CLARA ABRAHAM Yale University 333 Cedar Street, 1080 LMP New Haven, CT 06520 email: [email protected] UNDERGRADUATE EDUCATION: University of Illinois, Champaign-Urbana, Illinois College of Engineering Bachelors of Science; High Honors in Computer Science/Engineering GRADUATE EDUCATION: University of Chicago-Pritzker School of Medicine, Chicago, Illinois Medical Doctorate Rheumatology elective at Tel Hashomer Hospital, Israel Hematology elective at Eugenio Espejos Hospital, Ecuador POSTGRADUATE EDUCATION: Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois Internal Medicine Residency Recognition for outstanding teaching of medical students Pulmonary elective at Beaumont Hospital, Ireland University of Chicago Hospitals and Clinics, Chicago, Illinois Fellowship in Gastroenterology University of Chicago Hospitals and Clinics, Chicago, Illinois Postdoctoral research in Immunology ACADEMIC APPOINTMENTS: Assistant Professor, Section of Gastroenterology October, 2002–November, 2007 University of Chicago, Chicago, IL Assistant Professor, Department of Medicine, Digestive Diseases, December, 2007-June, 2010 Human Translational Immunology Yale University, New Haven, CT Associate Professor, Department of Medicine, Digestive Diseases, July, 2010-June, 2017 Human Translational Immunology Yale University, New Haven, CT Professor (tenure), Department of Medicine, Digestive Diseases July, 2017-present Human Translational Immunology Yale University, New Haven, CT BOARD CERTIFICATION: American Board of Internal Medicine, Gastroenterology CURRENT MEDICAL LICENSURE: State of Connecticut, 2008-present MEMBERSHIPS, EDITORSHIPS: PROFESSIONAL SOCIETIES: American Association of Immunologists American Gastroenterological Association Crohn’s and Colitis Foundation INVITED REVIEWER: American Journal of Pathology, American Journal of Physiology--Gastrointestinal and Liver Physiology, Cell Reports, Cellular and Molecular Gastroenterology and Hepatology, Clinical Immunology, Digestive Diseases and Sciences, Gastroenterology, Gut, The Journal of Immunology, Laboratory Investigation, Mucosal Immunology, The New England Journal of Medicine, Pharmacogenomics, PLoS One, Proceedings of the Clara Abraham 2 National Academy of Sciences, Science, Science Immunology EDITORIAL BOARD: 2006-2009 Laboratory Investigation 2009-2011 Associate Editor, Journal of Immunology 2011-2015 Section Editor, Journal of Immunology UNIVERSITY ACTIVITIES/COMMITTEES: 2002-2007 Digestive Disease Research Core Center, University of Chicago 2003-2007 Committee on Immunology, University of Chicago 2005-2007 Committee on Molecular Medicine, University of Chicago 2005-2007 Cancer Research Center, University of Chicago 2005-2007 Committee on Molecular Metabolism and Nutrition, University of Chicago 2005-2007 Department of Medicine’s Committee on Women’s Issues, University of Chicago 2005-2007 Curriculum Committee, Section of Gastroenterology, University of Chicago 2007 Promotions and Evaluations Committee, Section of Gastroenterology, U of Chicago 2009-present MD-PhD Admissions Committee, Yale University 2011-present Human Translational Immunology Steering Committee, Yale University 2014-2016 Stakeholder, Energy and Metabolism Master Course, Yale University 2014-2016 Human Translational Immunology T32 Training Grant, Executive Committee, Yale Univ EXTRAMURAL COMMITTEES: Grant Reviewer: 2007 Member, NIH Special Emphasis Panel ZDK1 GRB-R 2007-present CCFA Research Training Awards Review Committee 2009 Ad hoc reviewer, The Wellcome Trust Training Fellowships 2010-2018 Ad hoc reviewer, The Broad Foundation 2010 Member, NIH Special Emphasis Panel ZDK1 GRB-7 2010-2018 American Gastroenterological Association; Chair: Student-Fellows Awards (2013) 2012 Ad hoc reviewer, NIH DDK-C Study Section 2012-present Member, NIH DDK-C Study Section 2013 Ad hoc reviewer, NIH NIAID-Mucosal Immunology Studies Team 2015-present Co-chair, CCFA Research Training Award Review Committee 2017 Ad hoc reviewer, NIH NIAID-Mucosal Immunology Studies Team 2018-present Litwin IBD Pioneers Initiative Review Committee Conference Abstracts Reviewer: 2007-present Abstract Review Committee (Immunology, Microbiology & Inflammatory Diseases Section) for the annual American Gastroenterological Association Meeting (2017-present—Chair) Miscellaneous: American Gastroenterological Association 2007-2010 Member, Education & Training Committee 2008-2010 CME Subcommittee 2009-2010 Liaison to Woman’s Committee Task Force on mentoring/career development 2010-2013 Research Awards Panel 2015-2018 Research Policy Committee Crohn’s and Colitis Foundation 2011-2015 CCFA Challenges: Innate Immunity Working Group 2015-present National Scientific Advisory Committee 2017-present CCFA Challenges: Deep Genotype/Phenotype Working Group 2019-present Flagship Awards Review Committee Task Force American Association of Immunologists 2012-2015 Member, Clinical Immunology Committee 2013-2018 Chair, Abstract Programming, ‘Immune Mechanisms of Human Disease’ American Society for Clinical Investigation 2015-2018 Council Member Clara Abraham 3 Advisory Committees 2015-2016 T35 external advisory committee, University of Minnesota RESEARCH AWARDS/HONORS: Edmund J. James Scholar, University of Illinois, Urbana Graduation with High Honors, University of Illinois, Urbana Bronze Tablet Award (Top 3% of graduating class), University of Illinois, Urbana University of Chicago Medical Student Research Grant American Digestive Health Foundation Advanced Research Training Award (July 1998-June 2000) Gastro-Intestinal Research Foundation Award (May 1998) ($15,000) NIH NIDDK Pilot and Feasibility Award, University of Chicago (2003- 2004) ($20,000) GRG-AGA Japan Research Symposium Award (December 2003) The Louis Block Award, University of Chicago (July 2005-June 2006) ($25,000) Department of Medicine Research Day, University of Chicago, Faculty Research Award (March 2006) American Association of Immunologists Junior Faculty Award (May 2006) Sir William Osler Young Investigator Award, Interurban Clinical Club (March 2010) NIH/NIDDK 60th Anniversary Early Career Investigator/Scholar Award (September 2010) Member, American Society for Clinical Investigation (2014) ORIGINAL PEER REVIEWED PUBLICATIONS: Khare S, Bolt M, Wali RK, Skarosi SF, Roy HK, Niedziela S, Scaglione-Sewell B, Aquino B, Abraham C, Sitrin MD, Brasitus TA and Bissonnette M. 1,25 Dihydroxyvitamin D3 stimulates phospholipase C- in rat colonocytes: role of c-Src in PLC- activation. Journal of Clinical Investigation, 99:1831-1841, 1997. Abraham C, Scaglione-Sewell BA, Skarosi SF, Qin W, Bissonnette M, Brasitus TA. Protein kinase C modulates growth and differentiation in Caco-2 cells. Gastroenterology, 114:503-509, 1998. Scaglione-Sewell BA, Abraham C, Bissonnette M, Skarosi SF, Hart J, Davidson NO, Wali RK, Davis BH, Sitrin M, Brasitus TA. Decreased PKC- expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of Caco-2 cells. Cancer Research, 58:1074-1081, 1998. Abraham C, Griffith J, Miller J. The dependence for LFA-1/ICAM-1 interactions in T cell activation cannot be overcome by expression of high density TCR ligand. The Journal of Immunology, 162:4399-4405, 1999. Scaglione-Sewell BA, Bissonnette M, Skarosi SF, Abraham C, Brasitus TA. A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. Endocrinology, 141:3931-3939, 2000. Abraham C and Miller J. Molecular mechanisms of IL-2 gene regulation following costimulation through LFA- 1. The Journal of Immunology, 167:5193-5201, 2001. Li J, Moran T, Swanson E, Julian C, Harris J, Bonen DK, Hedl M, Nicolae DL, Abraham C, Cho JH. Regulation of IL-8 and IL-1 expression with Crohn’s disease associated NOD2/CARD15 mutations. Human Molecular Genetics, 13:1715-1725, 2004. Kandula S and Abraham C. LFA-1 on CD4+ T cells is required for optimal antigen-dependent activation in vivo. The Journal of Immunology, 173:4443-4451, 2004. Wang J, Anders RA, Wang Y, Turner JR, Abraham C, Pfeffer K, and Fu YX. The critical role of LIGHT in promoting intestinal inflammation and Crohn’s Disease. The Journal of Immunology, 174:8173-8182, 2005. Marski M, Kandula S, Turner JR, Abraham C. CD18 is required for optimal development and function of CD4+ CD25+ T regulatory cells. The Journal of Immunology, 175: 7889-7897, 2005. Wang F, Schwarz BT, Graham, WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR. IFN--induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology. 131:1153-1163, 2006. Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee A, Gregersen PK, Barmada MM, Rotter JI, Nicolae KL, Cho JH. A Genome-wide association study identifies Clara Abraham 4 IL23R as an inflammatory bowel disease gene. Science, 314:1461-1463, 2006. Marski M, Ye AL, Abraham C. CD18 is required for intestinal T cell responses at multiple immune checkpoints. The Journal of Immunology, 178:2104-2112, 2007. Molinero L, Zhou P, Wang Y, Harlin H, Cosmano J, Yokota Y, Kee B, Abraham C, Alegre ML. Epidermal Langerhans cells play a major role in skin allograft rejection in mice with NF-B-impaired T cells. American Journal of Transplantation, 8:21-31, 2008. Epub Nov 16, 2007. Hedl M, Li J, Cho JH, Abraham C. Chronic stimulation of NOD2 mediates tolerance to bacterial products. Proceedings