Prior Approaches and Future Directions Marna Williams1, Anna Spreafico2, Kapil Vashisht3, Mary Jane Hinrichs4
Author Manuscript Published OnlineFirst on June 16, 2020; DOI: 10.1158/1535-7163.MCT-19-0993 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Patient Selection Strategies to Maximize Therapeutic Index of Antibody Drug Conjugates: Prior Approaches and Future Directions Marna Williams1, Anna Spreafico2, Kapil Vashisht3, Mary Jane Hinrichs4 1Translational Medicine, Oncology, AstraZeneca, Gaithersburg, USA 2Drug Development Program, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada 3AstraZeneca, Gaithersburg, USA. 4Early Development Oncology, Ipsen LLC, USA Corresponding author: Marna Williams Email: marna.williams@astrazeneca.com Postal address: One MedImmune Way, Gaithersburg, MD, 20878 Phone: 301-398-1241 Fax: 240-306-1545 Running title Patient Selection Strategies for Antibody Drug Conjugates Keywords Antibody drug conjugates; therapeutic index; patient selection; biomarkers; cancer Conflicts of interest This study was funded by AstraZeneca. MW, KV and MJH are all current or former employees of AstraZeneca with stock/stock options in AstraZeneca. AS has been Advisory Board Consultant to Merck, Bristol-Myers Squibb, Novartis, Oncorus, Janssen, and has received Grant/Research support from Novartis, Bristol-Myers Squibb, Symphogen AstraZeneca/Medimmune, Merck, Bayer, Surface Oncology, Northern Biologics, Janssen Oncology/Johnson & Johnson, Roche, Regeneron, and Alkermes. Word count: Abstract: 197 Manuscript: 5,268 (excluding abstract) + 683 figure/table legends and footnotes Figures/tables: 5 (as agreed) 1 Downloaded from mct.aacrjournals.org on September 24, 2021. © 2020 American Association for Cancer Research. Author Manuscript Published OnlineFirst on June 16, 2020; DOI: 10.1158/1535-7163.MCT-19-0993 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited.
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