SRBR 2010 Program Book
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Company Profile - Mmc Movies Cologne
COMPANY PROFILE - MMC MOVIES COLOGNE MMC Movies Köln GmbH co-produces and co-finances national and international feature films for cinema and TV. As co-producer, we participate in, and contribute financially to, film projects. If required, we can also assume the executive production in Cologne, Germany and Europe, bearing full financial responsibility—from pre-production to filming and post-production, up to execution. As co-production partner and film financer, we make substantial contributions to your production, while offering you a wide range of financing options. These include private equity, regional, national and European funding, Gap-financing and pre-sales. Thanks to our location in North Rhine-Westphalia, we also benefit from the support of the Film Foundation North Rhine-Westphalia—the Film- und Medienstiftung NRW—one of Germany’s largest regional film grant programs. On this basis, and together with you, we will draw up plans for a reliable and efficient financing structure for your project. Numerous national and international film productions have already benefited from MMC Movies’ superior location and the many years of experience in the financing and realization of film projects. Parallel to the production activity, MMC Movies also provides services for film productions. Our production services include leasing of soundstages and production offices, as well as set construction, among others. FILMOGRAPHY MMC MOVIES COLOGNE (October 2017) 2017 DIE RÜDEN (Service Production) directed by Connie Walter Zero One Film with Nadin -
Circadian Disruption: What Do We Actually Mean?
HHS Public Access Author manuscript Author ManuscriptAuthor Manuscript Author Eur J Neurosci Manuscript Author . Author manuscript; Manuscript Author available in PMC 2020 May 07. Circadian disruption: What do we actually mean? Céline Vetter Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA Abstract The circadian system regulates physiology and behavior. Acute challenges to the system, such as those experienced when traveling across time zones, will eventually result in re-synchronization to the local environmental time cues, but this re-synchronization is oftentimes accompanied by adverse short-term consequences. When such challenges are experienced chronically, adaptation may not be achieved, as for example in the case of rotating night shift workers. The transient and chronic disturbance of the circadian system is most frequently referred to as “circadian disruption”, but many other terms have been proposed and used to refer to similar situations. It is now beyond doubt that the circadian system contributes to health and disease, emphasizing the need for clear terminology when describing challenges to the circadian system and their consequences. The goal of this review is to provide an overview of the terms used to describe disruption of the circadian system, discuss proposed quantifications of disruption in experimental and observational settings with a focus on human research, and highlight limitations and challenges of currently available tools. For circadian research to advance as a translational science, clear, operationalizable, and scalable quantifications of circadian disruption are key, as they will enable improved assessment and reproducibility of results, ideally ranging from mechanistic settings, including animal research, to large-scale randomized clinical trials. -
Chronic Hyperaldosteronism in Cryptochrome-Null Mice Induces High-Salt- and Blood Pressure- Independent Kidney Damage in Mice
Hypertension Research (2014) 37, 202–209 & 2014 The Japanese Society of Hypertension All rights reserved 0916-9636/14 www.nature.com/hr ORIGINAL ARTICLE Chronic hyperaldosteronism in Cryptochrome-null mice induces high-salt- and blood pressure- independent kidney damage in mice Dwi Aris Agung Nugrahaningsih1, Noriaki Emoto1,2, Nicolas Vignon-Zellweger2, Eko Purnomo1, Keiko Yagi2, Kazuhiko Nakayama1,2, Masao Doi3, Hitoshi Okamura3 and Ken-ichi Hirata1 Although aldosterone has an essential role in controlling electrolyte and body fluid homeostasis, aldosterone also exerts certain pathological effects on the kidney. Several previous studies have attempted to examine these deleterious effects. However, the majority of these studies were performed using various injury models, including high-salt treatment and/or mineralocorticoid administration, by which the kidney changes observed were not only due to aldosterone but also due to prior injury caused by salt and hypertension. In the present study, we investigated aldosterone’s pathological effect on the kidney using a mouse model with a high level of endogenous aldosterone. We used cryptochrome-null (Cry 1, 2 DKO) mice characterized by high aldosterone levels and low plasma renin activity and observed that even under normal salt exposure conditions, these mice showed increased albumin excretion and kidney tubular injury, decreased nephrin expression and increased reactive oxygen species production in the absence of hypertension. Exposure to high salt levels exacerbated the kidney damage observed in these mice. Moreover, we noted that decreasing blood pressure without blocking aldosterone action did not provide beneficial effects to the kidney in high-salt-treated Cry 1, 2 DKO mice. Thus, our findings support the hypothesis that aldosterone has deleterious effects on the kidney independent of high-salt exposure and high blood pressure. -
A FILM by NICOLAS MAURY CG CINÉMA Presents
A FILM BY NICOLAS MAURY CG CINÉMA presents NICOLAS MAURY NATHALIE BAYE PRESS RENDEZ-VOUS VIVIANA ANDRIANI / AURÉLIE DARD [email protected] / [email protected] Tel.: +33 1 42 66 36 35 A FILM BY NICOLAS MAURY Mob : +33 6 80 16 81 39 INTERNATIONAL SALES LES FILMS DU LOSANGE 22 Avenue Pierre 1er de Serbie - 75116 Paris Tél.: +33 1 44 43 87 24 www.filmsdulosange.com FRANCE • 2020 • 1H50 • IMAGE 2,35 • SOUND 5.1 Photos and press pack can be downloaded at https://filmsdulosange.com/en/film/my-best-part/ 4 5 pcoming actor Jérémie is going through an existential crisis. Pathologically jealous and plagued by romantic, professional and familial misadventures, he flees Paris to reset in the country with his mother – who turns out to be more than a little invasive… 6 7 The main theme of My Best Part is jealousy. passionate characters. I think that jealousy is a Jérémie, the lead character says that it burns powerful decipherer of the world, in the sense his blood. Did you do research? that it encourages the urge to overcome what The most basic item of research was my you imagine. The tragedy, if I can call it that, is own life. When I arrived in Paris as a teenager that the jealous person is not always wrong. raised in the country, in the Limousin region, They picture things in their mind, and crazily almost immediately I fell head over heels in enough it turns out the picture is often right. love and, like all devouring passions, it involved Jealousy is like tinnitus, background noise only overpowering jealousy. -
Department of Systems Biology
DIVISION OF BIOINFORMATICS AND CHEMICAL GENOMICS Research Profile Department of Systems Biology Professor: Hitoshi Okamura, Associate Professor: Masao Doi, Assistant Professor: Yoshiaki Yamaguchi, Senior Lecturer: Jean-Michel Fustin Research Projects: How TIME is generated and tuned? We will clarify feedback loop of clock genes. the secret of generation and tuning of TIME in 1.3 Clock genes and cell metabolism, birth, and mammalian circadian system by multi-layered view death at intracellular, intercellular and individual levels. Why virtually all cells in the body have the clock Through clarifying the integration network mecha- inside the cell? We will identify how clock genes nism of TIME, we will develop new drugs for tuning work on the energy metabolism, cell cycles, and TIME. cell death. The subject of our study is circadian timing system 2. Intercellular system for synchronizing TIME in mammals. In this system, the circadian TIME gen- 2.1 Region-specific knockdown of SCN erated at molecular clock in the suprachiasmatic SCN biological clock is composed of thousands nucleus (SCN) evokes the synchronized oscillation of clock cells which are subdivided into several of molecular clocks in the whole body. Between groups. We will perform region-specific knockdown them, TIME is transmitted in multilayer systems: 1) of these subdivisions to address the functional sub- intracellular system of generation of cyclic TIME, 2) division of SCN. Intercellular system for synchronizing TIME, and 3) 2.3 Geography of SCN Symphony of TIME in individuals. SCN clock cells are highly organized in time and 1. Clarification of clock machinery to generate space. For example, in our real-time luciferase- TIME imaging system at cell level, time is generated and 1.1 Identification of all components of CLOCK synchronized in a very highly organized system. -
And Low-Dose Melatonin Therapies
diseases Review Divergent Importance of Chronobiological Considerations in High- and Low-dose Melatonin Therapies Rüdiger Hardeland Johann Friedrich Blumenbach Institute of Zoology and Anthropology, University of Göttingen, 37073 Göttingen, Germany; [email protected] Abstract: Melatonin has been used preclinically and clinically for different purposes. Some applica- tions are related to readjustment of circadian oscillators, others use doses that exceed the saturation of melatonin receptors MT1 and MT2 and are unsuitable for chronobiological purposes. Conditions are outlined for appropriately applying melatonin as a chronobiotic or for protective actions at elevated levels. Circadian readjustments require doses in the lower mg range, according to receptor affinities. However, this needs consideration of the phase response curve, which contains a silent zone, a delay part, a transition point and an advance part. Notably, the dim light melatonin onset (DLMO) is found in the silent zone. In this specific phase, melatonin can induce sleep onset, but does not shift the circadian master clock. Although sleep onset is also under circadian control, sleep and circadian susceptibility are dissociated at this point. Other limits of soporific effects concern dose, duration of action and poor individual responses. The use of high melatonin doses, up to several hundred mg, for purposes of antioxidative and anti-inflammatory protection, especially in sepsis and viral diseases, have to be seen in the context of melatonin’s tissue levels, its formation in mitochondria, and detoxification of free radicals. Citation: Hardeland, R. Divergent Keywords: circadian; entrainment; inflammation; melatonin; mitochondria; receptor saturation Importance of Chronobiological Considerations in High- and Low-dose Melatonin Therapies. Diseases 2021, 9, 18. -
MELATONIN and HUMAN RHYTHMS INTRODUCTION It Has
Chronobiology International, 23(1&2): 21–37, (2006) Copyright # 2006 Taylor & Francis Group, LLC ISSN 0742-0528 print/1525-6073 online DOI: 10.1080/07420520500464361 MELATONIN AND HUMAN RHYTHMS Josephine Arendt Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, England Melatonin signals time of day and time of year in mammals by virtue of its pattern of secretion, which defines ‘biological night.’ It is supremely important for research on the physiology and pathology of the human biological clock. Light suppresses melatonin secretion at night using pathways involved in circadian photoreception. The melatonin rhythm (as evidenced by its profile in plasma, saliva, or its major metabolite, 6-sulphatoxymelatonin [aMT6s] in urine) is the best peripheral index of the timing of the human circadian pacemaker. Light suppression and phase-shifting of the melatonin 24 h profile enables the characterization of human circadian photore- ception, and circulating concentrations of the hormone are used to investigate the general properties of the human circadian system in health and disease. Suppression of melatonin by light at night has been invoked as a possible influence on major disease risk as there is increasing evidence for its oncostatic effects. Exogenous melatonin acts as a ‘chronobiotic.’ Acutely, it increases sleep propensity during ‘biological day.’ These properties have led to successful treatments for serveal circadian rhythm disorders. Endogenous melatonin acts to reinforce the functioning of the human circadian system, probably in many ways. The future holds much promise for melatonin as a research tool and as a therapy for various conditions. Keywords Melatonin, Light, Circadian and Circaanual Rhythms, Chronobiotic, Sleep, Sleep Disorders, Photoperiodism INTRODUCTION It has been nearly 50 yrs since Aaron Lerner identified melatonin and, after self-administration, reported that it made him feel sleepy (Lerner et al., 1958). -
Dark-Phase Light Contamination Disrupts Circadian Rhythms in Plasma Measures of Endocrine Physiology and Metabolism in Rats
Comparative Medicine Vol 60, No 5 Copyright 2010 October 2010 by the American Association for Laboratory Animal Science Pages 348–356 Dark-Phase Light Contamination Disrupts Circadian Rhythms in Plasma Measures of Endocrine Physiology and Metabolism in Rats Robert T Dauchy,1,* Erin M Dauchy,1 Robert P Tirrell,2 Cody R Hill,1 Leslie K Davidson,2 Michael W Greene,2 Paul C Tirrell,2 Jinghai Wu,2 Leonard A Sauer,2 and David E Blask1 Dark-phase light contamination can significantly disrupt chronobiologic rhythms, thereby potentially altering the endocrine physiology and metabolism of experimental animals and influencing the outcome of scientific investigations. We sought to de- termine whether exposure to low-level light contamination during the dark phase influenced the normally entrained circadian rhythms of various substances in plasma. Male Sprague–Dawley rats (n = 6 per group) were housed in photobiologic light-exposure chambers configured to create 1) a 12:12-h light:dark cycle without dark-phase light contamination (control condition; 123 µW/cm2, lights on at 0600), 2) experimental exposure to a low level of light during the 12-h dark phase (with 0.02 , 0.05, 0.06, or 0.08 µW/cm2 light at night), or 3) constant bright light (123 µW/cm2). Dietary and water intakes were recorded daily. After 2 wk, rats underwent 6 low-volume blood draws at 4-h intervals (beginning at 0400) during both the light and dark phases. Circadian rhythms in dietary and water intake and levels of plasma total fatty acids and lipid fractions remained entrained during exposure to either control conditions or low-intensity light during the dark phase. -
Role of Melatonin in the Regulation of Human Circadian Rhythms and Sleep
Journal of Neuroendocrinology, 2003, Vol. 15, 432–437 Role of Melatonin in the Regulation of Human Circadian Rhythms and Sleep C. Cajochen, K. Kra¨ uchi and A. Wirz-Justice Center for Chronobiology, Psychiatric University Clinic, Basel, Switzerland. Key words: chronobiotic, soporific, EEG power density, thermoregulation, sleepiness. Abstract The circadian rhythm of pineal melatonin is the best marker of internal time under low ambient light levels. The endogenous melatonin rhythm exhibits a close association with the endogenous circadian component of the sleep propensity rhythm. This has led to the idea that melatonin is an internal sleep ‘facilitator’ in humans, and therefore useful in the treatment of insomnia and the readjustment of circadian rhythms. There is evidence that administration of melatonin is able: (i) to induce sleep when the homeostatic drive to sleep is insufficient; (ii) to inhibit the drive for wakefulness emanating from the circadian pacemaker; and (iii) induce phase shifts in the circadian clock such that the circadian phase of increased sleep propensity occurs at a new, desired time. Therefore, exogenous melatonin can act as soporific agent, a chronohypnotic, and/or a chronobiotic. We describe the role of melatonin in the regulation of sleep, and the use of exogenous melatonin to treat sleep or circadian rhythm disorders. entrained (6, 7) and in sighted subjects with non 24-sleep–wake Endogenous melatonin and the circadian sleep–wake cycle syndrome (8, 9). Even more impressive are the results cycle and thermoregulation obtained from studies using the forced desynchrony protocol to Under entrained conditions, the phase relationship between the separate out circadian- and wake-dependent components of beha- endogenous circadian rhythm of melatonin and the sleep–wake viour. -
Blood, Smoke & Tears ... Jean-Baptiste Mondino: Three at Last
SCHIRMER/MOSEL VERLAG WIDENMAYERSTRASSE 16 • D-80538 MÜNCHEN TELEFON 089/21 26 70-0 • TELEFAX 089/33 86 95 e-mail: [email protected] Munich, October 2014 PRESS RELEASE Blood, Smoke & Tears ... Jean-Baptiste Mondino: Three at Last The “image guru’s” long-awaited third illustrated book An international Schirmer/Mosel publication It was certainly worth the wait: Following Déjà vu (1999) and Two Much (2003), Jean-Baptiste Mondino Jean-Baptiste Mondino’s third Schirmer/Mosel illustrated book Three at Last also Three at Last radiates wit, glamour, black humor and bizarre eroticism. Once again Mondino, Book design by Michel Mallard who counts among the most important and internationally most successful 304 pages advertising photographers and video artists, impressively demonstrates his 243 color and black-and-white plates inexhaustible imaginativeness. The cover alone is a manifesto combining smoking ISBN 978-3-8296-0669-1 pleasures and acrobatic skills. In an elegant smoker’s pose, a carefully pedicured € 78.–, US $ 99.95 lady’s foot with toenails lacquered in black is holding a burning cigarette between its toes. What’s this all about? Smoking pleasures, artistry, foot fetishism, a sadomasochistic torture game? Anyhow, the atmosphere is aestival, along with the cigarette smoke beach pleasures are in the air. However, the 243 black-and-white photographs in Three at Last revolve around tougher subjects as well: blood, smoke & tears, as implied by the book’s subtitle. Smoking young women are as steely hard as the motorcycles they are draped over, tattooed men are shown ironing and cradling babies. Often and against all notions of political correctness, a the cigarette hangs casually in the corner of the mouth, elsewhere merely its smoke encircles the delicate features of the models. -
Potential Circadian and Circannual Rhythm Contributions to the Obesity Epidemic in Elementary School Age Children Jennette P
Moreno et al. International Journal of Behavioral Nutrition and Physical Activity (2019) 16:25 https://doi.org/10.1186/s12966-019-0784-7 DEBATE Open Access Potential circadian and circannual rhythm contributions to the obesity epidemic in elementary school age children Jennette P. Moreno1* , Stephanie J. Crowley2, Candice A. Alfano3, Kevin M. Hannay4, Debbe Thompson1 and Tom Baranowski1 Abstract Children gain weight at an accelerated rate during summer, contributing to increases in the prevalence of overweight and obesity in elementary-school children (i.e., approximately 5 to 11 years old in the US). Int J Behav Nutr Phys Act 14:100, 2017 explained these changes with the “Structured Days Hypothesis” suggesting that environmental changes in structure between the school year and the summer months result in behavioral changes that ultimately lead to accelerated weight gain. The present article explores an alternative explanation, the circadian clock, including the effects of circannual changes and social demands (i.e., social timing resulting from societal demands such as school or work schedules), and implications for seasonal patterns of weight gain. We provide a model for understanding the role circadian and circannual rhythms may play in the development of child obesity, a framework for examining the intersection of behavioral and biological causes of obesity, and encouragement for future research into bio-behavioral causes of obesity in children. Keywords: Sleep, Circadian rhythms, Circannual rhythms, Children, School, Summer, Growth -
Single-Cell Analysis on the Biological Clock Using Microfluidic
SINGLE-CELL ANALYSIS ON THE BIOLOGICAL CLOCK USING MICROFLUIDIC DROPLETS by ZHAOJIE DENG (Under the Direction of Leidong Mao and Jonathan Arnold) ABSTRACT Single-cell analysis has become crucial for uncovering the underlying mechanism for cell heterogeneity. Different biological questions pose different challenges for single-cell analysis. In order to answer questions like, whether a single-cell has a biological clock and how the clocks synchronize among cells to overcome the heterogeneity, continuous long-term measurement on large numbers of single-cells is required. However traditional measurement techniques usually involve measurement on millions of cells. My dissertation addresses these challenges by developing a microfluidic droplet platform capable of measuring the biological clock on >1000 Neurospora crassa single-cells for up to 10 days. The results show that in Neurospora crassa a single cell has the three major properties of a biological clock: a circadian oscillator, light entertainment, and temperature compensation and that single-cells synchronize their biological clock with each other possibly through quorum sensing. INDEX WORDS: Single-cell analysis, Microfluidic droplets, Neurospora crassa, Circadian rhythm, Biological clock, Stochastic noise, Synchronization SINGLE-CELL ANALYSIS ON THE BIOLOGICAL CLOCK USING MICROFLUIDIC DROPLETS by ZHAOJIE DENG B.A., Huazhong University of Science and Technology, China, 2008 M.S., Huazhong University of Science and Technology, China, 2011 A Dissertation Submitted to the Graduate Faculty