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Electronic Supplementary Material (ESI) for Molecular BioSystems. This journal is © The Royal Society of Chemistry 2014

Supplementary Information

Supplementary table S1- Hu-PPI and Hu-Vir PPI data before and after the removal of ambiguous and redundant protein identifiers (those with identities >98% and ±20 of protein length in BLAST searches). ‘*’ strains not merged and ‘**’ strains merged.

Identity cut off DATA Interactions Interactions after Proteins in BLAST before BLAST BLAST (no. of proteins involved)

98% Hu-PPI 49879 49772 10446

(10658)

98% Hu-Vir PPI 12649 12623 1735 – Human

(human (1754 human 763 – Viral proteins) +763 viral)

98% Hu-Vir PPI 12623 9732* 1735 – Human

(viral proteins) (1735 human + 518 – Viral 763 viral)

30% Hu-Vir PPI 12623 3389** 1735 – Human

(viral proteins) (1735 human 267** – Viral +763 viral) Supplementary table S2 - Salient features of used in the study. This table gives number of proteins encoded by , number of Hu-Vir PPI for that virus, virus host or disease caused, site and type of infection caused by virus and .

Virus No. of No. of Virus host /disease Site and type of infection Classification ORFs or Hu- protein Vir encode PPI by virus

Adeno associated 7 2 no known disease found in semen ssDNA, virus 2

Autographa californica 156 1 insect virus coelum dsDNA, nuclear polyhedrosis virus

Avian sarcoma virus NA 2 Bird lymphoma and connective tissue, ssRNA-RT, mammals lymphatic tissue Retroviridae

Bovine herpes virus 1 70 1 cattle rhinotracheitis, vaginitis, dsDNA, conjunctivitis

Bovine leukemia virus 6 7 cattle B-cell leukemia ssRNA-RT, Retroviridae

Bovine 8 28 cattle skin, bladder cancer dsDNA, virus 1

Bovine papilloma 9 1 cattle skin, bladder cancer dsDNA, virus 2 Papillomaviridae

Bovine NA 1 cattle diarrhoea intestinal tract dsRNA,

Chicken anemia virus 4 1 birds bone marrow atrophy ssDNA,

Cotton tail rabbit 10 5 rabbit skin, bladder cancer dsDNA, papilloma virus Papillomaviridae

Dengue virus 7 140 humans, dengue hemorrhagic, fever, (+)ssRNA, fever diarrhoea

Epstein barr virus 94 315 humans, cancer, B-cells and epithelial cells dsDNA, Burkitt's lymphoma Herpesviridae

Equine herpes virus 1 NA 1 horse, pneumonia pneumonia, paralysis dsDNA, Herpesviridae

Equine herpes virus 4 NA 2 horse conjuctivitis, swollen dsDNA, lymph nodes Herpesviridae

Equine infectious 4 1 horse, anemia and break down of blood cells ssRNA-RT, anemia virus fever Retroviridae

Foamy virus NA 1 humans, simians, lymhoblastoid, carcinoma ssRNA-RT, camcer Retroviridae

Fowl adenovirus A 39 2 fowl, infection respiratory dsDNA,

Hantaan virus 1 4 human, blood vessels, kidney, (-)ssRNA, hemorrhagic fever lungs, liver Bunyaviridae

Hepatitis 7 27 humans, liver and pancreas cancer, dsDNA-RT, cirrhosis

Hepatitis C virus 2 91 humans, hepatocytes (+)ssRNA, Flaviviridae

Hepatitis D virus 2 2 humans, alongwith liver and pancreas cancer, (-)ssRNA, hepatitis B cirrhosis unassigned

Hepatitis E virus 10 2 humans, liver (+)ssRNA,

Human adenovirus A 36 19 human, infection respiratory dsDNA, Adenoviridae

Human adenovirus B 38 4 human, infection respiratory dsDNA, Adenoviridae

Human adenovirus C 38 62 human, infection respiratory dsDNA, Adenoviridae

Human adenovirus D 38 1 human, infection respiratory dsDNA, Adenoviridae

Human adenovirus E 38 3 human, infection respiratory dsDNA, Adenoviridae

Human adenovirus F 34 1 human, infection respiratory dsDNA, Adenoviridae

Human entero virus B, 1 1 humans, menigitis brain, meingitis (+)ssRNA, Echovirus Picornaviridae

Human herpes virus 3 73 1 humans, mucoepithelial, skin and dsDNA, and nerve cells Herpesviridae

Human herpes virus 1 77 76 humans, oral and mucoepithelial and nerve dsDNA, cells Herpesviridae

Human herpes virus 2 77 4 humans, oral and mucoepithelial and nerve dsDNA, genital herpes cells Herpesviridae

Human herpes virus 165 6 humans, infectious Monocyte, lymphocyte, dsDNA, 5() mononucleosis-like and epithelial cells Herpesviridae syndrome

Human herpes virus 6 104 2 humans, sixth T-cells dsDNA, disease or rose rash Herpesviridae disease Human 15 1399 humans, T-cells SsRNA-RT, immunodeficiency AIDS(global) Retroviridae virus 1

Human 9 85 humans, T-cells ssRNA-RT, immunodeficiency AIDS(west Africa) Retroviridae virus 2

Human Papilloma 9 115 humans, cervical and epithelial dsDNA, virus High risk cancer and cells Papillomaviridae

Human papilloma 9 53 humans, cervical keratinocytes and epithelial dsDNA, virus type Low Risk cancer and warts cells Papillomaviridae

Human T-lymphocytic 6 232 humans, HTLV T-cells, B-cells and ssRNA-RT, virus 1 myelopathy, dendritic cells Retroviridae leukemia

Human T-lymphocytic 6 75 humans, HTLV T-cells, B-cells and ssRNA-RT, virus 2 myelopathy dendritic cells Retroviridae

Influenza A virus 9 293 humans, bronchial epithelial cells (-)ssRNA, H1N1

Influenza A virus 9 2 humans, Influenza bronchial epithelial cells (-)ssRNA, H3N2 Orthomyxoviridae

Influenza A virus 9 1 humans, Influenza bronchial epithelial cells (-)ssRNA, H7N3 Orthomyxoviridae

JC polyomavirus 6 3 humans, tonsils, gastrointestinal dsDNA, progressive tract, nervous tissue multifocal leukoencephalopath y

Kaposi sarcoma 2 10 humans, kaposi Lymphocyte dsDNA, associated herpes virus sarcoma Herpesviridae

Measles virus 7 6 humans, respiratory tract (-)ssRNA,

Mokola virus 5 1 humans and nervous system (-)ssRNA, animals, encephalitis

Murine adenovirus 26 1 mice, acute CNS hemorrhage in brain and dsDNA, disease spinal cord Adenoviridae

Murine herpes virus 4 74 2 mice, infection nasal passages dsDNA, Herpesviridae

Murine polyoma virus 6 5 mice, leukemia gangliosides dsDNA, Polyomaviridae

Nipah virus 8 1 humans and respiratory and nervous (-)ssRNA, mammals, infection system Paramyxoviridae virus 130 1 sheep and humans, skin dsDNA, Poxvidae sheep pox

Papiine herpes virus 75 4 baboon, infection neuro-virulent dsDNA, Herpesviridae

Para influenza virus 9 2 humans, Croup respiratory tract (-)ssRNA, Paramyxoviridae

Polio virus 1 2 humans, nervous system (+)ssRNA, poliomyelitis Picornaviridae

Puumala virus 1 2 human, hemorrhagic fever with (-)ssRNA, hemorrhagic fever renal syndrome Bunyaviridae

Rabies virus 5 1 humans and dogs, Nervous system (-)ssRNA, Rhabdoviridae

Rous sarcoma virus 4 9 chicken, sarcoma connective tissue ssRNA-RT, Retroviridae

Saimiriine herpesvirus 76 6 sqirrel monkeys, skin and epithelial cells dsDNA, 2 humans in Herpesviridae laboratory

SARS 14 4 humans, SARS respiratory tract (+)ssRNA,

Sendai virus 9 1 mammals, infection respiratory tract and lungs (-)ssRNA, Paramyxoviridae

Seoul virus NA 3 humans hemorrhagic fever (-)ssRNA, Bunyaviridae

Simian 7 2 primates, related to T-cell ssRNA-RT, immunodeficiency HIV Retroviridae virus

Simian rotavirus NA 2 primates, diarrhoea gut and intestine dsRNA, Reoviridae

Simian virus 40 7 46 primates, latent vacuolating dsDNA, infection Polyomaviridae

Stomatitis virus 5 2 mammals(infection cytolytic (-)ssRNA, ), Rhabdoviridae humans(oncolytic)

Tula virus 1 1 humans, fever NA (-)ssRNA, Bunyaviridae

Vaccinia virus 223 198 humans, skin dsDNA, Poxvidae

West nile virus 1 1 mammals, nervous system and (+)ssRNA, meningitis and lymphatic tisse Flaviviridae encephalitis

Zaire ebolavirus 9 1 humans, endothelial lining and (-)ssRNA, hemorrhage blood vessels

Supplementary Figure S1- Venn diagram showing distribution of human proteins in Hu-PPI and Hu-Vir PPI data

Supplementary Figure S2 – Ontology (GO) molecular function enrichment for peripheral proteins in Hu-PPI network (a) and 176 human proteins interacting with viruses but not part of Hu-PPI network (b). Supplementary Figure S3 – Gene Ontology (GO) biological process enrichment for peripheral proteins in Hu-PPI network (a) and 176 human proteins interacting with viruses but not part of Hu-PPI network(b). Supplementary Figure S4 – Gene Ontology (GO) cellular component enrichment for peripheral proteins in Hu-PPI network (a) and 176 human proteins interacting with viruses but not part of Hu-PPI network (b).