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(12) United States Patent (10) Patent No.: US 7,597,910 B2 Mcdowell, Jr

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(12) United States Patent (10) Patent No.: US 7,597,910 B2 Mcdowell, Jr US00759791 OB2 (12) United States Patent (10) Patent No.: US 7,597,910 B2 McDowell, Jr. (45) Date of Patent: Oct. 6, 2009 (54) COMPOSITIONS AND METHODS FOR http://web.archive.org/web/*/http://www.xs4all.nl/~4davidpipe. TREATING PROSTATE DSORDERS html (Web Publication Date: Dec. 3, 1998). Date Accessed: Apr. 21. 2006. (75) Inventor: John W. McDowell, Jr., Rehoboth, DE http://web.archive.org/web/*/http://www.marijuana-cannabis (US) seeds.co.uk/choosing-cannabis-seeds.asp (Web Publication Date: Oct. 20, 2003). Date Accessed: Feb. 2, 2007.* (73) Assignee: SLGM Medical Research Institute, http://web.archive.org/web//http://www.greenmanspage.com/ Rehoboth, DE (US) guides/nutrientdisorders.html (Web Publication Date: Feb. 13, 2003). Date Accessed: Feb. 4, 2007.* (*) Notice: Subject to any disclaimer, the term of this Efroymson RA. Sample BE, Suter GW. Environmental toxicology patent is extended or adjusted under 35 and chemisrtry. 2001; 20 (11): 2561-2571. Abstract only.* U.S.C. 154(b) by 171 days. (U1) Wood M. Agricultural Research. 2005. pp. 12-13.* (V1) Brawley, OW. Reviews in Urology. 2002; 4 (Suppl. 5): S11 (21) Appl. No.: 11/207,700 S17.* (W1) http://web.archive.org/web/*/http://www.xs4all.nl/~4david (22) Filed: Aug. 20, 2005 pipe.html (Web Publication Date: Dec. 3, 1998). Date Accessed: Apr. 21, 2006.* (65) Prior Publication Data The American Heritage R. Dictionary of the English Language online 2000 Retrieved on Sep. 28, 2007. Retrieved from the US 2007/OO41994 A1 Feb. 22, 2007 Internet, <http://www.bartleby.com/61/92/E0149200. html>'enhance. (51) Int. Cl. The American Heritage R. Dictionary of the English Language A6 IK 36/00 (2006.01) online 2000 Retrieved on Sep. 28, 2007. Retrieved from the AOIN 65/00 (2006.01) Internet: <http://www.bartleby.com/61/43/E01543.00.html> A6 IK 36/06 (2006.01) “enrich.* A6 IK 36/09 (2006.01) Bogdanos et al. New Strategies for the treatment of hormone-inde (52) U.S. Cl. .................................. 424/725; 424/195.15 pendent prostate cancer, Journal of B.U.ON.: Official Journal of the (58) Field of Classification Search ....................... None Balkan Union of Oncology, vol. 7, No. 2 (Apr.-Jun. 2002) 107-112, See application file for complete search history. Abstract only.* Szöke et al. “The possible role of anaerobic bacteria in chronic (56) References Cited prostatitis.” IntJ Androl. vol. 21, No. 3 (Jun. 1998) 163-168, Abstract only.* U.S. PATENT DOCUMENTS (U1) BUPA: Enlarged Prostate onlineFeb. 6, 2004 Retrieved on Sep. 28, 2007). Retreived from the Internet: <http://web.archive.org/ 5,071,658 A 12/1991 Fahim ........................ 424,643 web/*/http://hcd2.bupa.co.uk/fact sheets/Mosby factsheets/BPH. 5,543,146 A 8/1996 Perez ...................... 424, 1951 html>. 5,854.404 A 12/1998 Nanba et al. .... ... 532,424 6,120,825 A * 9/2000 Cirigliano et al. ... 426,435 (V1) Sarfaraz, S.; Afaq. F.; Adhami, V. M.; Mukhtar, H. Cancer Res. 6, 197,309 B1 3, 2001 Wheeler ........ 424, 1951 2005; 65(5): 1635-1641.* 6,261,607 B1 7/2001 Newmarket al. ... 424,727 6,448,288 B1 9/2002 Burstein et al. ............. 514.454 (Continued) 6,486,204 B2 11/2002 Waldstreicher et al. ..... 514,473 Primary Examiner Christopher R Tate 6,582,723 B2 6/2003 Gorsek ....................... 424/439 6,616,928 B1 9/2003 Tazawa et al. .. 424, 19515 Assistant Examiner—Amy L. Clark 6,630,507 B1 10/2003 Hampson et al. ... 514.454 (74) Attorney, Agent, or Firm Janet M. Kerr 6,670,392 B2 12/2003 Fleshner ..... ... 514,458 6,805,866 B2 10/2004 Keith et al. .. 424, 19515 (57) ABSTRACT 6,914,072 B2 7/2005 Burstein et al. ............. 514.454 2004/0001856 A1 1/2004 Jin et al. ................ 424, 19515 2004/0049059 A1 3f2004 Mueller ...................... 549,390 Compositions and methods are described for the treatment of 2005, OOO8690 A1* 1/2005 Miller ..... ... 424/451 prostatitis, benign prostatic hypertrophy, and prostate cancer. 2005/0113327 A1* 5/2005 Roiz et al. .................... 514,44 The compositions contain either aqueous extracts or dried mixtures of selenium- and zinc-enriched cannabis plant FOREIGN PATENT DOCUMENTS material, Shiitake mushrooms, and maitake mushrooms. The compositions are effective in treating prostate disorders by JP 2003231644. A * 8, 2003 alleviating pain and Voiding symptoms, decreasing inflam WO WOO3O11217 A2 * 2/2003 mation and prostate size, reducing cellular proliferation in prostate tissue, and/or reducing PSA levels to within the OTHER PUBLICATIONS normal range of 0-4. Sarfaraz, S.; Afaq. F.; Adhami, V.M.; Mukhtar, H. Cancer Res. 2005; 65(5): 1635-1641.* 16 Claims, No Drawings US 7,597,910 B2 Page 2 OTHER PUBLICATIONS (U4) Ruiz et al. "A-Tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via receptor-dependent mechanism'. (W1) http://web.archive.org/web/*/http://www.marijuana-cannabis FEBS Letters, vol. 485 (1999) 400-404.* seeds.co.uk/choosing-cannabis-seeds.asp (Web Publication Date: (V4) Cannabis Nutrient Disorders. Internet Archive Date: Feb. 13, Oct. 20, 2003). Date Accessed: Feb. 2, 2007.* 2003 <Retrieved from the Internet on: Aug. 21, 2009>. Retrieved (X1) http://web.archive.org/web//http://www.greenmanspage.com/ from: <http://web.archive.org/web/20030213000839/http://www. guides/nutrientdisorders.html (Web Publication Date: Feb. 13, greenmanspage.com/guides nutrientdisorders/html>. 2003). Date Accessed: Feb. 4, 2007.* (W4) Johnson, Graham. "A Tea of Pot'. Sunday Mirror, Dec. 15. (U2) Efroymson RA. Sample BE, Suter GW. Environmental toxicol 2002 <Retrieved from the Internet on: Aug. 21, 2008>. Retrieved ogy and chemistry. 2001; 20 (11): 2561-2571. Abstract only.* from http://findarticles.com/p/articles/mi qn4161/is 20021215/ ai n12855888.* (V2) Wood M. Agricultural Research. 2005. pp. 12-13.* Ruiz et al., “A-Tetrahydrocannabinol Induces Apoptosis in Human (W2) Brawley OW. Reviews in Urology. 2002; 4 (Suppl. 5): S11 Prostate PC-3 cells Via a Receptor Independent Mechanism.” FEBS S17.* Letters 458:400-404 (1999). (X2) "Smokeless Marijuana' online Apr. 20, 2003 Retrived on Burstein, S. H., “The Cannabinoid Acids: Nonpshychoactive Deriva Sep. 28, 2007). Retrieved from the Internet: <http://web.archive.org/ tives with Therapeutic Potential”. Pharmacol. Ther. 82(1): 87 web/*/http://www.onlinepot.org/medical/smokelesspot.htm>.* 96(1999). (U3) “New Cannabis Seeds' online Jan. 9, 2005 Retrived on Sep. Ruiz - Llorente et al., “Expression of Functionally Active Can 28, 2008). Retrieved from the Internet: <http://web.archive.org/web/ nabinoid Receptor CB in the Human Prostate Gland”. The Prostate */http://www.planetskunk.com/products new. 54:95-102 (2003). php?products id=75&page=3>.* Kristal et al., “Vitamin and Mineral Supplement Use Is Associated (V3) Mushrooms (medicinal): Maitake (Grifola frondosa), Reishi With Reduced Risk of Prostate Cancer', Cancer Epidemiology, (Ganoderma lucidum) Shiitake (Lentinus edodes). OnlineAug. 4. Biomarkers & Prevention, 8: 887-892 (1999). 2005 Retrieved on Sep. 28, 2007). Retrieved from the Internet: Thomas, J.A., “Diet, Micronutrients, and the Prostate Gland'. Nutri <http://www.canceractive.com/page/php?n=n248&style=print >.* tion Reviews 7 (4): 95-103 (1999). (W3) CANCERactive Issue 4- Oct. 2003 online Oct. 2003 Kue et al., “Essential Role for G Proteins in Prostate Cancer Cell retrieved on Sep. 28, 2008). Retrieved from the Internet: <http://web. Growth and Signaling'. J. Urol. 164: 2162-2167 (2000). archive.org/web/*/http://www.worldhealth.net/p/aadr-mushrooms Galve-Repechet al., “Anti-tumoral action of cannabinoids: Involve medicinal-maitake-grifola-frondosa--reishi-ganoderma-lucidum ment of Sustained Ceramide Accumulation and Extracellular Signal shitake-lentinus-edodes.html>. Regulated Kinase Activation.”. Nature MED. 6(3): 313-314 (2000). (X3) Segelman et al. “Cannabis sativa L (Marijuana) IV: Chemical Internet Website Address http://dictionary reference.com/browse/ Basis for Increased Potency Related to Novel Method of Prepara finely accessed Jan. 25, 2009. tion”, J Pharm Sci., vol. 62, No. 12 (Dec. 1973) 2044-2046.* * cited by examiner US 7,597,910 B2 1. 2 COMPOSITIONS AND METHODS FOR observed with prostatitis. The etiology of BPH is unknown, TREATING PROSTATE DSORDERS but may involve hormonal changes associated with aging. With age, testosterone is converted into dihydroxytestoster CROSS-REFERENCE TO RELATED one (DHT) at higher levels within the prostate via the enzyme, APPLICATIONS 5-alpha-reductase. DHT binds to androgen receptors, stimu lating growth of the prostate. This growth can eventually lead Not Applicable to progressive restriction or obstruction of urine outflow. Incomplete bladder emptying causes stasis and predisposes to STATEMENT REGARDING FEDERALLY infection with secondary inflammatory changes in the blad SPONSORED RESEARCH ORDEVELOPMENT 10 der. Treatment is directed toward reducing prostate size, sta Not Applicable bilizing renal function, eradicating infection, and discontinu ing drugs that may induce obstruction. The most widely used REFERENCE TO SEQUENCE LISTING, A drug therapy has been systemic administration of an alpha TABLE, ORACOMPUTER PROGRAM LISTING 15 blocker. Administration of a 5-alpha-reductase inhibitor, COMPACT DISC APPENDIX which decreases the conversion of testosterone to DHT, has also been used. These drugs can have undesirable side effects Not Applicable of postural hypotension, impotence, and decreased libido. Surgery is the most definitive therapy, and the most widely FIELD OF THE INVENTION used Surgical procedure is transurethral resection of the pros tate. However, approximately 5 to 10% of patients experience The present invention relates to compositions and methods Some post Surgical problems including impotence and incon of using the compositions for the treatment of prostatic dis tinence. orders in men. More specifically, the invention relates to Prostate cancer, i.e., adenocarcinoma of the prostate, is the compositions comprising ingredients having anti-inflamma 25 most common malignancy in men greater than 50 years in the tory, antioxidant, and antitumorigenic activities, and methods US. The incidence increases with each decade of life.
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