Amizide Contains the Active Ingredients Hydrochlorothiazide and Amiloride Hydrochloride CONSUMER MEDICINE INFORMATION

Total Page:16

File Type:pdf, Size:1020Kb

Amizide Contains the Active Ingredients Hydrochlorothiazide and Amiloride Hydrochloride CONSUMER MEDICINE INFORMATION Amizide contains the active ingredients hydrochlorothiazide and amiloride hydrochloride CONSUMER MEDICINE INFORMATION What is in this leaflet whilst retaining potassium. This Some of the symptoms of an allergic helps reduce high blood pressure and reaction may include skin rash, This leaflet answers some common some forms of swelling, while at the itching or hives, swelling of the face, questions about Amizide. same time helping to maintain lips or tongue which may cause normal levels of potassium in your difficulty in swallowing or breathing, It does not contain all of the available blood. wheezing or shortness of breath. information. It does not take the place of talking to your doctor or Amizide may be taken alone or in Do not take Amizide if you have: pharmacist. combination with other medicines to · certain kidney problems treat your condition. All medicines have benefits and · no production of urine Your doctor may have prescribed risks. Your doctor has weighed the · high potassium levels in your risks of you taking Amizide against Amizide for another reason. Ask your doctor if you have any questions blood (hyperkalaemia), possibly the benefits they expect it will have due to a high potassium diet, for you. about why Amizide has been prescribed for you. taking potassium supplements, or If you have any concerns about other potassium-sparing taking this medicine, talk to your Amizide is available only with a medication. doctor or pharmacist. doctor©s prescription. There is no evidence that Amizide is addictive. Amizide helps maintain normal Keep this leaflet with your medicine. levels of potassium in your blood. If You may need to read it again. you are taking potassium tablets or supplements, other potassium- conserving medicines or a potassium Before you take rich diet, your potassium levels may Amizide What Amizide is used increase too much. for Ask your doctor or pharmacist if When you must not take it you are not sure whether you are Amizide is used for: Do not take Amizide if you are taking too much potassium. · oedema, swelling of the ankles, allergic to medicines containing Do not take Amizide if you are feet and legs either amiloride or pregnant or intend to become hydrochlorothiazide or any of the · ascites due to liver disease pregnant unless you and your ingredients listed at the end of this resulting in fluid accumulation in doctor have discussed the risks and leaflet. the stomach area benefits involved. Do not take Amizide if you are · lower high blood pressure Like most diuretic medicines, allergic to medicines which contain (hypertension). Amizide is not recommended for use sulfur (sulfonamides). during pregnancy. Amizide contains a combination of Hydrochlorothiazide, one of the two diuretics, amiloride Do not take Amizide if you are active ingredients of Amizide, is a hydrochloride and breastfeeding or plan to sulfur containing medicine. hydrochlorothiazide as the active breastfeed. Therefore, if you are allergic to ingredients. It helps reduce the sulfur medicines, such as some Amizide passes into breast milk and amount of excess fluid in the body by antibiotics, you are likely to be may affect your baby. increasing the amount of urine allergic to Amizide. If you are not Do not take Amizide if the expiry produced, while at the same time, sure if you have an allergy to date (Exp.) printed on the pack has minimizing potassium loss. sulfonamide medicines, check with passed. Amizide works by making your your doctor or pharmacist. Do not take Amizide if the kidneys pass more water and salt packaging shows signs of AMIZIDE 1 tampering or the tablets do not · cyclosporin, tacrolimus, How to take Amizide look quite right. medicines used to suppress the immune system Do not give Amizide to children. How much to take The safety of Amizide in children has · lithium, a medicine used in the The usual dose is one or two tablets not been established. treatment of mood swings and some types of depression daily. Before you start to take it · non-steroidal anti-inflammatory Your doctor may advise you to take a drugs (NSAIDs) such as different dose. This depends on your Tell your doctor if you are allergic ibuprofen, naproxen, diclofenac, condition and whether or not you are to any other medicines, foods, dyes indomethacin, medicines used to taking any other medicines. Your or preservatives. relieve pain, swelling and other initial dose will be maintained or Tell your doctor if you have, or symptoms of inflammation adjusted until a satisfactory response have had, any medical conditions, including arthritis is noted, but should not exceed 4 especially the following: tablets per day. · barbiturates such as · diabetes phenobarbitone, and Your doctor may increase your dose · kidney problems carbamazepine, medicines used to if necessary. No more than four treat epilepsy tablets a day should be taken. · liver problems · strong pain killers such as Follow all directions given to you · heart and lung problems codeine, morphine and by your doctor and pharmacist · asthma dextropropoxyphene carefully. · gout or hyperuricaemia · insulin and tablets used to treat They may differ from the · systemic lupus erythematosus diabetes information contained in this leaflet. · high cholesterol levels. · steroid-based medicines such as How to take Amizide Your doctor may want to take special prednisone, dexamethasone Swallow the tablets with a glass of care if you have any of these · adrenaline, a medicine used in water. conditions. emergency situations such as an anaphylactic reaction If you have not told your doctor When to take Amizide about any of the above, tell them · cholestyramine, colestipol resins, before you start taking Amizide. medicines used to lower blood If you are taking Amizide once a cholesterol levels day, take it in the morning, for example, at breakfast time. Taking other medicines · medicines used to relax muscles Amizide takes about two hours to Tell your doctor if you are taking before and during surgery start working. any other medicines, including any · medicines used in emergency that you buy without a situations such as adrenaline If you are taking more than one prescription from a pharmacy, dose a day, take the last dose no · alcohol supermarket or health food shop. later than 6 p.m, unless your These medicines may be affected Some medicines may be affected by doctor tells you otherwise. by Amizide or may affect how well Amizide, or may affect how well it Amizide may increase the amount of it works. You may need to take works. These include: water (urine) you pass and also the different amounts of your number of times you go to the toilet. · preparations which contain medicine, or may need to take By taking the last dose no later than 6 potassium different medicines. p.m there may be less chance of your · potassium conserving medicines Your doctor can tell you what to do if sleep being disturbed. · angiotensin converting enzyme you are taking any of these (ACE) inhibitors and angiotensin medicines. If you forget to take Amizide receptor antagonists, a group of If you are not sure whether you are If it is almost time for your next medicines used to treat high taking any of these medicines, dose, skip the dose you missed and blood pressure and some heart check with your doctor or take your next dose when you are conditions pharmacist. meant to. · other medicines to treat high Your doctor and pharmacist have Otherwise, take the missed dose as blood pressure more information on medicines to be soon as you remember, and then go careful with or avoid while taking back to taking your tablets as you Amizide. would normally. AMIZIDE 2 Do not take a double dose to make · excessive vomiting or diarrhoea Be careful getting up from a sitting up for the dose you missed. · dry mouth, thirst or lying position. If you are not sure what to do, ask · weakness, tiredness, drowsiness Dizziness, lightheadedness or your doctor or pharmacist. fainting may occur, especially when · muscle pain or cramps If you have any questions about you get up quickly. Getting up · fast heart beat this, check with your doctor or slowly may help. If this problem gets pharmacist. · passing less urine than normal. worse or continues, talk to your doctor. You may be dehydrated from losing How long to take Amizide for too much water if you experience any Be careful when drinking alcohol or taking strong pain killers while It is important to take Amizide every of these symptoms. taking Amizide. day as it helps control your condition If you plan to have surgery, and lower the fluid build-up in your including dental surgery, which Combining Amizide with alcohol or body. needs a general anaesthetic, tell strong pain killers can make you more dizzy or lightheaded. Keep taking Amizide for as long as your doctor or dentist that you are your doctor recommends. taking Amizide. Be aware of foods or drinks that If you have to have any blood tests, have a high potassium content. If you take too much tell your doctor that you are taking Amizide helps to maintain normal Amizide (overdose) Amizide. potassium levels in your body. However, if you eat foods or have Immediately telephone your Amizide may affect the results of drinks that are high in potassium this doctor, or the Poisons Information some tests. may lead to an increase of potassium Centre (telephone 13 11 26), or go Visit your doctor regularly so they in your body. Too much potassium to Accident and Emergency at the can check on your progress. can be harmful, therefore it is nearest hospital, if you think you Your doctor may want to check your important to discuss your diet with or anyone else may have taken too blood pressure and potassium levels your doctor or pharmacist.
Recommended publications
  • SPIRONOLACTONE Spironolactone – Oral (Common Brand Name
    SPIRONOLACTONE Spironolactone – oral (common brand name: Aldactone) Uses: Spironolactone is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat swelling (edema) caused by certain conditions (e.g., congestive heart failure) by removing excess fluid and improving symptoms such as breathing problems. This medication is also used to treat low potassium levels and conditions in which the body is making too much of a natural chemical (aldosterone). Spironolactone is known as a “water pill” (potassium-sparing diuretic). Other uses: This medication has also been used to treat acne in women, female pattern hair loss, and excessive hair growth (hirsutism), especially in women with polycystic ovary disease. Side effects: Drowsiness, lightheadedness, stomach upset, diarrhea, nausea, vomiting, or headache may occur. To minimize lightheadedness, get up slowly when rising from a seated or lying position. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur; dizziness, increased thirst, change in the amount of urine, mental/mood chances, unusual fatigue/weakness, muscle spasms, menstrual period changes, sexual function problems. This medication may lead to high levels of potassium, especially in patients with kidney problems. If not treated, very high potassium levels can be fatal. Tell your doctor immediately if you notice any of the following unlikely but serious side effects: slow/irregular heartbeat, muscle weakness. Precautions: Before taking spironolactone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
    [Show full text]
  • Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy Using Machine Learning
    Prediction of Premature Termination Codon Suppressing Compounds for Treatment of Duchenne Muscular Dystrophy using Machine Learning Kate Wang et al. Supplemental Table S1. Drugs selected by Pharmacophore-based, ML-based and DL- based search in the FDA-approved drugs database Pharmacophore WEKA TF 1-Palmitoyl-2-oleoyl-sn-glycero-3- 5-O-phosphono-alpha-D- (phospho-rac-(1-glycerol)) ribofuranosyl diphosphate Acarbose Amikacin Acetylcarnitine Acetarsol Arbutamine Acetylcholine Adenosine Aldehydo-N-Acetyl-D- Benserazide Acyclovir Glucosamine Bisoprolol Adefovir dipivoxil Alendronic acid Brivudine Alfentanil Alginic acid Cefamandole Alitretinoin alpha-Arbutin Cefdinir Azithromycin Amikacin Cefixime Balsalazide Amiloride Cefonicid Bethanechol Arbutin Ceforanide Bicalutamide Ascorbic acid calcium salt Cefotetan Calcium glubionate Auranofin Ceftibuten Cangrelor Azacitidine Ceftolozane Capecitabine Benserazide Cerivastatin Carbamoylcholine Besifloxacin Chlortetracycline Carisoprodol beta-L-fructofuranose Cilastatin Chlorobutanol Bictegravir Citicoline Cidofovir Bismuth subgallate Cladribine Clodronic acid Bleomycin Clarithromycin Colistimethate Bortezomib Clindamycin Cyclandelate Bromotheophylline Clofarabine Dexpanthenol Calcium threonate Cromoglicic acid Edoxudine Capecitabine Demeclocycline Elbasvir Capreomycin Diaminopropanol tetraacetic acid Erdosteine Carbidopa Diazolidinylurea Ethchlorvynol Carbocisteine Dibekacin Ethinamate Carboplatin Dinoprostone Famotidine Cefotetan Dipyridamole Fidaxomicin Chlormerodrin Doripenem Flavin adenine dinucleotide
    [Show full text]
  • Exforge HCT in Patients with These Highlights Do Not Include All the Information Needed to Use Diabetes (4) EXFORGE HCT Safely and Effectively
    HIGHLIGHTS OF PRESCRIBING INFORMATION Do not coadminister aliskiren with Exforge HCT in patients with These highlights do not include all the information needed to use diabetes (4) EXFORGE HCT safely and effectively. See full prescribing information for EXFORGE HCT. -----------------------WARNINGS AND PRECAUTIONS ----------------------- Hypotension: Correct volume depletion prior to initiation (5.2) ® EXFORGE HCT (amlodipine, valsartan, and hydrochlorothiazide) Increased angina and/or myocardial infarction (5.3) tablets, for oral use Monitor renal function and potassium in susceptible patients (5.4, 5.5) Initial U.S. Approval: 2009 Exacerbation or activation of systemic lupus erythematosus (5.7) WARNING: FETAL TOXICITY Observe for signs of fluid or electrolyte imbalance (5.9) See full prescribing information for complete boxed warning. Acute angle-closure glaucoma (5.10) When pregnancy is detected, discontinue Exforge HCT as soon as possible. (5.1) ------------------------------ADVERSE REACTIONS ------------------------------ Drugs that act directly on the renin-angiotensin system can cause Most common adverse events (≥ 2% incidence) are dizziness, peripheral injury and death to the developing fetus. (5.1) edema, headache, dyspepsia, fatigue, muscle spasms, back pain, nausea, and nasopharyngitis. (6.1) ---------------------------INDICATIONS AND USAGE --------------------------- Exforge HCT is a combination tablet of amlodipine, a dihydropyridine To report SUSPECTED ADVERSE REACTIONS, contact Novartis calcium channel blocker (DHP CCB), valsartan, an angiotensin II receptor Pharmaceuticals Corporation at 1-888-669-6682 or FDA at 1-800-FDA- blocker (ARB), and hydrochlorothiazide, a thiazide diuretic. Exforge HCT is 1088 or www.fda.gov/medwatch. indicated for the treatment of hypertension to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, ------------------------------DRUG INTERACTIONS ------------------------------ primarily strokes, and myocardial infarctions.
    [Show full text]
  • Karger AG, Basel Published Online: November 26, 2018 by S
    Neurosignals 2018;26:77-93 DOI: 10.1159/000495425 © 2018 The Author(s).© 2018 Published The Author(s) by S. Karger AG, Basel Published online: November 26, 2018 www.karger.com/nsgPublished by S. Karger AG, Basel 77 www.karger.com/nsg Accepted:Hundehege November et al.: Pregabalin 08, 2018 in Experimental Autoimmune Encephalitis This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Interna- tional License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission. Original Paper Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis Petra Hundehegea Juncal Fernandez-Ortha Pia Römera Tobias Rucka Thomas Münteferinga Susann Eichlera Manuela Cerinaa Lisa Eppinga Sarah Albrechta Amélie F. Menkea Katharina Birknerb Kerstin Göbela Thomas Buddec Frauke Zippb Heinz Wiendla Ali Gorjid Stefan Bittnerb Sven G. Meutha aNeurology Department with Institute of Translational Neurology, University of Münster, bDepartment of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, cInstitute of Physiology I, University of Münster, dNeurology Department with Institute of Translational Neurology and Neurosurgery Department, University of Münster, Germany Key Words Multiple sclerosis • Pregabalin • Experimental autoimmune encephalomyelitis • Neuroprotection Abstract Background/Aims: Multiple sclerosis (MS) is a prototypical autoimmune central nervous system (CNS) disease. Particularly progressive forms of MS (PMS) show significant neuroaxonal damage as consequence of demyelination and neuronal hyperexcitation. Immuno-modulatory treatment strategies are beneficial in relapsing MS (RMS), but mostly fail in PMS.
    [Show full text]
  • AMILORIDE HYDROCHLORIDE and HYDROCHLOROTHIAZIDE- Amiloride Hydrochloride and Hydrochlorothiazide Tablet Mylan Pharmaceuticals Inc
    AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE- amiloride hydrochloride and hydrochlorothiazide tablet Mylan Pharmaceuticals Inc. ---------- DESCRIPTION Amiloride hydrochloride and hydrochlorothiazide tablets, USP combine the potassium- conserving action of amiloride hydrochloride with the natriuretic action of hydrochlorothiazide. Amiloride hydrochloride is designated chemically as 3,5-diamino-6-chloro-N-(diamino- methylene)pyrazinecarboxamide monohydrochloride, dihydrate. It has the following structural formula: C6H8ClN7O•HCl•2H2O MW = 302.12 Hydrochlorothiazide is designated chemically as 6-chloro-3,4-dihydro-2H-1,2,4- benzothiadiazine-7-sulfonamide 1,1-dioxide. It has the following structural formula: C7H8ClN3O4S2 MW = 297.74 It is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution. Each tablet, for oral administration, contains 5 mg of amiloride hydrochloride, USP (calculated on the anhydrous basis) and 50 mg of hydrochlorothiazide, USP. In addition, each tablet contains the following inactive ingredients: croscarmellose sodium, FD&C Yellow No. 6 Aluminum Lake, lactose monohydrate, magnesium stearate, pregelatinized starch (corn), and sodium lauryl sulfate. CLINICAL PHARMACOLOGY Amiloride hydrochloride and hydrochlorothiazide tablets provide diuretic and antihypertensive activity (principally due to the hydrochlorothiazide component), while acting through the amiloride component to prevent the excessive potassium loss that may occur in patients receiving
    [Show full text]
  • Ambetter 90-Day-Maintenance Drug List- 2020
    Ambetter 90-Day-Maintenance Drug List Guide to this list: What is Ambetter 90‐Day‐Maintenance Drug List? Ambetter 90‐Day‐Supply Maintenance Drug List is a list of maintenance medications that are available for 90 day supply through mail order or through our Extended Day Supply Network. How do I find a pharmacy that is participating in Extended Day Supply Network? To find a retail pharmacy that is participating in our Extended Day Supply Network please consult information available under Pharmacy Resources tab on our webpage. Alternatively, you can utilize our mail order pharmacy. Information on mail order pharmacy is available in Pharmacy Resources tab on our webpage. Are all formulary drugs covered for 90 day supply? No, certain specialty and non‐specialty drugs are excluded from 90 day supply. Please consult 90‐Day‐ Supply Maintenance Drug List for information if your drug is included. A Amitriptyline HCl Acamprosate Calcium Amlodipine Besylate Acarbose Amlodipine Besylate-Atorvastatin Calcium Acebutolol HCl Amlodipine Besylate-Benazepril HCl Acetazolamide Amlodipine Besylate-Olmesartan Medoxomil Albuterol Sulfate Amlodipine Besylate-Valsartan Alendronate Sodium Amlodipine-Valsartan-Hydrochlorothiazide Alendronate Sodium-Cholecalciferol Amoxapine Alfuzosin HCl Amphetamine-Dextroamphetamine Aliskiren Fumarate Anagrelide HCl Allopurinol Anastrozole Alogliptin Benzoate Apixaban Alosetron HCl Arformoterol Tartrate Amantadine HCl Aripiprazole Amiloride & Hydrochlorothiazide Armodafinil Amiloride HCl Asenapine Maleate Amiodarone HCl Aspirin-Dipyridamole
    [Show full text]
  • FDA's) Current Thinking on This Topic
    Contains Nonbinding Recommendations Draft Guidance on Amiloride Hydrochloride This draft guidance, once finalized, will represent the Food and Drug Administration's (FDA's) current thinking on this topic. It does not create or confer any rights for or on any person and does not operate to bind FDA or the public. You can use an alternative approach if the approach satisfies the requirements of the applicable statutes and regulations. If you want to discuss an alternative approach, contact the Office of Generic Drugs. Active ingredient: Amiloride Hydrochloride Form/Route: Tablet; Oral Recommended studies: 2 Studies 1. Type of study: Fasting Design: Single-dose, two-way crossover in-vivo Strength: EQ 5 mg Base Subjects: Healthy males, nonpregnant females and non-elderly, general population. Additional Comments: Subjects with impaired renal function, diabetes mellitus, should be excluded from the study. As amiloride treatment may cause hyperkalemia, serum potassium levels should be monitored carefully during the bioequivalence study. ________________________________________________________________________ 2. Type of study: Fed Design: Single-dose, two-way crossover in-vivo Strength: EQ 5 mg Base Subjects: Healthy males, nonpregnant females and non-elderly, general population. Additional Comments: Please see above. ________________________________________________________________________ Analytes to measure (in appropriate biological fluid): Amiloride in plasma Bioequivalence based on (90% CI): Amiloride Waiver request of in-vivo testing: Not applicable Dissolution test method and sampling times: Please note that a Dissolution Methods Database is available to the public at the OGD website at http://www.accessdata.fda.gov/scripts/cder/dissolution/. Please find the dissolution information for this product at this website. Please conduct comparative dissolution testing on 12 dosage units each of all strengths of the test and reference products.
    [Show full text]
  • Investigating Neuroprotectants for the Treatment of Chemotherapy-Induced Peripheral Neuropathy
    THE UNIVERSITY OF NEW SOUTH WALES Translational Neuroscience Facility School of Medical Sciences Faculty of Medicine UNSW Australia A thesis in fulfilment of the requirements for the degree of: Masters Investigating Neuroprotectants for the Treatment of Chemotherapy-Induced Peripheral Neuropathy by Munawwar Abdulla Supervisor: Dr. Gila Moalem-Taylor Co-supervisor: Dr. Justin Lees Co-supervisor: Dr. Patsie Pollie August, 2018 i The University of New South Wales Thesis/Dissertation Sheet Surname or Family name: Abdulla First name/s: Munawwar Abbreviation for degree as given in the University calendar: MSc School: School of Medical Sciences Faculty: Medicine Title: Investigating neuroprotectants for the treatment of chemotherapy-induced peripheral neuropathy Abstract 350 words maximum: Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating and dose-limiting side effect of many chemotherapy regimens and is becoming a more prevalent issue as the longevity of cancer patients continues to increase. Sensory symptoms include neuropathic pain, paraesthesia, and numbness and usually spread in a glove-and-stocking distribution. At present, there are no effective medications to treat or prevent CIPN, and the mechanisms by which symptoms are induced have not been fully elucidated. Paclitaxel (PTX) is a commonly used chemotherapeutic that induces neuropathy in a high percentage of patients. The broad aim of this thesis was to establish a model of CIPN in vitro and in vivo and test clinically approved drugs for potential neuroprotective effects. Since the dorsal root ganglion (DRG) has been implicated in CIPN, we cultured dissociated primary DRG neurons from 5-week-old C57BL/6 mice and treated them with PTX to observe neurotoxic effects.
    [Show full text]
  • Ketamine Inhibits Lung Fluid Clearance Through Reducing Alveolar Sodium Transport
    Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2011, Article ID 460596, 6 pages doi:10.1155/2011/460596 Research Article Ketamine Inhibits Lung Fluid Clearance through Reducing Alveolar Sodium Transport Yong Cui,1 Hongguang Nie,2 Hong Ma,1 Lei Chen,3 Lin Zhang,4 Junke Wang,1 and Honglong Ji5 1 Department of Anesthesiology, First Affiliated Hospital, China Medical University, Shenyang 110001, China 2 Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110001, China 3 School of Pharmaceutical Sciences, China Medical University, Shenyang 110001, China 4 Department of Thoracic Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China 5 Department of Biochemistry, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA Correspondence should be addressed to Yong Cui, [email protected] Received 28 May 2011; Revised 13 July 2011; Accepted 1 August 2011 Academic Editor: Daniel T. Monaghan Copyright © 2011 Yong Cui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Ketamine is a broadly used anaesthetic for analgosedation. Accumulating clinical evidence shows that ketamine causes pulmonary edema with unknown mechanisms. We measured the effects of ketamine on alveolar fluid clearance in human lung lobes ex vivo. Our results showed that intratracheal instillation of ketamine markedly decreased the reabsorption of 5% bovine serum albumin instillate. In the presence of amiloride (a specific ENaC blocker), fluid resolution was not further decreased, suggesting that ketamine could decrease amiloride-sensitive fraction of AFC associated with ENaC.
    [Show full text]
  • Amiloride Hydrochloride and Hydrochlorothiazide Tablets USP
    AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE- amiloride hydrochloride and hydrochlorothiazide tablet Teva Pharmaceuticals USA, Inc. ---------- Amiloride Hydrochloride and Hydrochlorothiazide Tablets USP 5 mg/50 mg Rx only DESCRIPTION Amiloride Hydrochloride and Hydrochlorothiazide Tablets USP combine the potassium-conserving action of amiloride hydrochloride with the natriuretic action of hydrochlorothiazide. Amiloride HCl, USP is designated chemically as N-amidino-3,5,-diamino-6-chloropyrazine- carboxamide monohydrochloride dihydrate and its structural formula is: C6H8CIN7O•HCl•2H2O M.W. 302.12 Hydrochlorothiazide, USP is designated chemically as 6-chloro-3,4-dihydro-2H-1, 2, 4-benzo- thiadiazine-7-sulfonamide 1, 1-dioxide. Its structural formula is: C7H8CIN3O4 S2 M.W. 297.74 It is a white, or practically white, crystalline powder which is slightly soluble in water, but freely soluble in sodium hydroxide solution. Each tablet, for oral administration, contains 5 mg of amiloride hydrochloride, USP (calculated on the anhydrous basis) and 50 mg of hydrochlorothiazide, USP. Inactive Ingredients: Croscarmellose sodium, D&C yellow no. 10 (aluminum lake), lactose monohydrate, magnesium oxide, magnesium stearate, microcrystalline cellulose. CLINICAL PHARMACOLOGY Amiloride hydrochloride and hydrochlorothiazide tablets provide diuretic and antihypertensive activity (principally due to the hydrochlorothiazide component), while acting through the amiloride component to prevent the excessive potassium loss that may occur in patients receiving a thiazide diuretic. Due to its amiloride component, the urinary excretion of magnesium is less with amiloride and hydrochlorothiazide than with a thiazide or loop diuretic used alone (see PRECAUTIONS). The onset of the diuretic action of this product is within 1 to 2 hours and this action appears to be sustained for approximately 24 hours.
    [Show full text]
  • Using Medications, Cosmetics, Or Eating Certain Foods Can Increase Sensitivity to Ultraviolet Radiation
    USING MEDICATIONS, COSMETICS, OR EATING CERTAIN FOODS CAN INCREASE SENSITIVITY TO ULTRAVIOLET RADIATION. INDIVIDUALS SHOULD CONSULT A PHYSICIAN BEFORE USING A SUNLAMP, IF THEY ARE TAKING MEDICATIONS. THE ITEMS LISTED ARE POTENTIAL PHOTOSENSITIZING AGENTS THAT MAY INCREASE SENSITIVITY TO ULTRAVIOLET LIGHT THAT MAY RESULT IN A PHOTOTOXIC OR PHOTOALLERGIC RESPONSES. PHOTOSENSITIZING MEDICATIONS Acetazolamide Amiloride+Hydrochlorothizide Amiodarone Amitriptyline Amoxapine Astemizole Atenolol+Chlorthalidone Auranofin Azatadine (Optimine) Azatidine+Pseudoephedrine Bendroflumethiazide Benzthiazide Bromodiphenhydramine Bromopheniramine Captopril Captopril+Hydrochlorothiazide Carbaamazepine Chlordiazepoxide+Amitriptyline Chlorothiazide Chlorpheniramine Chlorpheniramin+DPseudoephedrine Chlorpromazine Chlorpheniramine+Phenylopropanolamine Chlorpropamide Chlorprothixene Chlorthalidone Chlorthalidone+Reserpine Ciprofloxacin Clemastine Clofazime ClonidineChlorthalisone+Coal Tar Coal Tar Contraceptive (oral) Cyclobenzaprine Cyproheptadine Dacarcazine Danazol Demeclocycline Desipramine Dexchlorpheniramine Diclofenac Diflunisal Ditiazem Diphenhydramine Diphenylpyraline Doxepin Doxycycline Doxycycline Hyclate Enalapril Enalapril+Hydrochlorothiazide Erythromycin Ethylsuccinate+Sulfisoxazole Estrogens Estrogens Ethionamide Etretinate Floxuridine Flucytosine Fluorouracil Fluphenazine Flubiprofen Flutamide Gentamicin Glipizide Glyburide Gold Salts (compounds) Gold Sodium Thiomalate Griseofulvin Griseofulvin Ultramicrosize Griseofulvin+Hydrochlorothiazide Haloperidol
    [Show full text]
  • Stembook 2018.Pdf
    The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances FORMER DOCUMENT NUMBER: WHO/PHARM S/NOM 15 WHO/EMP/RHT/TSN/2018.1 © World Health Organization 2018 Some rights reserved. This work is available under the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). Under the terms of this licence, you may copy, redistribute and adapt the work for non-commercial purposes, provided the work is appropriately cited, as indicated below. In any use of this work, there should be no suggestion that WHO endorses any specific organization, products or services. The use of the WHO logo is not permitted. If you adapt the work, then you must license your work under the same or equivalent Creative Commons licence. If you create a translation of this work, you should add the following disclaimer along with the suggested citation: “This translation was not created by the World Health Organization (WHO). WHO is not responsible for the content or accuracy of this translation. The original English edition shall be the binding and authentic edition”. Any mediation relating to disputes arising under the licence shall be conducted in accordance with the mediation rules of the World Intellectual Property Organization. Suggested citation. The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances. Geneva: World Health Organization; 2018 (WHO/EMP/RHT/TSN/2018.1). Licence: CC BY-NC-SA 3.0 IGO. Cataloguing-in-Publication (CIP) data.
    [Show full text]