International Journal of Molecular Sciences Article Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature 1, , 1,2, 1 Hyeun Sung Kim y * , Pang Hung Wu y and Il-Tae Jang 1 Nanoori Gangnam Hospital, Seoul, Spine Surgery, Seoul 06048, Korea;
[email protected] (P.H.W.);
[email protected] (I.-T.J.) 2 National University Health Systems, Juronghealth Campus, Orthopaedic Surgery, Singapore 609606, Singapore * Correspondence:
[email protected]; Tel.: +82-2-6003-9767; Fax.: +82-2-3445-9755 These authors contributed equally to this work. y Received: 31 January 2020; Accepted: 20 February 2020; Published: 21 February 2020 Abstract: Degenerative disc disease is a leading cause of chronic back pain in the aging population in the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with the pain pathway as a result of neurotization. Our goal is to perform a prospective study using radiofrequency ablation on sinuvertebral nerve and basivertebral nerve; evaluating its short and long term effect on pain score, disability score and patients’ outcome. A review in literature is done on the pathoanatomy, pathophysiology and pain generation pathway in degenerative disc disease and chronic back pain. 30 patients with 38 levels of intervertebral disc presented with discogenic back pain with bulging degenerative intervertebral disc or spinal stenosis underwent Uniportal Full Endoscopic Radiofrequency Ablation application through either Transforaminal or Interlaminar Endoscopic Approaches. Their preoperative characteristics are recorded and prospective data was collected for Visualized Analogue Scale, Oswestry Disability Index and MacNab Criteria for pain were evaluated.