DOCSLIB.ORG

Adrenal Insufficiency: Stress (Physical, Current Practice 2012 Psychological) Hypothalamus - CRH Or Vasopressin + Lawrence S

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Adrenal Insufficiency: Stress (Physical, Current Practice 2012 Psychological) Hypothalamus - CRH Or Vasopressin + Lawrence S Hypothalamus-Pituitary-Adrenal Axis Adrenal Insufficiency: Stress (physical, Current Practice 2012 psychological) Hypothalamus - CRH or Vasopressin + Lawrence S. Kirschner, MD, PhD Pituitary - Professor of Medicine ACTH: Major direct regulator Division of Endocrinology, Diabetes, and Metabolism of cortisol secretion The Ohio State University’s Wexner Medical Center + Adrenals Cortisol, Aldosterone, Androgens Overview Actions of cortisol • A very brief review of adrenal function • What is adrenal insufficiency? • Adrenal insufficiency in the outpatient setting • Adrenal insufficiency during critical illness • Therapy for adrenal insufficiency 1 What is Adrenal insufficiency? • Actions of Aldosterone – Promotes sodium/water retention • When discussing adrenal insufficiency – Promotes potassium excretion (Addison disease), we are almost always – May be involved in tissue remodeling talking about glucocorticoid (cortisol) ((ge.g. in the heart) insufficiency • Actions of adrenal androgens • However, other adrenal hormones can also – Responsible for initiation of puberty be affected in primary adrenal failure • Secondary sex characteristics in women Adrenal Insufficiency Clinical Addison disease (Addison disease) Image courtesy of Wellcome Images http://images.wellcome. ac.uk/ 2 Clinical Features of Chronic Features of Acute Adrenocortical Insufficiency Adrenocortical Insufficiency (Adrenal Crisis) • Hypotension •Weakness, fatigue 100% •Weight loss 100% • Weakness (prox. muscle), •Anorexia 100% confusion •Hyperpigmentation 92% • Nausea, vomiting , abdominal pain •Hypotension 88% • Dehydration, hypovolemia •Nausea, abdominal pain 56% • Hyperthermia •Salt craving 19% •Hypoglycemia ?? • Hypoglycemia »more common in children and women TREAT FIRST, AND DIAGNOSE LATER!! Hyperpigmentation, Adrenal Crisis toxic appearance Addison disease • Acute loss of adrenal function – Acute loss of adrenals • Surgery • Hemorrhage/thrombosis – Acute loss of pituitary function – Acute loss of steroid replacement OR • Acute stress in the setting of compensated Hyperpigmentation, including chronic adrenal failure Images courtesy of knuckles and palmar creases Wellcome Images – Precipitating event (e.g., like DKA) http://images.wellcome.ac.uk/ 3 Normal Adrenal Function Secondary Adrenal Insufficiency • Primary Hypothalamus – Adrenal gland Hypothalamus CRH – Destruction of Pituitary glands CRH Pituitary • Secondary ACTH – Pituitary ACTH – Inadequate ACTH Adrenals – NO increased Adrenals pigment Cortisol Aldosterone – Fewer electrolyte imbalances Cortisol Aldosterone (regulated by Renin/Angiotension system) Primary Adrenal Insufficiency Causes of adrenal failure • Primary Hypothalamus – Adrenal gland • Like CS, iatrogenic causes are probably most common CRH – Destruction of Pituitary glands • Inherited forms of adrenal failure – Typically presenting early in life (<1 yr) • CAH, especially salt-wasters (steroid biosynthesis defect) Adrenals • Other rare genetic diseases (lipoid CAH, AHC) – Typically presenting in childhood, and dx should be “obvious” • AAA Cortisol Aldosterone – Alacrima, Achalasia, Adrenal failure • Autoimmune Polyendocrine Syndrome (APS), Type I (APECED) – Ectodermal dysplasia, mucocutaneous candidiasis 4 Causes of adrenal failure Causes of adrenal failure • Like CS, iatrogenic causes are probably most • Like CS, iatrogenic causes are probably most common common • Inherited forms of adrenal failure • Inherited forms of adrenal failure – Typically presenting early in life (<1 yr) – Typically presenting early in life (<1 yr) • CAH, especially salt-wasters (steroid biosynthesis • CAH, especially salt-wasters (steroid biosynthesis defect) defect) • Other rare genetic diseases (lipoid CAH, AHC) • Other rare genetic diseases (lipoid CAH, AHC) – Typically presenting in childhood, and dx – Typically presenting in childhood, and dx should be “obvious” should be “obvious” • AAA • AAA – Alacrima, Achalasia, Adrenal failure – Alacrima, Achalasia, Adrenal failure • Autoimmune Polyendocrine Syndrome (APS), • Autoimmune Polyendocrine Syndrome (APS), Type I (APECED) Type I (APECED) – Ectodermal dysplasia, mucocutaneous – Ectodermal dysplasia, mucocutaneous candidiasis candidiasis Causes of adrenal failure • Presenting later in life • Like CS, iatrogenic causes are probably most – Autoimmune Polyendocrine Syndrome common (APS), Type II • Type I DM, thyroid disease • Inherited forms of adrenal failure – Typically presenting early in life (<1 yr) • May occur as sole autoimmune feature • CAH, especially salt-wasters (steroid biosynthesis (although rare) defect) – Adrenal hemorrhage • Other rare genetic diseases (lipoid CAH, AHC) – Typically presenting in childhood, and dx • Resulting from sepsis should be “obvious” – HIV, other viral diseases • AAA – Adrenalectomy – Alacrima, Achalasia, Adrenal failure • Autoimmune Polyendocrine Syndrome (APS), Type I (APECED) • Note that non-classical CAH rarely causes – Ectodermal dysplasia, mucocutaneous candidiasis adrenal insufficiency 5 Adrenal hemorrhage! Pre-bleed Post-bleed Secondary adrenal failure Diagnosis of Adrenal Insufficiency in the Outpatient setting: Static Testing • Pituitary malfunction • A GOOD HISTORY IS ESSENTIAL! – Tumor destroying normal cells – History of steroid use, including nasal steroids or injected steroids (e.g., – Autoimmune hypophysitis back injections) • May be quite specific for loss of ACTH-producing cells • 8 AM cortisol (probably NOT reliable in – Infiltrative diseases of pituitary hospitalized patients) • Histiocytosis X Strongly Very unlikely suggestive • Sarcoidosis Normal range • Metastatic disease 0 37 18 25 8am Cortisol (ug/dl) 6 Diagnosis of Adrenal Insufficiency in the Outpatient setting: Static Testing - 2 Adrenal Insufficiency: • ACTH measurements – Generally not helpful, particularly low Current Practice 2012 values – Elevated values may suggest primary Adrenal Insufficiencyyg in the right clinical setting Rami N. Khayat, MD Associate Professor • “Suggestive” findings: Pulmonary, Critical Care, and Sleep Medicine – Eosinophilia, hyperchloremia, The Ohio State University’s Wexner Medical Center acidosis, hypercalcemia, azotemia, hyponatremia/hyperkalemia and fasting hypoglycemia Diagnosis of Adrenal Insufficiency: Adrenal Insufficiency during Critical ACTH stim test Illness • Give IV/IM bolus of 250 mcg ACTH, measure blood at 0, 30, 60 min • Adrenal function during critical illness Cortisol ug/dl • Relative adrenal insufficiency • Normal response is for cortisol to reach >18 20 • Overv iew o f Cor ticos tero id th erapy i n th e mcg/dl 10 ICU • Caveat :ACTH stim test • Conclusions will be “normal” in early pituitary failure. Once adrenal atrophy sets in, test becomes subnormal 03060 7 Acute injury Adrenal Function in Critical Illness • Adrenal Gland Death Acute critical illness Recovery • Synthetic inhibition • Drugs • Cytokines Sub-acute; chronic critical • Etomidate llness • Ketoconazole » Corticosteroids • Destruction Maladaptive Adaptive • Pre-existing • Acute responses responses • Autoimmune • Hemorrhage • Infection • Infection • HIV • CMV Impaired Adrenal Decreased • TB • Fungal immune function Inflammatory • Metastasis response response The Adrenal Response to Prolonged Adrenal Function in Critical Illness Critical Illness • Hepatic metabolism of cortisol • Rifampin • Phenytoin • Phenobarbital • Glucorticoid Resistance J Clin End Met. 1995;80:1238. 8 Cortisol and Septic Shock Group % Basalbasal cortisol maxmax mortalitymortality Good 30% <34 >9 26% Intermediate1 <34 <9 50% 67% “The fact that cortical hormone therapy exerts beneficial effects in so many conditions makes it rather likely that Intermediate2 >34 >9 the hormone is not a specific antidote in any one of these cases but raises shock resistance in general because a Poor 20% >34 <9 82% condition of relative adrenal insufficiency exists in organisms exposed to non-specific damage.” Annane JAMA 2000; 283:1038-1045 Prognostic Value of Cortisol Levels and ACTH Cortisol Levels-Marker of Survival Response Venkatesh and Cohen 2011 Annane, D. et al. JAMA 2000;283:1038-1045 9 Effect of Low Dose Hydrocortisone on Mortality in Patients with Septic Shock Annane, D. et al. JAMA 2002;288:862-871 Steroids In Septic Shock Effect of Low Dose Hydrocortisone on Mortality in Patients with Septic Shock Catechlamine dependent septic shock (300) ACTH Stim Test 76% Non-Respp()onders (229) 24% Responders (70) <9 ug/dl cortisol >9 ug/dl cortisol Steroids Placebo Steroids Placebo 50 mg Hydrocortisone q6º 50 mg Hydrocortisone q6º 50 ug Fludrocortisone qd 50 ug Fludrocortisone qd Annane, D. et al. JAMA 2002;288:862-871 Annane JAMA 2002; 288:862-871 10 Steroids In Septic Shock Approach to Suspected Adrenal Insufficiency < 25 ug/dL 25 ug/dL to 40 ug/dL > 40 ug/dL Non- Responders Mortality Responders ACTH stim test Steroids Placebo Steroids Placebo 28 Day 53%* 63% 61% 53% < 9 ug/dL > 9 ug/dL ICU 58%* 70% 67% 59% Hospital 61%* 72% 69% 59% 1 Year 68%* 77% 69% 71% Persistent hypotention Vasopressor 57%* 40% 50% 53% Therapeutic Trial Withdrawal Median Median Median Median (28 days) 7 10 9 7 Steroid Replacement Treatment Annane JAMA 2002; 288:862-871 Effects of Corticosteroids on Mortality ICU Severe Sepsis and Septic Shock Concerns • High mortality in the Control group • Use of Etomidate • Design and power • Severe refractory shock required for enrollment Annane BMJ 2004;329:480 11 Hydrocortisone Therapy for Patients with Septic Shock Kaplan–Meier curves for survival at 28 days according to CORTICUS response to corticotropin test Sprung
Load more

Recommended publications
  • Congenital Adrenal Hyperplasia in the Newborn
    The Leo Fung Center for CAH and Disorders of Sex Development Congenital Adrenal Hyperplasia in the Newborn Contents Introduction 1 What is congenital adrenal hyperplasia? 1 Types of CAH 3 Diagnosing CAH in newborns 4 Treating CAH 5 Untreated CAH 7 CAH in children and young adults 8 Frequently asked questions 9 Glossary 11 Resources 13 Acknowledgments 14 Congenital Adrenal Hyperplasia in the Newborn 1 Introduction This handbook will provide you and your family information about congenital adrenal hyperplasia (CAH). While this guide will not answer all of your questions, it will provide basic medical facts that will help you to talk to your doctors. It is important to know that CAH cannot be cured but it can be treated. Your child will need to take medicine for the rest of his or her life. If your child takes this medicine, he or she should have a completely normal life in every way. Successful treatment requires teamwork between you and your doctor. The doctor will monitor your child in order to know what dose of medicine is needed. We ask that you give your baby the medication on the schedule recommended by your doctor. Your family is not alone. The Leo Fung Center for CAH and Disorders of Sex Development (DSD) at University of Minnesota Amplatz Children’s Hospital, provides a large network of support, including medical specialists, therapists and counselors who all have expertise in caring for patients with CAH. What is congenital adrenal hyperplasia? Let’s begin by examining each word. • Congenital means existing at birth (inherited). • Adrenal means that the adrenal glands are involved.
    [Show full text]
  • Conduct Protocol in Emergency: Acute Adrenal Insufficiency
    ORIGINAL ARTICLE FARES AND SANTOS Conduct protocol in emergency: Acute adrenal insufficiency ADIL BACHIR FARES1*, RÔMULO AUGUSTO DOS SANTOS2 1Medical Student, 6th year, Faculdade de Medicina de São José do Rio Preto (Famerp), São José do Rio Preto, SP, Brazil 2Degree in Endocrinology and Metabology from Sociedade Brasileira de Endocrinologia e Metabologia (SBEM). Assistant Physician at the Internal Medicine Service of Hospital de Base. Researcher at Centro Integrado de Pesquisa (CIP), Hospital de Base, São José do Rio Preto. Endocrinology Coordinator of the Specialties Outpatient Clinic (AME), São José do Rio Preto, SP, Brazil SUMMARY Introduction: Acute adrenal insufficiency or addisonian crisis is a rare comor- bidity in emergency; however, if not properly diagnosed and treated, it may progress unfavorably. Objective: To alert all health professionals about the diagnosis and correct treatment of this complication. Method: We performed an extensive search of the medical literature using spe- cific search tools, retrieving 20 articles on the topic. Results: Addisonian crisis is a difficult diagnosis due to the unspecificity of its signs and symptoms. Nevertheless, it can be suspected in patients who enter the emergency room with complaints of abdominal pain, hypotension unresponsive to volume or vasopressor agents, clouding, and torpor. This situation may be associated with symptoms suggestive of chronic adrenal insufficiency such as hyperpigmentation, salt craving, and association with autoimmune diseases such as vitiligo and Hashimoto’s thyroiditis. Hemodynamically stable patients Study conducted at Faculdade may undergo more accurate diagnostic methods to confirm or rule out addiso- de Medicina de São José do nian crisis. Delay to perform diagnostic tests should be avoided, in any circum- Rio Preto (Famerp), São José do Rio Preto, SP, Brazil stances, and unstable patients should be immediately medicated with intravenous glucocorticoid, even before confirmatory tests.
    [Show full text]
  • Preventable Deaths: Panhypopituitarism and Adrenal Insufficiency
    Preventable Deaths: Panhypopituitarism and adrenal insufficiency. What you need to know What is panhypopituitarism? Your child has been diagnosed with a big scary sounding word, and all you can think is: 'What does this mean? and 'Why have I never heard of this?' Simply put, panhypopituitarism means that your child's pituitary gland does not function properly and as a result, your child is deficient in one or several hormones. Some children have congenital panhypopituitarism, meaning they are born with it. Others have acquired panhypopituitarism following an event such as head trauma, brain tumor surgery, or brain radiation. It is rare enough that is entirely possible, in fact, probable, that you will not initially know anyone else with this disorder. What will my child need? Although the diagnosis and condition can seem intimidating, it is very manageable once you understand what is needed. Unfortunately the condition cannot be cured or reversed, but again, it can be effectively managed. Your child will need to take medications to replace the missing hormones. These might include thyroid hormone, growth hormone, cortisol, and/or possibly others. Your doctor will go over these with you, as dosages vary from child to child. Most medications are taken orally, but growth hormone must be taken by daily injection. Your endocrinologist will work with you and your child to achieve the proper dosages and will guide you in how to administer any necessary medications. Why is it sometimes life threatening? What is adrenal insufficiency? Of the hormone deficiencies your child may have, the most critical is cortisol, also known as the 'stress hormone.' Cortisol is essential for life , and is therefore the central focus of this guide.
    [Show full text]
  • Mechanisms and Clinical Consequences of Critical Illness Associated Adrenal Insufficiency Paul E
    Mechanisms and clinical consequences of critical illness associated adrenal insufficiency Paul E. Marik Purpose of review Abbreviations Adrenal insufficiency is being diagnosed with increasing ACTH adrenocorticotrophic hormone frequency in critically ill patients. There exists, however, ARDS acute respiratory distress syndrome CBG corticosteroid-binding globulin much controversy in the literature as to the nature of this CIRCI critical illness-related corticosteroid insufficiency entity, including its pathophysiology, epidemiology, CRH corticotrophin-releasing hormone HDL high-density lipoprotein diagnosis and treatment. The review summarizes our HPA hypothalamic–pituitary–adrenal current understanding of the causes and consequences of SAS sympatho-adrenal system TNF tumor necrosis factor adrenal insufficiency in critically ill patients. Relevant findings Activation of the hypothalamic–pituitary–adrenal axis with ß 2007 Lippincott Williams & Wilkins the production of cortisol is a fundamental component of 1070-5295 the stress response and is essential for survival of the host. Dysfunction of the hypothalamic–pituitary–adrenal axis with decreased glucocorticoid activity is being increasingly Introduction recognized in critically ill patients, particularly those with The stress system receives and integrates a diversity of sepsis. This condition is best referred to as ‘critical illness- cognitive, emotional, neurosensory and peripheral related corticosteroid insufficiency’. Critical illness-related somatic signals that arrive through distinct
    [Show full text]
  • Anemia LECTURE in INTERNAL MEDICINE for IV COURSE
    Essentials of Diagnosis, Treatment and Prevention of Major Endocrine Diseases: Diseases of the Adrenal Glands. Adrenal Insufficiency. Adrenal Hyperfunction. Hormonally Active Tumors. LECTURE IN INTERNAL MEDICINE FOR IV COURSE STUDENTS M. Yabluchansky, L. Bogun, L. Martymianova, O. Bychkova, N. Lysenko, N. Makienko V.N. Karazin National University Medical School’ Internal Medicine Dept. Plan of the Lecture • Definition • Epidemiology • Risk factors • Etiology • Mechanisms • Classification • Clinical presentation • Diagnosis • Treatment • Prognosis • Prophylaxis • Abbreviations • Diagnostic guidelines http://www.thelancet.com/pb/assets/raw/pb/assets/raw/Lancet/clinical/diseases/Cushing's.jpg http://peninsulamassage.com.au/wp-content/uploads/2012/08/Adrenal_Glands_1.jpg Definition Diseases of the Adrenal Glands • Diseases of the Adrenal Glands are conditions that interfere with the normal functioning of the adrenal glands and may cause hyperfunction (Overactive Adrenal Glands) or hypofunction (Underactive Adrenal Glands), and may be congenital or acquired. • There are two parts of the adrenal glands, the cortex, derived from mesenchymal cells, and the medulla, derived from neuroectodermal cells; first one produces mineralocorticoids, glucocorticoids, and androgens; and second one produces epinephrine (adrenaline) and norepinephrine(noradrenaline). https://en.wikipedia.org/wiki/Adrenal_gland_disorder Epidemiology Epidemiologic study of adrenal gland disorders in Japan • The total numbers of patients in Japan in 1997 were estimated as 1,450
    [Show full text]
  • A Case of Waterhouse-Friderichsen Syndrome in a Patient with Streptococcus Pyogenes Bacteremia
    A Case of Waterhouse-Friderichsen Syndrome in a Patient with Streptococcus Pyogenes Bacteremia D. I. BACAL, B. E. CATALDO, P. M. LUCERI, G. VARALLO Rowan University School of Osteopathic Medicine, and Jefferson University Hospital System, NJ INTRODUCTION Waterhouse-Friderichsen Syndrome (WFS) is a rare condition of adrenal insufficiency (AI) due to adrenal hemorrhage after a severe infection. The incidence of WFS has been estimated at 0.14-1.8% based on post-mortem studies.1 It has been associated with a 55-60% mortality rate.2 Meningococcal disease comprises up to 80% of WFS, but additional causative agents continue to be identified.3 This is the case of a 52-year-old female with toxic shock syndrome from Group A Streptococcal (GAS) bacteremia who developed bilateral adrenal hemorrhage & subsequent AI. Septic shock occurred during an initial hospitalization & resolved. Four weeks after discharge she presented with evidence of an adrenal crisis. CT scans demonstrated bilateral adrenal enlargement concerning for adrenal hemorrhage. Primary AI was confirmed via ACTH stimulation testing. A literature search found fewer than ten cases of WFS described due to streptococcal bacteremia. BACKGROUND OF WATERHOUSE-FRIDERICHSEN SYNDROME CONCLUSIONS • Bilateral adrenal hemorrhage has multiple causes: coagulopathies, sepsis from infection, hypotension (i.e. MI), severe volume loss, or surgical WFS is a rare, often fatal, clinical condition that can develop after a intervention 4 severe infection & leads to adrenal hemorrhage. Many factors • Signs include pallor, weakness, fatigue, anorexia, nausea, vomiting, and lethargy 5,6 & labs often depict hyponatremia & hyperkalemia contribute to the pathogenicity of WFS, including coagulopathy, • Increased skin pigmentation develops due to an increase in proopiomelanocortin (POMC), Bacterial ischemia & bacterial toxins.
    [Show full text]
  • Case 1: 54-Year-Old Woman with Adrenal Insufficiency
    ENDORAMA March 22, 2012 54-year-old woman with adrenal insufficiency Celeste Thomas, MD Case 1 Chief Complaint Adrenal crisis in Dec 2011 I didn’t know what was going on When I finally reached my doctor she told me a story of one of her patients who has a crisis every time her grandchildren visit What do you think? History of Present Illness Feeling Horrible – Dermatologist recommended she see an Intolerable myalgias endocrinologist, Diagnosed with diagnosed with fibromyalgia panhypopituitarism 2004 2009 2011 Viral illness: 2007 2010 myalgias, weakness, 2012 fatigue Adrenal Needed Help: Not returned to Crisis fibroandfatigue.com previous state of health since Started natural supplements History Past Medical History Medications Raynaud’s phenomena Synthroid 50 mcg daily diagnosed in 2000 Hydrocortisone 12.5 mg Fibromyalgia in 2007 8AM, 5 mg at noon, 2.5 Hypopituitarism in 2010 mg at 4pm, 2.5 mg at 8pm Allergies Omnitrope (recombinant human growth hormone) Iodinated contrast causes 0.3 mg subcutaneous anaphylaxis daily Hydroxychloroquine Clonazepam 0.5 mg 2- causes a rash 3x/night Nexium Calcium Vitamin D Probiotics History Family History Social History Mother is 80 years old Lives with her husband with history of ER+ and youngest son breast cancer Spends her days in Father is 80 years old pajamas due to fatigue with T2DM and obesity and weakness 1 sibling, brother who Smoked cigarettes for is well two years in college 3 children, all are well Does not drink alcohol or use illicit drugs Review of Systems Constitutional:
    [Show full text]
  • Management of Hypopituitarism
    Journal of Clinical Medicine Review Management of Hypopituitarism Krystallenia I. Alexandraki 1 and Ashley B. Grossman 2,3,* 1 Endocrine Unit, 1st Department of Propaedeutic Medicine, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens, Greece; [email protected] 2 Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford OX3 7LE, UK 3 Centre for Endocrinology, Barts and the London School of Medicine, London EC1M 6BQ, UK * Correspondence: [email protected] Received: 18 November 2019; Accepted: 2 December 2019; Published: 5 December 2019 Abstract: Hypopituitarism includes all clinical conditions that result in partial or complete failure of the anterior and posterior lobe of the pituitary gland’s ability to secrete hormones. The aim of management is usually to replace the target-hormone of hypothalamo-pituitary-endocrine gland axis with the exceptions of secondary hypogonadism when fertility is required, and growth hormone deficiency (GHD), and to safely minimise both symptoms and clinical signs. Adrenocorticotropic hormone deficiency replacement is best performed with the immediate-release oral glucocorticoid hydrocortisone (HC) in 2–3 divided doses. However, novel once-daily modified-release HC targets a more physiological exposure of glucocorticoids. GHD is treated currently with daily subcutaneous GH, but current research is focusing on the development of once-weekly administration of recombinant GH. Hypogonadism is targeted with testosterone replacement in men and on estrogen replacement therapy in women; when fertility is wanted, replacement targets secondary or tertiary levels of hormonal settings. Thyroid-stimulating hormone replacement therapy follows the rules of primary thyroid gland failure with L-thyroxine replacement.
    [Show full text]
  • Congenital Adrenal Hyperplasia
    Patient Information Publications Clinical Center National Institutes of Health Facts about CAH Congenital Adrenal Hyperplasia This information was prepared by your An organ at the base of the brain, called health care team to help you learn about the pituitary gland, helps regulate the congenital adrenal hyperplasia (CAH). adrenal glands. CAH is a genetic disorder of the adrenal glands that affects the body's general health, growth, and development. What are the adrenal glands? The adrenal glands are a pair of walnut-sized organs above the kidneys. They make hormones, which act like chemical messengers to affect other organs in the body. Each adrenal gland has two parts: the medulla (the inner part), and the cortex (the outer part).The medulla makes the hormone adrenaline. The cortex makes the hormones cortisol, aldosterone, and androgens. CAH affects how the adrenal cortex works. In severe cases, the adrenal medulla may also not function normally. What do adrenal hormones do? Hormones made by the adrenal glands are important for the body's normal function. Cortisol affects energy levels, sugar levels, blood pressure, and the Patient Information Publications 1 Facts about CAH: Congenital Adrenal Hyperplasia body's response to illness or injury. short stature. Girls exposed to high levels Aldosterone helps maintain the proper of androgens before birth may have salt level. Androgens are male-like abnormal external genitalia at birth. hormones needed for normal growth Although their internal female organs are and development in both boys and girls. normal, excess androgens may also Adrenalin affects blood sugar levels, affect puberty and cause irregular men- blood pressure, and the body's response strual periods.
    [Show full text]
  • Adrenal Insufficiency
    Adrenal Insufficiency Moises Auron, MD,*† Nouhad Raissouni, MD‡ *Department of Hospital Medicine, Medicine Institute, Cleveland Clinic, Cleveland, OH. †Department of Pediatric Hospital Medicine, Cleveland Clinic Children’s, Cleveland, OH. ‡Department of Pediatric Endocrinology, Cleveland Clinic Children’s, Cleveland, OH. Educational Gaps Pediatricians must have increased awareness of clinical and biochemical manifestations of congenital adrenal hyperplasia in newborns to institute appropriate diagnostic workup and early initiation of corticosteroid supplementation. Pediatricians must also have increased awareness of clinical and biochemical manifestations of adrenal insufficiency (regardless of its cause) and institute prompt treatment with corticosteroid supplementation. Objectives After completing this article, readers should be able to: 1. Recognize the clinical and biochemical manifestations of congenital adrenal hyperplasia and its different subtypes. 2. Appraise the importance of early administration of corticosteroid supplementation in patients with congenital adrenal hyperplasia. 3. Recognize early the clinical and biochemical manifestations of adrenal insufficiency. 4. Distinguish the different levels of treatment of patients with adrenal insufficiency: long term, stress supplementation, and treatment of adrenal crisis. Abstract Adrenal insufficiency is a life-threatening condition that occurs secondary to impaired secretion of adrenal glucocorticoid and mineralocorticoid hormones. This condition can be caused by primary destruction or AUTHOR DISCLOSURE Drs Auron and dysfunction of the adrenal glands or impairment of the hypothalamic- Raissouni have disclosed no financial pituitary-adrenal axis. In children, the most common causes of primary relationships relevant to this article. This fi commentary does not contain a discussion of adrenal insuf ciency are impaired adrenal steroidogenesis (congenital an unapproved/investigative use of adrenal hyperplasia) and adrenal destruction or dysfunction a commercial product/device.
    [Show full text]
  • Hypothyroidism and Adrenal Insufficiency in Sepsis and Hemorrhagic Shock
    ORIGINAL ARTICLE Hypothyroidism and Adrenal Insufficiency in Sepsis and Hemorrhagic Shock Hao Chih Ho, MD; Alyssa D. Chapital, MD; Mihae Yu, MD Hypothesis: We hypothesized that hypothyroidism and Main Outcome Measures: Incidence of hypothyroid- adrenal insufficiency frequently occur together in criti- ism and adrenal insufficiency and mortality. cally ill patients. Results: Mean (SD) age was 62 (19) years. The mean Design: A prospective observational study. (SD) Acute Physiology and Chronic Health Evaluation II score was 21 (5). Twenty-seven patients (40.9%) had severe sepsis, 31 (46.9%) had septic shock, and 8 (12.1%) Setting: Surgical intensive care unit of a university- affiliated tertiary referral center. had hemorrhagic shock. Five patients (7.6%) had hy- pothyroidism alone and 35 (53.0%) had only adrenal in- sufficiency. Eight patients (12.1%) had both hypothy- Patients: Sixty-six consecutive patients with severe sep- roidism and adrenal insufficiency. All patients with sis, septic shock, and hemorrhagic shock who required endocrine abnormalities were treated. Mortality for the pulmonary artery catheterization for resuscitation were total group was 15 (22.7%) of 66 patients. studied. Conclusion: There is a 12% incidence of simultaneous Interventions: Thyrotropin and baseline cortisol lev- hypothyroidism and adrenal insufficiency in our study els were obtained at 3 AM followed by intravenous injec- and the routine testing for both may be indicated in this tion of 250 µg of cosyntropin, a synthetic adrenocorti- population of critically ill patients. cotropic hormone derivative. A second measurement of the cortisol level was performed 1 hour later. Arch Surg. 2004;139:1199-1203 ULTIPLE ENDOCRINE reported incidences of adrenal insuffi- derangements have ciency in critically ill patients ranging from been described in criti- 0% to 95%.
    [Show full text]
  • Adrenal Fatigue • Steroid Replacement the HPA Axis in Adrenal Insufficiency
    Demystifying Medicine: Addison’s Disease Meets Chromatin Biology 4/25/2017 Lynnette K. Nieman Daniel R. Larson DEOB, NIDDK LRBGE, NCI Disclosure • Adrenal Section editor and author, UpToDate Cortisol is a bi-modal hormone • Made by the adrenal gland cortex (outer layer) • Baseline/day-to-day control of metabolism (fuel) • Stress à increased amounts immunosuppressant and anti-inflammatory Adrenal Gland Hormones Cortisol Aldosterone DHEA (glucocorticoids) (mineralocorticoids) (androgens) Hypothalamic-Pituitary-Adrenal Axis CRH hypothalamus pituitary ACTH Cortisol adrenal Renin ALDO Cortisol daily rhythm The right amout of cortisol is critical Too much Just right! Too little Cushing’s Adrenal Syndrome Insufficiency Untreated, complete adrenal insufficiency leads to circulatory collapse and death. FAQs about Adrenal Insufficiency • Causes • Diagnosis – Clinical Features • Adrenal fatigue • Steroid Replacement The HPA Axis in Adrenal Insufficiency Primary Secondary Normal Adrenal Adrenal Insufficiency Insufficiency hypothalamus CRH CRH CRH pituitary ACTH ACTH ACTH Cortisol Cortisol Cortisol adrenal Renin ALDO Renin ALDO Renin ALDO Primary Adrenal Insufficiency: Causes Causes Suggestive features Primary AI Pigmentation, hypotension Idiopathic Autoimmune Most common Infections: TB, fungal, 15% of patients in US series AIDS-associated (CMV) Space occupying mass Metastases (lung, breast, kidney, gut, lymphoma), blood, heparin Rx Bilat Adx or Rx Ketoconazole, mitotane, aminoglutethimide, metyrapone, etomidate Polyglandular Failure 1 Hypopara, candidiasis,
    [Show full text]