Kasr Al-Ainy Inernational Publications 2014 Vol
Total Page：16
File Type：pdf, Size：1020Kb
Kasr Al-Ainy Inernational Publications 2014 Vol. 8(1), May 2014 Faculty of Medicine Substantial advances have occurred in the understanding of the pathophysiology of erectile dysfunction thatultimately led to the Dept. of Anatomy development of successful oral therapies, namely the 982. Thyroid Hormone Dysfunctions Affect the phosphodiesterase type 5 inhibitors. However, oral phosphodiesterase type 5 inhibitors have limitations, and present Structure of Rat Thoracic Aorta: A Histological and research is thus investigatingcutting- edge therapeutic strategies Morphometric Study including gene and cell-based technologies with the aim of S.M. Zaki and M.F. Youssef discovering a cure for erectile dysfunction. Folia Morphologica, 72(4): 333-339 (2013) IF: 0.469 984. Drug Addiction and Sexual Dysfuntion Background: There are limited data about the influence of Adham Zaazaa, Anthony J. Bella and Rany Shamloul hypothyroidism and hyperthyroidism on the connective tissue Endocrinology and Metabolism Clinics of North America, 42: component and smooth muscle cells of the thoracic aorta. The 585-592 (2013) IF:3.792 aim was to study the histological changes of the wall of the thoracic aorta in the hypothyroid and hyperthyroid rats. Morphometric measurements were also done. Even though alcohol is prevalent in many societies with many Materials and Methods: Thirty adult rats were used. They were myths surrounding itssexual-enhancing effects, current scientific divided into control, hyperthyroid, and hypothyroid groups. Each research cannot provide a solid conclusionon its effect on sexual group consisted of 10 rats. The animals were sacrificed at the end function. The same concept applies to tobacco smoking; however, of 8 weeks and the descending aorta was excised. Sections were most of the current knowledge tends to support the notion that it, stained with haematoxylin and eosin, orcein and Masson’s indeed, can negatively affect sexual function. Cannabinoid trichrome stains. The morphometric measurement included: receptors in the human cavernous report the nonrelaxing effects number of smooth muscle cell nuclei, number of the elastic ofmarijuana. Heroin exerts a depletion effect on plasma levels of Medical Sector lamellae, thickness of the tunica media, elastic fibre optic density, free testosterone and raisestestosterone-binding globulin levels, and relative collagen area. irrespective of age, amount of heroin intake perday, and period of Results: Atheromatous plagues had been observed in the contact with the drug with no effect on the pituitary hyperthyroid group. Thinning and rupture of the elastic lamellae gonadotropins. Initially, the use of cocaine may enhance the had been observed in the hypothyroid group; these were sexual functioning of men, but prolonged usemay diminish sexual accompanied with intimal ulceration and aortic dissection. The desire and performance and may contribute to difficulty in average number of smooth muscle cell nuclei in the hyperthyroid achievingorgasm. group had do- ubled and tripled compared to their fellows in the Keywords: Drug addiction; Sexual dysfunction; Heroin; Cocaine. control and hypothyroid groups, respectively. The thickness of the tunica media increased in the hyperthyroid and hypothyroid 985. Androgen Receptor Expression Relationship groups by 75% and 35%. in addition, the relative collagen area with Semen Variables in Infertile Men with incre- ased in the previously mentioned groups by 142% and Varicocele 120%, respectively. on the other hand, the mean elastic fibre optic density decreased in both groups by 30%. Adel A. Zalata, Naglaa Mokhtar, Abd El-Naser Badawy, Gamal Conclusions: Structure wall affections of the intima and media of Othman, Moheiddin Alghobary and Taymour Mostafa the descending aorta were associated with the thyroid hormone dysfunctions. These changes were more severe in the hypothyroid J. Urology, 189 (6): 2243-2247 (2013) IF: 3.696 group. Keywords: Hyperthyroidism; Hypothyroidism; Descending Purpose: Androgen receptor, a member of the nuclear receptor Aorta. superfamily, has important roles in male reproductive function. It is required for sexual differentiation, pubertal development, spermatogenesis regulation, meiosis completion and spermatocyte Dept. of Andrology and Sexology transition to haploid round spermatids. We assessed the 983. Erectile Dysfunction association of androgen receptor expression and semen variables in infertile men with varicocele. Rany Mohamed Mahmoud Shamloul and Hussein Ghanem Materials and Methods: A total of 299 men were grouped into healthy, fertile controls, infertile men without varicocele and men The Lancet, 381:153-165 (2013) IF:39.06 with infertility associated with varicocele. A history was obtained, clinical examination and semen analysis were done and Erectile dysfunction is a common clinical entity that aff ects reproductive hormones were estimated. Androgen receptor mainly men older than 40 years. in addition to theclassical causes expression and the acrosome reaction were determined in of erectile dysfunction, such as diabetes mellitus and recovered spermatozoa. hypertension, several common lifestyle factors, such as obesity, Results: Androgen receptor expression was significantly limited or an absence of physical exercise, and lower urinary tract decreased in infertile men with varicocele more than in infertile symptoms, have been linked to the development of erectile men without varicocele compared to fertile controls. Androgen dysfunction. Substantial steps have been taken in the study of the receptor correlated positively with sperm count, motility, normal association between erectile dysfunction and cardiovascular forms, velocity, linear velocity, acrosome reaction and a- disease. Erectile dysfunction is a strong predictor for coronary glucosidase. It correlated negatively with serum follicle- artery disease, and cardiovascular assessment of a non- cardiac stimulating hormone and estradiol. Multiple stepwise regression patient presenting with erectile dysfunction is now recommended analysis of androgen receptor expression revealed that the sperm www.gsrd.cu.edu.eg 247 International Publications Awards, CairoUniversity (IPACU) acrosome reaction and linearity index were the most affected nearly all life domains including interpersonal, family, and independent variables. business relationships. Conclusions: Androgen receptor expression was significantly Aim: The aim of this study is to provide an updated overview on decreased in infertile men with varicocele more than in infertile currently used and available conservative treatment options for men without varicocele compared to fertile men. Androgen ED with a special focus on their efficacy, tolerability, safety, receptor expression correlated positively with sperm count, merits, and limitations including the role of combination therapies motility, normal forms, velocity, linear velocity and acrosome for monotherapy failures. reaction. Methods: The methods used were PubMed and MEDLINE Keywords: Testis; Infertility; Male; Spermatozoa; Varicocele; searches using the following keywords: ED, phosphodiesterase Receptors; Androgen. type 5 (PDE5) inhibitors, oral drug therapy, intracavernosal injection therapy, transurethral therapy, topical therapy, and 986. Position Paper: Management of Men vacuum-erection therapy/constriction devices. Additionally, expert opinions by the authors of this article are included. Complaining of a Small Penis Despite an Actually Results: Level 1 evidence exists that changes in sedentary Normal Size lifestyle with weight loss and optimal treatment of concomitant Hussein Mohamed Hafez Ghanem, Sidney Glina, Pierre Assalian diseases/risk factors (e.g., diabetes, hypertension, and and Jacques Buvat dyslipidemia) can either improve ED or add to the efficacy of ED-specific therapies, e.g., PDE5 inhibitors. Level 1 evidence The Journal of Sexual Medicine, 10 (1): 294-303 (2013) IF:3.513 also exists that treatment of hypogonadism with total testosterone < 300 ng/dL (10.4 nmol/L) can either improve ED or add to the Introduction: with the worldwide increase in penile efficacy of PDE5 inhibitors. There is level 1 evidence regarding augmentation procedures and claims of devices designed to the efficacy and safety of the following monotherapies in a elongate the penis, it becomes crucial to study the scientific basis spectrum-wide range of ED populations: PDE5 inhibitors, of such procedures or devices, as well as the management of a intracavernosal injection therapy with prostaglandin E1 (PGE1, complaint of a small penis in men with a normal penile size. synonymous alprostadil) or vasoactive intestinal peptide (VIP)/ Aim: The aim of this work is to study the scientific basis of phentolamine, and transurethral PGE1 therapy. There is level 2 opting to penile augmentation procedures and to develop evidence regarding the efficacy and safety of the following ED guidelines based on the best available evidence for the treatments: vacuum-erection therapy in a wide range of ED management of men complaining of a small penis despite an populations, oral L-argin/ine (3–5 g), topical PGE1 in special ED actually normal size. populations, intracavernosal injection therapy with papaverine/ Methods: We reviewed the literature and evaluated the evidence phentolamine (bimix), or papaverine/ phentolamine/ PGE1 about what the normal penile size is, what patients complaining of (trimix) combination mixtures. There is level 3 evidence a small penis usually suffer from, benefits vs. complications