bioRxiv preprint doi: https://doi.org/10.1101/395012; this version posted January 11, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. Perivascular space fluid contributes to diffusion tensor imaging changes in white matter Running title: A systematic bias in DTI findings Authors: Farshid Sepehrband Ph.D.1, *, Ryan P Cabeen Ph.D.1, Jeiran Choupan Ph.D.1, 2, Giuseppe Barisano M.D.1, 3, Meng Law M.D.1, 4, Arthur W Toga Ph.D.1, for the Alzheimer’s Disease Neuroimaging Initiative Affiliations: 1. Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, USA 2. Department of Psychology, University of Southern California, Los Angeles, USA 3. Neuroscience Graduate Program, University of Southern California, Los Angeles, USA 4. Radiology and Nuclear Medicine, Alfred Health, Melbourne, Australia Correspondence to: Farshid Sepehrband, PhD Laboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA T: (+1) 323-442-7246 E:
[email protected] Word count: 4700 Number of figures: 7 Number of tables: 0 Keywords: diffusion tensor imaging, bias, perivascular space Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report.