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(12) United States Patent (10) Patent No.: US 6,258,995 B1 Gilding Et Al

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(12) United States Patent (10) Patent No.: US 6,258,995 B1 Gilding Et Al USOO6258995B1 (12) United States Patent (10) Patent No.: US 6,258,995 B1 Gilding et al. (45) Date of Patent: Jul. 10, 2001 (54) WOUNDTREATMENT COMPOSITION (30) Foreign Application Priority Data (75) Inventors: pens singsa. YiminVisa Qin, both of Aug.Jul. 18,19, 1995 (GB) .................................................. 95169259514838 (51) Int. Cl." .................................................. A61F 13/00 (73) Assignee: Advanced Medical Solutions Limited, (52) us. c. ... 602/48; 602/41; 602/42; Winsford (GB) 602/43 (*) Notice: Subject to any disclaimer, the term of this (58) Field of Search ........................................... 6O2/41-48 patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days. Primary Examiner-Michael A. Brown ASSistant Examiner-Lalita M Hamilton (21) Appl. No.: 08/983,379 (74) Attorney, Agent, or Firm- Woodard, Emhardt, (22) PCT Filed: Jul.e -19, 19 1996 Naughton, Moriarty & McNett (86) PCT No.: PCT/GB96/01719 (57) ABSTRACT A wound treatment composition comprises an amorphous S371 Date: Jan. 12, 2000 hydrogel incorporating fibers which have provided cations S 102(e) Date: Jan. 12, 2000 for cross-linking the hydrogel and a bacteria Static agent. (87) PCT Pub.U). No.:TNO. WO97/03710 The composition has a viscosity of 20,000 to 1,000,000 cps. PCT Pub. Date: Feb. 6, 1997 19 Claims, No Drawings US 6,258,995 B1 1 2 WOUNDTREATMENT COMPOSITION used in the preparation of the dehydrated hydrogel. Typi cally the hydrogel precursor will provide at least 1%, and The present invention relates to compositions which are more usually at least 2% of the admixture. The exact amount useful in the treatment of wounds. The invention relates of the hydrogel precursor used will depend on the Viscosity more particularly to Such compositions in the form of an required for the amorphous hydrogel. amorphous hydrogel. Preferred compositions in accordance with the invention have a viscosity in the range 500,000 to 1,000,000 cps. A hydrogel is a croSS-linked macromolecular network Examples of hydrogel precursor material which may be Swollen with water or biological fluids. An amorphous used include Sodium alginate, Sodium carboxymethyl hydrogel is a partially croSS-linked macromolecular network cellulose, Sodium pectinate, Sodium O-carboxymethyl chi that has the three dimensional stability of a gel but still has tosan (OCC), sodium N.O-carboxymethyl chitosan the flow characteristics of a viscous fluid. (NOCC), Sodium polyacrylate, and naturally occurring WO-A-96/13285 (Innovative Technologies) discloses gums and Synthetic polymers containing pendant carboxylic dehydrated hydrogels produced by dispersing fibres into an acid groups (hummectants). aqueous Solution of a hydrogel precursor incorporating a The hydrogel precursor may consist wholly or partially plasticiser. The fibres incorporate cations which are capable 15 of the Ace Mannas or other component of Alloe Vera) which of croSS-linking Said precursor material to form a hydrogel. is a natural polymer known to accelerate healing of wounds. Water is then evaporated to produce a dehydrated hydrogel The Ace Mannas may, for example, provide up to 80% of the incorporating Said fibres, the dehydrated hydrogel being matrix. The Ace Mannas may be clinical grade material croSS-linked by Said cations. The dehydrated hydrogel may obtainable from Carrington Laboratories, Dallas, Tex., USA. be in the form of a film or a sheet. In the process described Ace Mannas is particularly Suitable for use in admixture in the aforementioned application, the amount of hydrogel with Sodium alginate and/or Sodium pectinate as hydrogel precursor used in the initial Solution (comprising the precursor. Combinations of the above precursors may also precursor, plasticiser, fibres and water) is about 0.5%. This be used. gives an amorphous hydrogel with a Viscosity of usually leSS If desired, the hydrogel precursor material may be than 1,000 cps prior to conversion of that amorphous 25 admixed with another water Soluble polymer Such as hydrogel to the final dehydrated hydrogel. Such low viscos hydroxypropyl cellulose or hydroxyethyl cellulose to pro ity amorphous hydrogels are not Suitable as wound treatment vide the required Viscosity properties for the final, amor compositions. phous hydrogel. According to a first aspect of the present invention there The fibres which are used contain a di- or higher valent is provided a wound treatment composition comprising an cation which is effective for cross-linking the hydrogel. amorphous hydrogel incorporating fibreS which have pro Examples of suitable cations include Ca", Zn", and cations Vided cations for cross-linking the hydrogel and a bacterio which also act as enzyme cofactors. Particular preferred Static agent, the composition having a Viscosity of 20,000 to examples of fibres which may be used are calcium alginate 1,000,000 cPs. fibres. The fibres will generally have a length of 1 to 80 mm Viscosity may be measured in a Brookefield Viscometer 35 and a thickness of 10 to 50 microns. using Spindle No. 4. The fibres may be such that they absorb water from the The Viscosity of compositions of the invention is Such aqueous Solution of the hydrogel precursor material during that the compositions are are capable of being spread easily manufacture of the amorphous hydrogel. and evenly and may therefore be used as wound treatment The bacterioStatic agent is preferably propylene glycol. compositions. Compositions in accordance with the inven 40 Typically amorphous hydrogels in accordance with the tion are capable of absorbing exudate from a highly exuding invention will comprise 0.5% to 5% of fibre, 1% to 5% of wound and are capable of donating water to a relatively polymer forming the gel, 10% to 30% of the bacteriostatic “dry” wound. The fibres stabilise the viscosity of the gel agent, and a balance Substantially of water, the percentages (without effecting its flow characteristics) and provide good being by weight. A particularly preferred amorphous hydro coherent Strength even when the amorphous hydrogel 45 gel comprises about 2% of fibre, about 2.5% of polymer absorbs exudate. The cations provided by the fibres may be forming gel, about 15% of the bacterioStatic agent, and a calcium cations So as to provide a controlled release of Ca", balance Substantially of water, the percentages again being into the matrix as the Na" concentration from the exudate on a weight basis. SCS. In a typical method of preparing an amorphous hydrogel When the amorphous hydrogel dries, the fibre reinforces 50 in accordance with the invention, the fibres, polymer and the dry gel which may then be removed easily from a wound. bacterioStatic agent in their relative requisite amounts are Compositions in accordance with the invention are par admixed with water. Preferably the fibres and polymer ticularly useful in the treatment of cavity wounds, e.g. together provide 4-6% (e.g. about 5%) by weight of the decubitus ulcers. The compositions are introduced into the resultant mixture. wound and pressed firmly into the base thereof. For prefer 55 If desired the mixture may also incorporate an agent to ence the wound is then covered and Sealed by a film having enhance the Swelling of the fibres and/or assist the disper a high MVTR, typically 3,000 to 20,000 gm° 24 hr' (e.g. Sion thereof. A Suitable agent is a citrate Salt, particularly Hydroderm (ex Wilshire Medical) or IT425 or IT625 (ex Sodium citrate. Other examples include Sodium chloride. Innovative Technologies)). The composition may also be The agent is preferably used in an amount up to 0.5%, used in the treatment of Sinuses. 60 preferably about 0.1% by weight. Amorphous hydrogels in accordance with the invention After thorough mixing the dispersion may be filled into may be produced by admixing water, a hydrogel precursor Sachets or Squeeze bottles of appropriate size for Subsequent material, a bacteriostatic agent, and fibres incorporating use as a wound treatment composition. cations which are capable of croSS-linking the precursor If desired, the amorphous hydrogel may incorporate an material to form an amorphous hydrogel having the fibres 65 active agent (e.g. an antimicrobial agent, growth factor, disposed throughout the hydrogel. The amounts of hydrogel connective tissue matrix degradation inhibitor or other precursor material in the admixture will be higher than those cythokine). US 6,258,995 B1 3 4 The invention will be further described by the following 7. A hydrogel as claimed in claim 1 wherein the fibres non-limiting Examples. have a thickness of 10 to 50 microns. 8. A hydrogel as claimed in claim 1 for use as a wound EXAMPLE 1. treatment composition. 1 kg of calcium alginate fibres having a length of about 10 5 9. A method of producing an amorphous hydrogel com mm, 1.2 kg of Sodium alginate and 50 g of Sodium citrate prising admixing an aqueous Solution of a hydrogel precur were dispersed in a mixture of 40 liters of water and 8.5 kg Sor material, a bacterioStatic agent, and fibres incorporating of propylene glycol. Thorough mixing produced an amor cations which are capable of cross-linking Said precursor phous hydrogel having a viscosity of 800,000 cp. material to form an amorphous hydrogel having fibres The product was eminently Suitable for use as a wound dispersed therein. treatment composition. 10. A method as claimed in claim 9 wherein the hydrogel precursor material is Selected from Sodium alginate, Sodium EXAMPLE 2 carboxymethyl cellulose, Sodium pectinate, Sodium 6 grams of MF1-2B calcium alginate fibres (ex Innovative 15 O-carboxymethyl chitosan (OCC), sodium N, O Technologies) were cut to a length of about 10 to 15 mm. carboxymethyl chitosan (NOCC), sodium polyacrylate, and The fibres were mixed together with 3 grams of sodium naturally occurring gums and Synthetic polymers containing alginate powder (HF120 ex Pronova Biopolymers), 20 pendant carboxylic acid groups (hummectants), Ace Mannas grams of hydroxypropyl cellulose (ex Hercules), 85 grams and mixtures thereof.
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