Unlocking the Body's Capacity for Self-Repair Engineer Biomedical

Home , Regeneration in humans

4/16/2019

Healing from within: unlocking the body’s capacity for self-repair

Brandon J. Tefft, Ph.D. Assistant Professor

Engineer

Biomedical Engineer

http://topnews.in

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Regenerative Medicine

http://apexbiologix.com

Cells: Microscopic Tissue Engineers

131 million times per year

Outline

• Implantable medical devices • Regenerative medicine • Rapidly healing cardiovascular devices

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IMPLANTABLE MEDICAL DEVICES

Top 10 in US

Rank Device # per year in US $ per year in US 1 Artificial eye lenses 2,582,000 $8-10 billion 2 Ear tubes 715,000 $1-2 billion 3 Coronary stents 560,000 $7.5 billion 4 Artificial knees 543,000 $12 billion 5 Bone repair hardware 453,000 $4.5 billion 6 Intra-uterine devices 425,000 $340 million 7 Spinal fusion hardware 413,000 $10 billion 8 Breast implants 366,000 $992 million 9 Cardiac pacemakers 235,567 $4.5 billion 10 Artificial hips 230,000 $10.5 billion https://www.businessinsider.com

Cardiac Pacemaker

1960 Today

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Artificial Hip

1962 Today

Coronary Stent

1986 Today

Cochlear Implant

1982 Today

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Coronary Bypass Graft

1955 Today

Lessons from a Splinter

https://www.tips-and-tricks.co

REGENERATIVE MEDICINE

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Salamander Limb

James Monaghan laboratory, Northeastern University

Newborn Mouse Heart

Science. 2011; 331(6020):1078-80

Regeneration in Humans

http://thechart.blogs.cnn.com

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Heart Regeneration

http://news.bbc.co.uk/2/hi/health/4904914.stm

Early Days

Science. 1993; 260(5110):920-6 Plast Reconstr Surg. 1997; 100(2):297-302

Cells Within Us

• 200 types • 37 trillion cells • Stem cells

http://www.equatorias.com/stem-cell-therapy-stem-cell-pluripotent-stem-cells/

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Skin

Arch Dermatol. 1999; 135(10):1219-22

Bladder

https://www.newscientist.com

Cardiovascular Tissues

Humacyte

Miromatrix

Xeltis

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Musculoskeletal Tissues

Bone Ligament

Cartilage PLoS One. 2017; 12(6):e0179249 http://meeting.nesps.org/2011/47.cgi http://tuftsjournal.tufts.edu

Nervous Tissues

Peripheral Nerve Spinal Cord

Prog Neurobiol. 2009; 89(3):231-9 PLoS One. 2015; 10(3):e0117709

RAPIDLY HEALING CARDIOVASCULAR DEVICES

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Coronary Stents

www.adventisthealth.org

Rapid Healing

Magnetic Cell Capture

US patent #8,465,453 B2 J Am Coll Cardiol. 2006;48(9):1839-45

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Magnetic Stents

Ann Biomed Eng. 2014;42(12): 2416-24 J Vis Exp. 2015;103

Magnetic Nanoparticles

Fe3O4 core (10 nm) PLGA-coated Fe3O4 (120 nm)

J Vis Exp. 2015;105

Magnetic Cell Labeling

Blood outgrowth endothelial cells Circ Res. 2003;93:1023-1025 IEEE Trans Magn. 2013;49(1):463-6 J Vis Exp. 2015;105

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In Vitro Cell Capture

Tissue Engineering A. 2018;24(13-14):1157-1166

Rapid Healing in Pig Model

Distal Middle Proximal Magnetic Magnetic Non-Magnetic

Tissue Engineering A. 2018;24(13-14):1157-1166

Rapid Healing in Pig Model

316L stainless steel 2205 stainless steel (non-magnetic) (magnetic)

Tissue Engineering A. 2018;24(13-14):1157-1166

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Rapid Healing in Pig Model

316L stainless steel 2205 stainless steel (non-magnetic) (magnetic) Tissue Engineering A. 2018;24(13-14):1157-1166

Rapid Healing in Pig Model

316L stainless steel 2205 stainless steel (non-magnetic) (magnetic) Tissue Engineering A. 2018;24(13-14):1157-1166

Rapidly Healing Vascular Grafts

Non-magnetically cell seeded Magnetically cell seeded

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Rapid Healing Heart Valves

Regenerative Medicine

http://apexbiologix.com

Acknowledgments

• Medical College of Wisconsin • Marquette University • Mayo Clinic • National Institutes of Health