Wholly Rickettsia! Metabolic Profile of the Quintessential Bacterial Parasite of Eukaryotic Cells Item Type Poster/Presentation Authors Driscoll, Timothy P.; Verhoeve, Victoria I.; Guillotte, Mark L.; Lehman, Stephanie S.; Rennoll, Sherri A.; Beier-Sexton, Magda; Rahman, M. Sayeedur; Azad, Abdu F.; Gillespie, Joseph J. Publication Date 2018-06 Keywords Metabolic Networks and Pathways; Rickettsia--genetics; Rickettsia--metabolism Download date 01/10/2021 05:45:11 Link to Item http://hdl.handle.net/10713/16003 Wholly Rickettsia! Metabolic Profile of the Quintessential Bacterial Parasite of Eukaryotic Cells Timothy Driscoll a a b b b b b b b Timothy P. Driscoll , Victoria I. Verhoeve , Mark L. Guillotte , Stephanie S. Lehman , Sherri A. Rennoll , Magda Beier-Sexton , M. Sayeedur Rahman , Abdu F. Azad , and Joseph J. Gillespie
[email protected] Department of Biology, West Virginia University, Morgantown, WV 26505, USAa; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USAb @driscollMML (twitter, fb, reddit, github) BACKGROUND RESULTS Figure 2. Synopsis of known and predicted metabolites imported from Figure 3. Fatty acids and glycerophospholipids are synthesized Figure 5A. Cell envelope glycoconjugates are synthesized from Bacteria in the genus Rickettsia (Rickettsiaceae; Alphaproteobacteria) Our metabolic reconstruction (Fig. 1) identified 51 host metabolites (including 21 the eukaryotic cytoplasm by rickettsiae. from host precursors dephospho-CoA and biotin, DHAP and