper No. 9. Hymer L. Friedell, M.D., Ph.D. How does man-made ionizing radiation contribute to the welfare of mankind? 259 Discussion following the presentation 279 Issue Papers No. 10A and 10B. Sidney Wolfe, M.D. and Paul Slovic, Ph.D. What kinds of information must be developed to foster enlightened public discussion on control of man-made ionizing
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