X Chromosome Dosage of Histone Demethylase KDM5C Determines Sex Differences in Adiposity
X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity Jenny C. Link, … , Arthur P. Arnold, Karen Reue J Clin Invest. 2020. https://doi.org/10.1172/JCI140223. Research Article Genetics Metabolism Graphical abstract Find the latest version: https://jci.me/140223/pdf The Journal of Clinical Investigation RESEARCH ARTICLE X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity Jenny C. Link,1 Carrie B. Wiese,2 Xuqi Chen,3 Rozeta Avetisyan,2 Emilio Ronquillo,2 Feiyang Ma,4 Xiuqing Guo,5 Jie Yao,5 Matthew Allison,6 Yii-Der Ida Chen,5 Jerome I. Rotter,5 Julia S. El -Sayed Moustafa,7 Kerrin S. Small,7 Shigeki Iwase,8 Matteo Pellegrini,4 Laurent Vergnes,2 Arthur P. Arnold,3 and Karen Reue1,2 1Molecular Biology Institute, 2Human Genetics, David Geffen School of Medicine, 3Integrative Biology and Physiology, and 4Molecular, Cellular and Developmental Biology, UCLA, Los Angeles, California, USA. 5Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA. 6Division of Preventive Medicine, School of Medicine, UCSD, San Diego, California, USA. 7Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom. 8Human Genetics, Medical School, University of Michigan, Ann Arbor, Michigan, USA. Males and females differ in body composition and fat distribution. Using a mouse model that segregates gonadal sex (ovaries and testes) from chromosomal sex (XX and XY), we showed that XX chromosome complement in combination with a high-fat diet led to enhanced weight gain in the presence of male or female gonads.
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