biomolecules Review The Interrelationships between Intestinal Permeability and Phlegm Syndrome and Therapeutic Potential of Some Medicinal Herbs Junghyun Park 1,2 , Tae Joon Choi 2,3, Ki Sung Kang 1,* and Seo-Hyung Choi 4,* 1 College of Korean Medicine, Gachon University, Seongnam 13120, Korea;
[email protected] 2 Wooje Research Institute for Integrative Medicine, WoojeIM, 432 Yeoksam-ro, Gangnam-gu, Seoul 06200, Korea;
[email protected] 3 Department of Oriental Internal Medicine, Weedahm Oriental Hospital, 430 Yeoksam-ro, Gangnam-gu, Seoul 06200, Korea 4 Department of Oriental Internal Medicine, Gangnam Weedahm Oriental Hospital, 402 Samsung-ro, Gangnam-gu, Seoul 06185, Korea * Correspondence:
[email protected] (K.S.K.);
[email protected] (S.-H.C.); Tel.: +82-10-8108-2205 (K.S.K.); +82-1600-8850 (S.-H.C.) Abstract: The gastrointestinal (GI) tract has an intriguing and critical role beyond digestion in both modern and complementary and alternative medicine (CAM), as demonstrated by its link with the immune system. In this review, we attempted to explore the interrelationships between increased GI permeability and phlegm, an important pathological factor in CAM, syndrome, and therapeutic herbs for two disorders. The leaky gut and phlegm syndromes look considerably similar with respect to related symptoms, diseases, and suitable herbal treatment agents, including phytochemicals even though limitations to compare exist. Phlegm may be spread throughout the body along with other pathogens via the disruption of the GI barrier to cause several diseases sharing some parts Citation: Park, J.; Choi, T.J.; Kang, of symptoms, diseases, and mechanisms with leaky gut syndrome. Both syndromes are related to K.S.; Choi, S.-H.