Research in Siddha System of Medicine the Science of Holistic Health

Research in Siddha System of Medicine The Science of Holistic Health

Central council for Research in siddha ministry of ayush government of india 2 Siddha System of Medicine Central Council for Research in Siddha CCRS 3 Chief Editor Prof. Dr. R.S. Ramaswamy Director General Central Council for Research in Siddha Ministry of AYUSH Arumbakkam Chennai Editors Dr. P. Sathiyarajeswaran Research Officer (Siddha) - Scientist 2 Central Council for Research in Siddha Ministry of AYUSH Arumbakkam Chennai

Dr. M. Kannan Research Officer (Siddha) Siddha Central Research Institute Central Council for Research in Siddha Arumbakkam Chennai

Dr. Shyamala Rajkumar Research Officer (Siddha) Siddha Central Research Institute Central Council for Research in Siddha Arumbakkam Chennai

Dr. S. Natarajan Medical Officer (Siddha) Disclaimer Siddha Central Research Institute This document is not a formal publication of Ministry of AYUSH, Government of India. The document provides Central Council for Research in Siddha overview of research in Siddha system of medicine, however the views expressed are solely of the authors/ institutions and do not necessarily in any way reflect the opinion or views of Ministry of AYUSH and GOI. The Arumbakkam document may, however, be freely reviewed, abstracted, reproduced or translated, in part or whole, with due Chennai www.siddhacouncil.com acknowledgement, but is not for sale or for use in conjunction with commercial purposes.

e Book on Siddha Ministry of AYUSH SIDDHA CCRS

RED BORDERS Table of Contents

Introduction and Objectives 6 Organizational set-up 9 Governance to facilitate transparency and monitoring 12 Committees and Regulations 12 Notable achievements 13 Research Activities of CCRS 15 Accomplished Projects in Clinical Research 17 Clinical Research – Initiatives for Pilot Studies 19 Collaboration with various institutes 23 Extra Mural Research 23 Health Services 23

Road ahead 24

AYUSH Research Portal 25

Traditional Knowledge Digital Library (TKDL) 26 Workshops / Seminars / Conferences organized 27 Publication of books 28 Future Projects 29 Publication 31

International collaboration 38 6 Siddha System of Medicine Central Council for Research in Siddha CCRS 7

The objectives for which the Central Council for Research in Siddha has been established are: ZZThe formulation of aims and patterns of research on scientific lines in Siddha. ZZTo undertake any research or other programmes in Siddha. ZZThe prosecution of and assistance in research, propagation of knowledge and experimental measures generally in connection with the causation, mode of spread Central Council for Research in Siddha and prevention of diseases. ZZTo initiate, aid, develop and coordinate scientific research on various aspects, especially fundamental and applied aspects of Siddha and to promote and assist research institutions for the study of diseases their causes, prevention and remedy. ZZTo finance enquiries and researches for the furtherance of objectives of the Central The Central Council for Research in Siddha (CCRS), an Council. ZZTo exchange information with other institutions, associations and societies interested autonomous body under the Department of AYUSH, Union in the objects similar to those of the Central Council especially in observation and study Ministry of Health and Family Welfare is an apex body in India of diseases in India. ZZTo prepare, print, publish and exhibit papers, posters, pamphlets, periodicals and books for undertaking, coordinating, formulating, developing and for furtherance of the objectives of the Central Council. promoting research on scientific lines in Siddha. The activities ZZTo issue appeals and make applications for money and funds in furtherance of the objectives of the Central Council and to accept for the aforesaid purpose gifts, donations are being carried out through 5 peripheral Institutes / Units and subscriptions of cash and securities and of any property whether movable or located in Tamil Nadu, Kerala and Union Territory of Puducherry. immovable. Z The research activities of the Council include Preclinical, Clinical ZTo borrow or raise funds with or without security or on security mortgage charge, hypothecation or pledge of all or any of the immovable or movable properties belonging Research, Drug Research and Literary Research in Siddha. to the Central Council or in any other manner whatsoever. ZZTo invest and deal with the funds and monies of the Central Council or entrusted to the Central Council not immediately required in such a manner as may from time to time www.siddhacouncil.com be determined by the Governing Body of the Central Council. e Book on Siddha Ministry of AYUSH 8 Siddha System of Medicine Central Council for Research in Siddha CCRS 9

ZZTo permit the funds of the Central Council to be held by the Government of India. ZZTo enter into arrangements with scientific agencies of other Countries for exchange of sci- ZZTo acquire and hold, whether temporarily or permanently any movable or immovable entists, study tours, training in specialized areas, conducting joint projects etc. property necessary or convenient for the furtherance of the objects of the Central ZZTo provide technical assistance to Govt. / Private Agencies in matters consistent with the council. activities of the Council. ZZTo sell, lease, mortgage and exchange and otherwise transfer any of the properties ZZTo assist Medicinal Plants Board, Government of India in achieving its objectives. movable or immovable of the Central Council provided prior approval of the Central ZZTo constitute small Management Committees consisting of eminent Scientists / Physicians Government is obtained for the transfer of immovable property. of local areas to monitor the R & D activities and suggest remedial measures for the ZZTo purchase, construct, maintain and alter any buildings or works necessary or improvement of activities of all Central as well as Research Institutes of the Council. convenient for the purpose of the Central Council. ZZTo undertake and accept the management of any endowment or trust fund for donation, Organizational set-up: undertaking or acceptance whereof may seem desirable. Central Council for Research in Siddha, located with its headquarters in Chennai ZZTo offer prizes and grant of scholarships, including travelling scholarships in furtherance encounters its objectives via mandate fixed for the Institutes in 3 states—Tamil Nadu, of the objects of the Central Council. Puducherry and Kerala. IPD facilities for inpatient clinical research are available in ZZTo create administrative, technical and ministerial and other posts under the Society SCRI, Chennai and SRRI, Puducherry. SCRI, Chennai has a Licensed Central Pharmacy and to make appointments thereto in accordance with the rules and regulations of the preparing research drugs for Clinical trials and general health care delivery system. Society. ZZTo establish a provident fund and/or pension fund for the benefit of the Council’s S.No Institutes / Units Mandate of the Institute employees and / or their family members. 1 Siddha Central Research Institute, Chennai. Clinical Research, Literary Research and ZZTo do all such lawful things either alone or in conjunction with others as the Central Drug research 2 Siddha Regional Research Institute, Puducherry. Clinical Research Council may consider necessary or as being incidental or conducive to the attainment 3 Siddha Regional Research Institute, Clinical Research and Drug research of the above objects. Thiruvananthapuram. 4 Siddha Clinical Research Unit, Palayamkottai. Clinical Research ZZTo undertake R & D Consultancy projects and transfer of patents on drugs and pro- Siddha Medicinal Plants Garden, Mettur. Medicinal Plant Research and Cultivation cesses to industries. ZZTo undertake R & D projects sponsored by industries in public / private sector. ZZTo undertake international and inter-agency collaboration. ZZUtilization of results of research conducted and payment of share of royalties / consultancy fees to those who have contributed towards pursuit of such research. www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH 10 Siddha System of Medicine Central Council for Research in Siddha CCRS 11

CENTRAL COUNCIL FOR RESEARCH IN SIDDHA SCRI Building, Aringnar Anna Hospital Campus ORGANIZATIONAL SET UP OF CENTRAL COUNCIL FOR RESEARCH IN SIDDHA Arumbakkam, Chennai - 600106 GENERAL BODY Ministry of AYUSH Govt. of India PRESIDENT Ph: +91 44 26212421 EXECUTIVE [email protected] [email protected] COMMITTEE www.siddhacouncil.com SAB (SIDDHA) STANDING FINANCE COMMITTEE

TECHNICAL SECTION DIRECTOR GENERAL ADMINISTRATION SECTION The Central Council for Research in Siddha (CCRS) is an th ASST. DIRECTOR autonomous body registered on 27 July 2010. The Council ASST. DIRECTOR (HQRS.) DIRECTOR ADMINISTRATIVE (PERIPHERAL INSTITUTES) ADMINISTRATIVE (INSTITUTE) OFFICER (BUDGET & OFFICER (ADMN.& ESTT.) came into existence after bifurcation of the erstwhile Central ACCOUNTS)

PROGRAMME EXECUTION, COURT CASES & ACCOUNTANT Council for Research in Ayurveda and Siddha (CCRAS) into EMR SPC RCH OFFICE ADMINISTRATION COORDINATIONANDIMPLEMENTION SUPERINTENDENT RTI, SC & ST CELL Central Council for Research in Siddha (CCRS) GRIEVANCES RESEARCH OFFICERS VIGILANCE Siddha Central Research Institute, (MEDICAL / NON MEDICAL) ACCOUNTS/ INTERNAL AUDIT Chennai. ESTABLISHMENT 044 26214809 BUDGET & CASH

[email protected] RECRUITMENT BILLS & www.crisiddha.tn.nic.in RECORDS Siddha Regional Research Institute Puducherry. 0413-2244042

[email protected] CCRS NETWORK Siddha Clinical Research unit Palayamkottai. 0462-573736 [email protected] Central Research Institute Siddha Regional Research Institute Regional Research Institute Thiruvananthapuram SRRI, PUDUCHERRY 0471-2340628 SCRI, CHENNAI [email protected] SRRI, THIRUVANANTHAPURAM

Siddha Medicinal Plants Garden SCRU, PALAYAMKOTTAI Mettur 04298– 243773 SMPG, METTUR [email protected] www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH 12 Siddha System of Medicine Central Council for Research in Siddha CCRS 13 Governance to facilitate transparency and monitoring: CCRS has defined structures and institutional processes for governance. The following are the committees which guide CCRS in overall management, Notable achievements administrative excellence, Finance management and technical expertise. ÎÎ General Body, ÎÎ Executive Committee, ÎÎ Standing Finance Committee Clinical Research ÎÎ Scientific Advisory Board. ÏÏ Obtained a patent for Psoriasis ÏÏ Drug proving trial completed in Rasa under the erstwhile research Gandhi Mezhugu to prove its efficacy council for the drug 777 oil. in fibroid uterus size reduction.

ÏÏ Successfully completed clinical research ÏÏ Multicentric clinical trial in diabetes in peptic ulcer with trial drug Thambira mellitus have been completed with Chenduram and published a monograph. the coded polyherbal formulation D5 chooranam and drug is found ÏÏ Multicentric comparative trial to be efficacious among the conducted in Annabedhi Chenduram drug naïve diabetic population. for iron deficiency anaemia and proved its efficacy. PublishedÏÏ Drug proving clinical trial completed treatment guidelines for the same. in Urolithiasis with official Siddha formulation Sirupeelaiyathikudineer.

Drug Research

ÏÏ In animal studies, more than 10 drugs ÏÏ More than 50 single drugs and 20 have passed out toxicity studies and 150 compound formulations have been efficacy studies have been completed. standardized. Hon’ble Minister of State (IC)and Secretary, Ministry of AYUSH, Govt. of India

Committees and Regulations medicinal plants Research Ø Ø Clinical trials are monitored by respective Institutional Ethical Committee (IEC) strictly ÏÏ Sizable number of survey tours have ÏÏ Around 500 specimens are adhering GCP- AYUSH guidelines been conducted and folklore claims documented maintained in the museum and 1000 ØØ Animal Studies are monitored by Institutional Animal Ethics Committee (IAEC) and ÏÏ Conservation, Cultivation and herbarium sheets are in possession. Propagation of medicinal plants is active advices of CPCSEA are implemented regularly. in 18 acres of Siddha Medicinal plants ØØ The Good Agricultural and Cultivation Practices (GACP) are implemented in medicinal Garden at Mettur, Tamil Nadu.

plant research. www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH SIDDHA 14 Siddha System of Medicine Central Council for Research in Siddha CCRS 15 Research & Development

Notable achievements The activities and achievements of CCRS are mainly in the areas of clinical research, drug research &development, Medicinal plant research and literary literary Research & publications research and documentation. In the field ÏÏ 30 books have been published. of research, clinical research forms the core ÏÏ 1500 palm leaf manuscripts are conserved and digitized. activity adequately complemented and ÏÏ Scientific outcomes disseminated through publication in National and International supported by drug and literary research. peer reviewed journals. ÏÏ Supported in the publication of the following books published by government of India. Clinical Research: It involves evaluation àà The Siddha Pharmacopoeia of India Part I, Vol-I and Vol-II of the efficacy of selected drugs, herbal àà The Siddha Formulary of India Part I (Tamil & English) and Part II (Tamil) preparations, therapies and fundamental àà Essential Drugs List principles and Siddha concepts of diet, Body constitution (Udaliyal) etc.The clinical ÏÏ Published treatment guidelines for management of Chikungunya with Siddha drugs research programme of the Council mainly aims at the validation of therapeutic efficacy of Siddha medicines and therapies, in practice used for more than 10 decades. The council also concentrates on innovation of newer drugs for non-communicable diseases especially Diabetes Mellitus, Psoriasis, Vitiligo, Hypertension, Dyslipidemia, Urolithiasis, Fibroid Uterus, Osteo arthritis, Rheumatoid arthritis and in Benign Prostatic hypertrophy. www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH SIDDHA 16 Siddha System of Medicine Central Council for Research in Siddha CCRS 17

Development of research centers Accomplished Projects in Clinical Research:

S.NO Research Place Institute/Year Activities Knowing the importance about the manegement of Non communicable disesases, most of the 1 Literary Research Thanjavur 1964(Merged with Literary research &documen- clinical research have been done in NCDs. Unit CRI in 1979) tation 2 Literary Research Palayamkottai 1971(Merged with Literary research &documen- S. No Name of the Drug Name of the Disease Unit CRI in 1979) tation 1. P6 Vali Gunmam (Peptic Ulcer) 3 Central Research Chennai 1971 Clinical research 2. LingaChendooram and GowriChin- SanthuVathaSoolai (Rheumatoid Institute (Siddha) Drug Research tamani (Internal) Arthritis) 4 Literary Research Chennai 1979 Literary research &documen- MayanaThylam ( External) and Documentation tation 3. KP1 Chooranam( Internal) Kalanjagapadai( Psoriasis) 5 Drug Research Chennai 1979 Standardization KPE Thylam ( External) Scheme (Multi Displinary) 4. D2 Chooranam Neerizhivu ( Diabetes) 6 Mobile Clinical Re- Chennai 1979 Clinical research-Survey and- 5. D4 Chooranam Neerizhivu ( Diabetes) search Unit Survellience 6. RA1 Chooranam SanthuvathaSoolai 7 Siddha Regional Puducherry 1979 Clinical research Rheumatoid Arthritis) Research Institute 7. RGX PutruNoi (Cancer) 8 Clinical Research Palayamkottai 1980 Clinical research Unit -SIDDHA 8. SKX PutruNoi (Cancer) 9 Survey of Medicinal Palayamkottai 1971 march Survey of Medicinal plants 9. VK2 PutruNoi (Cancer) Plants Unit -SIDDHA Merged with Mettur 10. MahaVeeraMezhugu SanthuVathaSoolai from 2009 (Rheumatoid Arthritis) 10 Clinical Research Trivandrum 1986 Clinical research 11. VangaChunnam SanthuVathaSoolai (Rheumatoid Unit -SIDDHA Arthritis) 11 Project on Tribal Tiruppathur, 1985 Tribal research 12. G1 Venpadai ( Leucoderma) Research Programme Tamilnadu Merged with CRIS in Siddha Kalasa,Karnatka 13. G2 Venpadai ( Leucoderma) 12 Clinical Research New delhi Upto 2000 Clinical research 14. G1+ ABKM Venpadai ( Leucoderma) Unit-Safdarjung 15. Annabedi Chenduram VeluppuNoi ( Anaemia) 13 Preliminary Screen- Trivandrum 1982-1999 Standardization 16. AvuriIlaiKalkam ManjalKamalai ( Jaundice) ing Institute for Siddha Drugs. 17. APNC Peenisam ( Sinusitis) 14 Siddha Medicinal Mettur Functioning from Cultivation and Survey Plants Garden 2005 www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH SIDDHA 18 Siddha System of Medicine Central Council for Research in Siddha CCRS 19 Projects in Clinical Research:

1.Multicentric studies on anemia with Annabedhichenduram: Outcome: 5. Multicentric open labelled clinical trial on Neerizhivu (Diabetes A multicentric study to assess the efficacy of the trial drug Treatment mellitus): IEC Approval No: Annabedhichenduram in anemia was conducted in SCRI, Chennai, guidelines for India has become the capital of diabetes. It hinders the economic IEC No: CCRS/ SRRI-Pudhucherry, and SCRU-Palayamkottai. It was found that Veluppunoi development of individual as well as the country. Indian system of SCRI-1/2011- Annabedhichenduram was better in increasing Hb, Serum iron, Serum published by medicine claims effective treatment for diabetes. Siddha medicine has ferritin, and TIBC. Among the 359 cases screened 40 cases were recruited CCRAS 12/04 many formulations indicated for diabetes. Evidence based research about CTRI Registration and the trial was completed. 75% of the cases showed good response and Approved by IEC the efficacy of such formulations are being carried out by Central council their general conditions improved. of SCRI. No/Ref no: for Research in Siddha. Considering the above facts CCRS has started a 2013/08/005563 Multicentric open clinical trial on Neerizhivu with D5 chooranam involving 2. Open observational studies on metallic drugs: Approved by IEC its peripheral institutes SCRI, SRRI Puducherry, SCRU Palayamkottai. The Observational studies were conducted in SCRI, Chennai, to evaluate of SCRI. trial has been started after getting IEC approval from respective institutes. the clinical safety of 3 selected Siddha herbomineral preparations such The interim analysis shows promising results in reducing the blood sugar. as Ayabringarajakarpam, Ayaveerachenduram, and Lingachenduram. 15 The trial was completed with promising results in controlling the blood subjects were recruited for this trial and they were observed for the metallic sugar. Data analysis is in progress. There is a plan to apply for patent for this load in their body. LFT, KFT, USG were the parameters observed in this study. particular formulation. NOAEL was the observation in this study.

6. Clinical evaluation of Sirupeelaiyathikudineer in the 3. Documentation of Treatment Guidelines in vector borne IEC No:CCRS/SRRI management of kalladaippu (urolithiasis): – 1/2011-12/03 diseases: This documentation project is highly useful in collecting Outcome: Reduction of pain, reduction in the size of the calculus have been reflected various treatment claims on vector borne diseases used for treatment Monograph clinically and radiologically supporting the claim of the drug to be beneficial and prevention. Among the 38 claims more than 60% reported for published in Urolithiasis. chikunguniya. NilavembuKudineer and BramanandaBairavam tablets are by CCRAS - the frequently documented claims. It is noteworthy to mention here that Treatment mass treatment with NilavembuKudineer is adopted in southern states guidelines for especially in Tamil Nadu whenever there is a reported outbreak of either Chikungunya chikunguniya or dengue

4. Open Labelled Clinical Trial on KaruppaiSathaikattigal (Fibroid Uterus): The effect of Rasaganthi Mezhugu was tested among 20 cases Approved by diagnosed as fibroid uterus and the drug was given for 90 days in a split of IEC of SRRI, 45 days with a drug holiday period of 15 days. 16 out of 20 cases showed Puducherry. good response in reduction of the size in fibroid uterus. As a secondary IEC Approval objective, the values of LFT and KFT were observed for all the cases and No: CCRS/SRRI- the results revealed that the drug was found to be very safe. This study was 1/2011-12/02.

www.siddhacouncil.com conducted in SRRI, Puducherry.

e Book on Siddha Ministry of AYUSH 20 Siddha System of Medicine Central Council for Research in Siddha CCRS 21 Observational studies Drug Research: 1. Survey questionnaire for assessment of Siddha treatment in A preclinical setting is there in the council’s research programme to comply OPD of Siddha Central Research Institute. with international standards and also as per WHO guidelines. All the trial drugs and official Awareness about the usage of traditional systems of medicine has IEC Approval no: formulations pass through standardization, pharmacological activity, and safety evaluation. increased greatly at present. Siddha is one among the oldest systems in IEC No: CCRS/ More than 120 drugs have been tested for their activity and 50 drugs have been tested India. It is being used by a large community for a long time. Even though SCRI-1/2013- for toxicity. More than 200 single drugs have been tested for Pharmacognostic studies. 30 it is being used long the safety and efficacy of the medicines have to be 14/11 formulations and 50 single drugs have been tested for standardization. In Pharmacognosy established scientifically. The validity of the benefits using Siddha system research, 15 Single drugs and 5 Compound formulations are to be tested every financial year. is planned with an observational study in the form of survey questionnaire In Medicinal Plant Research, undertaking of 4 Medicinal plants Survey tours and cultivation in Siddha Central Research Institute, Chennai. This study will provide the of 5 numbers of Medicinal Plants Species are fixed as target every year. In Standardization and overview of patients’ attitude towards Siddha medicine which helps in Quality assurance, 30 numbers of Single drugs and 10 numbers of Compound formulations developing strategies for research in Siddha. have to be subjected. Under Pharmacology / Toxicology research 5 drugs are continuing. Drug Research and Development: 2. Survey questionnaire for assessment of ‘Add-on Therapy’ for It involves survey of medicinal plants, cultivation of medicinal plants including tissue Diabetes culture, pharmacognosy, phyto-chemistry, pharmacology/toxicity and drug standardization. Non-communicable diseases are the challenging ones for the developing IEC Approval no: countries. Diabetes is one of the major threatening diseases among the IEC No: CCRS/ Literary Research: SCRI-1/2013- NCDs. Siddha medicine is being used by a large number of people for Literary research works lay platform to any basic research in Siddha system 14/09 controlling diabetes. It is the need of the hour to ensure the quality of as they are scientific reflection of the intuitions of Siddhars. The preservation of life of the patients who are taking Siddha medicine for diabetes. An open ancient Siddha literatures in scribed in the palm leaves and paper manuscripts observational study is planned to assess the QoL of diabetics in the form and unfolding of scientific details in them constitute literary research. of questionnaire. IEC approval to conduct the study was obtained. The outcome will help to incorporate newer dimensions in research to enhance QoL in diabetics. 3.Survey questionnaire for assessing Udaliyal (Body Constitution) for the patients attending SCRI, Chennai Traditional systems of medicine are being esteemed high as their treatment methodology is patient centric. Tailor made medicines IEC Approval no: for the ailments of particular individuals form the backbone of IEC No: CCRS/ traditional systems. The validation of body constitution evaluation SCRI-1/2013- in the drug metabolism is to be established in terms of contemporary 14/15 pharmacogenomics. At present there is no database on body constitution of the patients attending SCRI. A pilot study is planned to explore the body constitution evaluation of the patients attending SCRI. We have got the IEC approval to conduct the study. The outcome www.siddhacouncil.com of the study will help in designing the clinical trial in accordance with Traditional wisdom conserved for future innovations body constitution(Udaliyal) evaluation. e Book on Siddha Ministry of AYUSH SIDDHA 22 Siddha System of Medicine Central Council for Research in Siddha CCRS 23

Medicinal Plant Research: Collaboration with various institutes: The Siddha Medicinal Plants Garden (SMPG), Mettur is engaged in the maintenance and development of Herbal Garden and cultivation of Medicinal Plants. Cultivation of S.No Name of the collabora- Purpose of Collaboration Remarks Medicinal plants, Conservation of endangered and RET species, Photo documentation tive institute of medicinal plants, Trial cultivation, Development of Seed bank, Survey, exhibition and 1. TANUVAS(Tamilnadu Study of Nandhi Mezhugu Completed and documentation of folklore claims are the important activities of medicinal plant research University of Veterinary / Cancer Gajakesari Report submitted to and Animal studies) Council 2. National Institute of Sid- Utilization of Patients bank. Study subjects dha recruited and study completed in Multi centric trial for Ane- mia. 3. The Tamilnadu Dr MGR PhD center for Siddha Re- Students started do- Medical University search ing Registration. 4. Centre for Traditional Digitization Project (AYUSH On going medicine Research Project) 5. Scientific Study intend Technical review in Community knowl- with FRLHT, IAIM, Banga- The documented treat- edge Register Re- lore ment claims of Anemia. leased after Valida- (AYUSH Project) tion. 6. MMRC, Chennai. Digitization Project (AYUSH On going Project) 7. ATSVS Siddha Medical Digitization Project (AYUSH On going college, Munchirai. Project)

Extra Mural Research: Extra-mural research (EMR) – facilitates monitoring and implementation of research projects under extra mural research scheme of the Department of AYUSH related to Siddha. So far 4 studies have been recommended.

Health Services: SCRI Chennai and SRRI Puducherry have 50 and 25 bed hospitals respectively. All the clinical research units (SCRI, SRRI (P), SRRI (T), SCRU, Palayamkottai) are recognized institutional hospitals which provide the following services other than research.General OPD, Flu like illness OPD, Geriatric OPD and Varmam/Thokkanam OPD and recruitment of trial subjects is enhanced through this health care services facility. In hospital and health Siddha Medicinal plants Garden, Mettur – Model Garden/Aquatic plants Pond services for the past 5 years the research units under CCRS have served 3, 61,678 cases www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH SIDDHA 24 Siddha System of Medicine Central Council for Research in Siddha CCRS 25

Road ahead: ZZEstablishment of separate units for Vector and Virology studies. Z ZZCCRS hits its stride in globalization of its Research activities. ZEstablishment of Model Herbal Garden to conserve, cultivate and exhibit medicinal ZZExpanding the geographical areas of Siddha through research and translation of research plants and to develop a repository of raw drugs used in Siddha Medicine in Siddha into benefits for the humanity. Medicinal Plants Garden in Mettur. Z ZZCCRS initiates, aids, develops and coordinates scientific research works in different ZDeveloping the existing Pharmacy to cater to the needs of different units under CCRS aspects-- fundamental and applied aspects-- of Siddha and helps to promote/ assist with proper credentials like GMP/HACCP Accreditation. Z institutions of research for the study of diseases, their prevention, causation and remedy. ZFocusing on public health research and adopting the national policies in health ZZR & D Consultancy projects, patenting of drugs and processes and other supports to research. industry. AYUSH Research Portal: ZZCreation of international and inter-agency collaboration to improve and disseminate In order to make research findings of AYUSH systems and the other allied faculties research. accessible through web, the Department of AYUSH has started AYUSH Research Portal. ZZRebounding research by entering into arrangements with scientific agencies of other Central Council for Research in Ayurvedic Sciences (CCRAS) and the National Institute of Countries for exchange of Scientists, study tours, training in specialized areas, working Indian Medical Heritage (NIIMH), Hyderabad are coordinating and maintaining this freely on collaborative projects accessible web portal in collaboration with National Informatics Centre. All the research ZZConservation of medicinal plants and to support Medicinal Plants Board, Government of findings of Central Council for Research in Siddha are made available in this portal. 607 India in achieving its objectives. articles are uploaded in various headings like Literary research, Drug research and Clinical ZZAccreditation of Hospitals and Treatment centres under CCRS by NABH. research. ZZDeveloping of existing laboratories to NABL standards. ZZAugmentation of Literary Research and creation of new historical research Unit specifically for Siddha. ZZScientific validation ofV armam, Thokkanam and other non- invasive Siddha procedures and simple techniques to treat diseases. ZZEstablishment of separate unit for research in Varmam, Thokkanam and traditional Bone setting. ZZClinical research in the areas of cancer, HIV, Tuberculosis ZZRevalidation of techniques and processes of converting metals and minerals from inorganic to organic form through the advanced modern techniques and subjecting them to Pharmaco-dynamic and Pharmaco-kinetic studies. ZZValidation of Dietetics as Functional foods and Nutraceuticals. ZZDrug development strategies for high impact areas such as Diabetes, Hypertension, Hyperlipidemia, Osteoporosis, Cancer and incidentally detected Viral Hepatitis- B. ZZDrug research in the areas of alcoholic de-addiction, mother and child care, geriatric care, orthopaedics and psychiatry. www.siddhacouncil.com ZZClinical research in the areas of cancer, HIV, Tuberculosis e Book on Siddha Ministry of AYUSH SIDDHA 26 Siddha System of Medicine Central Council for Research in Siddha CCRS 27

Traditional Knowledge Digital Library (TKDL): Workshops / Seminars / Conferences organized: India’s vast traditional medicine knowledge exists in languages like Sanskrit, Hindi, Tamil, Arabic, Persian and Urdu and this made it inaccessible for patent examiners at the international patent offices to verify claims. This experience prompted the Department S.No Title Year of AYUSH to create a task force of experts i.e. patent examiners, IT experts, scientists and 1. Workshop on Dysfunctional Uterine bleeding 2007 technical officers for the creation of Traditional Knowledge Digital Library. 2. Workshop on Identification of New Source of Ancient Siddha 2007 TKDL is a collaborative project between Council of Scientific and Industrial Research Manuscripts (CSIR), Ministry of Science and Technology and Department of AYUSH. TKDL involves 3. Hands on Training in Experimental Pharmacology 2008 documentation of the knowledge available in public domain on traditional knowledge 4. Hands on Training in Experimental Pharmacology 2009 from the existing literature of Ayurveda, Unani, Siddha and Yoga in digitized format and 5. Pre-Clinical and Clinical Research workshop 2009 translates the information into the native languages of the patentexaminers, including 6. Hands on Training in Experimental Pharmacology 2010 the five international languages -- English, French, German, Spanish and Japanese. So far, 7. Workshop on Research Methodology 2010 the TKDL has included about 2.12 lakh medicinal formulations of Ayurveda, Unani and 8. National workshop on “Scientific Approach in Siddha Drugs for 2010 Siddha. Agreements have been signed with leading international patent offices such as Siddha Professionals SASDSD 2010 EPO, UKPTO and USPTO to protect traditional knowledge from bio-piracy, by giving access 9. National Workshop on Analytical Techniques in the Standard- 2010 to the TKDL database to patent examiners at International Patent Offices for patent search ization of Siddha Drugs and examination. This project first of its kind has found widespread appreciation in the 10. Workshop on Varmam & Thokkanam 2011 IGC as an initiative, which provides protection to our traditional medical knowledge by 11. Workshop on Manuscriptology 2011 preventing its misappropriation. 12. Workshop on Official Language Hindi 2010 13. National Workshop on Kalladaippu (Urolithiasis) and its man- 2012 agement in Siddha 14. C.M.E. Programme on Ayush portal system in Govt. Siddha 2011 Medical College, Chennai 15. National Workshop on “Evidence based Research on Safety 2012 and Efficacy of Metallic Preparations of Siddha” 16. National workshop on safety and efficacy of Herbo-mineral 2014 formulations of Siddha 17. Workshop on the Management of Obstetric and Gynaecologi- 2014 cal Disorders in Siddha, SRRI, Puducherry 18. National workshop on “The role of Siddha Medicine in the 2014 Transcription of the traditional medicine formulation (Siddha) in the Traditional management of Lifestyle disorders” knowledge Digital Library is given below:In Siddha, the number of texts (including volumes) used for transcription is 50 and the number transcribed is 23016. www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH SIDDHA 28 Siddha System of Medicine Central Council for Research in Siddha CCRS 29 Publication of books: Future Projects 1. Agathiyar Sowmiya Sagaram – 1200 (Tamil) 2. Agathiyar Vaidhya Valladhi – 600 (Tamil) S.No Title of project approved by SAB, CCRS 3. BogarKarukkidai Nigandu – 500 (Tamil) 1. Randomized community controlled trial to assess the effectiveness of 4. Konganar Kadai Kandam – 1000 (Tamil) Kadukkai Mathirai-a Siddha formulation in improving Hb levels and other 5. Konganar Mudhal Kandam – 1000 (Tamil) hematocrit 6. Konganar Nadu Kandam – 1000 (Tamil) 2. An Open labeled Clinical trial on Peenisam (Sinusitis) 7. Ramadevar – 1000 (Tamil) 3. Multicentric Open labelled clinical trial of OA1 Chooranam on 8. Siddhar Kaya Karpam (Tamil) 4. AzhalKeelvayu (Osteo arthritis – Knee joint) 9. Siddha Maruthuva Eliya Vazhakku Muraigal (Tamil) 5. A Multicentric trial to study the safety & lipid lowering effects of a poly- 10. Theraiyar Kudineer (Tamil) herbal formulation Nathaichoori chooranam 11. A Hand Book of Common Remedies in Siddha System on Medicine (English) 6. Multi-centric open clinical trial of a classical Siddha formulation Rasagan- 12. Agathiyar Vaidya Pooranam – 205 (English) dhi Mezhugu in KaruppaiSathaikattigal (Fibroid uterus) 13. Quality Control Standards for Certain Siddha Formulations (English) 7. Randomized Controlled Trial of two Siddha drugs in the management of 14. Sangamuni Visha Vaidhyam – 100 (English) Urolithiasis (Kalladaippu)- Phase II 15. Monograph of Thamira Chenduram (Peptic Ulcer) (English) 8. A Siddha polyherbal formulation (Nilappanai Chooranam) in the man- 16. Pulippaani Vaidhyam – 500(English) agement of Oligospermia (VindhanuKuraipadu) 17. A Hand Book of Common Siddha Kaya Kalpa (Rasayana) Herbs for Healthy Life(English) 9. Recent trends in the usage of Siddha medicine among the population of 18. Sangamuni Visha Vaidhyam – 100 - Hindi Puducherry region 19. Agathiyar Vaidya Pooranam – 205- Hindi 10. Siddha treatment guidelines for Non-communicable diseases 20. Agathiar Chillarai korvai (Tamil) 11 Vernacular name Encyclopaedia of Siddha drugs mentioned in Siddha 21. Theraiyar Sekarappa (Tamil) MateriaMedica (Gunapadam) 22. Theraiyar Yemaga venba (First part) 12. Database of Siddha preparations for certain diseases mentioned 23. Theraiyar Yemaga venba (Second part) 13. in the enlisted literatures of drugs and cosmetics act 1940 24. Theraiyar Yemaga venba (Third part) 14. Digitization and compilation of herbarium and folklore claims of survey 25. The monograph on Chikunguniya of Ayurveda and Siddha(English) of medicinal plants unit-Siddha at Palayamkottai 26. Ayurveda and Siddha for Anaemia (Pandu / Veluppunoi) (English) 15. Medico ethno-botanical study of Palamalai, Salem dt. 27. Compilation of claims on Vector Borne Diseases of Ayurveda and Siddha(English) 16. Anti-hyperlipidemic activity of D5 choornam 28. The Siddha Pharmacopoeia of India-Part I, Vol-I(English) 17. Hepatoprotective activity of Fluggeavirosa against chemical induced 29. The Siddha Pharmacopoeia of India-Part I, Vol- II(English) liver damage in Rats. 30. The Siddha Formulary-Part II (Tamil) 18. Alternative therapy for diabetic retinopathy / cataract of Fluggeavirosain 31. Essential drugs list (Siddha) rats. 32. Siddha Clinical Research Protocol for Lifestyle disorders. (English) 19. Toxicity studies of NathaichooriChoornam 33. A – Z Know your Alphabets through Siddha Medicinal Plants 20. Nephroprotective Effect of Sphaeranthus amarathoides Burm. f. (Siva- karanthai) against Gentamycin induced nephrotoxicity in Rats www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH SIDDHA 30 Siddha System of Medicine Central Council for Research in Siddha CCRS 31 Publications S.No Title of project approved by SAB, CCRS 21. Evaluation of anti-diabetic activity of Argyreiasericea Dalzell (Oonankodi) Dr. S. Natarajan Scientific Validation of Thiemee Journals / Ab- 11.04.2011 against streptozotocin induced diabetes in Rats. Dr. P. SathiyaRajeswaran & Purification Method of stract, Planta Med 2011; 22. Isolation of chemical marker from selected plants used in Reproductive Dr.M.Kannan Terminalia chebula in 77 DOI: 10.1055/s-0031- and Child Health Siddha Medical Practice 1273671 23. Analysis of inorganic composition of selected plants used in Siddha Sys- in India Impact factor : 2 Dr. S. Natarajan High Order Pharmaceu- Heritage Amruth – 02.04.2011 tem Dr. P. SathiyaRajeswaran & tical Forms in Siddha FRLHT, Bangalore Vol 7 24 Qualitative and Quantitative analysis of Chembu (Copper) containing Dr.M.Kannan System of Medicine issue 2 April 2011, ISSN plants – A scientific validation of Siddha claim. 0973-2764 Dr. P. SathiyaRajeswaran Conservation of Palm Journal of Siddha NIS, 2009 Dr.M.Kannan & Leaf manuscripts Chennai Dr. S. Natarajan Dr. Sasikala Ethirajulu Antidiarrheal Pharmaceutical Biology Published evaluation of Bauhinia – 2010 tomentosaL. Dr. Sasikala Ethirajulu Anthelmintic activity of Research in Pharmaceu- Published leaves of two species of tical sciences, Septem- CadabaForsk. ber 2010 Shyamala R., Some herbal drugs of Journal of Siddha, Published. Vijayakumar, controversial identity in March 2009 Masilamani, Siddha Medicine Sasikala Ethirajulu &T. Anandan Dr. Sasikala Ethirajulu Anthelmintic activity of Journal of Tropical Me- 2009 leaf extract of Cadaba dicinal Plants, Malaysis. Species. Vol.10. No.1, 19-22 Dr. Sasikala Ethirajulu Pharmacognostical Phcog J. (A supplement 2009 studies on leaves of to Pharmacognosy Cadabafruticosa (L.) Magazine) Vol.I, issue 1, Druce. 8-14 Dr. Sasikala Ethirajulu Antibacterial activity Indian Journal of Phar- 2009 of leaves of Cadaba maceutical sciences 72 trifoliate (Roxb.) W. & A. (2), 115-116. A.Saravana Gandhi, Pharmacognostical Journal of Plant Ar- 2009 M.Padma sorna subramanian, studies on Umarikeerai chives Vol.9 No.1, 2009 and E.Rajabudeen. (Suaedamaritima) (L.) pp.79-82 (ISSN 0972- Dumort 5210) A.Saravana Gandhi, Indigenous knowledge Published in the jour- Published M.Yogaraj and on natural dyeing nal of Natural Product M.Padma sorna subramanian, of Korai grass mat in Radiance Vol. 8(5), 2009, Pattamadai, Tirunelveli pp.542-545 district, Tamilnadu www.siddhacouncil.com

e Book on Siddha Ministry of AYUSH SIDDHA 32 Siddha System of Medicine Central Council for Research in Siddha CCRS 33

Saravana Gandhi and A research article Journal of Eco-toxicol- Published Dr. Kalavathy K Rao Bird eye view on Leuco- PP 38-44, JIM & H, Chen- January 2008 M.Padmasorna Subramanian namely “Isolation of the ogy and Environmental derma nai natural colorant from monitoring Dr. S. Natarajan An Open Clinical Trial Webmed Central Ar- 2012 the roots of Rubiacor- Dr. P. SathiyaRajeswaran and for CeganaVatham ticle ID: WMC002968 difolia L. and its use as Dr. M. Kannan using Varmam Source: http://www. a new neutralization Procedure webmedcentral.com/ indicator” article_view/2968 ISSN Dr. R. Rajasekaran The Roots of Siddha Journal of Indian Medi- 2009 2046-1690 Dr. Gomathy and system of medicine cal Heritage ISSN 0975 – Dr. S. Natarajan Management of Webmed Central 2012 Dr.M.Kannan in Thiruvasagam (An 430X Vol.XXXIX P.No.63 Dr. P. SathiyaRajeswaran and Kalladaippu Article ID: WMC003031 evidence based literary Dr. M. Kannan (Renal Calculi) Source: http://www. study) webmedcentral.com/ Dr. P. SathiyaRajeswaran Diffraction Finger Prints Journal of Siddha. Vol II. 2009 article_view/3031 and Dr.T.Anandan on Lingam and its JUNE - NOV ISSN 2046-1690 preparations. Sasikala Ethirajulu “Pharmacognostical JMAPS Vol.30, No.4, 2008 Dr. S. Natarajan Anemia (Pandu) Prima- Webmed Central 2012 SaradhaVasanth evaluation of 406-410 Dr. P. SathiyaRajeswaran and ry Care in Siddha Article ID: WMC003172 K. Balakrishna and Spermacocehispida L.” Dr. M. Kannan Source: http://www. G. Veluchamy webmedcentral.com/ Sasikala Ethirajulu “Pharmacognostical J.Econ.Taxon.Bot.No.3 2008 article_view/3172 SaradhaVasanth studies on Vol : 32, 533- 536 ISSN 2046-1690 K. Balakrishna and Catunaregam spinosa G. Veluchamy (Thunb.) Tiruv. – Root” Dr. P. SathiyaRajeswaran Conservation of Palm Journal of Siddha 2009 R. Mythreyi Analgesic activity Int. J. Pharmacol. Biol. 2008 Dr.M.Kannan Leaf manuscripts National Institute of E.Sasikala and of Sphaeranthus Sci. Vol. 2, (3), 81- 83 Dr.S. Natarajan Siddha A.Geetha amaranthoidesBurm. f. Dr. K. MeenakshiSundramurthy Vol 2, Issue 2, R. Mythreyi E.Sasikala and Evaluation of diuretic Pharmacology on line May 2008 and July –Dec 2009 A.Geetha activity of Jussiaeasuf- Dr. T. Anandan fruticosa L. R. Mythreyi E.Sasikala and Wound healing activity Adv. Pharmacol. &Toxi- 2008 Dr. T. Anandan Somato-typing study Journal of Siddha 2009 A.Geetha of chloroform extract col. - Vol. 9 (2), 141- 144 Dr. S. Natarajan and of Leucoderma accord- National Institute of of Acalyphaindica L.- Dr. J. Jeyakannan ing to Siddha System of Siddha root Medicine Vol 2, Issue 2, July –Dec 2009 R. Mythreyi E.Sasikala and Anthelmintic activity of Tropical Medicinal Published A.Geetha two species of Cadaba Plants P. SathiyaRajeswaran Preliminary phyto Indo American jour- 2011 G. Balamurugan, “Anti Epileptic Activity J. Sci. Res. (1), 153 – 159 chemical, acute toxicity nal of Pharmaceutical P. Muralidharan and of Poly Herbal Extract (2009) www.banglajol. 2009 and anti-inflammatory research. S. Selvarajan from Indian Medicinal info/index.php/JSR activity of Pitta Sura plants” Kudineer Dr. Kalavathy K. Rao and Chronology of Preven- PP 17-22 JIM & H Vol.4-7 January 2008 Dr. K.S. Kalaimani tive conservation of manuscripts. Pros and cons of materials used www.siddhacouncil.com and role of digitization e Book on Siddha Ministry of AYUSH SIDDHA 34 Siddha System of Medicine Central Council for Research in Siddha CCRS 35

P. Sathiya Rajeswaran, Evaluation of Immuno- JAPHR,Vol – I- Issue 3. 2011 Dr.H.Mubarak Prevalence of Siddha International Journal Vol.1. Issue 4. R.Ganesan, modulatory Activity of Clinical Conditions of Health and Pharma- 2012 G.Pramodreddy, SayaChurnam among Geriatric Popu- ceutical Sciences ISSN and Santhammal (A Poly Herbal Formula- lation in Puducherry- 2278-0564 tion) on Albino rats. cross sectional study R. Mythreyi, Antipyretic Activity of International Journal of 2012; 2(2): 40-45. P. Sathiyarajeswaran National projects in Siddha Papers.Org. 2011 Sasikala Ethirajulu, A. Geetha Cadabatrifoliata (Roxb.) Phytotherapy Research Mother and childcare W & A. R.Ganesan, Hepato-protective JAPHR,Vol - I - Issue 3. 2011 R. Rajamurugan, Brassica nigra plays a Pharmaceuti cal Biology 2012; Early On- P.Elankani, and activity on Azimatetra- A. Suyavaran, remedy role in hepatic line: 1–10. G.Pramodreddy, gantha. N. Selvaganabathy, and renal damage Dr. Shyamala Rajkumar Basic Philosophy of http://Siddhapapers. 2013 C.H. Ramamurthy, Neuropsychiatric webs.com/literaryre- G. Pramod Reddy, Diseases in Siddha views.htm. V. Sujatha and system of Medicine C. Thirunavukkarasu Dr.A.Saravana Gandhi, Exposure to Vehicular Quarterly Scientific October 2012 G. Pramod Reddy, Anti Gastric Ulcer Activ- Int J IntSci Inn Tech Sec 2013; 2(1): 31-33. Dr.M.PadmaSornaSubramanian pollution and its impact journal namely Nature L. Kavitha, ity Of Triphala Karpam A and Dr.E.Rajabudeen on Traffic Policemen in Environment and Pollu- GowthamanR. (Siddha formulation) In Tirunelveli City, India tion Technology (ISSN- Kumaresan, Rats 0972-6268) Vol.II No.3 R. Ganesan, PP.515-517, 2012.) P. Satya Rajeswaran, A.Saravanaganthi, Effect of Azotobacter International Research December 2012 S. Jega Jothi Pandian R.Lakshmanan, . on seedling growth of Journal of Basic and M. Kannan, The Health status of I J H P S 2012; July: 36-41 PadmaSorna Subramanian and Sesbania grandiflora Applied Sciences Spe- S. Natarajan, Geriatric population K.Subramonian (L.) Poir. For energy cial Issue of SCIENCIA P. Sathiyarajeswaran, attending the plantation ACTA XAVERIANA - SPE- K. Meenakshi Sundaramurthy specialSiddha Geriatric CIAL ISSUE DEC. 2012 Clinic of a Research vide IIN 0976- Institute Rajabudeen E., GC-MS Analysis of the Asian Jounal of Re- Nov.2012 P. Sathiyarajeswaran, Antenatal Care with I J H P S 2012; October Saravana Gandhi A., Methanol Extract of Te- search in Chemistry M. Kannan, Lotus Padma Sorna Subramanian M. phrosiavillosa (L.) Pers 5 (11): Nov.2012 ISSN S. Natarajan 0974-4169 Natarajan S, The Role of Webmed Central Indian 2012;3(9):WMC E.Rajabudeen, GC-MS analysis of International Jour- January 2013 Nagarajan T, Varma Therapy in Medicine 003717;3(9):W A Saravana Gandhi, biologically active nal of Plant Sciences Sathiyarajeswaran P, CakanaVatam MC003717 M.PadmaSorna Subramanian compounds in Indigo- Volume 8/Issue I/ Kannan M and K.Natarajan feraviscosa Lam. January 2013/116-119/ Natarajan S, Evidence based Siddha Webmed Central Public 2012;3(11):WM ISSN:0973-1547/Online Sathiyarajeswaran P, Medical Management Health C003808;3(11 ISSN 0976-593X Kannan M, of Dengue ):WMC003808 R.Sreekala Devi, ‘Investigation of Anti- International Journal of Vol. 5, Suppl. 1, Jega Jothi Pandian S P.M.Radhamany& oxidant principles from Pharmacy and Pharma- 2013 V.Gayathri Devi Psilanthestravancoren- ceutical Sciences sis (Wt. &Arn.) Leroy. – An Unexplored Taxon of www.siddhacouncil.com Rubiaceae’

e Book on Siddha Ministry of AYUSH SIDDHA 36 Siddha System of Medicine Central Council for Research in Siddha CCRS 37

Dr.A.Saravana Gandhi, Exposure to Vehicular Quarterly Scientific October 2012 Natarajan. S, Fasting – A medico International Refereed Feb. 2014 Dr.M.PadmaSorna Subramanian pollution and its impact journal namely Nature Kannan. M, historical review Journal of Reviews and and Dr.E.Rajabudeen on Traffic Policemen in Environment and Pollu- Sathiyarajeswaran. P Research Tirunelveli City, India tion Technology (ISSN- Volume 2 Issue 1 Janu- 0972-6268)Vol.II No.3 ary-February 2014 PP.515-517, 2012.) International A.Saravanaganthi, Effect of Azotobacter International Research December 2012 Manuscript ID : R.Lakshmanan, on seedling growth of Journal of Basic and M.PadmaSorna Subramanian Sesbania grandiflora Applied Sciences Spe- Mr. R. Ganesan Antioxidant activity International Journal of Jan. 2014 and K.Subramonian (L.) Poir. For energy cial Issue of SCIENCIA of coldeniaprocum- Pharmacy and Pharma- plantation ACTA XAVERIANA - SPE- benslinn. Whole plant ceutical Sciences Int J CIAL ISSUE DEC. 2012 methanolic extract Pharm PharmSci, Vol 6, vide IIN 0976-1152 of Suppl 1, 75-79 page nos 216-218. Anitha john, Chemical standardisa- Indian Journal of Phar- July, 2013 R. Ganesan Hepatoprotective effect International Journal Apr. 2013 V. Gayathri Devi, tion of Sidacordifolia macy and Technology of coldeniaprocumbens of Integrative sciences, Arjun Singh and Linn. a common Siddha (IJPT), July – 2013, Vol.5, Linn. against D-ga- Innovation and Technol- K. Gopakumar herbal drug Issue No.2, 5448-5457 lactosamine Induced ogy Int. J. Int sci. Inn. Sasikala Ethirajulu, Pharmacognostical Journal of Drug Re- 2013 acute liver damage in Tech. Sec. B, Apr. 2013, SaradaVasanth, evaluation of Toddaliaa- search in Ayurveda & rats Vol.2, Iss 2, pg 9-11 Balakrishna K, siatica (L.) Lam. Siddha, Vol. XXXII, No.1- Natarajan. S, Scientific Validation of International Journal Aug. 2013 Veluchamy G. 2, 37-46. Kannan. M, purification of Kadukkai of Pharmaceutical Shakila R Review on Sphaer- Phcog Rev 7(14): 157- 2013 Sathiyarajeswaran. P (Terminalia Chebula)- A Research and Develop- anthusindicus Linn. 169. Siddha Drug ment (IJPRD) IJPRD, (Koṭṭaikkarantai 2013: Vol 5 (06): August Shakila R Chromatographic stud- Asian J Pharm Life Sci 2013 2013(018- 024) ISSN No: ies on Artemisia nila- 3(3): 185-190. 0974- 9446 giria Leaf Volatile oil R. Ganesan, Hepato-protective International Journal 2013 Perundevi TS, Comparative evaluation Asian Journal of Bio- 2013 MathuramVenkatanarasimhan, activity of Coldeniapro- of Integrative Science, Kothai S, of flaxseed mucilage, chemical and Pharma- Sharadpawar, cumbenslinn against D- Innovation Technology, Shakila R gum acacia and peach ceutical Research 4(3): G. Pramod Reddy, galactosamine induced Vol 2 (2), 9-11, 2013. gum as pharmaceutical 181-190 T. Anandan and acute liver damage in excipients G. Masilamani rats Smt.Shakila. R Elankani P. Jega- Development of Fin- Research Journal of K. Manjula Devi, “Evaluation of Immu- Asian Journal of Phar- 2013 jothipandian S. ger Print Profiles for Pharmacognosy and January-March, G. Pramod Reddy, nomodulatory activity maceutical and Clinical Androgrphisechioi- Phytochemistry 6(1) 2014, A.R. Kothai, of aqueous extract of a Research Vol-6 (2), 129- desNees. and Androgra- 22-29. M. Thenmozhi, poly herbal formulation 133, 2013. phispaniculataNees. M. Dhanalakshmi, by invivo method” Meena R Ramaswamy Physico chemical IOSR Journal of Phar- 2014 S. Sarumathy R.S Shakila R analysis of Kandhaga- macy 4(2): 28-34. G. Devanand Venkatasubbu, In vitro and In vivo Biomed Microdevices 2013 Rasayanam, a Siddha S. Ramasamy, anticancer activity of (2013) 15:711–726 herbomineral formula- G. Pramod Reddy & surface modified pacli- tion J. Kumar taxel attached hydroxy- www.siddhacouncil.com apatite and titanium dioxide nanoparticles e Book on Siddha Ministry of AYUSH SIDDHA 38 Siddha System of Medicine

Priya F, Standardization of Mila- International J Herbal 2014 Shakila R, gathiChoornam Medicine 1(6): 69-74 Sathiyarajeswaran P, Pitchiahkumar M Shakila R, Development of fin- Research Journal of 2014 Elankani P, ger print profiles for Pharmacognosy and Jegajothipandian S Androgrphis echioi- Phytochemistry 6(1): desNees. and Androgra- 22-29 phispaniculataNees Shyamala Rajkumar, J.Annathai, Medicinal plants men- International Journal Of 2014 S.Natarajan tioned in the Holy Bible Reviews, Surveys And and in Siddha system Research 3(2) : 69-85 and their ethanome- dicinal studies Shyamala Rajkumar, V.Vijaya Management of Fibroid International Journal of 2014 Kumar, C.Ponmuthu Rani, Uterus with a Tradition- Multidisciplinary Health K.Gopakumar, R.S. Ramaswamy al Siddha formulation Sciences, July-Sep; 1( 1): – A Review 1-15 International collaboration CCRS officers are deputed periodically Ministry of AYUSH to train and conduct seminars/ workshops for the registered medical practioners of Siddha stream and other health officials of other countries as per the bilateral understanding.

In the year 2013, International Conference on Siddha Medicine was organized by Traditional and Complimentary Medicine Division, Ministry of Health, Malaysia and Malaysian Association Ma¼uppatu U¶aln°y Marunteºa L¡kum of Traditional Indian Medicine (MATIM) in which Siddha experts from India participated and CentralMa¼uppatu Council U½an°y for Research Marunteºac inC¡lum Siddha enhanced technological transfer through scientific discussion Ma¼uppatuMinistry Iºin°y of V¡r¡tirukka AYUSH Ma¼uppatuGovernment C¡vai Marunteºa of India L¡m® CentralArignar council Anna Hospital for Campus, Research Arumbakkam- Tirum£lar in siddha Chennai,ministry Tamil Nadu of -ayush 600106 governmentwww.siddhacouncil.com oCf india www.siddharesearchcouncil.org [email protected] Participants in the International Prof. Dr. R. S. Ramaswamy, DG, CCRS along with Datuk Ph: +91 44 26211621 Conference on Siddha Medicine 2013, Seri Dr. S. Subbramanian, Minister of Health, Govt. of Malaysia Malaysia and Datuk Dr. Jeyaindra Dy. Director General www.siddhacouncil.com (Medical) Ministry of Health, Govt. of Malaysia

e Book on Siddha