Learning from the 2017 Outbreak in the Democratic Republic of Congo
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Development, Manufacturing, and Supply of MSD's Ebola Vaccine
Engineering Conferences International ECI Digital Archives Vaccine Technology VI Proceedings 6-15-2016 Development, manufacturing, and supply of MSD’s Ebola vaccine Jeffrey T. Blue Director Vaccine Drug Product Development, Merck Sharp & Dohme Corp., USA, [email protected] Follow this and additional works at: http://dc.engconfintl.org/vaccine_vi Part of the Engineering Commons Recommended Citation Jeffrey T. Blue, "Development, manufacturing, and supply of MSD’s Ebola vaccine" in "Vaccine Technology VI", Laura Palomares, UNAM, Mexico Manon Cox, Protein Sciences Corporation, USA Tarit Mukhopadhyay, University College London, UK Nathalie Garçon, BIOASTER Technology Research Institute, FR Eds, ECI Symposium Series, (2016). http://dc.engconfintl.org/vaccine_vi/ 23 This Abstract and Presentation is brought to you for free and open access by the Proceedings at ECI Digital Archives. It has been accepted for inclusion in Vaccine Technology VI by an authorized administrator of ECI Digital Archives. For more information, please contact [email protected]. Development, Manufacturing, and Supply of MSD’s Ebola Vaccine Jeffrey T. Blue Director, Vaccine Drug Product Development Merck & Co. Inc. Vaccine Technology VI 15 June 2016 Albufeira, Portugal • Elements of this program has been funded in whole or in part with Federal Funds from the Department of Health and Human Services; Office of the Assistant Secretary for Preparedness and Response; Biomedical Advanced Research and Development Authority under Contract Number: HHSO100201500002C Presentation -
Defining Health Diplomacy: Changing Demands in the Era of Globalization
THE MILBANK QUARTERLY A MULTIDISCIPLINARY JOURNAL OF POPULATION HEALTH AND HEALTH POLICY Defining Health Diplomacy: Changing Demands in the Era of Globalization REBECCA KATZ, SARAH KORNBLET, GRACEARNOLD,ERICLIEF, and JULIE E. FISCHER George Washington University; Stimson Global Health Security Program Context: Accelerated globalization has produced obvious changes in diplomatic purposes and practices. Health issues have become increasingly preeminent in the evolving global diplomacy agenda. More leaders in academia and policy are thinking about how to structure and utilize diplomacy in pursuit of global health goals. Methods: In this article, we describe the context, practice, and components of global health diplomacy, as applied operationally. We examine the foundations of various approaches to global health diplomacy, along with their implications for the policies shaping the international public health and foreign policy environments. Based on these observations, we propose a taxonomy for the subdiscipline. Findings: Expanding demands on global health diplomacy require a delicate combination of technical expertise, legal knowledge, and diplomatic skills that have not been systematically cultivated among either foreign service or global health professionals. Nonetheless, high expectations that global health initia- tives will achieve development and diplomatic goals beyond the immediate technical objectives may be thwarted by this gap. Conclusions: The deepening links between health and foreign policy require both the diplomatic and global health communities to reexamine the skills, comprehension, and resources necessary to achieve their mutual objectives. Keywords: Global health, diplomacy, foreign policy. Address correspondence to: Sarah Kornblet, Stimson Global Health Security Program, 12th Floor, 1111 19th St. NW, Washington, DC 20036 (email: [email protected]). The Milbank Quarterly, Vol. -
(2005) Through Cooperative Bioengagement
ORIGINAL RESEARCH published: 13 October 2015 doi: 10.3389/fpubh.2015.00231 Implementation of the International Health Regulations (2005) through cooperative bioengagement Claire J. Standley , Erin M. Sorrell , Sarah Kornblet , Julie E. Fischer and Rebecca Katz* Global Health Security Program, Department of Health Policy and Management, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA Cooperative bioengagement efforts, as practiced by U.S. government-funded entities, such as the Defense Threat Reduction Agency’s Cooperative Biological Engagement Program, the State Department’s Biosecurity Engagement Program, and parallel pro- grams in other countries, exist at the nexus between public health and security. These programs have an explicit emphasis on developing projects that address the priorities of the partner country as well as the donor. While the objectives of cooperative bioengage- ment programs focus on reducing the potential for accidental or intentional misuse and/ or release of dangerous biological agents, many partner countries are interested in bio- engagement as a means to improve basic public health capacities. This article examines the extent to which cooperative bioengagement projects address public health capacity Edited by: Nathan Wolfe, building under the revised International Health Regulations and alignment with the Global Metabiota, USA Health Security Agenda action packages. Reviewed by: Keywords: International Health Regulations, Global Health Security Agenda, biological -
Democratic Republic of the Congo – Ebola Outbreaks SEPTEMBER 30, 2020
Fact Sheet #10 Fiscal Year (FY) 2020 Democratic Republic of the Congo – Ebola Outbreaks SEPTEMBER 30, 2020 SITUATION AT A GLANCE 128 53 13 3,470 2,287 Total Confirmed and Total EVD-Related Total EVD-Affected Total Confirmed and Total EVD-Related Probable EVD Cases in Deaths in Équateur Health Zones in Probable EVD Cases in Deaths in Eastern DRC Équateur Équateur Eastern DRC at End of at End of Outbreak Outbreak MoH – September 30, 2020 MoH – September 30, 2020 MoH – September 30, 2020 MoH – June 25, 2020 MoH – June 25, 2020 Health actors remain concerned about surveillance gaps in northwestern DRC’s Équateur Province. In recent weeks, several contacts of EVD patients have travelled undetected to neighboring RoC and the DRC’s Mai- Ndombe Province, heightening the risk of regional EVD spread. Logistics coordination in Equateur has significantly improved in recent weeks, with response actors establishing a Logistics Cluster in September. The 90-day enhanced surveillance period in eastern DRC ended on September 25. TOTAL USAID HUMANITARIAN FUNDING USAID/BHA1,2 $152,614,242 For the DRC Ebola Outbreaks Response in FY 2020 USAID/GH in $2,500,000 Neighboring Countries3 For complete funding breakdown with partners, see funding chart on page 6 Total $155,114,2424 1USAID’s Bureau for Humanitarian Assistance (USAID/BHA) 2 Total USAID/BHA funding includes non-food humanitarian assistance from the former Office of U.S. Foreign Disaster Assistance. 3 USAID’s Bureau for Global Health (USAID/GH) 4 Some of the USAID funding intended for Ebola virus disease (EVD)-related programs in eastern Democratic Republic of the Congo (DRC) is now supporting EVD response activities in Équateur. -
Ebola Virus Disease and Clinical Care Part I: History, Transmission, and Clinical Presentation
Ebola Virus Disease and Clinical Care Part I: History, Transmission, and Clinical Presentation This lecture is on Ebola virus disease (EVD) and clinical care. This is part one of a three-part lecture on this topic. Preparing Healthcare Workers to Work in Ebola Treatment Units (ETUs) in Africa This lecture will focus on EVD in the West African setting. Ebola Virus Disease and Clinical Care: The training and information you receive in this course will Part I: History, Transmission, and Clinical not cover the use of certain interventions such as intubation Presentation or dialysis which are not available in West African Ebola Treatment Units (ETUs). You will need supplemental training This presentation is current as of December 2014. This presentation contains materials from Centers for Disease Control and to care for patients appropriately in countries where advanced Prevention (CDC), Médecins Sans Frontières (MSF), and World Health Organization (WHO). care is available. U.S. Department of Health and Human Services U.S. Department of Health and Human Services Centers for Disease Control and Prevention Centers for Disease Control and Prevention version 12.03.2014 The learning objectives for this lecture are to: Learning Objectives ▶ Describe the routes of Ebola virus transmission Describe the routes of Ebola virus transmission Explain when and how patients are infectious ▶ Explain when and how patients are infectious Describe the clinical features of patients with Ebola ▶ Describe screening criteria for Ebola virus disease Describe the clinical features of patients with Ebola (EVD) used in West Africa Explain how to identify patients with suspected ▶ Describe screening criteria for EVD used in West Africa EVD who present to the ETU ▶ Explain how to identify patients with suspected EVD who present to the ETU This presentation contains materials from CDC, MSF, and WHO 2 A number of different viruses cause viral hemorrhagic fever. -
Understanding Ebola
Understanding Ebola With the arrival of Ebola in the United States, it's very easy to develop fears that the outbreak that has occurred in Africa will suddenly take shape in your state and local community. It's important to remember that unless you come in direct contact with someone who is infected with the disease, you and your family will remain safe. State and government agencies have been making preparations to address isolated cases of infection and stop the spread of the disease as soon as it has been positively identified. Every day, the Centers of Disease Control and Prevention (CDC) is monitoring developments, testing for suspected cases and safeguarding our lives with updates on events and the distribution of educational resources. Learning more about Ebola and understanding how it's contracted and spread will help you put aside irrational concerns and control any fears you might have about Ebola severely impacting your life. Use the resources below to help keep yourself calm and focused during this unfortunate time. Ebola Hemorrhagic Fever Ebola hemorrhagic fever (Ebola HF) is one of numerous Viral Hemorrhagic Fevers. It is a severe, often fatal disease in humans and nonhuman primates (such as monkeys, gorillas, and chimpanzees). Ebola HF is caused by infection with a virus of the family Filoviridae, genus Ebolavirus. When infection occurs, symptoms usually begin abruptly. The first Ebolavirus species was discovered in 1976 in what is now the Democratic Republic of the Congo near the Ebola River. Since then, outbreaks have appeared sporadically. There are five identified subspecies of Ebolavirus. -
9.5 Liu Ebola.Pptx
4/23/15 Ebola Update: One Year Later… Catherine Liu, MD Associate Professor, Department of Medicine, Division of, Infectious Diseases, University of California San Francisco Medical Director, Hospital Epidemiology and Infection Control, UCSF Disclosures • None 1 4/23/15 West African Ebola Outbreak: How Did it Begin? • Dec 2013: 1st case in Guinea • March 2014: WHO no<fied of outbreak in Guinea • July 2014: CDC releases first health advisory reGardinG Ebola epidemic • AuGust 2014: WHO declares epidemic a “public health emerGency of internaonal concern” Background • Member of Filoviridae family • Natural reservoir - ? Fruit bats • Named aer Ebola river in DRC • 5 species: – Zaire (1976) – Sudan (1976) – Reston (1989) – imported monkeys from Philippines – Cote d’Ivoire/ Tai Forest (1994) – Bungibugyo (2007) 2 4/23/15 What is Ebola Virus? • SinGle-stranded RNA virus, Filoviridae family • Natural reservoir unknown ? Fruit bats • Named aer the Ebola river in the DRC • 5 species: – Zaire (1976) – Sudan (1976) – Cote d’Ivoire/ Tai Forest (1994) – Reston (1989) – primate pathoGen – Bundibugyo (2007) 2014 West African Ebola Outbreak 3 4/23/15 2014 West Africa Outbreak – Why did it Happen? An Old Disease in A New Context Deforestation “The increase in Ebola outbreaks since 1994 is frequently associated with dras<c chanGes in forest ecosystems in tropical Africa” – 2012 study in Journal of Veterinary Research 4 4/23/15 Bushmeat Consumption Transmission During Burial Ceremonies for Dead 5 4/23/15 Spread of Infection from Movement of People Inadequate Medical Personnel (1 doctor per 100,000 population) 6 4/23/15 Ebola Disease Progression RECOVERY or Massive fluid losses (5-10 L/day*) Prolonged convalescence if survive *Dr. -
(GEVIT) Practical Guidance on the Use of Ebola Vaccine in an Outbreak Response
EBOLA STRATEGY Global Ebola Vaccine Implementation Team (GEVIT) Practical guidance on the use of Ebola vaccine in an outbreak response Draft Guidance, May 2016 Draft - Not for Implementation This guidance is being distributed for comment purposes only. © World Health Organization 2016. All rights reserved. The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted and dashed lines on maps represent approximate border lines for which there may not yet be full agreement. All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either expressed or implied. The responsibility for the interpretation and use of the material lies with the reader. In no event shall the World Health Organization be liable for damages arising from its use. Draft-Not for Implementation Contents Contents ......................................................................................................................................... 2 Abbreviations and acronyms ........................................................................................................... 4 Acknowledgements ........................................................................................................................ -
Can an Attribution Assessment Be Made for Yellow Rain? Systematic Reanalysis in a Chemical-And-Biological-Weapons Use Investigation
Can an attribution assessment be made for Yellow Rain? Systematic reanalysis in a chemical-and-biological-weapons use investigation Rebecca Katz, Ph.D.* Department of Health Policy George Washington University 2021 K Street, NW, Suite 800 Washington, DC 20006 [email protected] * Corresponding author. Burton Singer, Ph.D. Office of Population Research 245 Wallace Hall Princeton University Princeton, NJ 08544 [email protected] ABSTRACT. In intelligence investigations, such as those into reports of chemical- or biological-weapons (CBW) use, evidence may be difficult to assemble and, once assembled, to weigh. We propose a methodology for such investigations and then apply it to a large body of recently declassified evidence to determine the extent to which an attribution can now be made in the Yellow Rain case. Our analysis strongly supports the hypothesis that CBW were used in Southeast Asia and Afghanistan in the late 1970s and early 1980s, although a definitive judgment cannot be made. The proposed methodology, while resource-intensive, allows evidence to be assembled and analyzed in a transparent manner so that assumptions and rationale for decisions can be challenged by external critics. We conclude with a discussion of future research directions, emphasizing the use of evolving information-extraction (IE) technologies, a sub-field of artificial intelligence (AI). here is a science to the collection of evidence in ences from single, novel events. Standards of evidence an intelligence investigation. Experienced ana- and inference are ill-defined -
Implications and Lessons Learned from Response to the Ebola Virus Disease Outbreak for the Bwc
IMPLICATIONS AND LESSONS LEARNED FROM RESPONSE TO THE EBOLA VIRUS DISEASE OUTBREAK FOR THE BWC Research Project to Inform RecommendaCons for the 8th Review Conference Thursday, December 17, 2015 0900-1000 Hosted by the United States of America AGENDA u Opening remarks by U.S. Ambassador Robert Wood u Presentaon by Dr. Rebecca Katz (U.S. Department of State) and Dr. Mahew Lim (U.S. Department of Health and Human Services) u Comments from the World Health Organizaon and the United Naons Office for Disaster Risk Reduc9on u Discussion on recommendaons for topics to be discussed during the intersessional period. IMPLICATIONS AND LESSONS LEARNED FROM RESPONSE TO THE EBOLA VIRUS DISEASE OUTBREAK FOR THE BIOLOGICAL WEAPONS CONVENTION Research Project to Inform RecommendaCons for the 8th Review Conference Rebecca Katz, PhD MPH U.S. Department of State [email protected] Mahew Lim, MD U.S. Department of Health and Human Services [email protected] Objecves • Project background • About the project – Methodology – Interview Ques9ons • Preliminary findings • How findings fit within larger reform context Ebola Response & the BWC • Response to Ebola in West Africa has fundamentally challenged preconcep9ons about internaonal assistance following a public health emergency, straining global public health emergency response and necessitang sustained contribu9ons from: • Naonal Governments • Intergovernmental Organizaons • Internaonal Organizaons: and • Charitable Organizaons, Foundaons, and Individual Donors. Ebola Response & the BWC BWC States Par9es recommendaons to assess Ebola response for lessons relevant to Ar9cle VII of the Conven9on. About Our Project Intent: to learn from NGOs, IOS and bilateral donors how response to Ebola outbreak might have been different if there had been a deliberate component. -
CDC Fact Sheet Ebola Virus Disease
Ebola Virus Disease (EVD) Ebola Virus Disease (EVD) is a rare and deadly disease most commonly affecting people and nonhuman primates (monkeys, gorillas, chimpanzees). There are six known species of viruses within the genus Ebolavirus: Ebola virus (Zaire ebolavirus), Sudan virus (Sudan ebolavirus), Taï Forest virus (Taï Forest ebolavirus, formerly Cote d’Ivoire ebolavirus), Bundibugyo virus (Bundibugyo ebolavirus), Reston virus (Reston ebolavirus,) and Bombali virus (Bombali ebolavirus). Of these, only four are known to cause disease in people (Ebola, Sudan, Taï Forest, and Bundibugyo viruses). Reston virus is known to cause disease in nonhuman primates and pigs, but not in people. It is unknown if Bombali virus, which was recently identified in bats, causes disease in either animals or people. Ebola virus was first discovered in 1976 near the Ebola River in what is now the Democratic Republic of the Congo. Since then, outbreaks have occurred sporadically in Africa. The natural reservoir host of Ebola viruses remains unknown. However, based on the nature of similar viruses, experts think the virus is animal-borne, with bats being the most likely reservoir. Transmission How the virus first infects a person at the start of an outbreak is not known. However, experts think the first patient becomes infected through contact with an infected animal such as a fruit bat or nonhuman primate. People can be infected with the Ebola virus through direct contact (like touching) with: • Blood or body fluids (urine, saliva, sweat, feces, vomit, breast milk, semen) of a person who is sick with or has died from EVD • Objects (such as clothes, bedding, needles, and syringes) contaminated with body fluids from a person sick with EVD or a body of a person who died from EVD • Blood or body fluids of infected fruit bats or nonhuman primates such as apes and monkeys • Semen from a man who recovered from EVD (through oral, vaginal, or anal sex) Ebola virus CANNOT spread to others when a person has no signs or symptoms of EVD. -
Managing Dangerous Pathogens: Challenges in the Wake of the Recent West African Ebola Outbreak
Global Security: Health, Science and Policy An Open Access Journal ISSN: (Print) 2377-9497 (Online) Journal homepage: http://www.tandfonline.com/loi/rgsh20 Managing dangerous pathogens: challenges in the wake of the recent West African Ebola outbreak Akin Abayomi, Rebecca Katz, Scott Spence, Brian Conton & Sahr M. Gevao To cite this article: Akin Abayomi, Rebecca Katz, Scott Spence, Brian Conton & Sahr M. Gevao (2016): Managing dangerous pathogens: challenges in the wake of the recent West African Ebola outbreak, Global Security: Health, Science and Policy To link to this article: http://dx.doi.org/10.1080/23779497.2016.1228431 © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group Published online: 25 Oct 2016. Submit your article to this journal View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=rgsh20 Download by: [71.219.210.146] Date: 25 October 2016, At: 20:05 GLOBAL SECURITY: HEALTH, SCIENCE AND POLICY, 2016 http://dx.doi.org/10.1080/23779497.2016.1228431 OPEN ACCESS Managing dangerous pathogens: challenges in the wake of the recent West African Ebola outbreak Akin Abayomia, Rebecca Katzb, Scott Spencec,d, Brian Contone and Sahr M. Gevaof aDivision of Haematology, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Stellenbosch University, Cape Town, South Africa; bDepartment of International Health, Georgetown University, Washington, DC, USA; cGeneva Centre for Security Policy (GCSP), Geneva, Switzerland; dVERTIC, London, UK; ePhysio-Fitness Rehabilitation Centre, Freetown, Sierra Leone; fUniversity of Sierra Leone, Freetown, Sierra Leone ABSTRACT ARTICLE HISTORY In the aftermath of the 2014–2016 West Africa Ebola outbreak, there are a multitude of Ebola samples Received 13 May 2016 that are unaccounted for as well as virus samples stored in facilities that do not have an appropriate Accepted 10 August 2016 level of biosecurity and biosafety, creating serious threats to public health and security.