RESEARCH ARTICLE Proteometabolomic response of Deinococcus radiodurans exposed to UVC and vacuum conditions: Initial studies prior to the Tanpopo space mission Emanuel Ott1, Yuko Kawaguchi2, Denise KoÈlbl1, Palak Chaturvedi1,3, Kazumichi Nakagawa4, Akihiko Yamagishi2, Wolfram Weckwerth3,5*, Tetyana Milojevic1* 1 Department of Biophysical Chemistry, University of Vienna, Vienna, Austria, 2 School of Life Sciences, a1111111111 Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 3 Department of Ecogenomics and Systems Biology, University of Vienna, Vienna, Austria, 4 Graduate School of Human Development and Environment, a1111111111 Kobe University, Kobe, Japan, 5 Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria a1111111111 a1111111111 *
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[email protected] (WW) a1111111111 Abstract The multiple extremes resistant bacterium Deinococcus radiodurans is able to withstand OPEN ACCESS harsh conditions of simulated outer space environment. The Tanpopo orbital mission per- Citation: Ott E, Kawaguchi Y, KoÈlbl D, Chaturvedi P, forms a long-term space exposure of D. radiodurans aiming to investigate the possibility of Nakagawa K, Yamagishi A, et al. (2017) Proteometabolomic response of Deinococcus interplanetary transfer of life. The revealing of molecular machinery responsible for surviv- radiodurans exposed to UVC and vacuum ability of D. radiodurans in the outer space environment can improve our understanding of conditions: Initial studies prior to the Tanpopo underlying