PILRA Cat. No.: 30-252

PILRA Antibody

Specifications

HOST SPECIES: Rabbit

SPECIES REACTIVITY:

Antibody produced in rabbits immunized with a synthetic peptide corresponding a region IMMUNOGEN: of human PILRA.

TESTED APPLICATIONS: ELISA, WB

PILRA antibody can be used for detection of PILRA by ELISA at 1:1562500. PILRA antibody APPLICATIONS: can be used for detection of PILRA by western blot at 0.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

POSITIVE CONTROL: 1) Cat. No. 1211 - HepG2 Cell Lysate

PREDICTED MOLECULAR 18 kDa WEIGHT:

Properties

PURIFICATION: Antibody is purified by peptide affinity chromatography method.

CLONALITY: Polyclonal

CONJUGATE: Unconjugated

PHYSICAL STATE: Liquid

September 25, 2021 1 https://www.prosci-inc.com/pilra-antibody-30-252.html Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% BUFFER: sucrose.

CONCENTRATION: batch dependent

For short periods of storage (days) store at 4˚C. For longer periods of storage, store PILRA STORAGE CONDITIONS: antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

Additional Info

OFFICIAL SYMBOL: PILRA

ALTERNATE NAMES: PILRA, FDF03

ACCESSION NO.: NP_840057

PROTEIN GI NO.: 30179907

GENE ID: 29992

USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background and References

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of tyrosine residues is central to the regulation of several pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. This particular encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated BACKGROUND: dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non- ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor are located in a tandem head-to-tail orientation on 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.

REFERENCES: 1) Satoh, T., (2008) Cell 132 (6), 935-944.

ANTIBODIES FOR RESEARCH USE ONLY.

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