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2017 RESEARCH in the ROCK July • 2017 RESEARCH in the ROCK Building Cybersecurity Leaders Dr. Mengjun Xie prepares students for real-world attacks Page 16 OFFICE OF RESEARCH AND SPONSORED PROGRAMS Writer Lydia Perry Graphic Designer Klansee J. Tozer Contributing Photographers Arkansas Department of Parks and Tourism Center for Arkansas History and Culture Lonnie Timmons III Lydia Perry Office of Communications & Marketing Arkansas State Police Hot Springs Village Community Foundation IDEA Data & Research Office of Research and Sponsored Programs Abhijit Bhattacharyya Interim Vice Provost for Research and Dean of Graduate School Staff Tammie Cash, Director Stacey Moran, Administrative Specialist Lydia Perry, Editor Christina Laurentia, Research Technology Specialist Grants and Contracts Processing and Submission Sharon Kaufman, Associate Director Dan Shelton, Grants and Contracts Specialist Becky Denman, Grants and Contracts Specialist Grants and Contracts Management and Accounting Gayle Lenard, Associate Director Juanita Sherman, Grants and Contracts Specialist Leia Peek, Grants and Contracts Specialist Misty Stukenborg, Grants and Contracts Specialist ORSP Mission Statement ORSP provides information, services, and support to members of the UA Little Rock community to enable them to compete successfully for outside funding to conduct scientific research; create works of art; compose music; write books and articles; improve their performance in the classroom; and better serve their students, professions, and the public. 2 Contents Letter from Vice Provost for Research Launching Out Into the Deep and Dean of the Graduate School 4 23 Letter from the Director of ORSP 5 25 Advancing the Renewable Energy Miracle Enhancing Cancer Therapy 6 26 Lending a Hand Fast Track to Commercial Success 8 28 No Laughing Matter Spotlight on Student Researchers: Nigel Kelly 10 30 Life in the (Safe) Lane Preserving a Species Spotlight on Student Researchers: 11 31 Diamond McGehee Spotlight on Student Researchers: Predicting Social Media Flash Mobs Hunter Wayland 12 32 Assembling the Future 14 34 Turning Data into Ideas Building Cybersecurity Leaders 16 35 Lifelong Zest for Learning Spotlight on Student Researchers: Advancing the Arkansas Economy Ingrid Safina 18 36 A Three-Cord Strand Not Easily Broken Spotlight on Student Researchers: 19 38 John Siratt Students Making an Impact 21 39 Pioneering the Healthcare Technology Frontier 3 Letter from the Interim Vice Provost for Research and Dean of the Graduate School As I complete my first full year as the Interim Vice Provost for Research and Dean of the Graduate School, I am inspired by the exceptional research and creative activities occurring on our campus. Observing the unique and ambitious scholarly activity from the arts, humanities, social sciences, physical and the natural sciences, engineering, education, and information technology disciplines has given me great hope for the future of our institution and its impact on the region. As I embark on my second year in this position, I remain committed to my objective to maintain a vibrant research and creative activity enterprise that is open to active collaborations and learning opportunities. With Chancellor Andrew Rogerson’s leadership, UA Little Rock is entering a new era with fresh ideas, collaborations, and opportunities that will enhance research and creativity across the institution. Because of former Chancellor Joel Anderson’s commitment to leadership, UA Little Rock has established itself as one of the premiere research institutions in the state. Under his leadership, UA Little Rock established the Emerging Analytics Center, the Center for Integrative Nanotechnology Sciences, and the TechLaunch program that helps faculty researchers commercialize their research. In this new era, we can take this foundation and create even more avenues that allow faculty and students to engage in scholarly activity that positively impacts the community and the world. In April, I attended the UA Little Rock Student Research and Creative Works Expo, an event that allows student researchers to showcase their research and creative projects to the campus community. I was pleased to see the enthusiasm, innovation, and passion each student presented at this expo. UA Little Rock strives to engage students in an active learning environment to employ skills that will help them ask new questions, discover new solutions to problems, and work collaboratively to achieve their goals. This expo is one avenue for achieving that mission. I was especially delighted that the Research and Creative Works Committee led the effort to pilot several “exploratory presentations,” such as a digital humanities hub and a concrete canoe display, in preparation for a more diverse and expanded expo format for future years. As we move forward as an institution, let us continue to pursue innovative research opportunities and collaborations while engaging students to propel them into the future. Dr. Abhijit Bhattacharyya Interim Vice Provost for Research and Dean of the Graduate School 4 Letter from the Director of the Office of Research and Sponsored Programs Each year, the faculty of UA Little Rock continues to impress me with its innovative ideas, cutting-edge research, and creative works. At ORSP, we strive to help faculty with the grant submission and award administration process. That way, they can focus on the most important aspects of their projects and research. We have worked with faculty members who have submitted a variety of projects, such as cancer research, renewable energy, social media behavior modeling, and cybersecurity learning platforms. We are also proud to work with faculty and staff who establish programs that impact the community. UA Little Rock provides a variety of programs that assist citizens from all backgrounds in central Arkansas, including disadvantaged students, children with disabilities, and retired citizens looking to expand their educational horizons. Another part of our mission is to create networking and collaboration opportunities for researchers. On March 30, 2017, we held the Research Colloquium in Ottenheimer Library. Led by Drs. Nitin Agarwal and Eric Wiebelhaus-Brahm, this event allowed participants to learn about the challenges, joys, and opportunities for interdisciplinary research. Sharing experiences and learning the ins and outs of the grant funding process plays a crucial role in creating a successful grant. Researchers and creators, especially those who are new to the grant funding process, should not have to struggle on their own. We hope to create more opportunities in the future to help UA Little Rock faculty advance their research initiatives and creative projects. As our institution evolves with a new administration, I look forward to the new ideas and programs that will expand our research opportunities and creative endeavors. We have come a long way thanks to the wonderful leadership of former Chancellor Joel Anderson, and I am excited to see how Chancellor Andrew Rogerson will guide UA Little Rock into becoming an even more prestigious research institution. Tammie Cash Director of the Office of Research and Sponsored Programs 5 Enhancing Cancer Therapy Dr. Darin Jones works with Dr. John Tainer at MD Anderson Cancer Center to Make Cancer Treatment More Effective and Efficient ancer therapy has greatly progressed over the The Basics of Cancer Treatment Cyears as doctors and scientists have discovered In traditional cancer therapy, doctors can use new avenues for treatment and diagnosis. However, chemotherapy, a process in which specialized drugs many strides still need to be made to completely are used to target and destroy cancer cells in the eradicate this deadly disease. The National Cancer body, and/or hormonal therapy, in which specialized Institute says that cancer is one of the leading causes drugs target hormonal receptors that already exist of death in the world. In 2012, 8.2 million people in the body. These receptors are proteins found in worldwide died from cancer. cells that acquire and process signals from hormones such as estrogen and progesterone. In turn, these Thanks to the ongoing research of Dr. Darin Jones receptors tell the cells how they should grow. If from the UA Little Rock Department of Chemistry estrogen-prone receptors tell cancer cells to grow, and Dr. John Tainer from the MD Anderson Cancer then doctors target these receptors that stop this Center at the University of Texas, cancer treatment particular signal. can one day be more effective at specifically targeting tumors. Dr. Jones has been awarded “A lot of cancers are treated based on the phenotype $795,683 over five years for the project. of the cancer, based on whether there is a receptor present or not,” explains Dr. Jones. “If a certain type of 6 receptor is present, they get one type of treatment. then treat them with this therapy, and then it would If a different type of receptor is present, they get a kill the tumor. That’s the whole idea.” different type of treatment.” Because the treatment requires DNA damage, If a patient does not have a pre-existing receptor chemotherapy would still be the main procedure to in their body, however, the chance of survival is administer this type of therapy. However, for cancer very low. But with Drs. Jones and Tainer’s research, patients who already have genes that do not allow patients who do not have pre-existing receptors will DNA repair mechanisms, this treatment could be have a better chance of survival. successful without the need for chemotherapy. “This idea is borne out of the fact that you wouldn’t Dr. Jones focuses on creating the medicine for the have to have a receptor to receive treatment,” project, while Dr. Tainer focuses on testing the explains Dr. Jones. medicine. “Without a doubt, the creative chemistry from Dr. Jones is the heart of the project and what is The Hard Science driving its success” Dr. Tainer remarks. The process involves an enzyme (a chemical molecule that accelerates chemical reactions) called Expert in Cancer Research poly(ADP-ribose) polymerase 1, also called PARP1. Dr. Jones has already received attention for his Chemotherapy and hormonal therapies activate extensive cancer research.
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