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Skin Care in Atopic Dermatitis MAVI Nature and Technology in daily hair and skin care to Cleanse • Re-hydrate • Protect MAVI Oil 1AVI QiJ J r---oi1oshampoo Bodylotion MAVIQ-i/ 1w/t1rotfkO . BodywaStl d1oltN MAYI () MAVI (Jtf oe.owmµoo ""11'''* .a rBodylot mn .. .. ... '~'~·-···-­ ' ..... ...__ .... """'-" --- · ~ ~-­ l ·' tf H &.~ I......< t it ]O t ~,_,~ ... tor oily skin and hair o.... o tor dry skin and hair N ·e: tor sensitive skin and hair Ì5 LI.. ci ~ ~ innovaLazio200 ~ "~lJ l [f 1. I [/ www.mavicosmetics.it ~ Ì r: .~I r1( · -~ I /"r I_ [email protected] (.'.) lllJ ~ mav1 ~ MAVI sud srl -V.le dell'lndustria,1 -Aprilia (LT) - ltaly - Fax. +39.06.9281523 clinical/y correct cosmetic oodUICljS SOld ,.... 3SS3018 .._ 3SS3019 J\ oo !we4s •3SS30l9 wa1q0Jd pio uo o, uo!,n1os 'lfB!J alfl SSO/ J!Dl/ JO 1uaw1oaJ1 al/I JO:I oodWDlfS• .iuawa1ddns .ia!a• ® Clinical studies demonstrated Bioesse efficacy to treat mild 111 121 131 to moderate hair loss in the frontal parietal scalp ' ' 111 12 3 lncreases hair mass and number in a short period ' J,( l BIOESSE MEAN PERCENTAGE VARIATION OF TOTAL HAIR MASS PER cm2 OF PATIENTS WITH ANOROGENETIC ALOPECIA TREATEO BY GELATIN·CYSTINE ANO SERENOA REPENS TOPICAL ANO /OR BY ORAL ROUTE n • 60 10~~~~~~~~~~--.~~~~~~~~~~~~~~~--. ~-r-~~-r-~----:::::t;;;;;;;oiiiiiiii-f-lliiiiiiiiiiiii... iiiiiii---i: 60% 50 1 ~ I I I • • ,:Ie 71?1 I2 I ~ 1ncrease 1n i 10 hair mass '#. ·10 -20 -+-Placobo (Lollon) O Placo bo (Dlet) ....._. Activo Lollon "'*" Actlvo Olot All p v•luea ue hlghly algnlflc• nt (p < 0.005) H ba1elln• valu• •• to group1 ~~~~~~~--' MEAN PERCENTAGE VARIATION OF HAIR NUMBER PER cm 2 OF PATIENTS WITH ANOROGENETIC ALOPEC IA TREATEO BY GELATIN· CYSTIN E ANO SERENOA REPEN S TOPICA L ANO/OR BY ORAL ROUTE n • 60 40..--~~~~~.,..-~~~~~...--~~~~~...--~~~~--.~~~~~--. 1 ~ J ..• :I I J I 38% j~:~ 25 1 :t::d :ta . • • ,.. ,____,_,. I 1ncrease 1n '#-~ 10 .I I ·-.. I.. - • ----·• _Lii::ò hair number 51 o w ••k• 10 2G 30 40 50 I -+-Placebo (Lollon) Placobo(Dlolj ....._. Activolollon - ActlvoOlot ~ActlvoLo-ActlvoDietl All p valu•• ue hlghly 1lgnlflcant (p < 0.005) •• baaallna valua •• to group1 * Not•liP\lflcant NO SIDE EFFECT WAS RECORDED (1) Morganti P, Fabrizi G, James B, Bruno C, J. Appl. Cosmeto/.16,57,1998 MAVI sud srl V.le dell'Industria, 1 - 04011 Aprilia (Ln ltaly (2) Fabrizi G, Morganti P, (1999),SOFW-Joumal, 125, 2/3 :10-13 Tel. 06/9286261 - Fax 06/9281523 [email protected] (3) Morganti P, (1999),Eurocosmetics 9: 30-32 URL=http:l/www.mavlcosmetlcs.it The first moisturizing daily cream with EMBLICA ~14i~1 Active on wrinkles and age spots . o N .""'E ~ ci lì (/) u For further information: I www.mav1cosmetics.it [~] ~ ~ <(~ [email protected] innovalazio2oos • .!Mi,. ::;; lllJ.mav1 cuN1cALLvcoRREcrcosMEr1cs MAVI sud - V.le dell'Industria, 1 Aprilia (LT) ltaly - Fax. +39.06.9281523 ì BETAEliFE ·:; ro E i • • • Antiage • • • Tutti i giorni Every day r rJI Tutto l'anno All year I ~ ~- L [U~ fl" ll ~e '-....._; __,--i e fi 1 capsule in the evening ·==---=--= :...::::: :2 nrYl 1 L/f.AJ. ~ ~ mav1 innova lazio2oos .w. dltlic.i.)etlnC't~ [i] Mavi Sud srl ·V.le dell'Industria, 1 •. 04011 Ap~ilia (LT), . ,.,1111,. Te1. 06.9286261·Fax. 06.9281523 • [email protected] ,. , , ~ I ~ ALFA 4 ~ per tutti i tipi di pelle forali skin types ~ I ~ ALFA 4 senzaprofumo ~ per pelle ipereattiva, allergica e sensibilizzata for hyper-reactive, allergie and sensitized skin ~ I ~ ALFA 4 micospuma ~ per prevenire e contrastare lo sviluppo di batteri e funghi su piccole aree cutanee sensibilizzate for preventing the proliferation of bacterio and fungi on smoll skin areas ~ I ~ ALFA 4 micobody ~ perprevenireecontrostarelosviluppodibatteriefunghi for preventing the proliferation of bacterio and fungi ~ ~~~ innovaLazio2oos FOR MORE INFORMATION: e-mail: [email protected] ADENDA CON SISTEKA DI [Il Cl.V WllOHE PE~ LA QUALITÀ a RTIFICATO DA DNV mavi www.mavicosmetics.it :::UNI EN 1509001:2000::: 1NJlimoR MAV IGRAPHICS by G . Forniti ~OIOQY Trimestrale di Dermatologia Cosmetologica Quarterly Review of Cosmetic Dermatology EDITOR-IN-CHIEF P. MORGANTI. Ph.D. EDITING ASSISTANT M.L. NUNZIATA Secretary General Via Innocenzo Xl. 41 - 00165 Roma (ltaly) lntcmational Society of Cosmetic Dcrmalology Fax +39-06-92.8 1.523 Via Innocenzo Xl , 41 -00165 Roma (llaly) [email protected] [email protected] ASSOCIATE EDITORS HONG-DUO CHEN. MD C. JACOBSON, M.D. Professor of Dermatology Past Presideni - Iniernational Society of Cosmetic Dennatology No.1 Hospital of China Medicai University 3600 Gaston Ave. Suite 1051 Dallas Shcnyang 110001, China TX 75246 USA E-mail : [email protected] Fax +1-2 14-8241900 SCIENTIFIC SECTIONS AND EDITORIAL BOARD Ccli a nd Tissue Colture Natural Cosmesis and Balncology Cosmetics' Safety Evaluation G. Biagini (I) G . Agostini (I) E. Chiaccherini (I) L. Di Silvio (UK) B.R. Balda (D) N. Stark (USA) Clinica) Investigations Non-Invasive Methods and Biotechnologies in Cosmetic Dermatology Molecular Biology H. Tronnier (D) H. Maibach (USA) L. Bruckner-Tuderman (D) W. Gehring (D) Xing-Hua Gao (CHINA) V. Calabrese (I ) U. Heinrich (D) Hong-Duo Chen (CHINA) T. Krieg(D) E. Bcrardesca (I) J. Vitto (USA) P. Elsncr (D) Oral Mucosa and Dental Care Problems E. Benagiano (I) Skin Biology Skin and Cosmetic Microbiology B.Berra (I) J. Kabara (USA) Nail Care Cosmetics M. Ponce (NL) D.Onh (USA) R. Baran (F) D. Stcinberg (USA) B. Richcn (B) Photobiology A.Tosti (I) Skin Bioengineering H. Honigsmann (A) L. Andrcassi (I) F.P.Noonan (USA) Hair Care Cosmetics L. Rodrigues (P) Y.K.Park (Korea) S. Calvieri (I) P. Elsner (D) W.A.D. Griffiths (UK) Skin lmmunology C.E. Orfanos (D) Allergy Testing A. Giannetti (I) F.K.E. Andersen (NL) A. Senoli (I) Cosmetics and Skin Disorders Skin Perrneation V. Mordovstev (R) Chundi He (CHINA) J .P. Many (F) W. Raab (A) G. Pu glisi (I) Cosmetic Manuracture and Control T. Ru zicka (D) L. Nteta (SA) Skin Pharmacology A. Parsons (S A) Plastic and Aesthetic Surgery F.H. Kcmper (D) H.C. Roos (SA) P. Palombo (I) R. Paoletti (!) Cosmetics and Fragrances Cosmetic Pediatry Skin Toxicology G. Angelini (I) G. Fabrizi (I) S. Paglialunga (I) Y. Kazuya (J) M.G. Rozen (USA) Cosmetics and Environment A. Taieb (F) Retno I.S. Tranggono (Indonesia) Skin Ageing P. Suvanprakom (Thailand) Cosmetic Gynaecology S. Jablonska (PL) A. Lanzone (I) M. Noszczyk (PL) Aromatherapy and Natural Raw Materials S. Mancuso (I) M. Verschoore (F) G. Sai vatore (I) M. Massobrio (I) J. Appl. Cosmetol. 25, 85-92 (July/September 2007) SKIN CARE IN ATOPIC DERMATITIS K. Pytkowska, S. Majewski Academy of Cosmetics and Health Care, Warsaw - Poland Received: February, 2007. Presented at Persona/ Care & Homecare lngredients Conference, Warsaw, 25-26 October, 2006. Key words: Atopic dermatitis; Epidermal barrier: Emollients; Summary Atopic dermatitis (syn.: atopic eczema, AD) is the commonest childhood inflammatory skin disease. Many factors can influence the condition of the skin barrier in AD. They are linked with external environment as well as the generai body condition. In earlier publications concerning AD pathoge­ nesis, changes in barrier functioning were considered nearly solely as a consequence of infiamma­ tory state. Now, alternative approach to this subject is postulated perceiving changes in epidermal lipids composition and disorders in epidermal cells differentiation as a group of crucial factors in pathogenesis of the disease. The proper skin care, including omitting the factors responsible for barrier's damage (i.e. cleansing preparations based on aggressive surfactants, not containing refatting agents) as well as regular use of emoll ients, provide significant improvement in I ife quali ty of patients suffering from AD. It seems that emoll ient preparations for people with AD will be in the future based mainly on physicochemi­ cal forms that do not contribute to forming water-impermeable occlusive layer (o/w emulsions, lipid nanoparticles, w/o emulsions containing " light" emollients). Riassunto La dermatite atopica (DA) è la più comune affezione a carattere infiammatorio che colpisce i bam­ bini. Legata ad una alterazione della barriera cutanea è influenzata sia dalle condizioni ambientali che dalle condizioni generali dell'organismo. Mentre anni fa si pensava che il processo infiammatorio fosse esclusiva conseguenza dei cambia­ menti verificatisi a livello del cattivo funzionamento della barriera, ora è stato dimostrato come la 85 Skin care in atopic dermatitis composizione dei lipidi delle lamelle e la differenziazione cellulare rappresentano fattori cruciali di questa forma patologica. Così l'uso corretto di prodotti emollienti e l'eliminazione di detergenti aggressivi sono considerati molto utili a migliorare la qualità di vita delle persone affette da DA. Soprattutto tra gli emollienti si utilizzeranno nuove forme cosmetiche nanostrutturate risultate più adatte allo scopo. 86 K. Pytkowsko. S. Mojewski INTRODUCTION tes a number of factors that additionally deterio­ rate barrier condition (stress, itching and stratum Atopic dermatitis (syn.: atopic eczema, AD) is corneum damage related to it). the commonest inflammatory skin disease of In earlier publications conceming AD pathoge­ childhood, affecting 15-20% of children in indu­ nesis, changes in barrier functioning were consi­ strialized communities at any one time. Adults dered nearly solely as a consequence of inflam­ make up about one-third of all community cases. matory state. Now, alternative approach to this Moderate-to-severe atopic eczema can have a subject is postulated perceiving changes in epi­ profound effect on the quality of life for both dermal lipids composition and disorders in epi­ sufferers and their families. dermal cells differentiation as a group of crociai Major milestone in describing the main clinica! factors in pathogenesis of the disease [39] . In features of AD was the Hanifin and Rajka dia­ spite of th~s, there is stili no theory that explains gnostic criteria published in 1980.
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