Is Human Limb Regeneration a Dream? Lessons from Lizard Tail Regeneration

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Is human limb regeneration a dream? Lessons from lizard tail regeneration. Lorenzo Alibardi Univ Bologna, Italy Jan 23, 3-5 pm; including round table discussion after the talk. 6th Li-Fu Building, China Medical University Host by 整合幹細胞中心 (Integrative Stem Cell Center), CM Chuong and SC Hung. The seminar will report recent data on lizard tail regeneration and comparison with other appendages that do not regenerate. Dr. Alibardi will present new hypotheses that may explain the biological conditions on why many fish and amphibians can regenerate fins and/or limbs, while many terrestrial vertebrates lose this capacity and just form scars. The seminar may provide new insight for regenerative medicine in the attempt to stimulate digits and limb regeneration in higher vertebrates. References Alibardi L. Review: Limb regeneration in humans: Dream or reality? Ann Anat. 2018 May;217:1-6. Alibardi L. Perspective: Appendage regeneration in amphibians and some reptiles derived from specific evolutionary histories. J Exp Zool B Mol Dev Evol. 2018. Vitulo N, Dalla Valle L, Skobo T, Valle G, Alibardi L. Transcriptome analysis of the regenerating tail vs. the scarring limb in lizard reveals pathways leading to successful vs. unsuccessful organ regeneration in amniotes. Dev Dyn. 2017 Feb;246(2):116-134. Alibardi L. Regeneration evolved in anamniotes in relation to metamorphosis: indications for attempts to induce limb regeneration in humans Atlas of Science 2018 http://atlasofscience.org/regeneration-evolved-in-anamniotes-in-relation-to-metamorphosis- indications-for-attempts-to-induce-limb-regeneration-in-humans/ 1 Dr. Alibardi will be in the campus from Jan 21 to 24. Those who are interested to talk to him more, please contact Christine Chen 陳昱彣 <[email protected]> 2 .

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