DOCSLIB.ORG

Doubleblind Free

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Doubleblind Free FREE DOUBLEBLIND PDF Ann Aguirre | 310 pages | 29 Sep 2009 | Ace Books | 9780441017812 | English | New York, NY, United States Double-blind | Definition of Double-blind by Merriam-Webster A double-blind Doubleblind is one in which neither the participants nor the experimenters know who is receiving a particular treatment. This procedure is utilized Doubleblind prevent bias in research results. Double-blind studies are particularly useful for preventing bias due Doubleblind demand characteristics or the placebo effect. For example, let's imagine that researchers are investigating the effects of Doubleblind new drug. In a double-blind study, the researchers who interact with the participants would not know who was receiving the Doubleblind drug and who was receiving a placebo. As mentioned previously, double-blind indicates Doubleblind the participants and the experimenters are unaware of who is receiving the real treatment. In a psychology experiment, the Doubleblind is Doubleblind level of the independent variable that the experimenters are manipulating. This can be contrasted with a single-blind study in which the experimenters are aware of which participants are receiving Doubleblind treatment while the participants remain unaware. In such studies, researchers may use what is known as a placebo. A placebo is an inert substance, such as a sugar pill, that has Doubleblind effect on the individual taking it. The placebo pill is given Doubleblind participants who are randomly assigned to the control group. A control Doubleblind is a subset of participants who are not exposed to any levels of the independent variable. This group serves as a baseline to determine if exposure to the independent Doubleblind had any significant effects. Those randomly assigned to the experimental group are given the Doubleblind in question. Data collected from both groups are then compared to determine if the treatment had Doubleblind impact on the dependent variable. All participants in the study will take a pill, but only some of them will receive Doubleblind real Doubleblind under investigation. The rest of the subjects will receive an inactive placebo. With a double-blind study, the Doubleblind and Doubleblind experimenters have no Doubleblind who is receiving the real drug and who is receiving the Doubleblind pill. Double-blind experiments are simply not possible in some scenarios. For example, in an experiment Doubleblind at which type of psychotherapy is the most effective, it would be impossible to keep participants in the dark about whether or not they actually received therapy. So why would researchers opt for such a Doubleblind There are a couple of important reasons. The double-blind procedure helps minimize Doubleblind possible effects of experimenter bias. Researchers sometimes have subjective feelings and biases that might have an influence on how the subjects respond or how the data is collected. In one research article, randomized double-blind placebo studies were identified as the "gold standard" Doubleblind it comes to intervention-based studies. Imagine that researchers want to determine if Doubleblind energy bars before a demanding athletic event leads to an improvement in performance. The researchers might begin by forming a pool of participants that are fairly equivalent Doubleblind athletic ability. Some participants are randomly assigned to a control group while others are randomly assigned to the experimental group. Participants are Doubleblind be asked to eat an energy bar. All of the bars are packaged the same, but some are sports bars while others are simply bar-shaped brownies. The real energy bars contain high levels of protein and vitamins, while the placebo bars do not. Because this is a double-blind study, neither the participants nor the experimenters know who is Doubleblind the real energy bars and who is consuming the placebo bars. The participants then Doubleblind a predetermined athletic task, and researchers collect data performance. Once all the data has been obtained, researchers can then compare the results of each group and determine if the independent variable had any impact Doubleblind the dependent variable. A double-blind study can be a useful research tool in psychology and other scientific areas. By keeping Doubleblind the experimenters and the participants blind, bias is less likely to influence the results Doubleblind the experiment. Doubleblind double-blind experiment can be set up when the lead experimenter sets up the study but then has a colleague such as a graduate student collect the data from participants. The type of study that researchers decide to use, however, may depend upon a variety of factors, including Doubleblind of the situation, the participants, and the nature of the hypothesis under examination. Ever wonder what your personality type means? Sign up Doubleblind find out more in our Healthy Mind newsletter. National Institutes of Health. Updated September 12, Misra Doubleblind. Randomized double blind placebo control studies, the "Gold Standard" in intervention based studies. Goodwin, CJ. Research In Psychology: Methods and Design. More in Student Resources. Was Doubleblind page helpful? Thanks for your feedback! Sign Up. What are your concerns? Article Sources. Verywell Mind uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read Doubleblind editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Kalat, JW. Introduction to Psychology. Boston, MA: Doubleblind Learning; Related Articles. Understanding Internal and External Validity. Independent Variable in Psychology Experiments. Understanding the Frameworks Used in Developmental Psychology. Verywell Mind uses cookies to provide you with a great user experience. By using Doubleblind Mind, you accept our. Double-blind | Definition of Double-blind at See more words from the same year Dictionary Entries near double-blind double-bit ax double-bitt double-bitted double-blind double blossom double bogey Doubleblind boiler. Accessed 21 Oct. Keep scrolling for more More Definitions for double-blind double-blind. Please tell us where you read or heard it including the quote, if Doubleblind. Test Your Knowledge - and learn some interesting things along the way. Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free! You can never have too Doubleblind storage. What Does 'Eighty-Six' Mean? We're Doubleblind on clearing it up 'Nip it Doubleblind the butt' or 'Nip it in the bud'? We're gonna stop you right there Literally How to use a word that literally drives some pe Is Singular 'They' a Better Choice? Name that government! Or something like Doubleblind. Can you spell these 10 commonly misspelled words? Do you Doubleblind the person or title these quotes desc Login or Register. Save Word. Definition of double-blind. First Known Doubleblind of double-blind Doubleblind, in the meaning defined above. Keep scrolling for more. Learn More about double-blind. Time Traveler for double-blind The first known use of double-blind was in See more words Doubleblind the same Doubleblind. Dictionary Entries near double-blind double-bit Doubleblind double-bitt double-bitted double-blind double blossom double bogey double boiler See More Nearby Entries. Statistics for double-blind Look-up Popularity. More Definitions Doubleblind double-blind. Comments on double-blind What made you want to look up double-blind? Get Word of the Day daily email! Test Your Vocabulary. Love words? Need even Doubleblind definitions? The awkward case of 'his or her'. Take the quiz Forms of Government Quiz Name that government! Take the quiz Spell Doubleblind Can you spell these 10 commonly misspelled words? Take the quiz Citation Do you know Doubleblind person Doubleblind title Doubleblind quotes desc Play the game. Double bind - Wikipedia In a blind or blinded experimentinformation which may influence the participants of the experiment is withheld masked or blinded until after the experiment is complete. Good blinding can reduce or eliminate Doubleblind biases that arise from a participants' expectations, observer's effect Doubleblind the participantsobserver biasconfirmation biasand other sources. A blind can be imposed on Doubleblind participant of an experiment, including subjects, researchers, Doubleblind, data analysts, and evaluators. In some cases, while blinding would be useful, it is impossible or unethical. For example, it is not possible to blind a patient to their treatment in a physical therapy intervention. A good clinical protocol ensures that blinding is as effective as possible within ethical and practical constraints. During the course of an Doubleblind, a Doubleblind becomes unblinded Doubleblind they deduce or otherwise obtain information that has Doubleblind masked to them. For example, a patient who experience a side effect may correctly guess their treatment, becoming unblinded. Unblinding is common in blinded experiments, Doubleblind in pharmacological trials. In particular, trials on pain medication and antidepressants are poorly blinded. Unblinding that occurs before the conclusion of a study is Doubleblind source of experimental error, as the Doubleblind that was eliminated by blinding is re- introduced. In practice, very few studies do so. Blinding is an important tool of the scientific methodand is Doubleblind in many fields of research. In some fields, such as medicineDoubleblind is
Load more

Recommended publications
  • Clinical Research Methodology
    Indian Journal of Pharmaceutical Education and Research Association of Pharmaceutical Teachers of India Clinical Research Methodology Purvi Gandhi* Department of Pharmacology, B. S. Patel Pharmacy College, Mehsana, India. ABSTRACT Submitted: 29/5/2010 Revised: 29/8/2010 Accepted: 04/10/2010 Medical trials occupy a greater part of clinical trials and exceed in number over other types of clinical trials. Although clinical researches or studies other than those falling under the category of trial, lack the commercial aspect, they may contribute to the betterment of clinical practice and may constitute a base for large-scale commercial trials. Explanatory clinical studies are the most widely accepted and executed type of clinical researches/ trials. They explain not only the therapeutic aspects of a drug but also provide with a detailed description on adverse events and pharmacovigilance. Any new drug to be marketed first requires proving its safety, efficacy and the need over existing product range by passing through various phases of clinical trial that follows animal studies. For this reason, randomized controlled trials (RCTs) with placebo- control and blinding fashion is the only accepted form of clinical trials with few exceptions. Besides explanatory, descriptive clinical research is also useful for certain types of studies such as epidemiological research. While conducting RCTs on humans (either healthy volunteers or patients), various components of the trials viz. study design, patient population, control group, randomization, blinding or non-blinding, treatment considerations and outcome measures are important to strengthen the outcomes of the trial. Similarly, proper utilization of statistics, for sample-size calculation, data collection, compilation and analysis by applying proper statistical tests, signifies the outcomes of the clinical research.
    [Show full text]
  • Llovera 1..10
    RESEARCH ARTICLE STROKE Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia Gemma Llovera,1,2 Kerstin Hofmann,1,2 Stefan Roth,1,2 Angelica Salas-Pérdomo,3,4 Maura Ferrer-Ferrer,3,4 Carlo Perego,5 Elisa R. Zanier,5 Uta Mamrak,1,2 Andre Rex,6 Hélène Party,7 Véronique Agin,7 Claudine Fauchon,8 Cyrille Orset,7,8 Benoît Haelewyn,7,8 Maria-Grazia De Simoni,5 Ulrich Dirnagl,6 Ulrike Grittner,9 Anna M. Planas,3,4 Nikolaus Plesnila,1,2 Denis Vivien,7,8 Arthur Liesz1,2* Numerous treatments have been reported to provide a beneficial outcome in experimental animal stroke models; however, these treatments (with the exception of tissue plasminogen activator) have failed in clinical trials. To improve the translation of treatment efficacy from bench to bedside, we have performed a preclinical randomized controlled multicenter trial (pRCT) to test a potential stroke therapy under circumstances closer to the design and rigor of a Downloaded from clinical randomized control trial. Anti-CD49d antibodies, which inhibit the migration of leukocytes into the brain, were previously investigated in experimental stroke models by individual laboratories. Despite the conflicting results from four positive and one inconclusive preclinical studies, a clinical trial was initiated. To confirm the preclinical results and to test the feasibility of conducting a pRCT, six independent European research centers investigated the efficacy of anti-CD49d antibodies in two distinct mouse models of stroke in a centrally coordinated, randomized, and blinded approach. The results pooled from all research centers revealed that treatment with CD49d-specific antibodies signif- http://stm.sciencemag.org/ icantly reduced both leukocyte invasion and infarct volume after the permanent distal occlusion of the middle cerebral artery, which causes a small cortical infarction.
    [Show full text]
  • Interpreting Study Results: How Biased Am I? January 29, 2020
    WELCOME Interpreting Study Results: How Biased Am I? January 29, 2020 www.aacom.org/aogme Copyright © 2019 American Association of Colleges of Osteopathic Medicine. All Rights Reserved. HOUSEKEEPING NOTES • This webinar is being recorded, recording will be shared with participants and posted on the AOGME’s web page • Webinar participants are in listen-only mode • For technical issues, please use the chat feature and raise your hand and we will assist you • You may submit questions anytime during this live webinar using the chat feature, if time remains, questions will be addressed either during or at the end of the presentation. SPEAKERS Mark R. Speicher, PhD, MHA Senior Vice President for Medical Education and Research American Association of Colleges of Osteopathic Medicine (AACOM) Suporn Sukpraprut-Braaten, MSc, MA, PhD Graduate Medical Director of Research Unity Health In research, types of studies depend on the purpose of the study, data collection strategy, and other factors. Types of Study: Weaker Evidence I. Observational study (Cohort Study) 1.1 Cross-sectional study 1.2 Case-control study Prospective Observational Study 1.3 Observational study Retrospective Observational Study II. Non-randomized Controlled Trial Randomized Controlled Trial (Clinical Trial) . Phase I . Phase II . Phase III . Phase IV III. Systematic Review and Meta-analysis Stronger Evidence HIERARCHY OF RESEARCH EVIDENCE Strongest evidence Weakest evidence DIAGRAM 1 OVERVIEW OF TEST HYPOTHESES ANOVA – Analysis of variance ANCOVA – Analysis of covariance Source: Suporn Sukpraprut. Biostatistics: Specific Tests. American College of Preventive Medicine (ACPM) Board Review Course Material (Copyright) 6 DIAGRAM 2: TEST HYPOTHESES FOR CONTINUOUS OUTCOME Source: Suporn Sukpraprut.
    [Show full text]
  • Section 4.3 Good and Poor Ways to Experiment
    Chapter 4 Gathering Data Section 4.3 Good and Poor Ways to Experiment Copyright © 2013, 2009, and 2007, Pearson Education, Inc. Elements of an Experiment Experimental units: The subjects of an experiment; the entities that we measure in an experiment. Treatment: A specific experimental condition imposed on the subjects of the study; the treatments correspond to assigned values of the explanatory variable. Explanatory variable: Defines the groups to be compared with respect to values on the response variable. Response variable: The outcome measured on the subjects to reveal the effect of the treatment(s). 3 Copyright © 2013, 2009, and 2007, Pearson Education, Inc. Experiments ▪ An experiment deliberately imposes treatments on the experimental units in order to observe their responses. ▪ The goal of an experiment is to compare the effect of the treatment on the response. ▪ Experiments that are randomized occur when the subjects are randomly assigned to the treatments; randomization helps to eliminate the effects of lurking variables. 4 Copyright © 2013, 2009, and 2007, Pearson Education, Inc. 3 Components of a Good Experiment 1. Control/Comparison Group: allows the researcher to analyze the effectiveness of the primary treatment. 2. Randomization: eliminates possible researcher bias, balances the comparison groups on known as well as on lurking variables. 3. Replication: allows us to attribute observed effects to the treatments rather than ordinary variability. 5 Copyright © 2013, 2009, and 2007, Pearson Education, Inc. Component 1: Control or Comparison Group ▪ A placebo is a dummy treatment, i.e. sugar pill. Many subjects respond favorably to any treatment, even a placebo. ▪ A control group typically receives a placebo.
    [Show full text]
  • Correlation Experiment Or Quasi Experiment Worksheet
    Correlation Experiment Or Quasi Experiment Worksheet mannerlyWendell often Adrian gigging velarizing braggingly objectively when and unapproving hide his Herr Weslie sidewise tar communicatively and lithographically. and number Alejandro her depose octonaries. peremptorily? Eleusinian and Often not small studies conducted on specific, localized programs remain unpublished and can later be program directly. Often used for navigation and the economy and interviews were supposed to express our framework for rare or quasi experiment or worksheet in yellow cells and see how two major functions of a line. One response variables move in five standardized test taker isrequired to detect differences were? You should however to razor the span source material in these journals when surgery can. Sentences are more sensitive to both accurate and inaccurate recommendations for crimes that occur less frequently and have more complicated sentencing. JC participated in the literature review and helped draft the manuscript. Internal validity applies primarily to experimental research designs, in lake the researcher hopes to conclude following the independent variable has caused the dependent variable. What are experiments for or quasi experiment or more experience with correlations, correlation experiment or subscale, we wish to you! EAL Evidence Analysis Library. It is noted thto devalue the role of explicit grammar explanation in all cases of instructions. The students learned how low carbon cycle, photosynthesis, and cellular respiration are related. Imagination and strong correlation measured and have a psychology or quasi experiment must indicate the help. Why or how fresh it happening? Therefore, we accept the null hypothesis, showing no statistically significant difference in the stress levels of participants who color mandalas or coloring worksheets.
    [Show full text]
  • ORBITA and Coronary Stents: a Case Study in the Analysis and Reporting
    ORBITA and coronary stents: A case study in the analysis and reporting of clinical trials Andrew Gelman, John B. Carlin and Brahmajee K Nallamothu 25 Mar 2019 Department of Statistics and Political Science, Columbia University, New YorK City, NY, United States (Andrew Gelman, professor); Clinical Epidemiology & Biostatistics, Murdoch Children’s Research Institute, Melbourne School of Population and Global Health and Department of Paediatrics, University of Melbourne, Melbourne, Australia (John Carlin, professor); Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, United States (Brahmajee K Nallamothu, professor); Correspondence to: Brahmajee K Nallamothu [email protected] Acknowledgements: We thanK Doug Helmreich for bringing this eXample to our attention, Shira Mitchell for helpful comments, and the Office of Naval Research, Defense Advanced Research Project Agency, and the National Institutes of Health for partial support of this worK. Competing interests: Dr. Gelman and Dr. Carlin report no competing interests. Dr. Nallamothu is an interventional cardiologist and Editor-in-Chief of a journal of the American Heart Association but otherwise has no competing interests. Word Count: 3078 Appeared in American Heart Journal 214, 54-59 (2019) 1. Introduction Al-Lamee et al. (2017) report results from a randomized controlled trial of percutaneous coronary intervention using coronary stents for stable angina. The study, called ORBITA (Objective Randomised Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina), included approXimately 200 patients and was notable for being a blinded eXperiment in which half the patients received stents and half received a placebo procedure in which a sham operation was performed. In follow-up, patients were asKed to guess their treatment and of those who were willing to guess only 56% guessed correctly, indicating that the blinding was largely successful.
    [Show full text]
  • Blinding in Pharmacological Trials: the Devil Is in the Details
    Downloaded from adc.bmj.com on February 6, 2014 - Published by group.bmj.com Leading article measures involve some subjectivity, and Blinding in pharmacological trials: becomes less so to reduce observer bias for objective criteria.7 However, even the devil is in the details then, the lack of participant or healthcare provider blinding can lead to other pro- 1 2 3 2 Mandy Wan, Mine Orlu-Gul, Helene Legay, Catherine Tuleu blems, such as differential attrition and cointervention bias, which can likewise influence the assessment of clinical trial While the methodological principle of science underpinning blinding is very outcomes.710 ‘blinding’ for minimising bias in randomised much pharmaceutical based, and may be controlled trials (RCT) is widely debated technical at times, but part of this paucity BLINDING WITH PLACEBOS and accepted, rarely is this depth of thinking of knowledge is undoubtedly due to a The use of placebo in RCTs would appear applied to its correct handling with respect certain lack of recognition for the as a seemingly simple experimental to design, reporting and analysis. Beyond pharmaceutical properties of a medicine. scheme. Such perception is so deeply fi the general comprehension of the de nition This article, written with clinicians in embedded that we often implicitly accept of the word, the practical aspects of estab- mind, presents a discussion on the prac- clinical trial reporting with rather loose lishing blinding in investigator-initiated tical considerations for blinding in paedi- descriptions of blinding procedures as pharmacological trials are often grossly atric pharmacological trials, with the aim 1 adequate indication for the success of underestimated, and very much an after- to facilitate paediatricians in improving blinding.23Rarely do we ask ourselves thought.
    [Show full text]
  • Introduction to Clinical Trials Abstract
    Summer Institute in Statistics for Clinical Research July 22, 2019 Module 1: Introduction to Clinical Trials Scott S. Emerson, M.D., Ph.D. Professor Emeritus of Biostatistics University of Washington Seattle Institute for Statistics in Clinical Research July 22, 2019 1 © 2019 Scott S. Emerson, M.D., Ph.D. Abstract This module provides an overview of the clinical and scientific issues that must be considered by the many disciplines that collaborate on a clinical trial. In this module, we consider the clinical, scientific, and regulatory setting of clinical trials, describing the phased approach to “treatment discovery” in which the safety, efficacy, and effectiveness of candidate treatments is investigated. In particular, we discuss the issues surrounding identification of the target population, definition of the treatment, choice of clinical outcomes, and choice of comparators. It will include introductory discussion of the choice of randomization strategies, blinding, conduct and monitoring of the study, and plans for reporting of the result. The importance of a well-defined study protocol is emphasized. 2 : 1 Summer Institute in Statistics for Clinical Research July 22, 2019 Where Am I Going? Overview of Use of RCTs in Clinical Research Organization of the Course 1. Scientific / ethical setting: “Treatment Discovery” 2. Clinical trial goal: Estimands / endpoints 3. Materials and methods: a) Patient eligibility criteria b) Randomization / blinding c) Treatments / study procedures d) Data collection / management / analysis 4. Documentation:
    [Show full text]
  • Rapid, Accurate, Nucleobase Detection Using Fncas9
    medRxiv preprint doi: https://doi.org/10.1101/2020.09.13.20193581; this version posted September 14, 2020. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission. Rapid, accurate, nucleobase detection using FnCas9 Single sentence summary A method to identify nucleotide sequence or nucleobase identity using FnCas9 and its implementation in the rapid and accurate diagnosis of SARS-CoV-2 Authors Mohd. Azhar1,2,8, Rhythm Phutela1,2,8, Manoj Kumar1,2,8, Asgar Hussain Ansari1,2,8, Riya Rauthan1,2, Sneha Gulati1, Namrata Sharma1, Dipanjali Sinha1,2, Saumya Sharma1,2, Sunaina Singh1, Sundaram Acharya1,2, Deepanjan Paul1, Poorti Kathpalia1, Meghali Aich1,2, Paras Sehgal1,2, Gyan Ranjan1,2, Rahul C. Bhoyar1, Indian CoV2 Genomics & Genetic Epidemiology (IndiCovGEN) Consortium1, Khushboo Singhal1,2, Harsha Lad3, Pradeep Kumar Patra3, Govind Makharia4, Giriraj Ratan Chandak5, Bala Pesala7, Debojyoti Chakraborty1,2,8*, Souvik Maiti1,2,6,8* 1CSIR-Institute of Genomics & Integrative Biology, Mathura Road, New Delhi- 110025, India 2Academy of Scientific & Innovative Research (AcSIR), Ghaziabad, 201002, India 3CSIR-Sickle Cell Anemia Mission Laboratory, Chhattisgarh Institute of Medical Sciences, Bilaspur 495001, Chhattisgarh, India. 4All India Institute of Medical Sciences, Ansari Nagar East, New Delhi 110029, India 5CSIR-Center for Cellular and Molecular Biology, Uppal Road, Hyderabad, Telengana 500007 6CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411008, India 7CSIR-Central Electronics Engineering Research Institute, Chennai, India 8These authors contributed equally *Correspondence: [email protected] (D.C.); [email protected] (S.M.) 1 NOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.
    [Show full text]
  • Validation of Preferred Salt Concentration in Soup
    Hypertension Research (2020) 43:525–533 https://doi.org/10.1038/s41440-020-0397-1 ARTICLE Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan— influence of umami (L-glutamate) on saltiness and palatability of low-salt solutions 1 2 2 2 3 3 Hitomi Hayabuchi ● Rieko Morita ● Masanori Ohta ● Akiko Nanri ● Hideki Matsumoto ● Shoji Fujitani ● 3 4,5 6 7 8 9 Shintaro Yoshida ● Sadayoshi Ito ● Atsushi Sakima ● Hiroyuki Takase ● Miho Kusaka ● Takuya Tsuchihashi Received: 21 October 2019 / Revised: 8 December 2019 / Accepted: 22 December 2019 / Published online: 29 January 2020 © The Author(s) 2020. This article is published with open access Abstract Sodium reduction is an important public health goal. Individual and population approaches are necessary for reducing the sodium content of processed foods and meals. The aim of the present study is to affirm the effect of monosodium L-glutamate (MSG), an umami substance, on the saltiness or palatability of low-salt solutions and to explore the preferred salt concentration in soup. Five hundred and eighty-four healthy participants from nineteen regions in Japan tasted 0.3, 0.6, 1234567890();,: 1234567890();,: and 0.9% NaCl solutions with or without 0.3% MSG. Evaluations of saltiness and palatability for each solution were conducted using a visual analog scale in a double-blinded randomized manner. Saltiness gradually increased depending on the concentration of NaCl. The saltiness of the 0.3% NaCl solution with MSG was rated significantly higher than that without MSG. The palatability ratings were higher for the solutions with MSG than for those without MSG for all NaCl concentrations.
    [Show full text]
  • The London School of Economics and Political Science Philosophical
    The London School of Economics and Political Science Philosophical Issues in Evidence-Based Medicine: Evaluating the Epistemological Role of Double Blinding and Placebo Controls Jeremy Howick A thesis submitted to the Department of Philosophy, Logic, and Scientific Method of the London School of Economics for the degree of Doctor of Philosophy, London, March 2008 1 UMI Number: U615925 All rights reserved INFORMATION TO ALL USERS The quality of this reproduction is dependent upon the quality of the copy submitted. In the unlikely event that the author did not send a complete manuscript and there are missing pages, these will be noted. Also, if material had to be removed, a note will indicate the deletion. Dissertation Publishing UMI U615925 Published by ProQuest LLC 2014. Copyright in the Dissertation held by the Author. Microform Edition © ProQuest LLC. All rights reserved. This work is protected against unauthorized copying under Title 17, United States Code. ProQuest LLC 789 East Eisenhower Parkway P.O. Box 1346 Ann Arbor, Ml 48106-1346 F Qrtlah Ltoraf y o< P - and Eoonomc Sc<©f' >- Declaration I certify that the thesis I have presented for examination for the PhD degree to the London School of Economics and Political Science is solely my own work other than where I have clearly indicated that it is the work of others (in which case the extent of any work carried out jointly by me and any other person is clearly identified in it). The copyright of this thesis is with the author. Quotation from it is permitted, provided that full acknowledgment is made.
    [Show full text]
  • Chapter 1. Bootstrap Method
    1 Chapter 1. Bootstrap Method 1 Introduction 1.1 The Practice of Statistics Statistics is the science of learning from experience, especially experience that arrives a little bit at a time. Most people are not natural-born statisticians. Left to our own devices we are not very good at picking out patterns from a sea of noisy data. To put it another way, we all are too good at picking out non-existent patterns that happen to suit our purposes? Statistical theory attacks the problem from both ends. It provides optimal methods for finding a real signal in a noisy background, and also provides strict checks against the overinterpretation of random patterns. Statistical theory attempts to answer three basic questions: 1. Data Collection: How should I collect my data? 2. Summary: How should I analyze and summarize the data that I’ve collected? 3. Statistical Inference: How accurate are my data summaries? The bootstrap is a recently developed technique for making certain kinds of statistical infer- ences. It is only recently developed because it requires modern computer power to simplify the often intricate calculations of traditional statistical theory. 1.2 Motivated Example We now illustrate the just mentioned three basic statistical concepts using a front-page news from the New York Times of January 27, 1987. A study was done to see if small aspirin doses would prevent heart attacks in healthy middle-aged men. The data for the aspirin study were collected in a particularly efficient way: by a controlled, randomized, double- blind study. One half of the subjects received aspirin and the other half received a control substance, or placebo, with no active ingredients.
    [Show full text]