Indications & dosages zures—Adult, child: 1.1 units/kg or ➤ Inflammation, immunosuppression— 0.165 mg/kg over 60-90 sec. As precau- Adult: 4-48 mg/d PO in divided doses; tion, initial dose should be 20 units (3 mg) 40 mg IM wkly; 1 mg into lesions; or 2.5- < calculated dose. 40 mg into joints or soft tissue. ➤ Diagnosis of myasthenia gravis— ➤ Asthma—Adult: Azmacort 2 inhala- Adult: 4-33 mcg/kg IV 1 dose. tions tid or qid. Max 16 inhalations daily. Total daily dose may be given bid for Interactions maintenance. Child 6-12 yr: Azmacort Aminoglycosides, clindamycin, general 1-2 inhalations tid or qid. Max 12 inhala- anesthetics, lincomycin, magnesium salts, tions daily. polymyxin antibiotics, quinidine, quinine: May enhance neuromuscular blockade, Interactions causing increased skeletal muscle relax- None reported. ation and potentiated effect. Amphotericin B, ethacrynic acid, furose- tubocurarine chloride mide, methotrimeprazine, opioid anal- gesics, propranolol, thiazide diuretics, Nondepolarizing neuromuscular blocker; verapamil: May enhance neuromuscular skeletal muscle relaxant blockade, causing increased skeletal mus- PRC: C cle relaxation and possible respiratory paralysis. Available forms Injection: 3 mg (20 units)/ml urokinase Abbokinase Indications & dosages ➤ Adjunct to anesthesia to relax skeletal Thrombolytic enzyme; thrombolytic muscles; facilitate intubation and ortho- enzyme pedic manipulations; during pharmaco- PRC: B logically or electrically induced convul- sive treatment—Adult: 1.1 units/kg or Available forms 0.165 mg/kg IV slowly over 60-90 sec. Injection: 250,000-IU/vial Average dose initially 40-60 units IV. May give 20-30 units in 3-5 min. For longer Indications & dosages procedures, give 20 units prn. ➤ Lysis of acute massive PE and of PE ➤ Mechanical ventilation—Adult, child: with unstable hemodynamics—Adult: Initially 0.0165 mg/kg IV (average, 1 mg 4,400 IU/kg over 10 min via constant infu- or 7 units); adjust subsequent doses to sion pump; then 4,400 IU/kg/hr 12 hr. patient’s response. ➤ Lessen muscle contractions in phar- macologically or electrically induced sei-
*Canadian † Adjust in renal impairment ‡ Adjust in liver impairment