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MMR Vaccine, Thimerosal and Regressive Or Late Onset Autism (“Autistic Enterocolitis”)

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MMR Vaccine, Thimerosal and Regressive Or Late Onset Autism (“Autistic Enterocolitis”) MMR Vaccine, Thimerosal and Regressive or Late Onset Autism (“Autistic Enterocolitis”) A Review of the Evidence for a Link Between Vaccination and Regressive Autism March 2006 David Thrower, 49, Ackers Road, Stockton Heath, Warrington, England 1 email [email protected] 2 Contents Executive Summary Part A: A Novel Syndrome 1. What Is Acquired Autism/Autistic Enterocolitis 2. The New Syndrome 3. Regression 4. Presentation by Dr. Andrew Wakefield, April 2005 5. Presentation by Dr. Arthur Krigsman, April 2005 6. Some Wider Points Part B: The Scale of the Autism Problem 7. The Financial Costs - Autism Is Costing The Taxpayer £$Billions 8. Overall Cost Estimates 9. Failure to Monitor Increases In UK Autism Numbers 10. “Now Almost Everyone Knows Someone Who’s Autistic” 11. Is Autism Increasing Due To Changes In Criteria? 12. DSM-IV Autistic Disorder 13. Pervasive Developmental Disorder Not Otherwise Specified 14. Asperger’s 15. Paper by Mark Blaxill, June 2001 16. University of Cambridge Research 17. UK National Autistic Society Estimates 18. Review by Blaxill of Rates 19. Report by Loynes, UK All Party Parliamentary Group, Dec. 2001 20. Report, “Autism In Schools”, UK National Autistic Society May 2002 21. Autism in Scottish Schools 22. Is Autism Increasing? - Some Official UK Pronouncements 23. Autism In The USA 24. Close-Up On California 25. Close-Up On New Jersey 26. “Explaining” The US Increases 27. The US Amish Community 28. Autism Elsewhere Part C: MMR 29. The Introduction of MMR 30. Sudden UK Withdrawal of Pluserix & Immravax Vaccines 31. Recognised Adverse Reactions to MMR 32. US Vaccine Adverse Events Reporting System (VAERS) 33. Contraindications To Receiving MMR 34. The UK Department of Health’s Position over MMR and Autism 35. Single Vaccines In The UK 36. Measles In The UK and US 3 37. Promotion of MMR In The UK After Wakefield “Early Report” 38. Ten Thousand Vaccines? 39. Position of the US Centers For Disease Control on MMR/Autism 40. The Parents Have Seen What They’ve Seen..... 41 Some Examples of Suspected-Damaged children Part D: The Thimerosal/Thiomersal* Issue (*the two terms are interchangeable) 42. Thimerosal’s Possible Role 43. Thimerosal Safety Data Sheets 44. Joint Statement by American Acad. Of Ped./PH Service, July 1999 45. Removal of Thimerosal 46. Interview With Neal Halsey, Johns Hopkins University, Nov 2002 47. Waters & Kraus Press Release, 2002 48. Statement by Safe Minds group, US 49. US Use of Thimerosal - Statement by Dr. Geier, 2004 50. Thimerosal’s Use in the US 51. UK Vaccines With Thimerosal 52. UK Med. and Health. Products Regulatory Agency on Thimerosal 53. UK Joint C’ttee on Vaccination & Immunis Position on Thimerosal 54. UK Department of Health’s Position on Thimerosal 55. US CDC Thimerosal Studies 56. Report, “Mercury In Medicines”, US C’ttee on Govt. Reform 2003 57. Letter to Congress by the US Office of Special Counsel, 2004 58. California Votes To Ban Thimerosal, June 2004 59. Other US States 60. US CDC’s Current Position on Thimerosal 61. Memo by Merck Part E: Evidence That Autism Increases Are Real 62. Paper by Blaxill, The Rising Incidence of Autism, June 2001 63. The MIND Study, California 64. Atlanta Study, 2003 65. Paper by Gurney, Fritz et al, Trends on ASD In Minnesota, 2003 66. Paper by Yazbak, Autism In The US, J of Amer Phys & Surg 2003 67. Paper by Yazbak, Autism In Quebec, 2004 68. Paper by Blaxill, Public Health Reports, Nov-Dec 2004 69. Paper by Newschaffer, Falb and Gurney, Pediatrics, March 2005 Part F: Reviews Questioning the Autism Epidemic 70. Paper by Fombonne, UK Med Research Council, Pediatrics, Jan 2001 71. Paper by Wing, Centre for Soc & Commun. Disorders, London 2002 72. Position of Dr. B. S. Siegal, University of California, 2002 73. Study by Croen et al, July 2002 74. Editorial by Fombonne, J of the Am Medical Asscn., January 2003 4 75. Paper by Jick et al, Boston Un Sch of Med, Pharmacotherapy, Dec 2003 76. Study by Smeeth, Fombonne et al, November 2004 77. Study by Barbarisi et al, January 2005 78. Paper by Laidler, Portland State University, Pediatrics, July 2005 Part G: The MMR Original Safety Trials Debate 79. Wakefield & Montgomery “Through A Glass Darkly” (MMR safety) 80. Dr. Peter Fletcher Commentary, J of Adverse Drug Reactions, 2001 81. Dr. Stephen Dealler Commentary, J. of Adverse Drug Reactions, 2001 82. Dr. F. E. Yazbak Commentary, J of Adverse Drug Reaction, 2001 83. The Wakefield/Watson/Shattock Rebuttals 84. The UK Dept of Health’s Repudiation of “Through A Glass Darkly”. 85. The failure to undertake any proper large-scale test Part H: Studies and Papers That Point Towards The Plausibility Of Gut/Autism, MMR/Gut/Autism, Thimerosal/Autism or Autoimmunity/Autism Links 86. Paper by Nelson & Gottshall, Applied Microbiology, May 1967 87. Paper by Eggers, Klinical Paediatrics, March 1976 88 Weizman, Weizmann et al Study, Am. J of Psychiatry, Nov. 1982 89. Delgiudice-Asch and Hollander Study 90. Paper by Dr. H. Fudenberg 91. Paper by Dr. Reed Warren 92. Warren and Singh Study, Immunogenetics, 1992 93. Singh, Warren, Odell, Warren and Cole Paper, March 1993 94. Singh, Warren, Odell et al Study, Brain Behaviour, March 1993 95. Oleske and Zecca paper 96. Binstock paper 97. Anne-Marie Plesner Letter, Lancet, February 1995 98. Paper by Thompson, Montgomery et al, Lancet, April 1995 99. Gupta, Aggarwal & Heads Study, J of Autism and Dev Disorders, 1996 100. Montinari, Favoino and Roberto paper, Naples conference May 1996 101. Auwaerter & Griffin paper, Clin Immunol & Immunopath, May 1996 102. Cook, Courchesne et al Paper, Molecular Psychiatry, May 1996 103. Griffin and Hussy Study, Journal of Infectious Diseases, June 1996 104. Martinez et al Study, Proceedings of National Acad of Sciences, 1997 105. Paper by Zecca, Graffino et al, Meeting of Nat Inst of Health, Sept. 1997 106. Weibel, Caserta and Evans Study, March 1998 107. Wakefield et al “Early Report”, Lancet, February 1998 108. Paper by Montgomery, Morris et al (pub. date/details not yet known) 109. Sabra, Bellanti and Colon letter, Lancet, July 1998 110. Further Paper by Singh and Yang, Pharmaceutical Jnl, October 1998 111. Uhlmann, Sheils et al Paper 5 112. Bitnun et al Study, Clinical Infectious Diseases Journal, October 1999 113. Paper by Horvath, Papadimitriou et al, J of Pediatrics Nov 1999 114. Paper by Singh to the US Committee on Govt Reform, April 2000 115. O’Leary Paper Presented to Congressional Oversight C’ttee, April 2000 116. Kawashima, Takayuki et al Study, Digest Dis and Sciences, Apr 2000 117. Confidential Review, US CDC, Simpsonwood, June 2000 118. Hagenbuch, Kullak-Ublick et al Study, J of Pharm Exp Ther, July 2000 119. Wakefield et al Paper, American J. of Gastroenterology, September 2000 120. Statement by Professor Walter O. Spitzer, December 2000 121. Furlano, Anthony et al Study, Journal of Pediatrics, 2001 122. Paper by Enayati et al, Medical Hypotheses, 2001 123. Study by Jyonouchi, Sun and Le, J. of Allergy & Clin. Immun., Feb. 2001 124. Study by Jyonouchi, Sun and Le, J of Neuroimmunology, 2001 125. Paper by Spitzer, Aitken et al, J of Adverse Drug Reactions & Tox., 2001 126. Study by Holmes, Cave et al, June 2001 127. Paper by Blaxill, Institute of Medicine, July 2001 128. Paper by Dr. Ken Aitken to the Scottish Society for Autism, 2001 129. Paper by Imani and Kehoe, Clinical Immunology, September 2001 130. Paper by Redwood, Bernard et al, Neurotoxicology, October 2001 131. Paper by Buie, Oasis 2001 Conference for Autism, Portland, US 132. Paper by Uhlmann, Wakefield et al, J. of Clinical Pathology, Feb. 2002 133. Paper by Singh and Nelson, February 2002 134. Review by Wakefield, Pulestone et al, Aliment Pharm. Ther. 2002 135. Report of Study, Comi et al, Johns Hopkins Hosp, Baltimore, Apr 2002 136. Paper by Torrente, Ashwood, Day et al, Lancet, May 2002. 137. Paper to 102nd GM of Am. Soc for Microbiology, Singh et al, May 2002 138. Study by O’Leary et al to Path Soc of GB and Ireland July 2002 139. Wakefield Paper Presented to US Govt Reform Committee, June 2002 140. Paper to US Government Reform C’ttee by Dr Krigsman, June 2002 141. Unpublished Research by Shattock, Un. of Sunderland, June 2002 142. Paper by Sheils, Smyth, Martin & O’Leary, Trinity Coll Dublin, 2002 143. Paper by Dr. Vijendra Singh, Utah State University, August 2002 144. Paper by Finegold, Molitoris, Song, J. Of Clin. Infect. Dis., Sept 2002 145. Further paper, Jyonouchi, Sun & Itokazu, Un. of Minnesota, Oct 2002 146. Paper, Treat. of Late Onset Autism, Matarazzo, U.S-Paulo, Nov 2002 147. Paper by Makani, Gollapudi et al, Genes & Immunity, 2002 148. Paper by Westphal, Asgari et al, Arch of Toxicology, August 2002 149. Unpublished letter by Wakefield to New Eng. J. of Medicine, Nov 2002 150. Study by Croonenberghs et al, University of Antwerp, December 2002 151. Paper by Holmes, Blaxill & Haley, Internat J of Toxicology 2003 6 152. Paper by Singh and Jensen, Pediatric Neurology 2003 153. Paper by Geier & Geier, Soc. for Experimental Biology & Med. 2003 154. Study by Geier and Geier, International Pediatrics, May 2003 155. Further Paper by Geier & Geier, Ped. Rehabilitation, Apr-June 2003 156. Further Paper by Geier & Geier, J of Am Phys and Surg, Spring 2003 157. Paper by Blaxill, Redwood & Bernard, Safe Minds 158. Paper by Bradstreet, Geier et al, J of Am Phy and Surg Summer 2003 159. Letter by Geier & Geier, J of Am Phys. & Surgeons, Summer 2003 160. Paper by Baskin, Ngo et al, Toxicology Science Aug 2003 161. Paper by Via, Nguyen et al, Envir. Health Perspectives August 2003 162.
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