Ending Aging in the Shteyngart of Eden: Biogerontological Discourse in a Super Sad True Love Story
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
The Ageing Haematopoietic Stem Cell Compartment
REVIEWS The ageing haematopoietic stem cell compartment Hartmut Geiger1,2, Gerald de Haan3 and M. Carolina Florian1 Abstract | Stem cell ageing underlies the ageing of tissues, especially those with a high cellular turnover. There is growing evidence that the ageing of the immune system is initiated at the very top of the haematopoietic hierarchy and that the ageing of haematopoietic stem cells (HSCs) directly contributes to changes in the immune system, referred to as immunosenescence. In this Review, we summarize the phenotypes of ageing HSCs and discuss how the cell-intrinsic and cell-extrinsic mechanisms of HSC ageing might promote immunosenescence. Stem cell ageing has long been considered to be irreversible. However, recent findings indicate that several molecular pathways could be targeted to rejuvenate HSCs and thus to reverse some aspects of immunosenescence. HSC niche The current demographic shift towards an ageing popu- The innate immune system is also affected by ageing. A specialized lation is an unprecedented global phenomenon that has Although an increase in the number of myeloid precur- microenvironment that profound implications. Ageing is associated with tissue sors has been described in the bone marrow of elderly interacts with haematopoietic attrition and an increased incidence of many types of can- people, the oxidative burst and the phagocytic capacity of stem cells (HSCs) to regulate cers, including both myeloid and lymphoid leukaemias, and both macrophages and neutrophils are decreased in these their fate. other haematopoietic cell malignancies1,2. Thus, we need individuals12,13. Moreover, the levels of soluble immune to understand the molecular and cellular mechanisms of mediators are altered with ageing. -
Chapter 6: Old People Are People Too, So Let's Act
Career Planning & Adult Development JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Helen Harkness, Guest Editor QThe Future Q The End of Work as We Know It QJobs and Careers on the Front Line of the Future QSilicon Valley and the New Rules of Work Q Training Challenges Facing Education and Training and Career Development in the Future QOld people are people too, so let’s act accordingly Q Crisis of Human Capital in Aerospace: It’s All About the STEM QCollege for All – Reality or Flawed Myth? QOur Jobs: The American Workforce and Economy in Crisis Q The Future Has Arrived: The Future is Now the Present Summer 2015..............................Career Planning and Adult Development JOURNAL..............................1 CAREER PLANNING and ADULT DEVELOPMENT JOURNAL Volume 31, Number 2 ISSN 0736-1920 Summer 2015 OUR FUTURE: Projections of Work and Life Looking Ahead with the Journal,E\Steven E. Beasley, Managing Editor4 Introduction to this Issue, E\ Helen Harkness, PhD, Guest Editor5 Chapter 1: 7KH)XWXUHE\ Leigh Ellen Key8 Chapter 2: 7KH(QGRI:RUNDV:H.QRZ,Wby Andy Hines10 Chapter 3: -REVDQG&DUHHUVRQWKH)URQW/LQHRIWKH)XWXUHby Gary Marx20 Chapter 4: 6LOLFRQ9DOOH\DQGWKH1HZ5XOHVRI:RUNE\Gary A. Bolles28 Chapter 5: 7UDLQLQJ&KDOOHQJHV)DFLQJ(GXFDWLRQDQG7UDLQLQJ DQG&DUHHU'HYHORSPHQWLQWKH)XWXUHE\Timothy C. Mack40 Chapter 6: 2OGSHRSOHDUHSHRSOHWRRVROHW·VDFWDFFRUGLQJO\by Aubrey de Grey47 Chapter 7: &ULVLVRI+XPDQ&DSLWDOLQ$HURVSDFH,W·V$OO$ERXWWKH67(0 by Deborah Westphal51 Chapter 8: &ROOHJHIRU$OO²5HDOLW\RU)ODZHG0\WK"E\ -
Who Wants to Live Forever? Reader’S Digest
HEALTH Who Wantsto Live Forever? As a species, we humans appear to be the undisputed masters of our planet. Moreover, since Yuri Gagarin’s inaugural space flight in 1961, we can even leave the confines of Earth to travel in space. Yet, we have one Achilles’ heel—we’re mortal BY CHRIS MENON 1234567890 1234567890 36 BRAIN LIGHT/ALAMY STOCK PHOTO WHO WANTS TO LIVE FOREVER? READEr’s DIGEST T 122 YEARS, THE MAXIMUM HUMAN LIFESPAN lags well behind some species of giant tortoise (188 years), Greenland shark (400 years) and the record set by the lowly Icelandic clam (507 years). Even those relatively few humans who do manage to make it past 100—some 14,570 people in the UK in 2015—are invariably bedeviled byA poor health. Recently, efforts to extend the healthy of Amazon, has similarly invested human lifespan have achieved much in Unity Biotechnology, which aims publicity following the backing of “to design therapeutics that prevent, visionary, super-rich Silicon Valley halt, or reverse diseases of ageing”. tech entrepreneurs. In 2013, Google’s Unity intends to develop a new founders created a subsidiary class of therapies called “senolytic company called Calico (short for medicines”, designed to selectively the California Life Company), eliminate senescent cells. Senescent Billionaire researchers, which promptly hired a team of top cells accumulate with age and, Some believe that death, Arthur Levinson, Jeff technologies that scientists and now has more than unlike normal cells, they secrete like any disease, can be Bezos and Elon Musk the SENS Research £1bn in the bank to fund its work. -
From Here to Immortality: Anti-Aging Medicine
FromFrom HereHere toto Immortality:Immortaalitty: AAnti-AgingAnnntti-AAgging MMedicineedicine Anti-aging medicine is a $5 billion industry. Despite its critics, researchers are discovering that inter ventions designed to turn back time may prove to be more science than fiction. By Trudie Mitschang 14 BioSupply Trends Quarterly • October 2013 he symptoms are disturbing. Weight gain, muscle Shifting Attitudes Fuel a Booming Industry aches, fatigue and joint stiffness. Some experience The notion that aging requires treatment is based on a belief Thear ing loss and diminished eyesight. In time, both that becoming old is both undesirable and unattractive. In the memory and libido will lapse, while sagging skin and inconti - last several decades, aging has become synonymous with nence may also become problematic. It is a malady that begins dete rioration, while youth is increasingly revered and in one’s late 40 s, and currently 100 percent of baby boomers admired. Anti-aging medicine is a relatively new but thriving suffer from it. No one is immune and left untreated ; it always field driven by a baby- boomer generation fighting to preserve leads to death. A frightening new disease, virus or plague? No , its “forever young” façade. According to the market research it’s simply a fact of life , and it’s called aging. firm Global Industry Analysts, the boomer-fueled consumer The mythical fountain of youth has long been the subject of base will push the U.S. market for anti-aging products from folklore, and although it is both natural and inevitable, human about $80 billion now to more than $114 billion by 2015. -
Read Our New Annual Report
The seeds of a concept. The roots of an idea. The potential of a world free of age-related disease. Photo: Sherry Loeser Photography SENS Research Foundation Board of Directors Barbara Logan, Chair Bill Liao, Secretary Kevin Perrott, Treasurer Michael Boocher Jonathan Cain Kevin Dewalt Michael Kope Jim O’Neill Frank Schüler Sherry Loeser Photography 2 Contents CEO Letter (Jim O’Neill) 4 Finances 5 Donors 6 - 7 Fundraising & Conferences 8 - 9 Around the World with Aubrey de Grey 10 Outreach 11 Founding CEO Tribute & Underdog Pharmaceuticals 12 - 13 Investments 14 Welcome New Team Members 15 Education 16 - 17 Publications & Research Advisory Board 18 Research Summaries 19 - 22 Ways to Donate 23 The SRF Team Front row: Anne Corwin (Engineer/Editor), Amutha Boominathan (MitoSENS Group Lead), Alexandra Stolzing (VP of Research), Aubrey de Grey (Chief Science Officer), Jim O’Neill (CEO), Bhavna Dixit (Research Associate). Center row: Caitlin Lewis (Research Associate), Lisa Fabiny-Kiser (VP of Operations), Gary Abramson (Graphics), Maria Entraigues-Abramson (Global Outreach Coordinator), Jessica Lubke (Administrative Assistant). Back row: Tesfahun Dessale Admasu (Research Fellow), Amit Sharma (ImmunoSENS Group Lead), Michael Rae (Science Writer), Kelly Protzman (Executive Assistant). Not Pictured: Greg Chin (Director, SRF Education), Ben Zealley (Website/Research Assistant/ Deputy Editor) Photo: Sherry Loeser Photography, 2019 3 From the CEO At our 2013 conference at Queens College, Cambridge, I closed my talk by saying, “We should not rest until we make aging an absurdity.” We are now in a very different place. After a lot of patient explanation, publication of scientific results, conferences, and time, our community persuaded enough scientists of the feasibility of the damage repair approach to move SENS and SENS Research Foundation from the fringes of scientific respectability to the vanguard of a mainstream community of scientists developing medical therapies to tackle human aging. -
Longevity and Generosity. the Death of Death. July 2018. N° 112
Longevity and generosity. The death of death. July 2018. N° 112. Some people say, “Oh, you shouldn’t do enhancement” but the thing is we do enhancement all the time — to some extent, all aging reversal is enhancement. Vaccines are enhancement… I think I’m just now getting up to speed after 63 years of education. Aging reversal is something that will buy me and many of my colleagues a lot more time to make many more contributions, so you might consider that a meta-level contribution, if we can pull that off. World-renowned Harvard University biology researcher George Church (source). Theme of the month. How to contribute financially to research for a much longer healthy life Introduction If you have considerable financial means you can afford medical care more easily than less well-off citizens. But whether you are rich or not, with a good "genetic capital" or not, whatever your precautions and your anti-aging clinic visits, in the current state of knowledge your chances are low of living more than 100 years if you are a woman and beyond 95 years if you are of the weaker sex for longevity. And whatever happens, you will not live past 122 years for a woman et 116 years for a man. To go further will require complex and costly research. If informed citizens pay money to support this research, it will be positive in a direct way by funding the research. It will also be positive in that it will show the growing interest in these issues. What could you do about it? Moderate financial support If your financial means are limited or if you do not wish to make large donations, your action can still have an impact. -
2 the Biology of Ageing
The biology of ageing 2 Aprimer JOAO˜ PEDRO DE MAGALHAES˜ OVERVIEW .......................................................... This chapter introduces key biological concepts of ageing. First, it defines ageing and presents the main features of human ageing, followed by a consideration of evolutionary models of ageing. Causes of variation in ageing (genetic and dietary) are reviewed, before examining biological theories of the causes of ageing. .......................................................... Introduction Thanks to technological progress in different areas, including biomed- ical breakthroughs in preventing and treating infectious diseases, longevity has been increasing dramatically for decades. The life expectancy at birth in the UK for boys and girls rose, respectively, from 45 and 49 years in 1901 to 75 and 80 in 1999 with similar fig- ures reported for other industrialized nations (see Chapter 1 for further discussion). A direct consequence is a steady increase in the propor- tion of people living to an age where their health and well-being are restricted by ageing. By the year 2050, it is estimated that the per- centage of people in the UK over the age of 65 will rise to over 25 per cent, compared to 14 per cent in 2004 (Smith, 2004). The greying of the population, discussed elsewhere (see Chapter 1), implies major medical and societal changes. Although ageing is no longer considered by health professionals as a direct cause of death (Hayflick, 1994), the major killers in industrialized nations are now age-related diseases like cancer, diseases of the heart and 22 Joao˜ Pedro de Magalhaes˜ neurodegenerative diseases. The study of the biological mechanisms of ageing is thus not merely a topic of scientific curiosity, but a crucial area of research throughout the twenty-first century. -
Ÿþc R Y O N I C S M a G a Z I N E , Q 1 2 0
2007 RECAP 1st Quarter 2008 • Volume 29:1 2007 ANnual Review page 5 Member Profile: Wes Du Charme page 3 7th Alcor Conference Recap page 13 Cryonics and Religion: Friends or Foes? page 19 INSIDE CRYONICS 2 From the Editor 1ST QUARTER 2008 • VOLUME 29:1 19 Cryonics and Religion: Friends or Foes? The cryonics community recognizes the importance and challenge of being 1st Quarter 2008 • Volume 29:1 understood by the general 2007 RECAP public. Religion plays a sub- Cover shows opening reception stantial role in our diverse at the 7th Alcor conference. 2007 ANnual society and may seem to Review Photo by Brian Harris. page 5 some to be at odds with many facets of scientific COVER STORY: PAGE 5 advancement. Meet one theologian who feels the 2007 Annual Review: Today, over ultimate success of cryonics 850page people 3 in the world rely on the is contingent upon the sup- Member Profile: Wes Du CharmeAlcor Life Extension Foundation for Recap port of more than just great Conferencecryopreservation page 13 services. Enrich your 7th Alcor scientific minds. understanding of present-day clinical advancements with the potential to CryonicsFriends and Religion: or Foes?page 19 significantly benefit Alcor’s growing 22 Book Review: Ending membership base in years to come. Aging Likened to a good detective novel, Ending Aging allures the reader into a real- life tale of the mysteries of aging. The author, Dr. 3 Member Profile: Wes Du Charme Aubrey de Grey, has been Wes Du Charme – psychologist, author and barber shop quartet the center of controversy singer – celebrates his thirteenth year as an Alcor member in since proposing a systematic June 2008. -
Blurring Our Edges
NATURE|Vol 450|15 November 2007 BOOKS & ARTS not involve passing on truths from producer rigorous understanding of whose technical between colour perceivers and colour-blind to consumer, but takes the form of fallible expertise really should weigh in on techno- participants, probably because the latter had judgements made in situations in which all logical decision-making. This is what Collins been immersed since birth in the language of the desired information is not available. This and Evans call the “problem of extension”, or colour and acquired the ability to pass as per- applies to scientific collaborations and gov- “who is entitled to contribute to the technical ceivers. In another, judges could not pick out ernmental projects. “The speed of politics,” component of a technological decision”. If an Collins in a group of bona fide gravitational- they write in a characteristically succinct and extension is too technocratic, it will foster dis- wave researchers. clever remark, “exceeds the speed of scientific trust; if it is too broad, there is a risk of invoking These results have startling implications. consensus formation.” This leads them to ‘technological populism’, which means deci- For instance, Evans has shown that minorities defend their seemingly pedestrian conclusion sions could be overly influenced by politics or can acquire enough interactional expertise of that governments should rely on experts as lifestyle choice. mainstream culture to foil attempts to pick “the best way to distil human experience of an The authors address the problem of exten- them out by questioning alone. This suggests uncertain world” — even when those experts sion by offering a “periodic table of expertise” that if minorities live by different values, it is have no final answers. -
SENS Research Foundation Annual Report 2015
S E N S R e s e a r c h F o u n d a t i o n has a unique mission: to ensure the development of cures which repair the underlying cellular and molecular damage of aging. This document, our 2 0 1 5 R e p o r t, demonstrates our commitment to delivering on the promise of that mission, and to meeting the challenges facing the rapidly emerging rejuvenation biotechnology field. Our research program delivers key proof-of-concept results. Our education program prepares the first generation of rejuvenation biotechnology professionals. Our outreach program widens and connects our communi. Our Rejuvenation Biotechnology conferences unite stakeholders from academic, industrial, political, regulatory and financial institutions. Together, we are transforming the way the world researches and treats age-related disease. i n t r o d u c t i o n 2 l e t t e r f r o m t h e C E O 3 c o m m u n i t y 4 o u t r e a c h 6 e d u c a t i o n 8 r e s e a r c h 1 0 f i n a n c e s 1 4 r e s e a r c h : p r o j e c t b y p r o j e c t 1 5 s u p p o r t i n g t h e f o u n d a t i o n 2 3 FOUNDATION BOARD OF LEADERSHIP DIRECTORS Mike Kope Barbara Logan Jonathan Cain Chief Executive Officer Board Chair Kevin Dewalt Kevin Perrott Dr. -
Why We Should Reject Radical Enhancement.1
A peer-reviewed electronic journal published by the Institute for Ethics and Emerging Technologies ISSN 1541-0099 21(2) - November 2010 Thoughts about our species’ future: themes from Humanity’s End: Why We Should Reject Radical Enhancement.1 Nicholas Agar Philosophy, Victoria University of Wellington [email protected] Journal of Evolution and Technology - Vol. 21 Issue 2 – November 2010 - pgs 23-31 http://jetpress.org/agar.htm Abstract This paper summarizes a couple of the main arguments from my new book, Humanity’s End. In the book I argue against radical enhancement – the adjustment of human attributes and abilities to levels that greatly exceed what is currently possible for human beings. I’m curious to see what reaction this elicits in a journal whose readership includes some of radical enhancement’s most imaginative and committed advocates. Humanity’s End is motivated by the conviction that the debate about human enhancement must move beyond the binary “yes, I love it; no, it’s evil” dialectic that has tended to dominate philosophical discussion up till now. When we focus on the multiple means – cybernetic, genetic, nanotechnological, and so on – by which humans are likely to be enhanced, we find significant moral differences. Some human enhancements should be endorsed; many should be rejected. An additional motivation for Humanity’s End is a sense that the technologies of human enhancement are on the verge of something really big. If Ray Kurzweil is right, then improvements of the information technologies that may be used to enhance human attributes track an exponential path (Kurzweil 2005). -
Do Actuaries Believe in Longevity Deceleration? Edouard Debonneuil, Stéphane Loisel, Frédéric Planchet
Do actuaries believe in longevity deceleration? Edouard Debonneuil, Stéphane Loisel, Frédéric Planchet To cite this version: Edouard Debonneuil, Stéphane Loisel, Frédéric Planchet. Do actuaries believe in longevity decelera- tion?. 2015. hal-01219270v2 HAL Id: hal-01219270 https://hal.archives-ouvertes.fr/hal-01219270v2 Preprint submitted on 5 Aug 2017 HAL is a multi-disciplinary open access L’archive ouverte pluridisciplinaire HAL, est archive for the deposit and dissemination of sci- destinée au dépôt et à la diffusion de documents entific research documents, whether they are pub- scientifiques de niveau recherche, publiés ou non, lished or not. The documents may come from émanant des établissements d’enseignement et de teaching and research institutions in France or recherche français ou étrangers, des laboratoires abroad, or from public or private research centers. publics ou privés. DO ACTUARIES BELIEVE IN LONGEVITY DECELERATION? Edouard Debonneuil Stéphane Loisel Frédéric Planchet* Univ Lyon - Université Claude Bernard Lyon 1, ISFA, Laboratoire SAF EA2429, F-69366, Lyon, France Prim’Act, 42 avenue de la Grande Armée, 75017 Paris, France ActuRx Version 2.0 du 05/08/2017 ABSTRACT As more and more people believe that significant life extensions may come soon, should commonly used future mortality assumptions be considered prudent? We find here that commonly used actuarial tables for annuitants – as well as the Lee-Carter model – do not extrapolate life expectancy at the same rate for future years as for past years; instead they produce some longevity deceleration. This is typically because their mortality improvements decrease after a certain age, and those age-specific improvements are constant over time.