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Seaver Autism Center Researchers at IMFAR 2014

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Seaver Autism Center Researchers at IMFAR 2014 Vol.5, No.2, 2014 IN THIS ISSUE Seaver Autism Center Researchers SEAVER AUTISM CENTER at IMFAR 2014 1 RESEARCHERS AT IMFAR 2014 very year, autism researchers from around the Seaver Autism Center, was featured at the NEW RESEARCH INTERN BEGINS the world gather at the International annual IMFAR press conference, and the Seav- SECOND CAREER EMeeting for Autism Research (IMFAR) er Center hosted the annual Seaver IMFAR sponsored by the International Society for Au- Reunion Reception for current and former SEAVER AUTISM CENTER tism Research. This year in Atlanta, GA, over members, friends, and collaborators. See photos 2 RESEARCHERS ten current and former Seaver Autism Cen- on page 4. AT IMFAR 2014 (CONTINUED) ter researchers, including students and junior faculty, were featured in poster and oral pre- RESEARCH PRESENTATIONS RECENT EVENTS sentations. Joseph Buxbaum, PhD, Director of Researchers presented on a range of topics from genetics to animal models and clinical trials. 3 NEW GRANT AWARD Teresa Tavassoli, PhD, Seaver Postdoctoral NEW RESEARCH INTERN (CONT.) Fellow, gave an oral presentation titled, “How Can We Robustly Measure Sensory Reactivity; ANNUAL REUNION RECEPTION A New DSM-5 Criterion for Autism Spectrum 4 Disorder.” SAVE THE DATE 18TH ANNUAL Karim Ibrahim, MS, graduate student at the SEAVER AUTISM University of Hartford and former clinical psy- CENTER ADVANCES IN AUTISM chology trainee at the Seaver Autism Center, also CONFERENCE gave an oral presentation titled, “Here’s Looking Hala Harony-Nicolas, PhD, Seaver Fellow and Instructor at You: Neural Effects of a Cognitive-Behavioral in the Department of Psychiatry, gave an oral presentation titled, “A novel Shank3-deficient rat model to understand the neural basis of autism.” Continued on next page New Research Intern Begins Second Career e would like to introduce Ms. For many years, Carol worked in fi- Carol Eisenberg, a new re- nance and marketing at MCI in Wash- Wsearch intern at the Seaver ington, DC before leaving when she had Autism Center. Carol is currently pur- children. In 2002, Carol moved with suing her post-baccalaureate studies her children and husband, Harvey, to at Columbia University, and she will California to work with the University graduate this December. She is also the of California, Santa Barbara on Applied mother of two children – Emma, 18, Behavioral Analysis for their son David. who will be starting Sarah Lawrence In 2005, the Eisenbergs moved to the College in the fall, and David, 15, who New York area where Harvey is a part- attends Alpine Learning Group and is ner at the premier New York City law Silvia De Rubeis, PhD, Seaver Postdoctoral Fellow, on the autism spectrum. firm Weil, Gotshal & Manges. and Ms. Carol Eisenberg, Research Intern Researchers at IMFAR 2014 Continued from page 1 Social Skills Treatment on Eye Gaze Processing in Children SHANK3 mutations. IGF-1 is with Autism—a Randomized, Comparative Study.” Karim is a commercially available thera- conducting his dissertation research under the mentorship peutic compound that enters the of Ting Wang, PhD, Assistant Pro- brain and has beneficial effects fessor of Psychiatry at the Seaver on nerve development by pro- Autism Center. moting nerve cell survival, syn- aptic maturation, and synaptic PRESS CONFERENCE plasticity. We have now carried Dr. Buxbaum was featured in out a pilot study of IGF-1 treat- IMFAR’s annual press conference. ment in nine patients with PMS His abstract was one of only seven (ages 5-15) in order to evalu- Ting Wang, PhD, Assistant Professor to be selected for the press confer- of Psychiatry at the Seaver Autism ate safety, tolerability, and ef- Center, and Latha Soorya, PhD, Assis- ence, out of thousands submitted. ficacy for core deficits of ASD, tant Professor of Psychiatry at Rush University Medical Center, former Ozlem Bozdagi Gunal, MD, As part of the Scientific Panel including social impairment Chief Psychologist and current PhD, Assistant Professor of titled, “Insulin-like Growth Fac- and restricted and repetitive Adjunct Assistant Professor of Psy- Psychiatry at the Seaver Au- tor-1 and Its Analogs: Restoration behaviors. We approached this chiatry at the Seaver Autism Center, tism Center, gave a poster collaborated on a poster presentation presentation titled, “Cyfip1 of Biological Deficits in Neuro- aim by employing a placebo- titled, “Moderators and maintenance Developmentally Regulates developmental Disorders Associ- controlled, double-blind, cross- from social cognitive skills groups: Presynaptic Function.” Results from a randomized compara- ated with Autism,” Dr. Buxbaum over design with three months tive trial of Seaver-NETT” (Nonver- presented, “Insulin-like growth of treatment with IGF-1 and bal communication, Emotion recogni- factor-1 rescues synaptic and mo- three months of placebo in tion, and Theory of mind Training). tor deficits in a mouse model of random order, separated by a four week wash-out period. Re- autism and developmental delay sults provide evidence that IGF-1 is safe, well tolerated, and as- and shows evidence for safety and sociated with significant improvement in social impairment as efficacy in a controlled clinical measured by the Aberrant Behavior Checklist Social Withdraw- trial of Phelan McDermid Syn- al subscale and in repetitive behaviors as measured by the Re- drome.” Dr. Buxbaum’s presenta- petitive Behavior Scale. This study establishes the feasibility of tion abstract is reproduced below. IGF-1 treat- Alexa Mieses, medical student at Research Summary ment in PMS the Icahn School of Medicine at and contrib- Mount Sinai, gave a poster pre- SHANK3 gene deletions and mu- sentation titled, “Mapping the tations result in Phelan McDermid utes pilot data Phenotype of Phelan-McDermid Syndrome (PMS) and cause autism from the first Syndrome.” spectrum disorders (ASD) with a controlled frequency of 0.5% of ASD cases. treatment tri- Loss of SHANK3 is sufficient to al in the syn- cause the syndrome and is known drome. It also to produce significant disruption in provides proof nerve cell function and plasticity in of concept animal models. Our recent evidence to advance Summary of research findings from preclinical studies with mouse k n o w l e d g e models of SHANK3 deficiency in- about developing targeted treatments for additional causes dicates that Insulin-Like Growth of ASD associated with impaired synaptic development and function. Paige Weinger, PsyD, Seaver Factor-1 (IGF-1) can reverse syn- Postdoctoral Fellow, gave a aptic plasticity and motor learn- Several organizations and news outlets reported on research poster presentation titled, “Elec- ing deficits at clinically approved trophysiological Assessment of presented by Seaver researchers, including Autism Speaks Low-Contrast Visual Function doses. More recently another group and the Simons Foundation Autism Research Initiative. To and Neural Noise in Children has shown beneficial effects of IGF- watch Dr. Buxbaum’s IMFAR press conference presentation, with Autism Spectrum Disorder.” 1 in human nerve cells carrying please visit http://tiny.cc/IMFARpressconference. 2 Recent Events Celebration. To watch Dr. Buxbaum’s presentation, please visit http://tiny.cc/ASFpresentation. ▶ SEAVER AUTISM CENTER AT THE 2014 WALK NOW FOR AUTISM SPEAKS ▶ AUTISM SCIENCE Kaitlin Minnehan, Seaver Autism Cen- FOUNDATION’S (ASF) 5TH ter volunteer, Jesslyn Jamison, Clini- ANNIVERSARY CELEBRATION cal Research Coordinator at the Seaver Joseph Buxbaum, PhD, Director of the Center, and Ariella Carlin, Seaver Cen- Seaver Autism Center, presented at ter volunteer and Clinical Research ASF’s “Day of Learning,” a TED-style Coordinator in Psychiatry at the Icahn scientific conference on autism which School of Medicine at Mount Sinai rep- was part of ASF’s Fifth Anniversary resented the Seaver Autism Center. New Grant Award SEAVER IS Erin Li, medical student at the Icahn School of Medicine, completing CONTINUING TO a rotation in the Seaver Autism Center, is the recipient of the Autism GO GREEN! Science Foundation Predoctoral Research Grant for her project “Map- Please send your ping the Neurobehavioral Phenotype in Phelan-McDermid Syndrome (PMS).” Her research will be conducted over the next year under her email address to mentor Dr. Alex Kolevzon, Clinical Director of the Seaver Autism Cen- seavercentereditor@ ter. The aim for this project is to use a comprehensive assessment bat- msm.edu to receive this tery to characterize the behavioral, cognitive, language, sensory, and newsletter electronically. motor deficits in PMS. New Research Intern Continued from page 1 As a parent of a child with autism, Carol been involved with the Seaver Autism has strived to learn as much as she can Center for many years and seeing that about the disorder and different ways her research interests align closely with she can help her child. Carol said, “For those of the Seaver Center, she knew a ten years I sat around reading PubMed, research internship here would provide and I decided I needed a degree to better her with excellent experience. true expert at what she does.” understand the science behind autism.” Carol is working with Silvia De Rubeis, At the end of her three-month research It is for this reason that Carol decided PhD, Seaver Postdoctoral Fellow, in the internship, Carol will be taking the GRE to embark upon a second career, and laboratory of the Seaver Autism Center, and applying for PhD programs in ge- she began by pursuing her post-bacca- which is led by Joseph Buxbaum, PhD, netics or neuroscience. She is interested laureate studies at Columbia. She has Director of the Center. Dr. De Rubeis is in conducting sibling studies, and stud- taken two classes per semester for four teaching her the ins and outs of basic re- ies on children with severe autism. Car- years, and she is now completing a re- search, and Carol is assisting in current ol added, “The people I’m working with search internship to enhance her pre- studies. Carol said, “The experience here are extraordinary, and I am in awe graduate school experience.
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