Sanctions Within Conditional Benefit Systems

Total Page:16

File Type:pdf, Size:1020Kb

Sanctions Within Conditional Benefit Systems SanctionsChapter heading within conditional benefi t systems A review of evidence Julia Griggs and December 2010 Martin Evans This study reviews and consolidates international evidence on sanctions operating within welfare systems where benefi ts are conditional upon claimants’ behaviour. Recent reform of (workless) benefi t systems in Britain and other post-industrial nations has sought to promote employment through work-related conditions backed by fi nancial sanctions; the rationale being that sanctions will promote desired behaviour, and therefore favourable outcomes. This review examines an international body of evidence on sanctions, their impacts, outcomes and context, and explores how far the theoretical and political ‘assumptions’ that underlie them are met in practice. The report: • considers the different ways in which benefi t sanctions may (theoretically) affect claimant behaviour; • examines evaluative evidence of sanction impacts within unemployment benefi t and US welfare systems; • contextualises impact evidence within literature on the operation and administration of sanctions as well as the results of surveys and qualitative studies conducted with claimants; • explores the effect of sanctions and conditionality on other (non-employment-related) behaviours; • discusses how this evidence relates to the political justifi cations voiced in support of benefi t sanctions. www.jrf.org.uk ChapterContents heading List of fi gures and tables 3 Executive summary 4 1 Background 9 2 The review’s theory and methods 11 3 Sanctions linked to employment-related conditionality 16 4 Contextual studies of employment-related sanctions 29 5 Sanctions and other types of conditionality 38 6 Justifi cations for sanction-backed conditionality 42 7 Conclusions and recommendations 48 Glossary 50 Notes 51 References 55 Appendix 1 64 Appendix 2 66 Appendix 3 72 Acknowledgements 74 About the authors 74 2 Contents List of fi gures and tables Figures Tables 1 Theoretical framework for identifying 1 Sanctions and the destinations of welfare sanction effects 12 leavers – odds ratios 26 2 Timing effects of sanctions 13 2 Characteristics identifi ed as more prevalent among sanctioned than non-sanctioned 3 Results from post-reform observational benefi t recipients 32 studies on the effects of sanctions on caseload/welfare use (per cent effects) 25 3 Employment rates by sanction status and hardship experience 36 4 Impacts of sanctions on unemployment benefi ts 66 5 Impacts of sanctions in US welfare studies 69 List of fi gures and tables 3 ChapterExecutive heading summary Introduction 1 The type of sanction: whether the sanction results from an administrative failure This study reviews and synthesises international (e.g. not completing required paperwork/ evidence on sanctions operating as part of failure to attend a meeting), or from a conditional welfare systems. It considers evaluative behavioural ‘misdemeanour’ (e.g. not ‘actively evidence of sanction impacts, the wider literature looking’ for work, or refusing employment). on operational context and the qualitative In practice this distinction may not always experience of sanctioned claimants. It then be clear-cut. discusses how this evidence relates to the political justifi cations voiced in support of benefi t sanctions. 2 The type of effect: whether a sanction impact arises directly from lower levels of benefi t Background entitlement (i.e. welfare use/caseloads and spending) (entitlement effects), or from The rolling programme of welfare reform under the changed behaviour of claimants Gordon Brown’s Labour Government sought (treatment effects). to change the fundamental assumptions of many social security programmes to promote 3 The timing of the impact: whether the effect employment. This approach of increased is created by the threat of a sanction, or the sanctioned-backed conditionality has grown sanction itself. There are three points at which incrementally over time but has also broadened sanctions can have an impact: 1) before to include ‘new’ claimant groups. The move to the claim: the presence of sanction-backed conditionality has also extended purely work-related conditions and the prospect of (potentially) issues into a policy model that sees conditionality being sanctioned in the future may deter and sanctions as tools to change other behaviours, potential claimants from entering the system for example housing benefi t sanctions as a (take-up effects), 2) during the claim, but means of preventing anti-social behaviour. before the sanction: either the result of the The extension of benefi t conditionality and general threat of sanctions or an actual use of sanctions has not been confi ned to the warning (threat effects) and 3) during the UK, but is in evidence throughout Europe, North claim, following a sanction: a behavioural America and Australasia, with international and change or reaction to being sanctioned European bodies, such as the Organisation (imposition effects). for Economic Co-operation and Development (OECD) and the European Union (EU), overtly 4 The type of outcome: whether the impact is promoting the use of (sanction-backed) activation short-lived and limited, or is sustained over the policies (see, for example, OECD, 1996). longer term. Sanctions have the potential to impact on claimants and their families in many The theoretical approach to ways. In the short term they may promote sanction effects compliance or participation (intermediate outcomes), or encourage claimants to end When considering the impact of benefi t sanctions their claim (thus affecting caseloads and it is important to be aware of the different types of spending), possibly to enter employment. effect sanctions have (or might have) on claimants. In the longer term they may affect child There are four key dimensions to these differences: welfare, earnings and material hardship. 4 Executive summary Impacts: sanctions linked to • The one study exploring spill-over effects employment-related conditionality found that sanctions had unfavourable impacts on local crime rates (Machin and Despite the wide range of potential effects Marie, 2004). identifi ed in theory, empirical studies exploring the effectiveness of sanctions focus almost • An exploration of earning expectations exclusively on the post-claim impacts of imposed found no effects from imposed sanctions sanctions, with a small number also looking at (a fi nding that runs contrary to job the impact of direct warnings. Effects on take- search theory) (Schneider, 2008). up and on the presence of sanctions on the behaviour of the general claimant population are Despite this evidence there are still many not considered. This limits the messages we are unknowns. This creates a need for more able to draw from impact studies, as well as their evidence on the duration of effects, differences potential application to the current policy context. by claimant characteristics (e.g. gender) and Consolidating fi ndings of the unemployment infl ow and take-up effects, as well as on a benefi t and welfare evaluations identifi ed, we can range of exit destinations and longer-term conclude that sanctions for employment-related impacts, such as income, post-unemployment conditions (full-family sanctions in the case of work sustainability and earnings. US welfare systems) strongly reduce benefi t use and raise exits from benefi ts, but have generally Contextual studies of employment- unfavourable effects on longer-term outcomes related sanctions (earnings over time, child welfare, job quality) and spill-over effects (i.e. crime rates). However, The nature of the impact studies identifi ed means beyond this the evidence is harder to reconcile. that there are potential effects that are poorly For example, while unemployment benefi t covered by high-quality evidence. Thus the wider programmes tend to demonstrate positive impacts contextual literature that surrounds the ‘core’ on employment, this is not the case for impact and outcome evaluations is very useful welfare studies. both in its own right and in interpretation and To summarise: generalisation of fi ndings on sanction effects, particularly those studies offering direct insights • There is compelling and consistent evidence into claimant experiences. Also of importance of the short-term effects of sanctions in are those factors that affect the way that unemployment benefi t (UB) systems – raising sanctions operate (for example, claimant unemployment benefi t exits and job entry. knowledge of the system and bias in administration), factors which play a role in • Evidence of sanction effects in the US how effi cient, effective or equitable they are. welfare system is more mixed. While more Claimant knowledge and understanding: severe sanctions (in particular, immediate studies conducted with claimants demonstrate full-family sanctions) signifi cantly reduce low levels of awareness of sanctions; while welfare caseloads, evidence on employment people knew penalties were part of the system and earnings is far less conclusive or they rarely knew when they could be imposed favourable (two studies indicating a or how they could be reversed. This is signifi cant negative impact, the third a positive one). because claimants who do not know what is expected of them and what will happen if they • Recent evidence from a single study of fail to meet these expectations are effectively unemployment benefi t sanctions (Arni et al., being punished for a lack of understanding 2009) suggests earlier UB exits prompted by rather than (deliberate) non-compliance.
Recommended publications
  • Strategies and Experiences to Improve Research Uptake: the Royal Society and UK Science Funding
    Strategies and experiences to improve research uptake: The Royal Society and UK science funding Wider context Credit crunch UK Government Deficit New government Spending cuts The Royal Society Advisory Group Sir Martin Taylor FRS (Chair), Former Vice-President and Physical Secretary, The Royal Society Professor Glynis Breakwell, Vice-Chancellor, University of Bath Professor Ann Dowling DBE CBE FRS FREng, Professor of Engineering, University of Cambridge Sir Martin Evans FRS, Director, Cardiff School of Biosciences Sir Richard Friend FRS. Professor of Physics, University of Cambridge Professor Rachel Griffith FBA, Deputy Research Director, Institute for Fiscal Studies Professor Wendy Hall DBE FREng FRS, Professor of Computer Science, University of Southampton Dr Emily Holmes, Department of Psychiatry, University of Oxford Professor Richard Jones FRS, Professor of Physics, Sheffield University Professor Ben Martin, Science and Technology Policy Research Unit (SPRU) Paul Mountford, President, Emerging Markets, Cisco Professor Helga Nowotny, Vice-President, European Research Council Sir Paul Nurse FRS, President, Rockefeller University, New York City Dr David Roblin, Vice-President Global R&D, Pfizer Lord Sainsbury of Turville FRS, Gatsby Charitable Foundation Lord Waldegrave of North Hill, Provost, Eton College Sir Mark Walport, Director of the Wellcome Trust Sir Alan Wilson FRS FBA, Chairman, Arts and Humanities Research Council 7 Engagement across the political spectrum Lord Sainsbury of Turville FRS, Lord Waldegrave of North Hill, Conservative Labour Public R&D expenditure, 1970-2007 The UK punches above its weight The Cambridge phenomenon People in and outside science Global competition Average annual growth in R&D budgets, 1997-2007 ‘By the end of 2020…China will join the ranks of the world’s most innovative countries’ President Hu Jintao, Jan 2006 Investing in the downturn 0.60% 0.50% 0.40% Green technology R&D 0.30% GDP 0.20% 0.10% 0.00% Finland Norway Canada Portugal Germany Sweden USA Recommendations 1.
    [Show full text]
  • Biochemistry, Genetics, Molecular and Cell Biology) Hit the Newspaper Headlines on a Weekly Basis
    The Tenovus-Scotland Symposia and Medal Lectures Today medical advances as a result of discoveries in the Life Sciences (Biochemistry, Genetics, Molecular and Cell Biology) hit the newspaper headlines on a weekly basis. This was not the case at the time of the first Tenovus-Scotland Symposium nearly 35 years ago. Since the discovery of the structure of DNA twenty years earlier, great advances had been made in understanding, at the level of molecules, how genes work in the cell. From study of simple bacteria and viruses, it was known that the information for making all the different proteins in the cell was encoded in the sequence of nucleotides, the individual chemical units of DNA, but study of higher organisms seemed impossibly complex. The chromosomes in each human cell have about 23,000 genes in their DNA that contains a total of about three thousand million nucleotides - how would it be possible to study these genes individually? Three staff from the Biochemistry Department and the Beatson Institute planned a two day meeting at Glasgow University in 1974 to bring together scientists to discuss and learn about the new discoveries that were beginning to provide answers to that fundamental question. Sir Charles Illingworth, who had recently founded Tenovus- Scotland, saw the importance of these studies and their potential future application in medicine and agreed a grant towards the cost of the meeting, which we called the Tenovus-Scotland Symposium although the First Meeting was also jointly sponsored by the Nucleotide Group of the
    [Show full text]
  • Michael S. Brown, MD
    DISTINGUISHED PHYSICIANS AND Michael S. Brown, M.D. Sir Richard Roberts, Ph.D. Winner, 1985 Nobel Prize in Physiology or Medicine Winner, 1993 Nobel Prize in Physiology or Medicine MEDICAL SCIENTISTS MENTORING Winner, 1988 Presidential National Medal of Science A globally prominent biochemist and molecular biologist, DELEGATES HAVE INCLUDED... Dr. Brown received the world’s most prestigious medical Dr. Roberts was awarded the Nobel Prize for his prize for his work describing the regulation of the groundbreaking contribution to discovering RNA splicing. cholesterol metabolism. His work laid the foundation for Dr. Roberts is dedicating his future research to GMO crops the class of drugs now called statins taken daily by more than 20 million and food sources, and demonstrating the effect they have on humanity. — GRANDg MASTERS — people worldwide. Ferid Murad, M.D., Ph.D. Mario Capecchi, Ph.D. Boris D. Lushniak, M.D., M.P.H Winner, 1998 Nobel Prize in Physiology or Medicine Academy Science Director The Surgeon General of the United States (acting, 2013-2014) Winner, 2007 Nobel Prize in Physiology or Medicine A world-renowned pioneer in biochemistry, Dr. Murad’s Winner, 2001 National Medal of Science Rear Admiral Lushniak, M.D., M.P.H., was the United award-winning research demonstrated that nitroglycerin Winner, 2001 Lasker Award States’ leading spokesperson on matters of public health, and related drugs help patients with heart conditions by Winner, 2003 Wolf Prize in Medicine overseeing the operations of the U.S. Public Health Service releasing nitric oxide into the body, thus relaxing smooth Mario Capecchi, Ph.D., a biophysicist, is a Distinguished Commissioned Corps, which consists of approximately muscles by elevating intracellular cyclic GMP, leading to vasodilation and Professor of Human Genetics at the University of Utah School of Medicine.
    [Show full text]
  • Cambridge's 92 Nobel Prize Winners Part 4 - 1996 to 2015: from Stem Cell Breakthrough to IVF
    Cambridge's 92 Nobel Prize winners part 4 - 1996 to 2015: from stem cell breakthrough to IVF By Cambridge News | Posted: February 01, 2016 Some of Cambridge's most recent Nobel winners Over the last four weeks the News has been rounding up all of Cambridge's 92 Nobel Laureates, which this week comes right up to the present day. From the early giants of physics like JJ Thomson and Ernest Rutherford to the modern-day biochemists unlocking the secrets of our genome, we've covered the length and breadth of scientific discovery, as well as hugely influential figures in economics, literature and politics. What has stood out is the importance of collaboration; while outstanding individuals have always shone, Cambridge has consistently achieved where experts have come together to bounce their ideas off each other. Key figures like Max Perutz, Alan Hodgkin and Fred Sanger have not only won their own Nobels, but are regularly cited by future winners as their inspiration, as their students went on to push at the boundaries they established. In the final part of our feature we cover the last 20 years, when Cambridge has won an average of a Nobel Prize a year, and shows no sign of slowing down, with ground-breaking research still taking place in our midst today. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1.1996 James Mirrlees, Trinity College: Prize in Economics, for studying behaviour in the absence of complete information As a schoolboy in Galloway, Scotland, Mirrlees was in line for a Cambridge scholarship, but was forced to change his plans when on the weekend of his interview he was rushed to hospital with peritonitis.
    [Show full text]
  • The Nobel Prize in Physiology Or Medicine 2007
    PRESS RELEASE 2007-10-08 The Nobel Assembly at Karolinska Institutet has today decided to award The Nobel Prize in Physiology or Medicine 2007 jointly to Mario R. Capecchi, Martin J. Evans and Oliver Smithies for their discoveries of “principles for introducing specific gene modifications in mice by the use of embryonic stem cells” SUMMARY This year’s Nobel Laureates have made a series of ground-breaking discoveries concerning embryonic stem cells and DNA recombination in mammals. Their discoveries led to the creation of an immensely powerful technology referred to as gene targeting in mice. It is now being applied to virtually all areas of biomedicine – from basic research to the development of new therapies. Gene targeting is often used to inactivate single genes. Such gene “knockout” experiments have elucidated the roles of numerous genes in embryonic development, adult physiology, aging and disease. To date, more than ten thousand mouse genes (approximately half of the genes in the mammalian genome) have been knocked out. Ongoing international efforts will make “knockout mice” for all genes available within the near future. With gene targeting it is now possible to produce almost any type of DNA modification in the mouse genome, allowing scientists to establish the roles of individual genes in health and disease. Gene targeting has already produced more than five hundred different mouse models of human disorders, including cardiovascular and neuro-degenerative diseases, diabetes and cancer. Modification of genes by homologous recombination Information about the development and function of our bodies throughout life is carried within the DNA. Our DNA is packaged in chromosomes, which occur in pairs – one inherited from the father and one from the mother.
    [Show full text]
  • ILAE Historical Wall02.Indd 10 6/12/09 12:04:44 PM
    2000–2009 2001 2002 2003 2005 2006 2007 2008 Tim Hunt Robert Horvitz Sir Peter Mansfi eld Barry Marshall Craig Mello Oliver Smithies Luc Montagnier 2000 2000 2001 2002 2004 2005 2007 2008 Arvid Carlsson Eric Kandel Sir Paul Nurse John Sulston Richard Axel Robin Warren Mario Capecchi Harald zur Hauser Nobel Prizes 2000000 2001001 2002002 2003003 200404 2006006 2007007 2008008 Paul Greengard Leland Hartwell Sydney Brenner Paul Lauterbur Linda Buck Andrew Fire Sir Martin Evans Françoise Barré-Sinoussi in Medicine and Physiology 2000 1st Congress of the Latin American Region – in Santiago 2005 ILAE archives moved to Zurich to become publicly available 2000 Zonismide licensed for epilepsy in the US and indexed 2001 Epilepsia changes publishers – to Blackwell 2005 26th International Epilepsy Congress – 2001 Epilepsia introduces on–line submission and reviewing in Paris with 5060 delegates 2001 24th International Epilepsy Congress – in Buenos Aires 2005 Bangladesh, China, Costa Rica, Cyprus, Kazakhstan, Nicaragua, Pakistan, 2001 Launch of phase 2 of the Global Campaign Against Epilepsy Singapore and the United Arab Emirates join the ILAE in Geneva 2005 Epilepsy Atlas published under the auspices of the Global 2001 Albania, Armenia, Arzerbaijan, Estonia, Honduras, Jamaica, Campaign Against Epilepsy Kyrgyzstan, Iraq, Lebanon, Malta, Malaysia, Nepal , Paraguay, Philippines, Qatar, Senegal, Syria, South Korea and Zimbabwe 2006 1st regional vice–president is elected – from the Asian and join the ILAE, making a total of 81 chapters Oceanian Region
    [Show full text]
  • Embryo Tanulmányozási Módszerek
    Methods in developmental biology Dr. Nandor Nagy Developmental model organisms Often used model organisms in developmental biology include the following: Vertebrates Zebrafish Danio rario Medakafish Oryzias latipes Fugu (pufferfish) Takifugu rubripes Frog Xenopus laevis, Xenopus tropicalis Chicken Gallus gallus Mouse Mus musculus (Mammalian embryogenesis) Invertebrates Lancelet Branchiostoma lanceolatum Ascidian Ciona intestinalis Sea urchin Strongylocentrotus purpuratus Roundworm Caenorhabditis elegans Fruit fly Drosophila melanogaster (Drosophila embryogenesis) Plants (Plant embryogenesis) Arabidopsis thaliana Maize Snapdragon Antirrhinum majus Other Slime mold Dictyostelium discoideum Induction The Nobel Prize in Physiology or Medicine 1935 was awarded to Hans Spemann "for his discovery of the organizer effect in embryonic development". 2002 Nobel prize Psysiology and Medicine: Sydney Brenner, John E. Sulston, H. Robert Horovitz By establishing and using the nematode Caenorhabditis elegans as an experimental model system, possibilities were opened to follow cell division and differentiation from the fertilized egg to the adult. The Laureates have identified key genes regulating organ development and programmed cell death and have shown that corresponding genes exist in higher species, including man. The discoveries are important for medical research and have shed new light on the pathogenesis of many diseases. 2019 Lasker Awards highlight the invaluable role of animal research The Lasker Awards are among the most prestigious prizes
    [Show full text]
  • Professor Oliver Smithies Was Born on June 23, 1925, in Halifax, England, and As a Child Went to a Small School in Copley Village Near to Halifax
    Professor Oliver Smithies was born on June 23, 1925, in Halifax, England, and as a child went to a small school in Copley village near to Halifax. Subsequently he was a student at Heath Grammar School in Halifax until he was awarded a scholarship from Balliol College, Oxford University. At Oxford he received a Bachelor of Arts Degree in Physiology with First Class Honors in 1946. In 1951, he obtained his M.A. and D.Phil. degrees in Biochemistry from Oxford. Professor Smithies then moved to the United States as a Postdoctoral Fellow in Physical Chemistry at the University of Wisconsin. After two years at Wisconsin, Professor Smithies accepted a position at the Connaught Medical Research Laboratories in Toronto and stayed there from 1953 to 1960, first as a Research Assistant and then as a Research Associate. In 1960, Professor Smithies returned to Wisconsin as Assistant Professor of Medical Genetics and Genetics, advancing to Full Professor by 1963. He was named the Leon J. Cole Professor in 1971. In 1988, he joined the Department of Pathology at the University of North Carolina, as the Excellence Professor of Pathology. He is now the Weatherspoon Eminent Distinguished Professor of Pathology and Laboratory Medicine at UNC, and remains an actively engaged scientist working at the bench in the laboratory he shares with his wife, Nobuyo Maeda who is the Robert H. Wagner Distinguished Professor of Pathology and Laboratory Medicine. In the mid-1950s, Professor Smithies described the first high resolution electrophoresis system (starch gel), and with it he discovered that normal humans have unsuspected inherited differences in their proteins.
    [Show full text]
  • Close to the Edge: Co-Authorship Proximity of Nobel Laureates in Physiology Or Medicine, 1991 - 2010, to Cross-Disciplinary Brokers
    Close to the edge: Co-authorship proximity of Nobel laureates in Physiology or Medicine, 1991 - 2010, to cross-disciplinary brokers Chris Fields 528 Zinnia Court Sonoma, CA 95476 USA fi[email protected] January 2, 2015 Abstract Between 1991 and 2010, 45 scientists were honored with Nobel prizes in Physiology or Medicine. It is shown that these 45 Nobel laureates are separated, on average, by at most 2.8 co-authorship steps from at least one cross-disciplinary broker, defined as a researcher who has published co-authored papers both in some biomedical discipline and in some non-biomedical discipline. If Nobel laureates in Physiology or Medicine and their immediate collaborators can be regarded as forming the intuitive “center” of the biomedical sciences, then at least for this 20-year sample of Nobel laureates, the center of the biomedical sciences within the co-authorship graph of all of the sciences is closer to the edges of multiple non-biomedical disciplines than typical biomedical researchers are to each other. Keywords: Biomedicine; Co-authorship graphs; Cross-disciplinary brokerage; Graph cen- trality; Preferential attachment Running head: Proximity of Nobel laureates to cross-disciplinary brokers 1 1 Introduction It is intuitively tempting to visualize scientific disciplines as spheres, with highly produc- tive, well-funded intellectual and political leaders such as Nobel laureates occupying their centers and less productive, less well-funded researchers being increasingly peripheral. As preferential attachment mechanisms as well as the economics of employment tend to give the well-known and well-funded more collaborators than the less well-known and less well- funded (e.g.
    [Show full text]
  • A Scientific History Leading to the 2012 Nobel Prize
    From Stealing Fire to Cellular Reprogramming: A Scientific History Leading to the 2012 Nobel Prize The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Lensch, M. William, and Christine L. Mummery. 2013. “From Stealing Fire to Cellular Reprogramming: A Scientific History Leading to the 2012 Nobel Prize.” Stem Cell Reports 1 (1): 5-17. doi:10.1016/j.stemcr.2013.05.001. http://dx.doi.org/10.1016/ j.stemcr.2013.05.001. Published Version doi:10.1016/j.stemcr.2013.05.001 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:11877117 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Stem Cell Reports Review From Stealing Fire to Cellular Reprogramming: A Scientific History Leading to the 2012 Nobel Prize M. William Lensch1,2,3,* and Christine L. Mummery4 1Department of Pediatrics, Harvard Medical School, 250 Longwood Avenue, Boston, MA 02115, USA 2Division of Hematology/Oncology, Howard Hughes Medical Institute/Boston Children’s Hospital, 1 Blackfan Circle, Boston, MA 02115, USA 3Harvard Stem Cell Institute, Holyoke Center, Suite 727W, 1350 Massachusetts Avenue, Cambridge, MA 02138, USA 4Department of Anatomy and Embryology, Leiden University Medical Centre, P.O. Box 9600, 2300 RC Leiden, the Netherlands *Correspondence: [email protected] http://dx.doi.org/10.1016/j.stemcr.2013.05.001 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
    [Show full text]
  • Hypoxia As a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells
    biomolecules Review Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells 1, 1, 1 Paulina Podkalicka y, Jacek St˛epniewski y, Olga Mucha , Neli Kachamakova-Trojanowska 2 ,Józef Dulak 1 and Agnieszka Łoboda 1,* 1 Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland; [email protected] (P.P.); [email protected] (J.S.); [email protected] (O.M.); [email protected] (J.D.) 2 Malopolska Centre of Biotechnology, Jagiellonian University, 30-837 Kraków, Poland; [email protected] * Correspondence: [email protected]; Tel.: +48-12-664-6412 These authors contributed equally to this paper. y Received: 27 October 2020; Accepted: 24 November 2020; Published: 29 November 2020 Abstract: Inadequate supply of oxygen (O2) is a hallmark of many diseases, in particular those related to the cardiovascular system. On the other hand, tissue hypoxia is an important factor regulating (normal) embryogenesis and differentiation of stem cells at the early stages of embryonic development. In culture, hypoxic conditions may facilitate the derivation of embryonic stem cells (ESCs) and the generation of induced pluripotent stem cells (iPSCs), which may serve as a valuable tool for disease modeling. Endothelial cells (ECs), multifunctional components of vascular structures, may be obtained from iPSCs and subsequently used in various (hypoxia-related) disease models to investigate vascular dysfunctions. Although iPSC-ECs demonstrated functionality in vitro and in vivo, ongoing studies are conducted to increase the efficiency of differentiation and to establish the most productive protocols for the application of patient-derived cells in clinics.
    [Show full text]
  • The 2012 Nobel Prize in Physiology Or Medicine John B. Gurdon and Shinya Yamanaka for the Discovery That Mature Cells Can Be
    PRESS RELEASE 2012-10-08 The Nobel Assembly at Karolinska Institutet has today decided to award The 2012 Nobel Prize in Physiology or Medicine jointly to John B. Gurdon and Shinya Yamanaka for the discovery that mature cells can be reprogrammed to become pluripotent SUMMARY The Nobel Prize recognizes two scientists who discovered that mature, specialised cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Their findings have revolutionised our understanding of how cells and organisms develop. John B. Gurdon discovered in 1962 that the specialisation of cells is reversible. In a classic experiment, he replaced the immature cell nucleus in an egg cell of a frog with the nucleus from a mature intestinal cell. This modified egg cell developed into a normal tadpole. The DNA of the mature cell still had all the information needed to develop all cells in the frog. Shinya Yamanaka discovered more than 40 years later, in 2006, how intact mature cells in mice could be reprogrammed to become immature stem cells. Surprisingly, by introducing only a few genes, he could reprogram mature cells to become pluripotent stem cells, i.e. immature cells that are able to develop into all types of cells in the body. These groundbreaking discoveries have completely changed our view of the development and cellular specialisation. We now understand that the mature cell does not have to be confined forever to its specialised state. Textbooks have been rewritten and new research fields have been established. By reprogramming human cells, scientists have created new opportunities to study diseases and develop methods for diagnosis and therapy.
    [Show full text]