Nitrous Oxide and the Psychoactive Substances Act 2016 – an Ongoing Controversy by Joy Lewis

Total Page:16

File Type:pdf, Size:1020Kb

Nitrous Oxide and the Psychoactive Substances Act 2016 – an Ongoing Controversy by Joy Lewis Nitrous Oxide and the Psychoactive Substances Act 2016 – An Ongoing Controversy by Joy Lewis Is nitrous oxide, commonly known as ‘laughing gas’, a psychoactive substance under the Psychoactive Substances Act 2016? Although the ruling of the Court of Appeal in R v Chapman [2017] EWCA Crim 319 in November 2017 is often regarded as having dealt with the question decisively, a series of recent cases in the Crown Courts show that the question is still very much a live one. Psychoactive Substances Act 2016 Under the regime of the Misuse of Drugs Act 1971, the laws governing the supply and possession of illegal drugs have traditionally functioned by the categorisation of named substances in accordance with an assessment of harmfulness. In an attempt to keep pace with the ever-changing chemical make-up of harmful substances marketed as legal highs, the Psychoactive Substances Act 2016 (“the Act”) took a novel approach. Instead of listing banned substances by name, it created a broad prohibition on the production or supply of any ‘psychoactive substance’ which is likely to be consumed for its psychoactive effects. As defined under s.2(1) of the Act, a psychoactive substance means any substance which is capable of producing a psychoactive effect in a person who consumes it, but which is not an exempted substance. Exempted substances are set out in Schedule 1 to the Act, and include medicines and commonly consumed products such as caffeine, tobacco and alcohol. For the purposes of the Act, a substance produces a psychoactive effect in a person if, ‘by stimulating or depressing the person’s central nervous system, it affects the person’s mental functioning or emotional state’. Whilst at first glance this might appear to be a useful way to capture a new generation of harmful substances, its application to an old and largely unharmful substance has revealed the flaws in such a broad-brush definition. Nitrous Oxide Nitrous oxide, commonly known as laughing gas, was first synthesised by Joseph Priestley in 1772. By the early 19th century, nitrous oxide was widely used for recreational purposes, and its effects were memorably recorded by Humphrey Davy, who wrote that ‘I now had a great disposition to laugh…I felt a sense of tangible extension highly pleasurable in each limb.’ Although this recreational use has persisted, nitrous oxide was never categorised under the Misuse of Drugs Act, and it has not been associated with significant harms. When the Psychoactive Substances Act came into force in May 2016, the prosecuting authorities took the view that nitrous oxide is a psychoactive substance within the meaning of the Act, and a wave of arrests and prosecutions followed during the summer festival season of 2016. As cases started to reach the courts, most contested cases turned on the question of whether or not there was an intention to supply, as there is no restriction on personal possession or use of psychoactive substances under the 2016 Act. In many cases where supply was clearly made out, guilty pleas were entered, and in some cases, custodial sentences were passed. In late August 2017, two trials caught the headlines, one in Taunton and the other at Southwark Crown Court. In both cases, the prosecution case collapsed after the defence teams argued that nitrous oxide is an exempted substance, and the legal status of nitrous oxide was once again thrown into doubt. Aggrieved that they had been convicted on now doubtful charges, a number of defendants who had previously been convicted or pleaded guilty to charges relating to nitrous oxide took their cases before the Court of Appeal in the case of R v Chapman [2017] EWCA Crim 319. R v Chapman Chapman is often taken as authority that any challenge to the status of nitrous oxide as a psychoactive substance has been closed down. However, this is a misunderstanding of the judgment. The Court of Appeal rejected the appeal on the grounds that when nitrous oxide is used for recreational purposes, as opposed to medicinal purposes, it cannot fall under the exemption for medicinal products. It declined to rule on the question of whether it is to be regarded as a psychoactive substance in the first place. Subsequent trials in the Crown Courts In December 2017, I represented a defendant at Woolwich Crown Court charged with possession with intent to supply nitrous oxide after he was stopped by police on his return from a festival on the Isle of Wight, and a number of nitrous oxide cannisters were located in his vehicle. He disputed the charge on two grounds: First, that the nitrous oxide was for personal use, and not intended for supply to others; and second, that nitrous oxide is not a psychoactive substance within the definition set out at s.2(1) of the Psychoactive Substances Act 2016. Evidence was heard from Professor Cowen for the prosecution, and Professor Nutt for the defence, in what was the first trial to hear expert evidence directly on this point. In essence, Professor Cowen’s opinion was that, when one looks at the existing body of research on nitrous oxide, the only plausible explanation for the range of psychological effects caused by consumption of nitrous oxide, which include analgesic, anaesthetic, psychedelic and euphoric effects, is that nitrous oxide acts on neurotransmitters in the brain. In other words, that it acts directly upon the central nervous system. Professor Nutt argued that the current body of research, which is largely based upon studies in animals, is insufficient to conclude that the psychological effects of nitrous oxide are caused by a direct effect on the central nervous system. He draws a comparison with the substance nitric oxide, known as ‘poppers’, which are also used recreationally, but are not regarded as psychoactive substances under the 2016 Act. The jury unanimously acquitted the defendant. However, because it was open to the jury to acquit on either of the two defences advanced, we cannot know whether they found him not guilty because they were not sure that nitrous oxide is a psychoactive substance, or because they were not sure that he intended to supply it to others, or both. In contrast, in a subsequent case at Wood Green Crown Court in January 2018, a defendant was convicted by a jury after hearing expert evidence from Professor Cowen and Professor Nutt. There are further cases awaiting trial, in which the same issues will be heard in coming months. Where do we go from here? Until such a time as the Court of Appeal deals decisively with the question of whether nitrous oxide is a psychoactive substance for the purposes of the 2016 Act, it remains a live issue, and defence teams are justified in taking the point by calling expert evidence in all nitrous oxide cases, whether or not a second defence such as denial of intent to supply is available. However, this is far from a satisfactory situation, and has financial implications in a system under pressure. It is likely that it will take some time for another case to reach the Court of Appeal, and it is regrettable that the Court declined to address the point when it had the opportunity. There is also an argument that this is an issue entirely unsuitable for determination by a jury, even aided by expert evidence. How is a selection of 12 members of the public to choose between the testimony of two eminent professors of neuropsychopharmacology? As a member of my jury astutely asked in a note: Why are we deciding this? Is there not a law which says whether nitrous oxide is illegal or not? This, it seems, gets to the heart of the issue. It is not the function of a jury, nor indeed that of the Court of Appeal, to determine which substances are prohibited at law and which are not. That is a matter of public policy, the proper forum for which is Parliament. The nitrous oxide controversy has revealed the fundamental weakness in the drafting of the PSA, and until such time as Parliament takes responsibility for the resolution of the issue, the courts will continue to grapple with the interpretation of a flawed law. .
Recommended publications
  • Anaesthesia and Past Use Of
    177 Correspondence were using LSD. It is more popular than other commonly Anaesthesia and past use of used hallucinogens whose quoted incidence of clients are: LSD ketamine 0.1% (super-K/vitamin K.I), psilocybin and psilocin 0.6% (the active alkaloids in the Mexican "magic To the Editor: mushroom"), and 3,4 methylenedioxymethamphetamine We report the case of a 43-yr-old lady who was admitted ~MDMA" 1% (ecstasy). The effects of the concurrent to the Day Surgery Unit for release of her carpal tunnel ingestion of LSD on anaesthesia are well described. 2-4 retinaculum. During the preoperative visit, she reported The long-term effects of the past use of LSD are largely no intercurrent illnesses, drug therapy or allergies. She unknown. We wonder if the hallucinations experienced did say, however, that she was frightened of general anaes- by our patient during anaesthesia were due to her LSD thesia, since she had experienced terrifying dreams during intake many years before. We would be interested to surgery under general anaesthesia on three occasions dur- know if others have had experience anaesthetising patients ing the previous ten years. On further questioning, she who are past users of phencyclidine-derived drugs. admitted that she had used lysergic acid diethylamide (LSD) during the late 1960's, the last occasion being 1968 Geoffrey N. Morris MRCGPFRCA when she had experienced characterstic hallucinations. Patrick T. Magee MSe FRCA She had not experienced hallucinations in the ensuing Anaesthetic Department years, except on the surgical occasions mentioned. Royal United Hospital One of the three previous operations had been per- Combe Park formed at our hospital and the anaesthetic record was Bath BA1 3NG checked.
    [Show full text]
  • Evidence for the Involvement of Spinal Cord 1 Adrenoceptors in Nitrous
    Anesthesiology 2002; 97:1458–65 © 2002 American Society of Anesthesiologists, Inc. Lippincott Williams & Wilkins, Inc. Evidence for the Involvement of Spinal Cord ␣ 1 Adrenoceptors in Nitrous Oxide–induced Antinociceptive Effects in Fischer Rats Ryo Orii, M.D., D.M.Sc.,* Yoko Ohashi, M.D.,* Tianzhi Guo, M.D.,† Laura E. Nelson, B.A.,‡ Toshikazu Hashimoto, M.D.,* Mervyn Maze, M.B., Ch.B.,§ Masahiko Fujinaga, M.D.ʈ Background: In a previous study, the authors found that ni- opioid peptide release in the brain stem, leading to the trous oxide (N O) exposure induces c-Fos (an immunohisto- 2 activation of the descending noradrenergic inhibitory chemical marker of neuronal activation) in spinal cord ␥-ami- nobutyric acid–mediated (GABAergic) neurons in Fischer rats. neurons, which results in modulation of the pain–noci- 1 In this study, the authors sought evidence for the involvement ceptive processing in the spinal cord. Available evi- Downloaded from http://pubs.asahq.org/anesthesiology/article-pdf/97/6/1458/337059/0000542-200212000-00018.pdf by guest on 01 October 2021 ␣ of 1 adrenoceptors in the antinociceptive effect of N2O and in dence suggests that at the level of the spinal cord, there activation of GABAergic neurons in the spinal cord. appear to be at least two neuronal systems that are Methods: Adult male Fischer rats were injected intraperitone- involved (fig. 1). In one of the pathways, activation of ally with ␣ adrenoceptor antagonist, ␣ adrenoceptor antago- 1 2 ␣ nist, opioid receptor antagonist, or serotonin receptor antago- the 2 adrenoceptors produces either direct presynaptic nist and, 15 min later, were exposed to either air (control) or inhibition of neurotransmitter release from primary af- 75% N2O.
    [Show full text]
  • 5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate
    5-HT2A and 5-HT2C/2B Receptor Subtypes Modulate Dopamine Release Induced in Vivo by Amphetamine and Morphine in Both the Rat Nucleus Accumbens and Striatum Grégory Porras, M.S., Vincenzo Di Matteo, Ph.D., Claudia Fracasso, B.S., Guillaume Lucas, Ph.D., Philippe De Deurwaerdère, Ph.D., Silvio Caccia, Ph.D., Ennio Esposito, M.D., Ph.D., and Umberto Spampinato, M.D., Ph.D. In vivo microdialysis and single-cell extracellular neuron firing rate in both the ventral tegmental area and recordings were used to assess the involvement of the substantia nigra pars compacta was unaffected by SR serotonin2A (5-HT2A) and serotonin2C/2B (5-HT2C/2B) 46349B (0.1 mg/kg i.v.) but significantly potentiated by SB receptors in the effects induced by amphetamine and 206553 (0.1 mg/kg i.v.). These results show that 5-HT2A morphine on dopaminergic (DA) activity within the and 5-HT2C receptors regulate specifically the activation of mesoaccumbal and nigrostriatal pathways. The increase in midbrain DA neurons induced by amphetamine and DA release induced by amphetamine (2 mg/kg i.p.) in the morphine, respectively. This differential contribution may nucleus accumbens and striatum was significantly reduced be related to the specific mechanism of action of the drug by the selective 5-HT2A antagonist SR 46349B (0.5 mg/kg considered and to the neuronal circuitry involved in their s.c.), but not affected by the 5-HT2C/2B antagonist SB effect on DA neurons. Furthermore, these results suggest 206553 (5 mg/kg i.p.). In contrast, the enhancement of that 5-HT2C receptors selectively modulate the impulse accumbal and striatal DA output induced by morphine (2.5 flow–dependent release of DA.
    [Show full text]
  • Neurological Complications of Nitrous Oxide Abuse
    Katherine Shoults, MD Case report: Neurological complications of nitrous oxide abuse A patient who presented with limb paresthesia and B12 deficiency was eventually diagnosed with subacute combined degeneration neuropathy secondary to nitrous oxide abuse. Case data ABSTRACT: A 34-year-old female ary to nitrous oxide (“laughing gas”) A 34-year-old female presented with with a history of alcohol and crystal abuse that had affected B12 activa- a 2-week history of progressive bilat- methamphetamine abuse presented tion. The patient was continued on eral limb paresthesia and tenderness, to the emergency department with B12 therapy, neurology follow-up as well as an inability to balance. She limb paresthesia and difficulty walk- was arranged, and addiction coun- had been well previously, although ing. At a primary care visit a week seling services were recommended. she did have a history of alcohol and earlier her progressive neurological Unfortunately, the patient was lost crystal methamphetamine abuse. She compromise had been viewed in the to follow-up after discharge from the had abstained from crystal metham- context of anemia and she was start- hospital. Physicians should be aware phetamine for 5 years and from alco- ed on daily B12 injections. Further that nitrous oxide is easy to acquire hol for 2 months. She was working as a investigations in hospital revealed in the form of commercially available care aid and denied using illegal drugs diminished proprioception, hyperal- cartridges or whipped cream canis- currently, but reported she had been gesia with pinprick and temperature ters called “whippits” and abuse of inhaling nitrous oxide (“laughing tests, a wide-based high-steppage nitrous oxide is increasingly com- gas”) for 6 months, with an escalation gait, elevated levels of B12 and ho- mon.
    [Show full text]
  • Pharmacology – Inhalant Anesthetics
    Pharmacology- Inhalant Anesthetics Lyon Lee DVM PhD DACVA Introduction • Maintenance of general anesthesia is primarily carried out using inhalation anesthetics, although intravenous anesthetics may be used for short procedures. • Inhalation anesthetics provide quicker changes of anesthetic depth than injectable anesthetics, and reversal of central nervous depression is more readily achieved, explaining for its popularity in prolonged anesthesia (less risk of overdosing, less accumulation and quicker recovery) (see table 1) Table 1. Comparison of inhalant and injectable anesthetics Inhalant Technique Injectable Technique Expensive Equipment Cheap (needles, syringes) Patent Airway and high O2 Not necessarily Better control of anesthetic depth Once given, suffer the consequences Ease of elimination (ventilation) Only through metabolism & Excretion Pollution No • Commonly administered inhalant anesthetics include volatile liquids such as isoflurane, halothane, sevoflurane and desflurane, and inorganic gas, nitrous oxide (N2O). Except N2O, these volatile anesthetics are chemically ‘halogenated hydrocarbons’ and all are closely related. • Physical characteristics of volatile anesthetics govern their clinical effects and practicality associated with their use. Table 2. Physical characteristics of some volatile anesthetic agents. (MAC is for man) Name partition coefficient. boiling point MAC % blood /gas oil/gas (deg=C) Nitrous oxide 0.47 1.4 -89 105 Cyclopropane 0.55 11.5 -34 9.2 Halothane 2.4 220 50.2 0.75 Methoxyflurane 11.0 950 104.7 0.2 Enflurane 1.9 98 56.5 1.68 Isoflurane 1.4 97 48.5 1.15 Sevoflurane 0.6 53 58.5 2.5 Desflurane 0.42 18.7 25 5.72 Diethyl ether 12 65 34.6 1.92 Chloroform 8 400 61.2 0.77 Trichloroethylene 9 714 86.7 0.23 • The volatile anesthetics are administered as vapors after their evaporization in devices known as vaporizers.
    [Show full text]
  • Problematic Use of Nitrous Oxide by Young Moroccan–Dutch Adults
    International Journal of Environmental Research and Public Health Article Problematic Use of Nitrous Oxide by Young Moroccan–Dutch Adults Ton Nabben 1, Jelmer Weijs 2 and Jan van Amsterdam 3,* 1 Urban Governance & Social Innovation, Amsterdam University of Applied Sciences, P.O. Box 2171, 1000 CD Amsterdam, The Netherlands; [email protected] 2 Jellinek, Department High Care Detox, Vlaardingenlaan 5, 1059 GL Amsterdam, The Netherlands; [email protected] 3 Amsterdam University Medical Center, Department of Psychiatry, University of Amsterdam, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands * Correspondence: [email protected] Abstract: The recreational use of nitrous oxide (N2O; laughing gas) has largely expanded in recent years. Although incidental use of nitrous oxide hardly causes any health damage, problematic or heavy use of nitrous oxide can lead to serious adverse effects. Amsterdam care centres noticed that Moroccan–Dutch young adults reported neurological symptoms, including severe paralysis, as a result of problematic nitrous oxide use. In this qualitative exploratory study, thirteen young adult Moroccan–Dutch excessive nitrous oxide users were interviewed. The determinants of problematic nitrous oxide use in this ethnic group are discussed, including their low treatment demand with respect to nitrous oxide abuse related medical–psychological problems. Motives for using nitrous oxide are to relieve boredom, to seek out relaxation with friends and to suppress psychosocial stress and negative thoughts. Other motives are depression, discrimination and conflict with friends Citation: Nabben, T.; Weijs, J.; van or parents. The taboo culture surrounding substance use—mistrust, shame and macho culture— Amsterdam, J. Problematic Use of frustrates timely medical/psychological treatment of Moroccan–Dutch problematic nitrous oxide Nitrous Oxide by Young users.
    [Show full text]
  • FORANE (Isoflurane, USP)
    Forane ® (isoflurane, USP) Proposed Package Insert FORANE (isoflurane, USP) Liquid For Inhalation Rx only DESCRIPTION FORANE (isoflurane, USP), a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 1-chloro-2, 2,2-trifluoroethyl difluoromethyl ether, and its structural formula is: Some physical constants are: Molecular weight 184.5 Boiling point at 760 mm Hg 48.5°C (uncorr.) 20 1.2990-1.3005 Refractive index n D Specific gravity 25°/25°C 1.496 Vapor pressure in mm Hg** 20°C 238 25°C 295 30°C 367 35°C 450 **Equation for vapor pressure calculation: log10Pvap = A + B where A = 8.056 T B = -1664.58 T = °C + 273.16 (Kelvin) Partition coefficients at 37°C: Water/gas 0.61 Blood/gas 1.43 Oil/gas 90.8 1 Forane ® (isoflurane, USP) Proposed Package Insert Partition coefficients at 25°C – rubber and plastic Conductive rubber/gas 62.0 Butyl rubber/gas 75.0 Polyvinyl chloride/gas 110.0 Polyethylene/gas ~2.0 Polyurethane/gas ~1.4 Polyolefin/gas ~1.1 Butyl acetate/gas ~2.5 Purity by gas >99.9% chromatography Lower limit of None flammability in oxygen or nitrous oxide at 9 joules/sec. and 23°C Lower limit of Greater than useful concentration in flammability in oxygen anesthesia. or nitrous oxide at 900 joules/sec. and 23°C Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V.
    [Show full text]
  • 5-HT2A Receptor Agonist-Induced Hyperthermia Is Induced Via Vasoconstriction By
    Supplemental material to this article can be found at: http://jpet.aspetjournals.org/content/suppl/2018/09/11/jpet.118.250217.DC1 1521-0103/367/2/356–362$35.00 https://doi.org/10.1124/jpet.118.250217 THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS J Pharmacol Exp Ther 367:356–362, November 2018 Copyright ª 2018 by The American Society for Pharmacology and Experimental Therapeutics 5-HT2A Receptor Agonist-Induced Hyperthermia Is Induced via Vasoconstriction by Peripheral 5-HT2A Receptors and Brown Adipose Tissue Thermogenesis by Peripheral Serotonin Loss at a High Ambient Temperature s Mami Nakamura, Kaori Shintani-Ishida, and Hiroshi Ikegaya Department of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan Received April 26, 2018; accepted September 6, 2018 Downloaded from ABSTRACT Recreational drugs such as 3,4-methylenedioxymethamphet- destruction of central noradrenaline or serotonin neurons, amine and cocaine induce hyperthermia, which is affected by peripheral 5-HT2A receptors were considered contributors to ambient temperature. 2-(4-Bromo-2,5-dimethoxyphenyl)-N-(2- the development of hyperthermia at a high ambient temperature, methoxybenzyl)ethanamine (25B-NBOMe), a selective agonist of independently from central neurons. The temperature of brown jpet.aspetjournals.org 5-HT2A receptor used as a recreational drug, reportedly induces adipose tissue (BAT) increased 60–120 minutes postadministra- hyperthermia. This study aimed to verify whether 25B-NBOMe tion of 25B-NBOMe at 29°C, indicating thermogenesis. Previous induces ambient temperature-dependent hyperthermia and to studies have reported that peripheral serotonin contributes to clarify its mechanism. Eight-week-old male Sprague-Dawley rats the inhibition of BAT thermogenesis.
    [Show full text]
  • World Health Organization Model List of Essential Medicines, 21St List, 2019
    World Health Organizatio n Model List of Essential Medicines 21st List 2019 World Health Organizatio n Model List of Essential Medicines 21st List 2019 WHO/MVP/EMP/IAU/2019.06 © World Health Organization 2019 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. World Health Organization Model List of Essential Medicines, 21st List, 2019. Geneva: World Health Organization; 2019. Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data. CIP data are available at http://apps.who.int/iris.
    [Show full text]
  • Nitrous Oxide• What Is Nitrous Oxide?
    Nitrous oxide• What is nitrous oxide? Nitrous oxide is a colourless gas that is commonly used for sedation and pain relief, but is also used by people to feel intoxicated or high.1 It is commonly used by dentists and medical professionals to sedate patients undergoing minor medical procedures.1 It is also a food additive when used as a propellant for whipped cream, and is used in the automotive industry to enhance engine performance. It may be used to assist in treating alcohol withdrawal.2 Nitrous oxide is classified as a dissociative anaesthetic and has been found to produce dissociation of the mind from the body (a sense of floating), distorted perceptions and in rare cases, visual hallucinations.2 How is it used? The gas is inhaled, typically by discharging nitrous gas cartridges (bulbs or whippets) into another object, such as a balloon, or directly into the mouth.3 Inhaling nitrous oxide produces a rapid rush of euphoria and feeling of floating or excitement for a short period of time.3 Other names Laughing gas, nitro, N2O, NOS, nangs, whippet, hippy crack, buzz bomb, balloons. Effects of nitrous oxide If a large amount of nitrous oxide is inhaled it can produce: 3,5,7,8 There is no safe level of drug use. Use of any drug always carries risk. It’s important to be careful • loss of blood pressure when taking any type of drug. • fainting • heart attack. Nitrous oxide affects everyone differently, based on: Inhaling nitrous oxide can be fatal if you don’t get enough oxygen, which is known as hypoxia.7 • the amount taken • the user’s size, weight and health Long-term effects • whether the person is used to taking it Prolonged exposure to nitrous oxide may result in: 3,5,6 • whether other drugs are taken around the same time.
    [Show full text]
  • Nitrous Oxide
    Common Name: NITROUS OXIDE CAS Number: 10024-97-2 DOT Number: UN 1070 (Compressed) RTK Substance number: 1399 UN 2201 (Refrigerated Liquid) Date: March 1998 Revision: September 2004 --------------------------------------------------------------------------- --------------------------------------------------------------------------- HAZARD SUMMARY * Nitrous Oxide can affect you when breathed in. * Exposure to hazardous substances should be routinely * Nitrous Oxide should be handled as a TERATOGEN-- evaluated. This may include collecting personal and area WITH EXTREME CAUTION. air samples. You can obtain copies of sampling results * Contact with liquefied Nitrous Oxide may cause skin from your employer. You have a legal right to this burns and/or frostbite. information under OSHA 1910.1020. * Breathing Nitrous Oxide can irritate the eyes, nose and * If you think you are experiencing any work-related health throat causing coughing and/or shortness of breath. problems, see a doctor trained to recognize occupational * Exposure can cause you to feel lightheaded, giddy and diseases. Take this Fact Sheet with you. sleepy. High levels can cause you to pass out and very high levels can cause death. WORKPLACE EXPOSURE LIMITS * Repeated exposure may damage the nervous system NIOSH: The recommended airborne exposure limit is causing numbness, “pins and needles,” and weakness in 25 ppm averaged over a 10-hour workshift. the arms and legs. * Nitrous Oxide may damage the blood cells. ACGIH: The recommended airborne exposure limit is * Nitrous Oxide may damage the liver and kidneys. 50 ppm averaged over an 8-hour workshift. IDENTIFICATION * Nitrous Oxide may be a teratogen in humans. All contact Nitrous Oxide (laughing gas) is a colorless gas with a slightly with this chemical should be reduced to the lowest sweet odor and taste.
    [Show full text]
  • Psychedelic Agents
    PSYCHEDELIC AGENTS: CHANGES INDUCED IN SUBJECTIVE EXPERIENCE AND BRAIN ACTIVITY Bachelor Degree Project in Cognitive Neuroscience Basic level 22.5 ECTS Spring term 2019 Louise Andersson Supervisor: Katja Valli Examiner: Joel Parthemore Abstract This thesis combines phenomenological and neuroscientific research to elucidate the effects of psychedelic agents on the human brain, mind and psychological well-being. Psychoactive plants have been used for thousands of years for ceremonial and ritual purposes. Psychedelics are psychoactive substances that affect cognitive processes and alter perception, thoughts, and mood. Illegalization of psychedelics in the 1960s rendered them impossible to study empirically but in the last couple of decades, relaxed legal restrictions regarding research purposes, renewed interest in the effects of psychedelic drugs and new brain imaging techniques have started to reveal the possibilities of these mind-altering substances. Psychedelics mainly affect the serotonin receptor 5-HT2A which in turn affects the functioning of largescale cortical areas by changing cerebral blood flow, alpha oscillations and functional connectivity. These cortical changes not only induce immediate alterations in perception and cognition but have been shown to have positive effects in therapeutic interventions for depression, anxiety, and addiction, and also positively affect well-being in general. Although the pharmacology and neurobiology of psychedelics are still poorly understood, the potential benefits justify empirical research
    [Show full text]