<<

CLARA ABRAHAM Yale 333 Cedar Street, 1080 LMP New Haven, CT 06520 email: [email protected]

UNDERGRADUATE EDUCATION: University of , Champaign-Urbana, Illinois of Engineering Bachelors of Science; High Honors in Computer Science/Engineering

GRADUATE EDUCATION: University of -Pritzker School of Medicine, Chicago, Illinois Medical Doctorate Rheumatology elective at Tel Hashomer Hospital, Israel Hematology elective at Eugenio Espejos Hospital, Ecuador

POSTGRADUATE EDUCATION: Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois Internal Medicine Residency Recognition for outstanding teaching of medical students Pulmonary elective at Beaumont Hospital, Ireland

University of Chicago Hospitals and Clinics, Chicago, Illinois Fellowship in Gastroenterology

University of Chicago Hospitals and Clinics, Chicago, Illinois Postdoctoral research in Immunology

ACADEMIC APPOINTMENTS: Assistant Professor, Section of Gastroenterology October, 2002–November, 2007 University of Chicago, Chicago, IL

Assistant Professor, Department of Medicine, Digestive Diseases, December, 2007-June, 2010 Translational Immunology , New Haven, CT

Associate Professor, Department of Medicine, Digestive Diseases, July, 2010-June, 2017 Human Translational Immunology Yale University, New Haven, CT

Professor (tenure), Department of Medicine, Digestive Diseases July, 2017-present Human Translational Immunology Yale University, New Haven, CT

BOARD CERTIFICATION: American Board of Internal Medicine, Gastroenterology

CURRENT MEDICAL LICENSURE: State of Connecticut, 2008-present

MEMBERSHIPS, EDITORSHIPS: PROFESSIONAL SOCIETIES: American Association of Immunologists American Gastroenterological Association Crohn’s and Colitis Foundation

INVITED REVIEWER: American Journal of Pathology, American Journal of Physiology--Gastrointestinal and Liver Physiology, Cell Reports, Cellular and Molecular Gastroenterology and Hepatology, Clinical Immunology, Digestive Diseases and Sciences, Gastroenterology, Gut, The Journal of Immunology, Laboratory Investigation, Mucosal Immunology, The New England Journal of Medicine, Pharmacogenomics, PLoS One, Proceedings of the Clara Abraham 2

National Academy of Sciences, Science, Science Immunology

EDITORIAL BOARD: 2006-2009 Laboratory Investigation 2009-2011 Associate Editor, Journal of Immunology 2011-2015 Section Editor, Journal of Immunology

UNIVERSITY ACTIVITIES/COMMITTEES: 2002-2007 Digestive Disease Research Core Center, University of Chicago 2003-2007 Committee on Immunology, University of Chicago 2005-2007 Committee on Molecular Medicine, University of Chicago 2005-2007 Cancer Research Center, University of Chicago 2005-2007 Committee on Molecular Metabolism and Nutrition, University of Chicago 2005-2007 Department of Medicine’s Committee on Women’s Issues, University of Chicago 2005-2007 Committee, Section of Gastroenterology, University of Chicago 2007 Promotions and Evaluations Committee, Section of Gastroenterology, U of Chicago 2009-present MD-PhD Admissions Committee, Yale University 2011-present Human Translational Immunology Steering Committee, Yale University 2014-2016 Stakeholder, Energy and Metabolism Master Course, Yale University 2014-2016 Human Translational Immunology T32 Training Grant, Executive Committee, Yale Univ

EXTRAMURAL COMMITTEES: Grant Reviewer: 2007 Member, NIH Special Emphasis Panel ZDK1 GRB-R 2007-present CCFA Research Training Awards Review Committee 2009 Ad hoc reviewer, The Wellcome Trust Training Fellowships 2010-2018 Ad hoc reviewer, The Broad Foundation 2010 Member, NIH Special Emphasis Panel ZDK1 GRB-7 2010-2018 American Gastroenterological Association; Chair: Student-Fellows Awards (2013) 2012 Ad hoc reviewer, NIH DDK-C Study Section 2012-present Member, NIH DDK-C Study Section 2013 Ad hoc reviewer, NIH NIAID-Mucosal Immunology Studies Team 2015-present Co-chair, CCFA Research Training Award Review Committee 2017 Ad hoc reviewer, NIH NIAID-Mucosal Immunology Studies Team 2018-present Litwin IBD Pioneers Initiative Review Committee

Conference Abstracts Reviewer: 2007-present Abstract Review Committee (Immunology, Microbiology & Inflammatory Diseases Section) for the annual American Gastroenterological Association Meeting (2017-present—Chair)

Miscellaneous: American Gastroenterological Association 2007-2010 Member, Education & Training Committee 2008-2010 CME Subcommittee 2009-2010 Liaison to Woman’s Committee Task Force on mentoring/career development 2010-2013 Research Awards Panel 2015-2018 Research Policy Committee

Crohn’s and Colitis Foundation 2011-2015 CCFA Challenges: Innate Immunity Working Group 2015-present National Scientific Advisory Committee 2017-present CCFA Challenges: Deep Genotype/Phenotype Working Group 2019-present Flagship Awards Review Committee Task Force

American Association of Immunologists 2012-2015 Member, Clinical Immunology Committee 2013-2018 Chair, Abstract Programming, ‘Immune Mechanisms of Human Disease’

American Society for Clinical Investigation 2015-2018 Council Member Clara Abraham 3

Advisory Committees 2015-2016 T35 external advisory committee,

RESEARCH AWARDS/HONORS: Edmund J. James Scholar, University of Illinois, Urbana Graduation with High Honors, University of Illinois, Urbana Bronze Tablet Award (Top 3% of graduating class), University of Illinois, Urbana University of Chicago Medical Student Research Grant American Digestive Health Foundation Advanced Research Training Award (July 1998-June 2000) Gastro-Intestinal Research Foundation Award (May 1998) ($15,000) NIH NIDDK Pilot and Feasibility Award, University of Chicago (2003- 2004) ($20,000) GRG-AGA Japan Research Symposium Award (December 2003) The Louis Block Award, University of Chicago (July 2005-June 2006) ($25,000) Department of Medicine Research Day, University of Chicago, Faculty Research Award (March 2006) American Association of Immunologists Junior Faculty Award (May 2006) Sir William Osler Young Investigator Award, Interurban Clinical Club (March 2010) NIH/NIDDK 60th Anniversary Early Career Investigator/Scholar Award (September 2010) Member, American Society for Clinical Investigation (2014)

ORIGINAL PEER REVIEWED PUBLICATIONS: Khare S, Bolt M, Wali RK, Skarosi SF, Roy HK, Niedziela S, Scaglione-Sewell B, Aquino B, Abraham C, Sitrin MD, Brasitus TA and Bissonnette M. 1,25 Dihydroxyvitamin D3 stimulates phospholipase C- in rat colonocytes: role of c-Src in PLC- activation. Journal of Clinical Investigation, 99:1831-1841, 1997.

Abraham C, Scaglione-Sewell BA, Skarosi SF, Qin W, Bissonnette M, Brasitus TA. Protein kinase C  modulates growth and differentiation in Caco-2 cells. Gastroenterology, 114:503-509, 1998.

Scaglione-Sewell BA, Abraham C, Bissonnette M, Skarosi SF, Hart J, Davidson NO, Wali RK, Davis BH, Sitrin M, Brasitus TA. Decreased PKC- expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of Caco-2 cells. Cancer Research, 58:1074-1081, 1998.

Abraham C, Griffith J, Miller J. The dependence for LFA-1/ICAM-1 interactions in T cell activation cannot be overcome by expression of high density TCR ligand. The Journal of Immunology, 162:4399-4405, 1999.

Scaglione-Sewell BA, Bissonnette M, Skarosi SF, Abraham C, Brasitus TA. A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. Endocrinology, 141:3931-3939, 2000.

Abraham C and Miller J. Molecular mechanisms of IL-2 gene regulation following costimulation through LFA- 1. The Journal of Immunology, 167:5193-5201, 2001.

Li J, Moran T, Swanson E, Julian C, Harris J, Bonen DK, Hedl M, Nicolae DL, Abraham C, Cho JH. Regulation of IL-8 and IL-1 expression with Crohn’s disease associated NOD2/CARD15 mutations. Human Molecular Genetics, 13:1715-1725, 2004.

Kandula S and Abraham C. LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo. The Journal of Immunology, 173:4443-4451, 2004.

Wang J, Anders RA, Wang Y, Turner JR, Abraham C, Pfeffer K, and Fu YX. The critical role of LIGHT in promoting intestinal inflammation and Crohn’s Disease. The Journal of Immunology, 174:8173-8182, 2005.

Marski M, Kandula S, Turner JR, Abraham C. CD18 is required for optimal development and function of CD4+ CD25+ T regulatory cells. The Journal of Immunology, 175: 7889-7897, 2005.

Wang F, Schwarz BT, Graham, WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. IFN--induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology. 131:1153-1163, 2006.

Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee A, Gregersen PK, Barmada MM, Rotter JI, Nicolae KL, Cho JH. A Genome-wide association study identifies Clara Abraham 4

IL23R as an inflammatory bowel disease gene. Science, 314:1461-1463, 2006.

Marski M, Ye AL, Abraham C. CD18 is required for intestinal T cell responses at multiple immune checkpoints. The Journal of Immunology, 178:2104-2112, 2007.

Molinero L, Zhou P, Wang Y, Harlin H, Cosmano J, Yokota Y, Kee B, Abraham C, Alegre ML. Epidermal Langerhans cells play a major role in skin allograft rejection in mice with NF-B-impaired T cells. American Journal of Transplantation, 8:21-31, 2008. Epub Nov 16, 2007.

Hedl M, Li J, Cho JH, Abraham C. Chronic stimulation of NOD2 mediates tolerance to bacterial products. Proceedings of the National Academy of Sciences, 104:19440-19445, 2007.

Abraham C, Hart J, Locke S, Baker AL. Indomethacin Induced Acute Hepatitis Developing Into Chronic Autoimmune Hepatitis. Nature Clinical Practice Gastroenterology & Hepatology. 5:172-176, 2008.

Su L, Shen L, Clayburgh DR, Nalle SC, Sullivan EA, Meddings JB, Abraham C*, Turner JR*. Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of colitis. Gastroenterology, 136:551-563, 2008. *contributed equally

Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, Achkar JP, Goyette P, Scott R, Xu W, Barmada MM, Klei L, Daly MJ, Abraham C, Bayless TM, Bossa F, Griffiths AM, Ippoliti AF, Lahaie RG, Latiano A, Pare P, Proctor DD, Regueiro MD, Steinhart AH, Targan SR, Schumm LP, Kistner EO, Lee AT, Gregersen PK, Rotter JI, Brant SR, Taylor KD, Roeder K, Duerr RH. Ulcerative colitis-risk loci on chromosomes 1p36 and 12p15 identified by genome-wide association study. Nature Genetics, 41:216-220. 2009.

Molinero LL, Sattar H, Yang J, Gajweski TF, Abraham C, Farrar MA, Alegre ML. CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells. The Journal of Immunology, 182:6736- 6743, 2009.

Ballard D, Abraham C, Cho J, Zhao H. Pathway analysis comparison using Crohn’s disease genome wide association studies. BMC Med Genomics, 3:25, 2010.

Hedl M and Abraham C. Secretory mediators regulate Nod2-induced tolerance in human macrophages. Gastroenterology, 140:231-241, 2011. Epub, Sept 17, 2010.

Capurso NA, Look M, Jeanbart L, Nowyhed H, Abraham C, Craft J, Fahmy FM. Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells, Self/NonSelf, 1:1-6, 2010.

Sarin R, Wu X, Abraham C. Inflammatory disease protective R381Q IL23R polymorphism results in decreased primary CD4+ and CD8+ human T cell functional responses. Proceedings of the National Academy of Science, 108:9560-9565, 2011.

Menard L, Saadoun D, Isnardi I, Ng Y-S, Meyers G, Massad C, Price C, Abraham C, Motaghedi R, Buckner J, Gregersen P, Meffre E. PTPN22 risk allele interferes with the removal of developing autoreactive B cells in . The Journal of Clinical Investigation. 121:3635-3644, 2011.

Hedl, M and Abraham C. Distinct roles for Nod2 and autocrine IL-1 in MDP-induced MAPK activation and cytokine secretion in human macrophages. The Journal of Biological Chemistry. 286:26440-26449, 2011.

Kenny EE, Pe’er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, McGovern DPB, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH, Peter I. A Genome-Wide Scan of Ashkenazi Jewish Crohn’s Disease Suggests Novel Susceptibility Loci. PLoS Genetics, 8:e1002559, 2012.

Hedl M and Abraham C. IRF5 Risk Polymorphisms Contribute to Inter-Individual Variance in Pattern- Recognition Receptor-Mediated Cytokine Secretion in Human Monocyte-Derived Cells. The Journal of Immunology, 188:5348-5356, 2012.

Clara Abraham 5

Zhang W, Ferguson J, Ng SM, Hui K, Goh G, Lin A, Esplugues E, Flavell RA, Abraham C, Zhao H, Cho JH. Effector CD4+ T cell expression signatures and immune-mediated disease associated genes. PLoS One. 7:e38510, 2012.

Sarin R and Abraham C. CD18 is required for optimal lymphopenia-induced proliferation of mouse T cells. American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G851-60, 2012.

Hedl M and Abraham C. Nod2-induced autocrine IL-1 alters signaling by ERK and p38 to differentially regulate secretion of inflammatory cytokines. Gastroenterology. 143:1530-1543, 2012.

Huber S, Gagliani N, Zenewicz LA, Huber FJ, Hedl M, Zhang W, O’Connor W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Booth CJ, Cho JH, Ouyang W, Abraham C, Flavell RA. The IL-22—IL-22BP axis is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature. 491:259-263, 2012.

Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitjovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan A, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Buning C, Cohain A, Cichon S, D’Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghous D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson CK, Zhao H, The International IBD Genetics Consortium, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC, Cho JH. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature, 491:119-124, 2012.

Denson LA, Long, MD, McGovern DP, Kugathasan, S, Wu GD, Young VB, Pizarro TT, de Zoeten EF, Stappenbeck TS, Plevy SE, Abraham C, Nusrat A, Jobin C, McCole DF, Siegel CA, Higgins PD, Herfarth HH, Hyams J, Sandborn WJ, Loftus EV Jr, Kappelman MD, Lewis JD, Parkos CA, Sartor RB. Challenges in IBD Research: Update on Progress and Prioritization of the CCFA’s Research Agenda. Inflammatory Bowel Diseases. 19:677-682, 2013.

Zhang CK, Hewett J, Hemming J, Grant T, Zhao H, Cho J, Abraham C, Oikonomou I, Berkowitz M, Proctor D. The Influence of Depression on Quality of Life in Patients with Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 19:1732-1739, 2013.

Hedl M and Abraham C. NLRP1 and NLRP3 Inflammasomes are Essential for Distinct Outcomes of Decreased Cytokines but Enhanced Bacterial Killing Upon Chronic NOD2 Stimulation. American Journal of Physiology-Gastrointestinal and Liver Physiology, 304:G583-596, 2013.

Shen H, Zhang W, Abraham C, Cho JH. Age and CD161 expression contribute to inter-individual variation in interleukin-23 response in CD8 memory human T cells. PLoS One. 8:e57746, 2013.

Su L, Nalle SC, She L, Turner ES, Singh G, Khramtsova G, Fu YX, Abraham C, Turner JR. TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis. Gastroenterology. 145:407-415, 2013.

Zhang W, Hui KY, Gusev A, Warner N, Ng SM, Ferguson J, Choi M, Burberry A, Abraham C, Mayer L, Resnick RJ, Cardinale CJ, Hakonarson H, Waterman M, Chowers Y, Karban A, Brant SR, Silverberg MS, Gregersen PK, Katz S, Lifton RP, Zhao H, Nunez G, Pe’er I, Peter I, Cho JH. Extended haplotype associate study in Crohn’s disease identifies a novel, Ashkenazi Jewish-specific missense mutation in the NF-kB pathway gene, HEATR3. Genes & Immunity. 14:310-316, 2013.

Zheng S and Abraham C. NFB1 inhibits NOD2-induced cytokine secretion through ATF3-dependent mechanisms. Molecular and Cellular Biology. 33:4857-4871, 2013.

Wu X, Lahiri A, Haines, GK III, Flavell RA, Abraham C. NOD2 regulates CXCR3-dependent CD8+ T cell accumulation in intestinal tissues with acute injury. The Journal of Immunology, 192:3409-3418, 2014. Clara Abraham 6

Hedl M, Zheng S and Abraham C. The IL18RAP region disease polymorphism decreases IL18RAP/IL18R1/IL1R1 and Innate Receptor-Initiated Pathways. The Journal of Immunology, 192:5924-5932, 2014.

Hedl M, Lahiri A, Ning K, Cho JH, Abraham C. Pattern Recognition Receptor Signaling in Human Dendritic Cells is Enhanced by ICOS Ligand and Modulated by the Crohn’s Disease ICOSLG Risk Allele. Immunity, 40:734-746, 2014

Lahiri A and Abraham C. Activation of Pattern Recognition Receptors Upregulates Metallothioneins, Thereby Increasing Intracellular Accumulation of Zinc, Autophagy, and Bacterial Clearance by Macrophages. Gastroenterology. 147:835-846, 2014.

Hedl M and Abraham C. A TNFSF15 Disease-Risk Polymorphism Increases Innate Receptor Signaling Through Caspase-8-Induced IL-1. Proceedings of the National Academy of Science, 111:13451-13456, 2014.

Zheng S, Hedl M, Abraham C. TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to pro- inflammatory cytokines downregulation following chronic NOD2 stimulation of human macrophages. Journal of Immunology. 194(4):1928-37, 2015.

Wu X, Lahiri A, Sarin R, Abraham C. T cell-extrinsic CD18 attenuates antigen-dependent CD4+ T cell activation in vivo. Journal of Immunology. 194:4122-4129, 2015.

Zheng S, Hedl M, Abraham C. Twist1 and Twist2 contribute to cytokine downregulation following chronic NOD2 stimulation of human macrophages through the coordinated regulation of transcriptional repressors and activators. Journal of Immunology. 195:217-226, 2015.

Hedl M and Abraham C. A TPL2 (MAP3K8) disease risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and -8 activation, signalling and cytokine secretion. Gut. 65:1799-1811, epub 7/27/15.

Lahiri A, Hedl M and Abraham C. MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation. Proceedings of the National Academy of Science, 112:10461-10466, 2015.

Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Ng SM, Zhang W, Hsu NY, Facey JA, Luong T, Fernandez-Hernandez H, Li D, Rivas M, Schiff ER, Gusev A, Schumm LP, Bowen BM, Sharma Y, Ning K, Remark R, Gnjatic S, Legnani P, George J, Sands BE, Stempak JM, Datta LW, Lipka S, Katz S, Cheifetz AS, Barzilai N, Pontikos N, Abraham C, Dubinsky MJ, Targan S, Taylor K, Rotter JI, Scherl EJ, Desnick RJ, Abreu MT, Zhao H, Atzmon G, Pe'er I, Kugathasan S, Hakonarson H, McCauley JL, Lencz T, Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH. A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GMCSF. Gastroenterology, 151:710-723, 2016.

Boddupalli CS, Nair S, Gray S, Nowyhed H, Verma R, Gibson J, Abraham C, Narayan D, Vasquez J, Hedrick C, Flavell RA, Dhodapkar K, Kaech S, Dhodapkar M. ABC Transporters and NR4A1 in quiescent side- population+ tissue-resident memory T-cells. Journal of Clinical Investigation, 126:3905-3916, 2016.

Hedl M, Yan J, and Abraham C. IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 Macrophage Polarization by Regulating Proximal Signaling and Akt2 Activation. Cell Reports, 16:2442-2455, 2016.

Hedl M, Proctor D, and Abraham C. JAK2 Disease-risk variants are gain-of-function and decreasing JAK signaling below a threshold increases innate receptor-induced pro-inflammatory cytokines in human macrophages. Journal of Immunology, 197:3695-3704, 2016.

Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death & Disease. 23:e2622, 2017.

Clara Abraham 7

Yan J, Hedl M, and Abraham C. An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes. Journal of Clinical Investigation. 127:2192-2205, 2017.

Lahiri A, Hedl M, Yan J, and Abraham C. Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes. Nature Communications. 8:15614, 2017.

Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2-signaling and mediates induction of MDP-tolerance. Nature Communications. 8:15865, 2017.

Zhu S, Ding S, Wang P, Wei Z, Yang Y, Wang G, Lei X, Pan W, Palm NW, de Zoete M, Zhao Y, Yu H, Jurado K, Zheng Y, Zhao J, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. NLRP9 inflammasome recognizes and restricts enteric viral infection in intestinal epithelial cells. Nature. 546:667-670, 2017.

Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C*, Lencer WI*. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 7:e38539, 2018 *co-corresponding authors

Hedl M, Yan J, Witt H, Abraham C. IRF5 is required for bacterial clearance in human M1-polarized macrophages, and IRF5 immune-mediated disease risk variants modulate this outcome. The Journal of Immunology, epub 12/28/2018.

Gettler K, Giri M, Kenigsberg E, Martin J, Chuang LS, Hsu NY, Denson L, Hyams J, Griffiths A, Noe J, Crandall W, Mack D, Kellermayer R, Abraham C, Hoffman G, Kugathasan S, and Cho J. Prioritizing Crohn’s disease genes by integrating association signals with gene expression implicates monocyte subsets. Genes and Immunity, 2019 (in press)

INVITED REVIEWS: Abraham C and Cho JH. Clinical Implications of Basic Research: Inducing intestinal growth. New England Journal of Medicine, 353:2297-2299, 2005.

Abraham C and Cho JH. Functional consequences of NOD2 mutations. Inflammatory Bowel Diseases 12:641- 650, 2006.

Cho JH and Abraham C. Inflammatory Bowel Disease genetics: Nod2. Annual Review of Medicine. 58:401- 416. 2007.

Abraham C and Cho JH. Bugging of the Intestinal Mucosa. New England Journal of Medicine, 357:708-710, 2007.

Abraham C and Cho JH. IL-23 and Autoimmunity: New Insights into IBD Pathogenesis. Annual Review of Medicine, 60:97-110, 2008.

Abraham C and Cho JH. IL-23/Th17 pathways and Inflammatory Bowel Disease. Inflammatory Bowel Diseases. 15:1090-1100, 2009.

Abraham C and Cho J. Mechanisms of Disease: Inflammatory Bowel Disease. New England Journal of Medicine. 361:56-68, 2009.

Zenewicz LA, Abraham C, Flavell RA and Cho JH. Unraveling the Genetics of Autoimmunity. Cell. 140:791- 797, 2010.

Abraham C and Medzhitov R. Interactions between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease. Gastroenterology, 140:1729-1737, 2011

Hedl M and Abraham C, Negative regulation of human mononuclear phagocyte function, Mucosal Immunology, 6:205-223, 2013.

Abraham C, Dulai PS, Vermeire S, Sandborn WJ. Novel Therapeutic Agents and Targeting Cytokines Clara Abraham 8

Pathways: Lessons from Successes and Failures. Gastroenterology, 152:374-388, 2017.

TEXTBOOK CHAPTERS: Abraham C and Cho J. Genetic Tools in Gastrointestinal Physiology. Physiology of the Gastrointestinal Tract. 5th Edition, 2012

Abraham C, Vogel SN, Perkins DJ. Signaling mechanisms regulating innate immune responses. Mucosal Immunology, Editors: Jim Mestecky, Warren Strober, Michael Russell, Hilde Cheroutre, Bart Lambrecht and Brian Kelsall. 4th Edition, 2015.

ONLINE MATERIALS: Abraham C and Snapper S. Immune and Microbial Mechanisms in the Pathogenesis of Inflammatory Bowel Disease. UpToDate Editors: Rutgeerts P, Stiehm ER, Grover S. Publisher: Wolters Kluwer. 2016.