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Discovery of Rare Variants Associated with Blood Pressure Regulation Through Meta- 2 Analysis of 1.3 Million Individuals 3 4 Praveen Surendran1,2,3,4,266, Elena V

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Discovery of Rare Variants Associated with Blood Pressure Regulation Through Meta- 2 Analysis of 1.3 Million Individuals 3 4 Praveen Surendran1,2,3,4,266, Elena V 1 Discovery of rare variants associated with blood pressure regulation through meta- 2 analysis of 1.3 million individuals 3 4 Praveen Surendran1,2,3,4,266, Elena V. Feofanova5,266, Najim Lahrouchi6,7,8,266, Ioanna Ntalla9,266, Savita 5 Karthikeyan1,266, James Cook10, Lingyan Chen1, Borbala Mifsud9,11, Chen Yao12,13, Aldi T. Kraja14, James 6 H. Cartwright9, Jacklyn N. Hellwege15, Ayush Giri15,16, Vinicius Tragante17,18, Gudmar Thorleifsson18, 7 Dajiang J. Liu19, Bram P. Prins1, Isobel D. Stewart20, Claudia P. Cabrera9,21, James M. Eales22, Artur 8 Akbarov22, Paul L. Auer23, Lawrence F. Bielak24, Joshua C. Bis25, Vickie S. Braithwaite20,26,27, Jennifer A. 9 Brody25, E. Warwick Daw14, Helen R. Warren9,21, Fotios Drenos28,29, Sune Fallgaard Nielsen30, Jessica D. 10 Faul31, Eric B. Fauman32, Cristiano Fava33,34, Teresa Ferreira35, Christopher N. Foley1,36, Nora 11 Franceschini37, He Gao38,39, Olga Giannakopoulou9,40, Franco Giulianini41, Daniel F. Gudbjartsson18,42, 12 Xiuqing Guo43, Sarah E. Harris44,45, Aki S. Havulinna45,46, Anna Helgadottir18, Jennifer E. Huffman47, Shih- 13 Jen Hwang48,49, Stavroula Kanoni9,50, Jukka Kontto46, Martin G. Larson51,52, Ruifang Li-Gao53, Jaana 14 Lindström46, Luca A. Lotta20, Yingchang Lu54,55, Jian’an Luan20, Anubha Mahajan56,57, Giovanni Malerba58, 15 Nicholas G. D. Masca59,60, Hao Mei61, Cristina Menni62, Dennis O. Mook-Kanamori53,63, David Mosen- 16 Ansorena38, Martina Müller-Nurasyid64,65,66, Guillaume Paré67, Dirk S. Paul1,2,68, Markus Perola46,69, Alaitz 17 Poveda70, Rainer Rauramaa71,72, Melissa Richard73, Tom G. Richardson74, Nuno Sepúlveda75,76, Xueling 18 Sim77,78, Albert V. Smith79,80,81, Jennifer A. Smith24,31, James R. Staley1,74, Alena Stanáková82, Patrick 19 Sulem18, Sébastien Thériault83,84, Unnur Thorsteinsdottir18,80, Stella Trompet85,86, Tibor V. Varga70, Digna R. 20 Velez Edwards87, Giovanni Veronesi88, Stefan Weiss89,90, Sara M. Willems20, Jie Yao91, Robin Young1,92, 21 Bing Yu5, Weihua Zhang38,39,93, Jing-Hua Zhao1,20,68, Wei Zhao94, Wei Zhao24, Evangelos Εvangelou38,95, 22 Stefanie Aeschbacher96, Eralda Asllanaj97,98, Stefan Blankenberg90,99,100,101, Lori L. Bonnycastle102, Jette 23 Bork-Jensen103, Ivan Brandslund104,105, Peter S. Braund59,60, Stephen Burgess1,36,68, Kelly Cho106,107,108, 24 Cramer Christensen109, John Connell110, Renée de Mutsert53, Anna F. Dominiczak111, Marcus Dörr90,112, 25 Gudny Eiriksdottir79, Aliki-Eleni Farmaki113,114, J. Michael Gaziano106,107,108, Niels Grarup103, Megan L. 26 Grove-Gaona5, Göran Hallmans115, Torben Hansen103, Christian T. Have103, Gerardo Heiss37, Marit E. 27 Jørgensen116, Pekka Jousilahti46, Eero Kajantie46,117,118,119, Mihir Kamat1,68, AnneMari Käräjämäki120,121, 28 Fredrik Karpe57,122, Heikki A. Koistinen46,123,124, Csaba P. Kovesdy125, Kari Kuulasmaa46, Tiina 29 Laatikainen46,126, Lars Lannfelt127, I-Te Lee128,129,130,131, Wen-Jane Lee132,133, LifeLines Cohort Study, Allan 30 Linneberg134,135, Lisa W. Martin136, Marie Moitry137, Girish Nadkarni54, Matt J. Neville57,122, Colin N. A. 31 Palmer138, George J. Papanicolaou139, Oluf Pedersen103, James Peters1,3,140, Neil Poulter141, Asif Rasheed142, 32 Katrine L. Rasmussen30, N. William Rayner56,57, Reedik Mägi143, Frida Renström70,115, Rainer Rettig90,144, 33 Jacques Rossouw145, Pamela J. Schreiner146, Peter J. Sever141, Emil L. Sigurdsson147,148, Tea Skaaby149, Yan 34 V. Sun150, Johan Sundstrom151, Gudmundur Thorgeirsson18,80,152, Tõnu Esko143,153, Elisabetta Trabetti58, 35 Philip S. Tsao154, Tiinamaija Tuomi155,156,157, Stephen T. Turner158, Ioanna Tzoulaki38,95,265, Ilonca 36 Vaartjes159,160, Anne-Claire Vergnaud38, Cristen J. Willer161,162,163, Peter WF. Wilson164, Daniel R. 37 Witte165,166,167, Ekaterina Yonova-Doing1, He Zhang161, Naheed Aliya168, Peter Almgren169, Philippe 38 Amouyel170,171,172,173, Folkert W. Asselbergs17,174,175, Michael R. Barnes9,21, Alexandra I. Blakemore28,176, 39 Michael Boehnke77, Michiel L. Bots159,160, Erwin P. Bottinger54, Julie E. Buring41,177, John C. 40 Chambers38,39,93,178,179, Yii-Der Ida Chen91, Rajiv Chowdhury1, David Conen83,180, Adolfo Correa181, George 41 Davey Smith74, Rudolf A. de Boer182, Ian J. Deary44,183, George Dedoussis113, Panos Deloukas9,21,50,184, 42 Emanuele Di Angelantonio1,2,3,68,185,186, Paul Elliott38,39,187,188, EPIC-CVD, EPIC-InterAct, Stephan B. 43 Felix90,112, Jean Ferrières189, Ian Ford92, Myriam Fornage5,73, Paul W. Franks70,190,191,192, Stephen Franks193, 44 Philippe Frossard142, Giovanni Gambaro194, Tom R. Gaunt74, Leif Groop195,196, Vilmundur Gudnason79,80, 45 Tamara B. Harris197, Caroline Hayward47, Branwen J. Hennig27,198, Karl-Heinz Herzig199,200, Erik 46 Ingelsson201,202,203,204, Jaakko Tuomilehto46,205,206,207, Marjo-Riitta Jarvelin28,38,39,208, J. Wouter Jukema86,209, 47 Sharon L. R. Kardia24, Frank Kee210, Jaspal S. Kooner39,93,179,211, Charles Kooperberg212, Lenore J. 48 Launer197, Lars Lind151, Ruth J. F. Loos54,213, Abdulla al Shafi Majumder214, Markku Laakso126, Mark I. 49 McCarthy56,57,122, Olle Melander34, Karen L. Mohlke215, Alison D. Murray216, Børge Grønne Nordestgaard30, 50 Marju Orho-Melander34, Chris J. Packard217, Sandosh Padmanabhan218, Walter Palmas219, Ozren Polasek220, 51 David J. Porteous221,222, Andrew M. Prentice27,223, Michael A. Province14, Caroline L. Relton74, Kenneth 52 Rice224, Paul M. Ridker41,177, Olov Rolandsson191, Frits R. Rosendaal53, Jerome I. Rotter225, Igor Rudan226, 1 53 Veikko Salomaa46, Nilesh J. Samani59,60, Naveed Sattar111, Wayne H.-H. Sheu128,129,227,228, Blair H. Smith229, 54 Nicole Soranzo230,231,232, Timothy D. Spector62, John M. Starr44,233, Sebert Sylvain234,235,236, Kent D. 55 Taylor237, Timo A. Lakka71,72,238, Nicholas J. Timpson74, Martin D. Tobin60,239, Understanding Society 56 Scientific Group, Pim van der Harst240,241,242, Peter van der Meer242, Ramachandran S. Vasan51,243, Niek 57 Verweij244, Jarmo Virtamo46, Uwe Völker89,90, David R. Weir31, Eleftheria Zeggini245,246, Fadi J. 58 Charchar59,247,248, Million Veteran Program, Nicholas J. Wareham20, Claudia Langenberg20, Maciej 59 Tomaszewski22,249, Adam S. Butterworth1,2,3,68,185, Mark J. Caulfield9,21, John Danesh1,2,3,68,185,186, Todd L. 60 Edwards250, Hilma Holm18, Adriana M. Hung251, Cecilia M. Lindgren35,252,253, Chunyu Liu254, Alisa K. 61 Manning108,255, Andrew P. Morris10,252,256, Alanna C. Morrison5, Christopher J. O’Donnell257, Bruce M. 62 Psaty25,258,259,260, Danish Saleheen1,261,262, Kari Stefansson18,80, Eric Boerwinkle5,263,267, Daniel I. 63 Chasman41,177,267, Daniel Levy51,264,267, Christopher Newton-Cheh6,7,267, Patricia B. Munroe9,21,267 and Joanna 64 M. M. Howson1,68,265,267 65 66 67 68 1. British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and 69 Primary Care, University of Cambridge, Cambridge, UK. 70 2. British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK. 71 3. Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, 72 Cambridge, UK. 73 4. Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, 74 Cambridge, UK. 75 5. Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX, 76 USA. 77 6. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, 78 USA. 79 7. Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, 80 Boston, MA, USA. 81 8. Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental 82 Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands. 83 9. William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen 84 Mary University of London, London, UK. 85 10. Department of Biostatistics, University of Liverpool, Liverpool, UK. 86 11. College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar. 87 12. Framingham Heart Study, Framingham, MA, USA. 88 13. Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood 89 Institute, National Institutes of Health, Bethesda, MD, USA. 90 14. Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and 91 Systems Biology, Washington University School of Medicine, St. Louis, MO, USA. 92 15. Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, 93 Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System 94 (626)/Vanderbilt University, Nashville, TN, USA. 95 16. Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics 96 Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt 97 University, Nashville, TN, USA. 98 17. Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht 99 University, Utrecht, The Netherlands. 100 18. deCODE genetics/Amgen, Inc., Reykjavik, Iceland. 101 19. Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA. 102 20. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK. 2 103 21. National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen 104 Mary University of London, London, UK. 105 22. Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of 106 Manchester, Manchester, UK. 107 23. Joseph J. Zilber School of Public Health, University of Wisconsin, Milwaukee,
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