Histopathological Changes in the Choroid Plexus After Traumatic Brain Injury in the Rats: a Histologic and Immunohistochemical Study H
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The Strain Rates in the Brain, Brainstem, Dura, and Skull Under Dynamic Loadings
Mathematical and Computational Applications Article The Strain Rates in the Brain, Brainstem, Dura, and Skull under Dynamic Loadings Mohammad Hosseini-Farid 1,2,* , MaryamSadat Amiri-Tehrani-Zadeh 3, Mohammadreza Ramzanpour 1, Mariusz Ziejewski 1 and Ghodrat Karami 1 1 Department of Mechanical Engineering, North Dakota State University, Fargo, ND 58104, USA; [email protected] (M.R.); [email protected] (M.Z.); [email protected] (G.K.) 2 Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA 3 Department of Computer Science, North Dakota State University, Fargo, ND 58104, USA; [email protected] * Correspondence: [email protected]; Tel.: +1-7012315859 Received: 7 March 2020; Accepted: 5 April 2020; Published: 7 April 2020 Abstract: Knowing the precise material properties of intracranial head organs is crucial for studying the biomechanics of head injury. It has been shown that these biological tissues are significantly rate-dependent; hence, their material properties should be determined with respect to the range of deformation rate they experience. In this paper, a validated finite element human head model is used to investigate the biomechanics of the head in impact and blast, leading to traumatic brain injuries (TBI). We simulate the head under various directions and velocities of impacts, as well as helmeted and unhelmeted head under blast shock waves. It is demonstrated that the strain rates for the brain 1 are in the range of 36 to 241 s− , approximately 1.9 and 0.86 times the resulting head acceleration under impacts and blast scenarios, respectively. The skull was found to experience a rate in the range 1 of 14 to 182 s− , approximately 0.7 and 0.43 times the head acceleration corresponding to impact and blast cases. -
Telovelar Approach to the Fourth Ventricle: Microsurgical Anatomy
J Neurosurg 92:812–823, 2000 Telovelar approach to the fourth ventricle: microsurgical anatomy ANTONIO C. M. MUSSI, M.D., AND ALBERT L. RHOTON, JR., M.D. Department of Neurological Surgery, University of Florida, Gainesville, Florida Object. In the past, access to the fourth ventricle was obtained by splitting the vermis or removing part of the cere- bellum. The purpose of this study was to examine the access to the fourth ventricle achieved by opening the tela cho- roidea and inferior medullary velum, the two thin sheets of tissue that form the lower half of the roof of the fourth ven- tricle, without incising or removing part of the cerebellum. Methods. Fifty formalin-fixed specimens, in which the arteries were perfused with red silicone and the veins with blue silicone, provided the material for this study. The dissections were performed in a stepwise manner to simulate the exposure that can be obtained by retracting the cerebellar tonsils and opening the tela choroidea and inferior medullary velum. Conclusions. Gently displacing the tonsils laterally exposes both the tela choroidea and the inferior medullary velum. Opening the tela provides access to the floor and body of the ventricle from the aqueduct to the obex. The additional opening of the velum provides access to the superior half of the roof of the ventricle, the fastigium, and the superolater- al recess. Elevating the tonsillar surface away from the posterolateral medulla exposes the tela, which covers the later- al recess, and opening this tela exposes the structure forming -
Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers
International Journal of Molecular Sciences Review Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers Mariana Castro Dias *, Josephine A. Mapunda, Mykhailo Vladymyrov and Britta Engelhardt * Theodor Kocher Institute, University of Bern, 3012 Bern, Switzerland; [email protected] (J.A.M.); [email protected] (M.V.) * Correspondence: [email protected] (M.C.D.); [email protected] (B.E.) Received: 14 October 2019; Accepted: 26 October 2019; Published: 29 October 2019 Abstract: The homeostasis of the central nervous system (CNS) is ensured by the endothelial, epithelial, mesothelial and glial brain barriers, which strictly control the passage of molecules, solutes and immune cells. While the endothelial blood-brain barrier (BBB) and the epithelial blood-cerebrospinal fluid barrier (BCSFB) have been extensively investigated, less is known about the epithelial and mesothelial arachnoid barrier and the glia limitans. Here, we summarize current knowledge of the cellular composition of the brain barriers with a specific focus on describing the molecular constituents of their junctional complexes. We propose that the brain barriers maintain CNS immune privilege by dividing the CNS into compartments that differ with regard to their role in immune surveillance of the CNS. We close by providing a brief overview on experimental tools allowing for reliable in vivo visualization of the brain barriers and their junctional complexes and thus the respective CNS compartments. Keywords: brain barriers; blood-brain barrier; neurovascular unit; blood-cerebrospinal fluid barrier; arachnoid barrier; glia limitans; tight junctions; adherens junctions 1. Introduction The brain barriers established by the endothelial blood-brain barrier (BBB), the epithelial blood-cerebrospinal fluid barrier (BCSFB), the meningeal brain barriers and the blood spinal cord barrier are essential for maintaining central nervous system (CNS) homeostasis [1]. -
Lecture 4: the Meninges And
1/1/2016 Introduction • Protection of the brain – Bone (skull) The Nervous System – Membranes (meninges) – Watery cushion (cerebrospinal fluid) – Blood-brain barrier (astrocytes) Meninges CSF The Meninges The Meninges • Series of membranes • Three layers • Cover and protect the CNS – Dura mater • Anchor and cushion the brain – Arachnoid mater – • Contain cerebrospinal fluid (CSF) Pia mater The Meninges • Dura mater – “Tough mother” Skin of scalp Periosteum – Strongest meninx Bone of skull Periosteal Dura – Fibrous connective tissue Meningeal mater Superior Arachnoid mater – sagittal sinus Pia mater Limit excessive movement of the brain Subdural Arachnoid villus – space Blood vessel Forms partitions in the skull Subarachnoid Falx cerebri space (in longitudinal fissure only) Figure 12.24 1 1/1/2016 Superior The Meninges sagittal sinus Falx cerebri • Arachnoid mater – “Spider mother” Straight sinus – Middle layer with weblike extensions Crista galli – Separated from the dura mater by the subdural space of the Tentorium ethmoid cerebelli – Subarachnoid space contains CSF and blood vessels bone Falx Pituitary cerebelli gland (a) Dural septa Figure 12.25a The Meninges • Pia mater – “Gentle mother” – Connected to the dura mater by projections from the arachnoid mater – Layer of delicate vascularized connective tissue – Clings tightly to the brain T Meningitis TT121212 Ligamentum flavumflavumflavum L • LL555 Lumbar puncture Inflammation of meninges needle entering subarachnoid • May be bacterial or viral spacespacespace LLL444 • Diagnosed by -
Neuroendoscopic Choroid Plexus Coagulation for Pediatric Hydrocephalus
32 Review Neuroendoscopic Choroid Plexus Coagulation for Pediatric Hydrocephalus: Review of Historical Aspects and Rebirth Coagulação Neuroendoscópica do Plexo Coróide: Revisão de Aspectos Históricos e Renascimento Roberto Alexandre Dezena1 Carlos Umberto Pereira2 Leopoldo Prézia de Araújo1 Monique Passos Ribeiro3 Helisângela Alves de Oliveira3 ABSTRACT This study aims to review historical aspects and rebirth of the neuroendoscopic choroid plexus coagulation (NCPC) for pediatric hydrocephalus. The literature covering this topic in PubMed was reviewed. The first NCPC procedure goes back to early 1930s. After the development of other treatment methods and the understanding of CSF dynamics, the application of NCPC dramatically decreased by 1970s. In 2000s, there was a rebirth of NCPC in combination with endoscopic third ventriculostomy (ETV). NCPC remains one of the options for the treatment of pediatric hydrocephalus in selected cases. NCPC might provide a temporary reduction in CSF production to allow a further development of CSF absorption in infant. Adding NCPC to ETV for infants with communicating hydrocephalus may increase the shunt independent rate thus avoiding the consequence of late complication related to the shunt device. This is important for patients who are difficult to be followed up, due to geographical and/or socioeconomic difficulties. Besides, adding NCPC to ETV for obstructive hydrocephalus in infant may also increase the successful rate. Furthermore, NCPC may be an option for cases with high chance of shunt complication such as multiloculated hydrocephalus, extreme hydrocephalus and hydranencephaly. In comparison with the traditional treatment of CSF shunting, the role of NCPC needs to be further evaluated in particular concerning the neurocognitive development. Key words: Pediatric hydrocephalus; Neuroendoscopic choroid plexus coagulation; Endoscopic third ventriculostomy. -
Meningioma ACKNOWLEDGEMENTS
AMERICAN BRAIN TUMOR ASSOCIATION Meningioma ACKNOWLEDGEMENTS ABOUT THE AMERICAN BRAIN TUMOR ASSOCIATION Meningioma Founded in 1973, the American Brain Tumor Association (ABTA) was the first national nonprofit advocacy organization dedicated solely to brain tumor research. For nearly 45 years, the ABTA has been providing comprehensive resources that support the complex needs of brain tumor patients and caregivers, as well as the critical funding of research in the pursuit of breakthroughs in brain tumor diagnosis, treatment and care. To learn more about the ABTA, visit www.abta.org. We gratefully acknowledge Santosh Kesari, MD, PhD, FANA, FAAN chair of department of translational neuro- oncology and neurotherapeutics, and Marlon Saria, MSN, RN, AOCNS®, FAAN clinical nurse specialist, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA; and Albert Lai, MD, PhD, assistant clinical professor, Adult Brain Tumors, UCLA Neuro-Oncology Program, for their review of this edition of this publication. This publication is not intended as a substitute for professional medical advice and does not provide advice on treatments or conditions for individual patients. All health and treatment decisions must be made in consultation with your physician(s), utilizing your specific medical information. Inclusion in this publication is not a recommendation of any product, treatment, physician or hospital. COPYRIGHT © 2017 ABTA REPRODUCTION WITHOUT PRIOR WRITTEN PERMISSION IS PROHIBITED AMERICAN BRAIN TUMOR ASSOCIATION Meningioma INTRODUCTION Although meningiomas are considered a type of primary brain tumor, they do not grow from brain tissue itself, but instead arise from the meninges, three thin layers of tissue covering the brain and spinal cord. -
Spinal Meninges Neuroscience Fundamentals > Regional Neuroscience > Regional Neuroscience
Spinal Meninges Neuroscience Fundamentals > Regional Neuroscience > Regional Neuroscience SPINAL MENINGES GENERAL ANATOMY Meningeal Layers From outside to inside • Dura mater • Arachnoid mater • Pia mater Meningeal spaces From outside to inside • Epidural (above the dura) - See: epidural hematoma and spinal cord compression from epidural abscess • Subdural (below the dura) - See: subdural hematoma • Subarachnoid (below the arachnoid mater) - See: subarachnoid hemorrhage Spinal canal Key Anatomy • Vertebral body (anteriorly) • Vertebral arch (posteriorly). • Vertebral foramen within the vertebral arch. MENINGEAL LAYERS 1 / 4 • Dura mater forms a thick ring within the spinal canal. • The dural root sheath (aka dural root sleeve) is the dural investment that follows nerve roots into the intervertebral foramen. • The arachnoid mater runs underneath the dura (we lose sight of it under the dural root sheath). • The pia mater directly adheres to the spinal cord and nerve roots, and so it takes the shape of those structures. MENINGEAL SPACES • The epidural space forms external to the dura mater, internal to the vertebral foramen. • The subdural space lies between the dura and arachnoid mater layers. • The subarachnoid space lies between the arachnoid and pia mater layers. CRANIAL VS SPINAL MENINGES  Cranial Meninges • Epidural is a potential space, so it's not a typical disease site unless in the setting of high pressure middle meningeal artery rupture or from traumatic defect. • Subdural is a potential space but bridging veins (those that pass from the subarachnoid space into the dural venous sinuses) can tear, so it is a common site of hematoma. • Subarachnoid space is an actual space and is a site of hemorrhage and infection, for example. -
The Choroid Plexus: a Comprehensive Review of Its History, Anatomy, Function, Histology, Embryology, and Surgical Considerations
Childs Nerv Syst (2014) 30:205–214 DOI 10.1007/s00381-013-2326-y REVIEW PAPER The choroid plexus: a comprehensive review of its history, anatomy, function, histology, embryology, and surgical considerations Martin M. Mortazavi & Christoph J. Griessenauer & Nimer Adeeb & Aman Deep & Reza Bavarsad Shahripour & Marios Loukas & Richard Isaiah Tubbs & R. Shane Tubbs Received: 30 September 2013 /Accepted: 11 November 2013 /Published online: 28 November 2013 # Springer-Verlag Berlin Heidelberg 2013 Abstract Keywords Choroid plexus . Anatomy . Neurosurgery . Introduction The role of the choroid plexus in cerebrospinal Hydrocephalus fluid production has been identified for more than a century. Over the years, more intensive studies of this structure has lead to a better understanding of the functions, including brain Introduction immunity, protection, absorption, and many others. Here, we review the macro- and microanatomical structure of the Around the walls of the ventricles, folds of pia mater form choroid plexus in addition to its function and embryology. vascularized layers named choroid plexus. This vasculature Method The literature was searched for articles and textbooks along with the overlying ependymal lining of the ventricles for data related to the history, anatomy, physiology, histology, forms the tela choroidea. Sometimes, however, the term embryology, potential functions, and surgical implications of choroid plexus is used to describe the entire structure [1]. The the choroid plexus. All were gathered and summarized narrow cleft, to which the choroids plexus is attached in the comprehensively. ventricles, is defined as the choroidal fissure. [2] The discovery Conclusion We summarize the literature regarding the choroid of the choroid plexus is attributed to Herophilus, who named it plexus and its surgical implications. -
The Role of the Pia Mater in Controlling Brain and Spinal Cord Intraparenchymal Pressure Daniel Harwell MD; Justin Louis Gibson; Richard D
The Role of the Pia Mater in Controlling Brain and Spinal Cord Intraparenchymal Pressure Daniel Harwell MD; Justin Louis Gibson; Richard D. Fessler MD; Jeffrey R. Holtz P.A.-C.; David B. Pettigrew MS PhD; Charles Kuntz, IV MD Department of Neurosurgery, University of Cincinnati and The Mayfield Clinic Introduction Conclusions Figure 2 Several multicenter randomized control trials have shown that decompression with The simulated edema model has durotomy/duroplasty significantly differential effects on brain and decreases intracranial pressure (ICP), spinal cord IPP. Brain IPP increased improving mortality. Currently, only slightly, consistent with the decompressive craniectomy combined with Figure 1 augmentative duraplasty is widely model that increased intracranial performed and is recommended by most pressure is primarily due to authors. However, there is a paucity of evidence regarding the effectiveness of constraints imposed by the cranium decompression of the spinal cord by and dura mater. In contrast, spinal Peak IPP, Final IPP after 5 days, Post- meningoplasty. cord IPP increased substantially. piotomy IPP. Key: left frontal (FL), right Piotomy immediately and frontal (FR), left parietal (PL), right parietal Methods (PR) lobes. Cervical (C) and thoracic (T) dramatically reduced spinal cord The supratentorial brain and spinal cord spinal cord. Bars: mean + standard were carefully removed from four fresh IPP. These data are consistent with deviation. * indicates statistical significance cadavers. The dura and arachnoid mater the hypothesis that intramedullary compared with FL, FR, PL, and PR peak investments were removed. ICP monitors IPP. were placed bilaterally in the frontal and pressure is primarily due to An example of one representative parietal lobes, as well as the cervical and constraints imposed by the pia preparation at baseline (A) and after (B) 5 Figure 3 thoracic spinal cord. -
Intraventricular Hemorrhage Caused by Intraventricular Meningioma: CT Appearance
Intraventricular Hemorrhage Caused by Intraventricular Meningioma: CT Appearance I. Lang, A. Jackson, and F. A. Strang Summary: In a patient with intraventricular meningioma present- which extended into the body of the lateral ventricle, ing with intraventricular hemorrhage, CT demonstrated a well- through the foramen of Monro and into the third and fourth defined tumor mass in the trigone of the left lateral ventricle with ventricles. On postcontrast CT (iohexol 340, 50 mL) the extensive surrounding hematoma. lesion showed homogeneous enhancement (Fig 2). At surgery, the occipital pole of the left lateral ventricle was opened via a temporoparietal craniotomy. A “hard” Index terms: Meninges, neoplasms; Brain, ventricles; Cerebral avascular tumor surrounded by fresh clot was exposed. hemorrhage The tumor arose from a pedicle attached to the choroid plexus. It was removed without complication, and the as- Intraventricular meningioma is a rare tumor sociated hematoma was evacuated. Histologic examina- with approximately 170 previously reported tion confirmed the diagnosis of a fibroblastic meningioma. cases (1–7). Despite this it is the most common Postoperatively, there was a good recovery of the left intraventricular tumor in adults, in whom it is hemiparesis, although there was some residual hemi- most often located in the trigone of the lateral anopia and dysphasia. ventricle (1, 2). Computed tomography (CT) features are similar to meningiomas elsewhere, and in most cases they appear as well-defined Discussion high-attenuation masses that show marked en- Meningiomas arising within the ventricular hancement (1, 2). Presentation with subarach- system are rare but well described, constituting noid hemorrhage is rare (9). We describe a case approximately 0.5% to 2% of all intracranial of intraventricular hemorrhage attributable to meningiomas (4, 6) (Kaplan ES, Parasagittal intraventricular meningioma and present the CT Meningiomas: A Clinico-pathological Study, appearance. -
Basic Stroke for the New Recruit
Basic Stroke for the New Recruit Authors • Erin Conahan MSN, RN, ACNS-BC, CNRN, SCRN • Julie Fussner BSN, RN, CPHQ, SCRN • The authors have nothing to disclose. 1 Objectives • List causes of small vessel stroke vs large vessel stroke and differences in treatment • Describe inclusion/exclusion criteria for tPA and endovascular treatment • List elements of acute stroke work-up to identify risk factors Stroke Facts • Each year 795,000 strokes occur in the United States • Stroke is the 5th leading cause of death in the United States • Stroke is the leading cause of adult disability • Up to 80% of strokes are preventable • During a stroke ~32,000 brain cells are lost per second… ~2 million brain cells lost per minute. • The brain ages 3.6 years for each hour untreated… •Time is Brain 2 What is stroke? Stroke occurs when a blood vessel to the brain is blocked or ruptured causing brain cells in the blood vessel territory to die . What does it look like? • Ischemic Stroke • Hemorrhagic Stroke 3 Cerebral Circulation • Circle of Willis • Located at the base of the skull • Provides collateral circulation • Anterior Circulation • Carotid arteries • Anterior cerebral • Middle cerebral • Anterior communicating • Posterior Circulation • Vertebral • Basilar • Posterior cerebral • Posterior communicating http://www.merckmanuals.com/professional/neurologic_disorders/stroke_cva/overview_of_stroke.html 5 Stroke Syndromes 1. Left Hemisphere 2. Right Hemisphere 3. Cerebellar 4. Brainstem 5. Hemorrhage 4 Left Hemisphere Signs: • Aphasia • Right side weakness • Right side sensory loss • Right visual field cut • Left gaze Right Hemisphere Signs: • Neglect • Left side weakness • Left side sensory loss • Left visual field cut • Right gaze 5 Cerebellar Signs: • Ataxia • Gait disturbance • Vertigo • Nystagmus • Ipsilateral Findings Brainstem Retrieved on 9/25/15 from: http://biology.clc.uc.edu/fankhauser/Labs/Anatomy_&_Physiology/A&P202/202_lecture_notes/05_Mesencephalon_Diencephalon.Jan12. -
CNS-Specific Immunity at the Choroid Plexus Shifts Toward Destructive Th2 Inflammation in Brain Aging
CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging Kuti Barucha,1, Noga Ron-Harelb,1, Hilah Galc,1, Aleksandra Deczkowskaa, Eric Shifrutc, Wilfred Ndifonc, Nataly Mirlas-Neisberga, Michal Cardona, Ilan Vaknina, Liora Cahalona, Tamara Berkutzkia, Mark P. Mattsond, Fernando Gomez-Pinillae,f, Nir Friedmanc,2, and Michal Schwartza,2,3 Departments of aNeurobiology and cImmunology, Weizmann Institute of Science, Rehovot 76100, Israel; bDepartment of Cell Biology, Harvard Medical School, Boston, MA 02115; dLaboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224; and Departments of eIntegrative Biology and Physiology and fNeurosurgery, University of California, Los Angeles, CA 90095 Edited* by Michael Sela, Weizmann Institute of Science, Rehovot, Israel, and approved November 13, 2012 (received for review July 4, 2012) In the present study, we show that the CP in young and aged The adaptive arm of the immune system has been suggested as an + important factor in brain function. However, given the fact that animals retains CD4 effector memory cells with a T-cell receptor fi interactions of neurons or glial cells with T lymphocytes rarely occur (TCR) repertoire speci c to CNS antigens. With aging, the CP mani- fl within the healthy CNS parenchyma, the underlying mechanism is fested signs of T helper type 2 (Th2) in ammation, linking its still a mystery. Here we found that at the interface between the functional plasticity to age-related cognitive decline. Using an immunological manipulation that induced homeostasis-driven brain and blood circulation, the epithelial layers of the choroid + proliferation and partially restored cognitive ability, we demon- plexus (CP) are constitutively populated with CD4 effector memory fi strate that peripheral rejuvenation of the immune system can cells with a T-cell receptor repertoire speci c to CNS antigens.