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2021

CARDIOVASCULAR RESEARCH SCHOLARSHIP PROGRAM

- THE 24TH TRANS-PACIFIC RESEARCH OPPORTUNITY -

Stanford University

The Cardiovascular Division at Stanford University features diverse faculty and provides opportunities for research in many cardiovascular . Stanford’s Center for Cardiovascular Technology (CCVT) facilities include animal laboratories, device development programs, and participation in multi-center trials, which are supported by Core Angiographic and Laboratories. Visiting Scholars to Stanford’s CCVT represent many countries and a variety of research disciplines, resulting in a stimulating and productive research environment.

URL: http://med.stanford.edu/ccvt

Stanford Scholarship Program Oce c/o: Abbott Medical Japan LLC, VASCULAR Div. Attention: Stanford Scholarship Program TEL: 03-4560-0780 FAX: 03-4560-0781 E-mail: [email protected] Address: Sumitomo Fudosan Mita Twin Building West 3-5-27 Mita, Minato, Tokyo, 108-6304, Japan URL: www.cardiovascular.abbott/jp/ja/hcp/resources/ education-training/stanford.html

* Abbott Medical Japan LLC, as a management representative, will jointly use the personal information disclosed in your application form with Stanford University Medical Center in the selection process for this study program and the enrollment procedures to Stanford University Medical Center.

© 2020 Abbott. All rights reserved. (APJ00000928-JPN-Rev.A) MEDICINE

Stanford Center for Cardiovascular Technology

Stanford University School of Medicine

Introduction Stanford Center for Cardiovascular Technology

Stanford University School of Medicine

The Stanford Center for Cardiovascular Technology, formally known as the Center for Research in Cardiovascular Interventions founded at Stanford in 1994, is a core facility for development and testing of new devices in cardiovascular medicine. The Center focuses on early-stage concepts for new technologies, providing a clearinghouse where these ideas can be refined and tested in animal models and clinical studies.

Dr. Peter Fitzgerald is Director of the Center for Cardiovascular Technology (CCVT) and the Cardiovascular Core Analysis Laboratory (CCAL) at Stanford University. He has a PhD in Engineering and is an interventional cardiologist. Dr. Fitzgerald, with Dr. Paul Yock, has pioneered the efforts in catheter-based ultrasound for the past two decades. Presently, Dr. Fitzgerald supervises 12 postdoctoral fellows and has served as the Principal Investigator for over 110 clinical trials involving intravascular ultrasound.

Dr. Fitzgerald has a joint appointment in the School of Medicine and Engineering. His research is focused on signal and image processing of intravascular ultrasound for plaque characterization and advanced engineering developments in signal processing and Peter Fitzgerald, MD, PhD, FACC Professor of Medicine & Engneering catheter device development. In addition, Dr. Fitzgerald serves as Director, Stanford Center for a consultant and medical/advisory board member for a number of Cardiovascular Technology biomedical device and e-health companies in and around the San Francisco Bay Area.

Dr. Paul Yock is the Martha Meier Weiland Professor of Medicine and Mechanical Engineering and Co-Chair of Department of Bioengineering. He also directs the Program in Biodesign, a unit of Stanford’s new Bio-X initiative that focuses on invention and technology transfer related to biomedical engineering. Dr. Yock is known for his work in inventing, developing and testing new devices, including the Rapid Exchange™ balloon angioplasty system, and Doppler-guided access system known as the Smart Needle™ and PD-Access™. He also authored the fundamental patents for intravascular ultrasound imaging and conducted the initial clinical trials. In 1986, he founded Cardiovascular Imaging Systems, which was acquired by Boston Scientific in 1994. He has authored over 40 US patents, 300 peer-reviewed publications, chapters and editorials, and textbooks. Paul Yock, MD, FACC Martha Meier Weiland Professor of Current research interests include development and testing of Medicine & Bioengineering catheter-based delivery systems for cardiac cell transplantation and Director, Program in Biodesign new catheter and molecular imaging techniques for cardiology.

2 Dr. Tomoaki Hinohara is Director of Cardiac Catheterization Laboratory at Sequoia Hospital. He is well known as one of the leading interventional cardiologists worldwide. He started his career at Montreal General Hospital in Canada in 1976 after he received his M.D. from Keio University School of Medicine in Japan. He experienced clinical and research programs at Duke University Medical Center in North Carolina from 1982 to 1988.

Dr. Hinohara has dedicated to the development of new technology, such as debulking, CTO, vascular closure devices and endovascular temperature management system for hypothermia treatment. He also participates in several international multicenter clinical trials to evaluate safety and efficacy of new devices. Dr. Hinohara has contributed his energy to universalize those Tomoaki Hinohara, MD, FACC Director, Cardiac cutting-edge technologies through the educational program Catheterization Laboratory, especially for the Japanese Interventional Cardiology Society. Sequoia Hospital

Dr. Yasuhiro Honda is Professor of Medicine and a faculty member of the Center for Cardiovascular Technology at Stanford University School of Medicine. He received his M.D. from Kyoto University Faculty of Medicine, Kyoto, Japan in 1990 and was trained in , , , and cardiovasclar medicine at Kobe General Hospital, Kobe, Japan. After completing cardiology training in 1995, he joined Stanford University as a postdoctoral fellow of the Division of Cardiovascular Medicine. Since 2018, he has been serving as Director of the CCAL at Stanford University.

Dr. Honda now supervises interpretation and quantitative analysis of advanced cardiovascular diagnostics, including IVUS, OCT, intravascular spectroscopy (NIRS) and MR/CT angiography, for Yasuhiro Honda, MD, FACC, FAHA pre-clinical and large-scale multicenter trials. He also serves as a Clinical Professor of Medicine faculty member of Stanford Center for Artificial Intelligence (AI) Director, Stanford CCAL in Medicine and Imaging, established in 2018 for the development, evaluation and dissemination of new machine learning and other AI techniques applied across the medical imaging life cycle. Dr. Honda was the model for the Stanford Scholarship Program as it exists today.

3 Stanford Cardiovascular Research Fellows

Dr. Takehiro Hashikata graduated from Kitasato University School of Medicine in 2009. After completing 2 years of junior residency program at Kitasato University Hospital, he worked as a cardiologist at Toshiba Rinkan Hospital. In 2012, he enrolled in Kitasato University Graduate School of Medicine. After receiving the PhD degree of Medical Science, he worked at NTT Medical Center Tokyo as a cardiovascular interventionist for 3 years, then he acquired fundamental skills of PCI and EVT accompanied with experiences of intravascular imaging systems. He joined the Cardiovascular Core Analysis Laboratory at Stanford University as the 19th recipient of the Stanford Scholarship Program. His clinical research interests include preventive medicine, especially diabetes mellitus and dyslipidemia, and endothelial function for cardiovascular disease.

Dr. Kuninobu Kashiyama graduated from University of Occupational and Environmental Health (UOEH) School of Medicine in 2006. After completing post-graduate clinical training at UOEH and its affiliated hospitals, he worked as a staff cardiologist at Kitakyushu Municipal Yahata Hospital for 2 years. In 2010, he returned to UOEH hospital as a senior resident of cardiovascular medicine where he was engaged in research on atherosclerosis in CKD patients. After receiving the degree of Doctor of Medical Science at UOEH in 2015, he served as an industrial for 2 years. Dr. Kashiyama then joined the Cardiovascular Core Analysis Laboratory at Stanford University as the 2018 recipient of the Stanford-Abbott Scholarship Program. His research interests include preventive medicine and characterization of atherosclerosis using intravascular imaging.

Dr. Shinji Imura graduated from Shiga University School of Medicine in 2010. He completed his residency training in internal medicine at Sakai City Medical Center in 2012, followed by a training at Hyogo Prefecture Amagasaki General Medical Center as a senior resident of cardiovascular medicine. From 2015, he worked at Okamura Memorial Hospital as an interventional cardiologist. Dr. Imura then joined the Cardiovascular Core Analysis Laboratory at Stanford University as the 2018 recipient of the Stanford-Abbott Scholarship Program. His research interests include the evaluation and treatment of vascular calcification. He is also interested in medical applications of Artificial Intelligence technologies.

4 Dr. Masayasu Ikutomi graduated from Chiba University School of Medicine in 2004. After 2 years of rotational internship, he was trained as a senior resident of cardiovascular medicine at NTT Medical Center Tokyo. In 2009, he enrolled in University of Tokyo Graduate School of Medicine, and did research on regeneration for atherosclerosis. After receiving the PhD degree of Medical Science, he worked at the Department of Cardiology in Teikyo University Chiba Medical Center as a cardiovascular interventionist. During these periods, he acquired many skills of PCI and various other catheter interventions. He then joined the Cardiovascular Core Analysis Laboratory at Stanford University as the 2016 recipient of the Stanford Scholarship Program. His research interests include the mechanical properties of coronary stents and characterization of atherosclerosis using multimodality intravascular imaging.

Dr. Kojiro Miki graduated from Hyogo College of Medicine in 2007. After completing post-graduate clinical training at Hyogo College of Medicine and its affiliated hospitals, he was appointed Research Associate at Hyogo College of Medicine in 2012. Following interventional cardiology training and clinical research in intravascular imaging, he received the degree of Doctor of Medical Science at Hyogo College of Medicine in March 2015. He then joined the Cardiovascular Core Analysis Laboratory at Stanford University as the 17th recipient of the Stanford Scholarship Program in June 2015. His research interests include vascular response after interventional therapy for the coronary artery and the peripheral artery disease.

Dr. Kozo Okada graduated from Yokohama City University School of Medicine in 2003. After completing 2 years of junior residency program at Yokohama City University, he worked as a staff cardiologist at University of Health and Welfare Atami Hospital, Saiseikai Yokohama City Nanbu Hospital, and Yokohama City University Medical Center. Dr. Okada then joined the Center for Cardiovascular Technology at Stanford University as the 16th recipient of the Stanford Scholarship Program in June 2013. His research interests include preventive medicine, especially metabolic disorders (hyperlipidemia, dysglycemia, obesity, etc.) and lifestyle modifications in association with cardiovascular disease.

5 Dr. Kyuhachi Otagiri graduated from Nihon University School of Medicine in 1999. He received his clinical training in internal medicine, cardiovascular medicine and interventional cardiology at Shinshu University Hospital, Azumi General Hospital and Joetsu General Hospital. In 2010, he received the degree of Doctor of Medical Science at Shinshu University Graduate School of Medicine. Dr. Otagiri then joined the Cardiovascular Core Analysis Laboratory at Stanford University as the 15th recipient of the Stanford Scholarship Program in 2012. His research interests include the mechanisms of plaque vulnerability and in- stent restenosis stratified by plaque components classified using multimodality intravascular imaging, such as IVUS and OCT with advanced tissue characterization techniques.

Dr. Hideki Kitahara graduated from Chiba University School of Medicine in 2002. After 2 years of clinical training in internal medicine at Chiba University Hospital and Narita Red Cross Hospital, he worked at Chiba Emergency Medical Center and Tobu Chiiki Hospital as a senior resident of cardiovascular medicine. In 2010, he received the degree of Doctor of Medical Science at Chiba University Graduate School of Medicine. Dr. Kitahara then joined the Center for Cardiovascular Technology at Stanford University as the 14th recipient of the Stanford Scholarship Program in June 2011. His research interests include intracoronary imaging and evaluation of vascular response to drug-eluting stents or new therapeutic devices for coronary artery disease.

Dr. Kenji Sakamoto graduated from Ehime University School of Medicine in 1999. After 2 years of residency program in cardiology and internal medicine at Kumamoto University and its affiliated hospitals, he worked at Kumamoto Red Cross Hospital and Miyazaki Prefectural Nobeoka Hospital as a senior resident of interventional cardiology and emergency department. In 2007, he received the degree of Doctor of Medical Sciences from Kumamoto University Graduate School. He was appointed Assistant Professor at Kumamoto University in 2008, and worked as the chief of the cardiovascular ward of Kumamoto University Hospital. He then joined the Center for Cardiovascular Technology at Stanford University as the 13rd recipient of the Stanford Scholarship Program in 2010. His research interests include the mechanism of vessel remodeling and in–stent restenosis.

6 Dr. Osami Kawarada graduated from Hiroshima University School of Medicine in 1997. After completing post- graduate clinical training at Kishiwada Tokushukai Hospital, he joined the Department of Cardiology at the same hospital where he was trained as an interventional cardiologist, involved in a variety of coronary and peripheral vascular interventions. He had been appointed Assistant Director of the Department of Cardiology since 2006 and Director of the Limb Salvage Center since 2008. He then joined the Stanford Center for Cardiovascular Technology as the 12th recipient of the Stanford Scholarship Program in June 2009. His research interests include a wide range of subjects including critical limb ischemia, infrapopliteal intervention, femoropopliteal intervention, chronic total occlusion, debulking, vascular imaging, acute stroke intervention, prevention of distal embolization in peripheral vasculature, and the relationship between cardiac function and renal artery stenosis.

Dr. Kenji Sakata graduated from Iwate Medical University School of Medicine in 1997. After completing his post-graduate clinical training in cardiology, emergency medicine and internal medicine at Kanazawa University and its affiliated hospitals, he received the degree of Doctor of Medical Science at Kanazawa University Graduate School of Medicine in 2004. Following interventional cardiology training and IVUS research experience at Ishikawa Prefectural Central Hospital, he was appointed Assistant Professor at Kanazawa University in 2007. The following year, he joined the Center for Cardiovascular Technology at Stanford University as the 11th recipient of the Stanford Scholarship Program. His research interests include the mechanism of drug-eluting stent restenosis, and the tissue characterization of vulnerable plaque with IVUS and novel diagnostic devices.

Dr. Hiromasa Otake graduated from Kobe University School of Medicine in 1999. After 3 years of clinical training in internal medicine, he worked at Himeji Cardiovascular Center (currently, Hyogo Brain and Heart Center) as a senior resident of cardiovascular medicine. In 2007, he received the degree of Doctor of Medical Science at Kobe University. He then joined the Center for Research in Cardiovascular Interventions at Stanford University as the 10th recipient of the Stanford Scholarship Program in June 2007. His research interests include cardiovascular imaging and new therapeutic devices that are useful to gain the optimal results in treating patients with coronary artery diseases.

7 Dr. Takao Shimohama graduated from Kitasato University School of Medicine in 1996. After completing the residency program of the Department of Internal Medicine at Kitasato University Hospital, he entered Kitasato University Graduate School of Medicine to research on coronary artery disease. In 2002, he was awarded the Doctor of Medical Science for his graduation thesis on the changes of Na+/H+ exchanger 1 mRNA and protein using myocardial infarction rat. During this period, he also learned skills of PCI and IVUS, followed by additional 4-year- experience as an interventional cardiologist at the Shimizu Kousei Hospital and the Cardiovascular Center in Kitasato University Hospital. In 2006, he was selected as a 9th recipient of the Stanford Scholarship Program, and his main research interests were the mechanisms of in-stent restenosis and plaque characterization by IVUS imaging.

Dr. Ichizo Tsujino graduated from Hokkaido University School of Medicine in 1992. He received his clinical training in internal medicine, cardiovascular medicine and interventional cardiology primarily at First Department of Medicine of Hokkaido University Hospital and at Hokkaido Social Insurance Hospital. In 2002, he received the degree of Doctor of Medical Science at Hokkaido University. He then joined the Center for Research in Cardiovascular Interventions at Stanford University as the 8th recipient of the Stanford Scholarship Program in July 2005. His research interests included the role of IVUS and other current imaging devices in field of the interventional cardiology, as well as the basic mechanisms of atherosclerosis particularly provoked by diabetes mellitus.

Dr. Akiyoshi Miyazawa graduated from Yamanashi Medical University in 1998. He trained in internal medicine at the Tokyo University Hospital and the Omiya Red-Cross Hospital. After his training in internal medicine, he worked at the Mitsui Memorial Hospital as resident of cardiovascular medicine. He joined Center for Research in Cardiovascular interventions in June 2004 as 7th postdoctoral fellow supported by the Stanford Scholarship Program. He was interested in atherosclerosis, mechanisms of coronary artery disease progression and improvement of medical treatment in interventional cardiology.

8 Dr. Tomomi Koizumi received his M.D. from Yamaguchi University School of Medicine, Japan in 1993. He completed post-graduate clinical training at Tsukuba University Hospital and its related hospitals in Japan. He entered Chiba University Graduate School of Medicine, Japan in 1998 and received his Ph.D. in 2002. After working at the Center for Cardiovascular Interventions in Chiba University Hospital for over a year, he joined the Center for Research in Cardiovascular Interventions at Stanford University in June 2003, as the 6th postdoctoral fellow supported by the Stanford Scholarship Program. His research interests included qualitative evaluation of intravascular ultrasound images and new device development in the field of interventional cardiology.

After several years' clinical training in Japan, Dr. Ryota Sakurai joined the Center for Research in Cardiovascular Interventions at Stanford University in June 2002, as the 5th postdoctoral fellow supported by the Stanford Scholarship Program. He concerned himself in several angiographic and intravascular ultrasound analyses of clinical trials involving drug- eluting stents. His researches were mainly focused on investigating the mechanisms of coronary artery diseases including restenosis in order to establish the optimal methods in treatment of ischemic heart disease in the real world. Besides these researches, he was interested in inventing new medical devices with regard to not only coronary interventions but also all other heart diseases.

Dr. Yoichiro Hongo graduated from Yokohama City University School of Medicine in 1988. After 5 years of clinical training in internal medicine, emergency medicine and cardiology, he worked at the National Cardiovascular Center in Japan for 3 years as a clinical resident, where he learned about IVUS under the guidance of Dr. Masakazu Yamagishi. After 5 years of experience as an emergency and interventional cardiologist, he was selected as the 4th Stanford Scholarship Program recipient in 2001. His main research interests included the development of new coronary diagnostic/therapeutic devices and the investigation of mechanisms involved in coronary artery disease progression.

9 Dr. Mamoo Nakamura received his M.D. from Mie University School of Medicine, Japan in 1993. After completion of the 2-years medical residency at Okinawa Chubu Hospital and the training of cardiovascular medicine at Mie University Hospital, he started working as an interventional cardiology fellow at Yamada Red-Cross Hospital. He also graduated Mie University Graduate School of Medicine and received a degree of Doctor of Medical Science in 1999. In July 2000, Dr. Nakamura joined the Center for Research in Cardiovascular interventions as a postdoctoral fellow supported by a Cardiovascular Research Scholarship of Stanford Scholarship Program. After dedicating to the IVUS analysis of pivotal drug-eluting stent trials as well as the pre-clinical evaluation of interventional devices in Stanford, Dr. Nakamura decided to join medical residency program in University of Pittsburgh and currently, is actively involved in patient care in the US.

Dr. Yoshihiro Morino received his M.D. from Gifu University School of Medicine, Japan in 1993. In 1998 he completed his residency in Medicine and a cardiovascular fellowship at the Mitsui Memorial Hospital, Tokyo, Japan. He had the distinction of being the 2th Stanford Scholarship Program recipient. He worked as a postdoctoral fellow at the Center for Research in Cardiovascular Interventions at Stanford Medical Center for 3 years. The focus of his research was the role of intravascular ultrasound for catheter- based brachytherapy, drug-eluting stent, and tissue characterization of vulnerable plaque. Currently, he works at Division of Cardiology in Iwate Medical University.

Dr. Kiyoshi Hibi worked as a postdoctoral fellow at the Center for Research in Cardiovascular Interventions, Stanford University from 1998 to June 2000. He graduated from Yokohama City University School of Medicine in 1992 and completed post- graduate clinical training there. He also entered Postgraduate School in 1995 and received his Doctor of Medical Science in 1998 researching "angiotensin converting enzyme gene polymorphism". He was the first Stanford Scholarship Program recipient in 1998. His main research projects included a validation study of the Blood Noise Reduction System in ultrasound imaging, investigation of the mechanism of vascular remodeling and debulking strategies prior to stenting.

10 Stanford Center for Cardiovascular Technology

Bibliography 2000-2020 CCVT Bibliography 2000-2020

Peer-Reviewed Journals

1. Fearon WF, Takagi A, Jeremias A, Yeung AC, Joye JD, Cohen DJ, Chou TM, Kern MJ and Yock PG. Use of fractional myocardial flow reserve to assess the functional significance of intermediate coronary stenoses. Am J Cardiol. 2000;86:1013-4. 2. Filardo SD, Schwarzacher SP, Lo ST, Herity NA, Lee DP, Huegel H, Mullen WL, Fitzgerald PJ, Ward MR and Yeung AC. Acute myocardial infarction and vascular remodeling. Am J Cardiol. 2000;85:760-2, A8. 3. Fitzgerald PJ, Oshima A, Hayase M, Metz JA, Bailey SR, Baim DS, Cleman MW, Deutsch E, Diver DJ, Leon MB, Moses JW, Oesterle SN, Overlie PA, Pepine CJ, Safian RD, Shani J, Simonton CA, Smalling RW, Teirstein PS, Zidar JP, Yeung AC, Kuntz RE and Yock PG. Final results of the Can Routine Ultrasound Influence Stent Expansion (CRUISE) study. Circulation. 2000;102:523-30. 4. Gilutz H, Russo RJ, Tsameret I, Fitzgerald PJ and Yock PG. Comparison of coronary stent expansion by intravascular ultrasonic imaging in younger versus older patients with diabetes mellitus. Am J Cardiol. 2000;85:559-62. 5. Herity NA, Lo ST, Oei F, Lee DP, Ward MR, Filardo SD, Hassan A, Suzuki T, Rezaee M, Carter AJ, Yock PG, Yeung AC and Fitzgerald PJ. Selective regional myocardial infiltration by the percutaneous coronary venous route: A novel technique for local drug delivery. Catheter Cardiovasc Interv. 2000;51:358-63. 6. Hibi K, Takagi A, Zhang X, Teo TJ, Bonneau HN, Yock PG and Fitzgerald PJ. Feasibility of a novel blood noise reduction algorithm to enhance reproducibility of ultra-high-frequency intravascular ultrasound images. Circulation. 2000;102:1657-63. 7. Holmes D, Fitzgerald P, Goldberg S, LaBlanche J, Lincoff AM, Savage M, Serruys PW, Willerson J, Granett JR, Chan R, Shusterman NH and Poland M. The PRESTO (Prevention of restenosis with tranilast and its outcomes) protocol: a double-blind, placebo-controlled trial. Am Heart J. 2000;139:23-31. 8. Ikonen TS, Briffa N, Gummert JF, Honda Y, Hayase M, Hausen B, Billingham ME, Yock PG, Robbins RC and Morris RE. Multidimensional assessment of graft vascular disease (GVD) in aortic grafts by serial intravascular ultrasound in rhesus monkeys. Transplantation. 2000;70:420-9. 9. Ikonen TS, Gummert JF, Hayase M, Honda Y, Hausen B, Christians U, Berry GJ, Yock PG and Morris RE. Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primates. Transplantation. 2000;70:969-75. 10. Ikonen TS, Gummert JF, Serkova N, Hayase M, Honda Y, Kobayase Y, Hausen B, Yock PG, Christians U and Morris RE. Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in non-human primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening. Transpl Int. 2000;13:S314- 20. 11. Jeremias A, Filardo SD, Whitbourn RJ, Kernoff RS, Yeung AC, Fitzgerald PJ and Yock PG. Effects of intravenous and intracoronary adenosine 5'-triphosphate as compared with adenosine on coronary flow and pressure dynamics. Circulation. 2000;101:318-23. 12. Jeremias A, Huegel H, Lee DP, Hassan A, Wolf A, Yeung AC, Yock PG and Fitzgerald PJ. Spatial orientation of atherosclerotic plaque in non-branching coronary artery segments. Atherosclerosis. 2000;152:209-15. 13. Jeremias A, Spies C, Herity NA, Pomerantsev E, Yock PG, Fitzgerald PJ and Yeung AC. Coronary artery compliance and adaptive vessel remodelling in patients with stable and unstable coronary artery disease. Heart. 2000;84:314-9. 14. Jeremias A, Whitbourn RJ, Filardo SD, Fitzgerald PJ, Cohen DJ, Tuzcu EM, Anderson WD, Abizaid AA, Mintz GS, Yeung AC, Kern MJ and Yock PG. Adequacy of intracoronary versus intravenous adenosine-induced maximal coronary hyperemia for fractional flow reserve measurements. Am Heart J. 2000;140:651-7. 15. Komiyama N, Berry GJ, Kolz ML, Oshima A, Metz JA, Preuss P, Brisken AF, Pauliina Moore M, Yock PG and Fitzgerald PJ. Tissue characterization of atherosclerotic plaques by intravascular ultrasound radiofrequency signal analysis: An in vitro study of human coronary arteries. Am Heart J. 2000;140:565-74. 16. Maehara A and Fitzgerald PJ. Coronary calcification: assessment by intravascular ultrasound imaging. Z Kardiol. 2000;89:112-6. 17. Maehara A, Takagi A, Okura H, Hassan AH, Bonneau HN, Honda Y, Yock PG and Fitzgerald PJ. Longitudinal plaque redistribution during stent expansion. Am J Cardiol. 2000;86:1069-72.

12 18. Pijls NH, Kern MJ, Yock PG and De Bruyne B. Practice and potential pitfalls of coronary pressure measurement. Catheter Cardiovasc Interv. 2000;49:1-16. 19. Raizner AE, Oesterle SN, Waksman R, Serruys PW, Colombo A, Lim YL, Yeung AC, van der Giessen WJ, Vandertie L, Chiu JK, White LR, Fitzgerald PJ, Kaluza GL and Ali NM. Inhibition of restenosis with beta-emitting radiotherapy: Report of the Proliferation Reduction with Vascular Energy Trial (PREVENT). Circulation. 2000;102:951-8. 20. Rockson SG, Kramer P, Razavi M, Szuba A, Filardo S, Fitzgerald P, Cooke JP, Yousuf S, DeVault AR, Renschler MF and Adelman DC. Photoangioplasty for human peripheral atherosclerosis : results of a phase I trial of photodynamic therapy with motexafin lutetium (Antrin). Circulation. 2000;102:2322-2324. 21. Schwarzacher SP, Uren NG, Ward MR, Schwarzkopf A, Giannetti N, Hunt S, Fitzgerald PJ, Oesterle SN and Yeung AC. Determinants of coronary remodeling in transplant coronary disease: a simultaneous intravascular ultrasound and Doppler flow study. Circulation. 2000;101:1384-9. 22. Takagi A, Hibi K, Zhang X, Teo TJ, Bonneau HN, Yock PG and Fitzgerald PJ. Automated contour detection for high- frequency intravascular ultrasound imaging: a technique with blood noise reduction for edge enhancement. Ultrasound Med Biol. 2000;26:1033-41. 23. Takagi T, Akasaka T, Yamamuro A, Honda Y, Hozumi T, Morioka S and Yoshida K. Troglitazone reduces neointimal tissue proliferation after coronary stent implantation in patients with non-insulin dependent diabetes mellitus: a serial intravascular ultrasound study. J Am Coll Cardiol. 2000;36:1529-35. 24. Takagi T, Yoshida K, Akasaka T, Kaji S, Kawamoto T, Honda Y, Yamamuro A, Hozumi T and Morioka S. Hyperinsulinemia during oral glucose tolerance test is associated with increased neointimal tissue proliferation after coronary stent implantation in nondiabetic patients: a serial intravascular ultrasound study. J Am Coll Cardiol. 2000;36:731-8. 25. Waksman R, White RL, Chan RC, Bass BG, Geirlach L, Mintz GS, Satler LF, Mehran R, Serruys PW, Lansky AJ, Fitzgerald P, Bhargava B, Kent KM, Pichard AD and Leon MB. Intracoronary gamma- after angioplasty inhibits recurrence in patients with in-stent restenosis. Circulation. 2000;101:2165-71. 26. Ward MR, Jeremias A, Huegel H, Fitzgerald PJ and Alan CY. Accentuated remodeling on the upstream side of atherosclerotic lesions. Am J Cardiol. 2000;85:523-526. 27. Baim DS, Flatley M, Caputo R, O'Shaughnessy C, Low R, Fanelli C, Popma J, Fitzgerald P and Kuntz R. Comparison of PRE-dilatation vs Direct stenting In Coronary Treatment using the Medtronic AVE S670 Coronary Stent System (the PREDICT trial). Am J Cardiol. 2001;88:1364-1369. 28. de La Fuente LM, Miano J, Mrad J, Penaloza E, Yeung AC, Eury R, Froix M, Fitzgerald PJ and Stertzer SH. Initial results of the Quanam drug eluting stent (QuaDS-QP-2) registry (BARDDS) in human subjects. Catheter Cardiovasc Interv. 2001;53:480-8. 29. Fearon WF, Luna J, Samady H, Powers ER, Feldman T, Dib N, Tuzcu EM, Cleman MW, Chou TM, Cohen DJ, Ragosta M, Takagi A, Jeremias A, Fitzgerald PJ, Yeung AC, Kern MJ and Yock PG. Fractional flow reserve compared with intravascular ultrasound guidance for optimizing stent deployment. Circulation. 2001;104:1917-22. 30. Fitzgerald PJ, Takagi A, Moore MP, Hayase M, Kolodgie FD, Corl D, Nassi M, Virmani R and Yock PG. Intravascular sonotherapy decreases neointimal hyperplasia after stent implantation in swine. Circulation. 2001;103:1828-31. 31. Han RO, Schwartz RS, Kobayashi Y, Wilson SH, Mann JT, Sketch MH, Safian RD, Lansky A, Popma J, Fitzgerald PJ, Palacios IF, Chazin-Caldie M and Goldberg S. Comparison of self-expanding and balloon-expandable stents for the reduction of restenosis. Am J Cardiol. 2001;88:253-9. 32. Hayase M, Woodbum KW, Perlroth J, Miller RA, Baumgardner W, Yock PG and Yeung A. Photoangioplasty with local motexafin lutetium delivery reduces macrophages in a rabbit post-balloon injury model. Cardiovasc Res. 2001;49:449-55. 33. Honda Y and Fitzgerald PJ. The renaissance of directional coronary atherectomy: a second look from the inside. J Invasive Cardiol. 2001;13:748-51. 34. Honda Y, Grube E, de La Fuente LM, Yock PG, Stertzer SH and Fitzgerald PJ. Novel drug-delivery stent: intravascular ultrasound observations from the first human experience with the QP2-eluting polymer stent system. Circulation. 2001;104:380-3. 35. Hur SH, Kitamura K, Morino Y, Honda Y, Jones M, Korr KS, Reen B, Cooper CJ, Niess GS, Christie L, Corey W, Messenger J, Yock PG, Cummins F and Fitzgerald PJ. Efficacy of postdeployment balloon dilatation for current generation stents as assessed by intravascular ultrasound. Am J Cardiol. 2001;88:1114-9. 36. Jeremias A, Spies C, Herity NA, Ward MR, Pomerantsev E, Yock PG, Fitzgerald PJ and Yeung AC. Coronary artery distensibility and compensatory vessel enlargement--a novel parameter influencing vascular remodeling? Basic Res Cardiol. 2001;96:506-12.

13 37. Kobayashi Y, Honda Y, Christie GL, Teirstein PS, Bailey SR, Brown CL, 3rd, Matthews RV, De Franco AC, Schwartz RS, Goldberg S, Popma JJ, Yock PG and Fitzgerald PJ. Long-term vessel response to a self-expanding coronary stent: a serial volumetric intravascular ultrasound analysis from the ASSURE Trial.A Stent vs. Stent Ultrasound Remodeling Evaluation. J Am Coll Cardiol. 2001;37:1329-34. 38. Limpijankit T, Honda Y, Mehran R, Waksman R, Lansky AJ, Mintz GS, Yock PG and Fitzgerald PJ. The effect of intracoronary gamma-radiation therapy for in-stent restenosis: an intravascular ultrasound study. Cardiovasc Radiat Med. 2001;2:54. 39. Luna Guerra J and Lopez Jimenez F. Intravascular treatment with ionizing radiation for the prevention of coronary restenosis: a new story involving a well-known character. Rev Invest Clin. 2001;53:206-8. 40. Mintz GS, Nissen SE, Anderson WD, Bailey SR, Erbel R, Fitzgerald PJ, Pinto FJ, Rosenfield K, Siegel RJ, Tuzcu EM and Yock PG. American College of Cardiology Clinical Expert Consensus Document on Standards for Acquisition, Measurement and Reporting of Intravascular Ultrasound Studies (IVUS). A report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents. J Am Coll Cardiol. 2001;37:1478-92. 41. Mintz GS, Weissman NJ and Fitzgerald PJ. Intravascular ultrasound assessment of the mechanisms and results of brachytherapy. Circulation. 2001;104:1320-5. 42. Morino Y, Honda Y, Okura H, Oshima A, Hayase M, Bonneau HN, Kuntz RE, Yock PG and Fitzgerald PJ. An optimal diagnostic threshold for minimal stent area to predict target lesion revascularization following stent implantation in native coronary lesions. Am J Cardiol. 2001;88:301-3. 43. Morino Y, Okura H, Bonneau HN and Fitzgerald PJ. Vascular brachytherapy: what have we learned from intravascular ultrasound? J Invasive Cardiol. 2001;13:409-16. 44. Nakamura M, Yock PG, Bonneau HN, Kitamura K, Aizawa T, Tamai H, Fitzgerald PJ and Honda Y. Impact of peri- stent remodeling on restenosis: a volumetric intravascular ultrasound study. Circulation. 2001;103:2130-2. 45. Nissen SE and Yock P. Intravascular ultrasound: novel pathophysiological insights and current clinical applications. Circulation. 2001;103:604-16. 46. Okura H, Hayase M, Shimodozono S, Bonneau HN, Yock PG and Fitzgerald PJ. Impact of pre-interventional arterial remodeling on subsequent vessel behavior after balloon angioplasty: a serial intravascular ultrasound study. J Am Coll Cardiol. 2001;38:2001-2005. 47. Okura H, Lee DP, Yeung AC, Oesterle SN, Waksman R, Kaluza GL, Ali NM, Yock PG, Raizner AE and Fitzgerald PJ. Impact of plaque burden on subsequent intimal proliferation and remodeling of the stented coronary arteries following intracoronary beta-radiation therapy. Cardiovasc Radiat Med. 2001;2:57. 48. Okura H, Morino Y, Oshima A, Hayase M, Ward MR, Popma JJ, Kuntz RE, Bonneau HN, Yock PG and Fitzgerald PJ. Preintervention arterial remodeling affects clinical outcome following stenting: an intravascular ultrasound study. J Am Coll Cardiol. 2001;37:1031-5. 49. Ward MR, Jeremias A, Hibi K, Herity NA, Lo ST, Filardo SD, Lee DP, Fitzgerald PJ and Yeung AC. The influence of plaque orientation (pericardial or myocardial) on coronary arterial remodeling. Atherosclerosis. 2001;154:179-83. 50. Ward MR, Smits P, Herity NA, Jeremias A, Fitzgerald PJ, Yeung AC, de Jaegere P, Serruys PW and Pasterkamp G. No relationship between compensatory arterial remodeling of focal stenotic atherosclerotic lesions and tortuosity of the arterial segment involved. Arterioscler Thromb Vasc Biol. 2001;21:1383. 51. Ward MR, Smits P, Herity NA, Jeremias A, Fitzgerald PJ, Yeung AC, de Jaegere P, Serruys PW and Pasterkamp G. Letter to the editor: no relationship between compensatory arterial remodeling of focal stenotic atherosclerotic lesions and tortuosity of the arterial segment involved. Arterioscler Thromb Vasc Biol. 2001;21:1383. 52. Courtney BK, Robertson AL, Maehara A, Luna J, Kitamura K, Morino Y, Achalu R, Kirti S, Yock PG and Fitzgerald PJ. Effects of transducer position on backscattered intensity in coronary arteries. Ultrasound Med Biol. 2002;28:81-91. 53. Grube E, Gerckens U, Buellesfeld L and Fitzgerald PJ. Images in cardiovascular medicine. Intracoronary imaging with optical coherence tomography: a new high-resolution technology providing striking visualization in the coronary artery. Circulation. 2002;106:2409-10. 54. Hibi K, Suzuki T, Honda Y, Hayase M, Bonneau HN, Yock PG, Yeung AC and Fitzgerald PJ. Quantitative and spatial relation of baseline atherosclerotic plaque burden and subsequent in-stent neointimal proliferation as determined by intravascular ultrasound. Am J Cardiol. 2002;90:1164-7. 55. Holmes DR, Jr., Savage M, LaBlanche JM, Grip L, Serruys PW, Fitzgerald P, Fischman D, Goldberg S, Brinker JA, Zeiher AM, Shapiro LM, Willerson J, Davis BR, Ferguson JJ, Popma J, King SB, 3rd, Lincoff AM, Tcheng JE, Chan R, Granett JR and Poland M. Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial. Circulation. 2002;106:1243-50.

14 56. Kaluza GL, Jenkins TP, Mourtada FA, Ali NM, Lee DP, Okura H, Fitzgerald PJ and Raizner AE. Targeting the adventitia with intracoronary beta-radiation: comparison of two dose prescriptions and the role of centering coronary arteries. Int J Radiat Oncol Biol Phys. 2002;52:184-91. 57. Kaneda H, Honda Y and Fitzgerald PJ. Combining a drug-eluting stent and platelet glycoprotein IIb/IIIa inhibition in a patient with acute coronary syndrome. J Invasive Cardiol. 2002;4. 58. Kataoka T, Grube E, Honda Y, Morino Y, Hur SH, Bonneau HN, Colombo A, Di Mario C, Guagliumi G, Hauptmann KE, Pitney MR, Lansky AJ, Stertzer SH, Yock PG and Fitzgerald PJ. 7-Hexanoyltaxol-Eluting Stent for Prevention of Neointimal Growth: An Intravascular Ultrasound Analysis From the Study to COmpare REstenosis rate between QueST and QuaDS-QP2 (SCORE). Circulation. 2002;106:1788-93. 59. Kataoka T, Honda Y, Bonneau HN, Yock PG and Fitzgerald PJ. New catheter-based technology for the treatment of restenosis. J Interv Cardiol. 2002;15:371-9. 60. Kuriyama N, Kobayashi Y, Kuroda N, Desai K, Yamamoto Y, Komiyama N, Komuro I and Fitzgerald PJ. Effect of coronary stent overexpansion on lumen size and intimal hyperplasia at follow-up. Am J Cardiol. 2002;89:1297-9. 61. Liao CK, Bonneau HN, Yock PG and Fitzgerald PJ. Arterial response during cutting balloon angioplasty: a volumetric intravascular ultrasound study. J Formos Med Assoc. 2002;101:756-61. 62. Morino Y, Kaneda H, Fox T, Takagi A, Hassan AH, Bonan R, Crocker I, Lansky AJ, Laskey WK, Suntharalingam M, Bonneau HN, Yock PG, Honda Y and Fitzgerald PJ. Delivered dose and vascular response after beta-radiation for in- stent restenosis: retrospective dosimetry and volumetric intravascular ultrasound analysis. Circulation. 2002;106:2334- 9. 63. Morino Y, Limpijankit T, Honda Y, Lansky AJ, Waksman R, Bonneau HN, Yock PG, Mintz GS and Fitzgerald PJ. Late vascular response to repeat stenting for in-stent restenosis with and without radiation: an intravascular ultrasound volumetric analysis. Circulation. 2002;105:2465-8. 64. Nakamura M, Fitzgerald PJ, Ikeno F, Honda Y, Sousa JE, Abizaid A, De Brito FS, Jr., Tofte A, Grube E, Patterson GR, Yock PG, Yeung AC and Carter AJ. Efficacy and feasibility of helixcision for debulking neointimal hyperplasia for in-stent restenosis. Catheter Cardiovasc Interv. 2002;57:460-6. 65. Okura H, Hayase M, Shimodozono S, Kobayashi T, Sano K, Matsushita T, Kondo T, Kijima M, Nishikawa H, Kurogane H, Aizawa T, Hosokawa H, Suzuki T, Yamaguchi T, Bonneau HN, Yock PG and Fitzgerald PJ. Mechanisms of acute lumen gain following cutting balloon angioplasty in calcified and noncalcified lesions: An intravascular ultrasound study. Catheter Cardiovasc Interv. 2002;57:429-36. 66. Okura H, Shimodozono S, Hayase M, Bonneau HN, Yock PG and Fitzgerald PJ. Impact of deep vessel wall injury and vessel stretching on subsequent arterial remodeling after balloon angioplasty: a serial intravascular ultrasound study. Am Heart J. 2002;144:323-8. 67. Stahr P, Voigtlander T, Rupprecht HJ, Aschenbrucker P, Mamtimin H, Brennecke R, Otto M, Fitzgerald PJ and Meyer J. Impact of vessel curvature on the accuracy of three-dimensional intravascular ultrasound: Validation by phantoms and coronary segments. J Am Soc Echocardiogr. 2002;15:823-30. 68. Stahr PM, Hofflinghaus T, Voigtlander T, Courtney BK, Victor A, Otto M, Yock PG, Brennecke R and Fitzgerald PJ. Discrimination of early/intermediate and advanced/complicated coronary plaque types by radiofrequency intravascular ultrasound analysis. Am J Cardiol. 2002;90:19-23. 69. Suzuki T, Hayase M, Hibi K, Hosokawa H, Yokoya K, Fitzgerald PJ, Yock PG, Cooke JP and Yeung AC. Effect of local delivery of L-arginine on in-stent restenosis in humans. Am J Cardiol. 2002;89:363-7. 70. Takagi T, Akasaka T, Yamamuro A, Honda Y, Hozumi T, Morioka S and Yoshida K. Impact of insulin resistance on neointimal tissue proliferation after coronary stent implantation. Intravascular ultrasound studies. J Diabetes Complications. 2002;16:50-5. 71. Takahashi T, Honda Y, Russo RJ and Fitzgerald PJ. Intravascular ultrasound and quantitative coronary angiography. Catheter Cardiovasc Interv. 2002;55:118-28. 72. Terashima M, Awano K, Honda Y, Yoshino N, Mori T, Fujita H, Ohashi Y, Seguchi O, Kobayashi K, Yamagishi M, Fitzgerald PJ, Yock PG and Maeda K. Images in cardiovascular medicine. "Arteries within the artery" after Kawasaki disease: a lotus root appearance by intravascular ultrasound. Circulation. 2002;106:887. 73. Uren NG, Schwarzacher SP, Metz JA, Lee DP, Honda Y, Yeung AC, Fitzgerald PJ and Yock PG. Predictors and outcomes of stent thrombosis. An intravascular ultrasound registry. Eur Heart J. 2002;23:124-32. 74. Ako J, Honda Y and Fitzgerald PJ. Tako-tsubo-like left ventricular dysfunction. Circulation. 2003;108:e158; author reply e158. 75. Ako M, Kawara T, Uchida S, Miyazaki S, Nishihara K, Mukai J, Hirao K, Ako J and Okubo Y. Correlation between electroencephalography and heart rate variability during sleep. Clin Neurosci. 2003;57:59-65.

15 76. Brodie BR, Cooper C, Jones M, Fitzgerald P and Cummins F. Is adjunctive balloon postdilatation necessary after coronary stent deployment? Final results from the POSTIT trial. Catheter Cardiovasc Interv. 2003;59:184-92. 77. Daida H, Ouchi Y, Saito Y, Yamada N, Nishide T, Mokuno H, Kurata T, Sato H, Eto M, Ako JY, Tango T and Yamaguchi H. Preventing angiographic progression of coronary atherosclerosis with pravastatin. J Atheroscler Thromb. 2003;10:25-31. 78. Dambrin C, Klupp J, Birsan T, Luna J, Suzuki T, Lam T, Stahr P, Hausen B, Christians U, Fitzgerald P, Berry G and Morris R. Sirolimus (rapamycin) monotherapy prevents graft vascular disease in nonhuman primate recipients of orthotopic aortic allografts. Circulation. 2003;107:2369-74. 79. Fearon WF, Balsam LB, Farouque HM, Robbins RC, Fitzgerald PJ, Yock PG and Yeung AC. Novel index for invasively assessing the coronary microcirculation. Circulation. 2003;107:3129-3132. 80. Fearon WF, Farouque HM, Balsam LB, Caffarelli AD, Cooke DT, Robbins RC, Fitzgerald PJ, Yeung AC and Yock PG. Comparison of coronary thermodilution and Doppler velocity for assessing coronary flow reserve. Circulation. 2003;108:2198-200. 81. Fearon WF, Nakamura M, Lee DP, Rezaee M, Vagelos RH, Hunt SA, Fitzgerald PJ, Yock PG and Yeung AC. Simultaneous Assessment of Fractional and Coronary Flow Reserves in Cardiac Transplant Recipients. Physiologic Investigation for Transplant Arteriopathy (PITA Study). Circulation. 2003. 82. Fearon WF and Yeung AC. Evaluating intermediate coronary lesions in the cardiac catheterization laboratory. Rev Cardiovasc Med. 2003;4:1-7. 83. Fearon WF, Yeung AC, Lee DP, Yock PG and Heidenreich PA. Cost-effectiveness of measuring fractional flow reserve to guide coronary interventions. Am Heart J. 2003;145:882-7. 84. Herity NA, Lo S, Lee DP, Ward MR, Filardo SD, Yock PG, Fitzgerald PJ, Hunt SA and Yeung AC. Effect of a change in gender on coronary arterial size. A longitudinal intravascular ultrasound study in transplanted hearts. J Am Coll Cardiol. 2003;41:1539-46. 85. Hibi K, Kimura K, Nakatogawa T, Okuda J, Umemura S and Yock PG. Images in cardiovascular medicine. Intracoronary ultrasound diagnosis of an aortic dissection causing anterior acute myocardial infarction. Circulation. 2003;108:e145-6. 86. Honda Y and Fitzgerald PJ. Stent thrombosis: an issue revisited in a changing world. Circulation. 2003;108:2-5. 87. Inagaki K, Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E and Mochly-Rosen D. Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Circulation. 2003;108:2304-7. 88. Jeon DS, Luo H, Fishbein MC, Miyamoto T, Horzewski M, Iwami T, Mirocha JM, Ikeno F, Honda Y and Siegel RJ. Noninvasive transcutaneous ultrasound augments thrombolysis in the left circumflex coronary artery--an in vivo canine study. Thromb Res. 2003;110:149-58. 89. Kereiakes DJ, Szyniszewski AM, Wahr D, Herrmann HC, Simon DI, Rogers C, Kramer P, Shear W, Yeung AC, Shunk KA, Chou TM, Popma J, Fitzgerald P, Carroll TE, Forer D and Adelman DC. Phase I drug and light dose-escalation trial of motexafin lutetium and far red light activation (phototherapy) in subjects with coronary artery disease undergoing percutaneous coronary intervention and stent deployment: procedural and long-term results. Circulation. 2003;108:1310-5. 90. Klupp J, Dambrin C, Hibi K, Luna J, Suzuki T, Hausen B, Birsan T, Van Gelder T, Fitzgerald PJ, Berry G and Morris RE. Treatment by mycophenolate mofetil of advanced graft vascular disease in non-human primate recipients of orthotopic aortic allografts. Am J Transplant. 2003;3:817-829. 91. Lee DP, Herity NA, Hiatt BL, Fearon WF, Rezaee M, Carter AJ, Huston M, Schreiber D, DiBattiste PM and Yeung AC. Adjunctive platelet glycoprotein IIb/IIIa receptor inhibition with tirofiban before primary angioplasty improves angiographic outcomes: results of the TIrofiban Given in the Emergency Room before Primary Angioplasty (TIGER- PA) pilot trial. Circulation. 2003;107:1497-501. 92. Miyamoto T, Neuman Y, Luo H, Jeon DS, Kobal S, Ikeno F, Horzewski M, Honda Y, Mirocha JM, Iwami T, Echt D, Fishbein MC and Siegel RJ. Coronary vasodilation by noninvasive transcutaneous ultrasound. An in vivo canine study. J Am Coll Cardiol. 2003;41:1623-7. 93. Morino Y, Limpijankit T, Honda Y, Somrantin M, Waksman R, Bonneau HN, Yock PG, Mintz GS and Fitzgerald PJ. Relationship between neointimal regrowth and mechanism of acute lumen gain during the treatment of in-stent restenosis with or without supplementary intravascular radiation. Catheter Cardiovasc Interv. 2003;58:162-7. 94. Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C, Caputo RP, Kereiakes DJ, Williams DO, Teirstein PS, Jaeger JL and Kuntz RE. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003;349:1315-23.

16 95. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Jr., Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK and Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation. 2003;108:1664-72. 96. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Rumberger J, Badimon JJ, Stefanadis C, Moreno P, Pasterkamp G, Fayad Z, Stone PH, Waxman S, Raggi P, Madjid M, Zarrabi A, Burke A, Yuan C, Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W, Jr., Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK and Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation. 2003;108:1772-8. 97. Nakamura M, Kataoka T, Honda Y, Bonneau HN, Hibi K, Kitamura K, Tamai H, Aizawa T, Yock PG and Fitzgerald PJ. Late incomplete stent apposition and focal vessel expansion after bare metal stenting. Am J Cardiol. 2003;92:1217- 9. 98. Nakamura M, Yock PG, Kataoka T, Bonneau HN, Suzuki T, Yamaguchi T, Honda Y and Fitzgerald PJ. Impact of deep vessel wall injury on acute response and remodeling of coronary artery segments after cutting balloon angioplasty. Am J Cardiol. 2003;91:6-11. 99. Okura H, Lee DP, Lo S, Yeung AC, Honda Y, Waksman R, Kaluza GL, Ali NM, Bonneau HN, Yock PG, Raizner AE, Mintz GS and Fitzgerald PJ. Late incomplete apposition with excessive remodeling of the stented coronary artery following intravascular brachytherapy. Am J Cardiol. 2003;92:587-90. 100. Sonoda S, Honda Y, Kataoka T, Bonneau HN, Sudhir K, Yock PG, Mintz GS and Fitzgerald PJ. Taxol-based eluting stents from theory to human validation: clinical and intravascular ultrasound observations. J Invasive Cardiol. 2003;15:109-14. 101. Whitbourn RJ, Sethi R, Pomerantsev EV and Fitzgerald PJ. High-speed rotational atherectomy and coronary stenting: QCA and QCU analysis. Catheter Cardiovasc Interv. 2003;60:167-71. 102. Ako J, Honda Y and Fitzgerald PJ. Conditions associated with ST-segment elevation. N Engl J Med. 2004;350:1152- 5; author reply 1152-5. 103. Chan C, Lim YL, Santoso T, Tresukosol D, Lim YT, Sonoda S and Fitzgerald P. Acute and long-term clinical and angiographic outcome after S-Stent implantation: S-Stent multicenter safety and efficacy trial. Catheter Cardiovasc Interv. 2004;62:439-44. 104. Courtney BK, Nakamura M, Tsugita R, Lilly R, Basisht R, Grube E, Honda Y, Yock PG and Fitzgerald PJ. Validation of a thermographic guidewire for endoluminal mapping of atherosclerotic disease: an in vitro study. Catheter Cardiovasc Interv. 2004;62:221-229. 105. Farouque HM, Kaltenbach T, Ako J, Tremmel JA, Fearon WF, Yeung AC and Vagelos RH. "Tako-tsubo-like left ventricular dysfunction": a clinical entity mimicking acute myocardial infarction with a favorable prognosis. Am J Geriatr Cardiol. 2004;13:323-6. 106. Fearon WF, Aarnoudse W, Pijls NH, De Bruyne B, Balsam LB, Cooke DT, Robbins RC, Fitzgerald PJ, Yeung AC and Yock PG. Microvascular resistance is not influenced by epicardial coronary artery stenosis severity: experimental validation. Circulation. 2004;109:2269-72. 107. Fearon WF, Ikeno F, Bailey LR, Hiatt BL, Herity NA, Carter AJ, Fitzgerald PJ, Rezaee M, Yeung AC and Yock PG. Evaluation of high-pressure retrograde coronary venous delivery of FGF-2 protein. Catheter Cardiovasc Interv. 2004;61:422-8. 108. Fitzgerald PJ. Ruptured plaque. Catheter Cardiovasc Interv. 2004;63:317-8. 109. Grube E, Sonoda S, Ikeno F, Honda Y, Kar S, Chan C, Gerckens U, Lansky AJ and Fitzgerald PJ. Six- and twelve- month results from first human experience using everolimus-eluting stents with bioabsorbable polymer. Circulation. 2004. 110. Holmes DR, Jr., Leon MB, Moses JW, Popma JJ, Cutlip D, Fitzgerald PJ, Brown C, Fischell T, Wong SC, Midei M, Snead D and Kuntz RE. Analysis of 1-year clinical outcomes in the SIRIUS trial: a randomized trial of a sirolimus- eluting stent versus a standard stent in patients at high risk for coronary restenosis. Circulation. 2004;109:634-40.

17 111. Ikeno F, Hinohara T, Robertson GC, Rezaee M, Yock PG, Reimers B, Colombo A, Grube E and Simpson JB. Early experience with a novel plaque excision system for the treatment of complex coronary lesions. Catheter Cardiovasc Interv. 2004;61:35-43. 112. Kaneda H, Nakamura M and Fitzgerald PJ. Pseudo-candy wrapper: bifocal radial artery graft spasm following stent implantation. J Invasive Cardiol. 2004;16:201-3. 113. Osman A, Otero J, Brizolara A, Waxman S, Stouffer G, Fitzgerald P and Uretsky BF. Effect of rosiglitazone on restenosis after coronary stenting in patients with type 2 diabetes. Am Heart J. 2004;147:e23. 114. Sonoda S, Morino Y, Ako J, Terashima M, Hassan AH, Bonneau HN, Leon MB, Moses JW, Yock PG, Honda Y, Kuntz RE and Fitzgerald PJ. Impact of final stent dimensions on long-term results following sirolimus-eluting stent implantation: serial intravascular ultrasound analysis from the SIRIUS trial. J Am Coll Cardiol. 2004;43:1959-63. 115. Yock CA and Yock PG. The drug-eluting stent information gap. Am Heart Hosp J. 2004;2:21-5. 116. Abizaid A, Albertal M, Ormiston J, Londero H, Ruygrok P, Seixas AC, Feres F, Mattos LA, Staico R, Silva RL, Webster M, Stewart J, Paoletti F, Kataoka T, Fitzgerald P, Sousa A and Sousa JE. IMPACT trial: Angiographic and intravascular ultrasound observations of the first human experience with mycophenolic acid-eluting polymer stent system. Catheter Cardiovasc Interv. 2005;66:491-5. 117. Ako J, Honda Y and Fitzgerald PJ. Impending coronary perforation after cutting balloon angioplasty. Heart. 2005;91:e8. 118. Ako J, Honda Y and Fitzgerald PJ. Transient left ventricular apical ballooning. Ann Intern Med. 2005;142:678; author reply 678-9. 119. Ako J, Morino Y, Honda Y, Hassan A, Sonoda S, Yock PG, Leon MB, Moses JW, Bonneau HN and Fitzgerald PJ. Late incomplete stent apposition after sirolimus-eluting stent implantation a serial intravascular ultrasound analysis. J Am Coll Cardiol. 2005;46:1002-5. 120. Eto M, Toba K, Akishita M, Kozaki K, Watanabe T, Kim S, Hashimoto M, Ako J, Iijima K, Sudoh N, Yoshizumi M and Ouchi Y. Impact of blood pressure variability on cardiovascular events in elderly patients with hypertension. Hypertens Res. 2005;28:1-7. 121. Hibi K, Ward MR, Honda Y, Suzuki T, Jeremias A, Okura H, Hassan AH, Maehara A, Yeung AC, Pasterkamp G, Fitzgerald PJ and Yock PG. Impact of different definitions on the interpretation of coronary remodeling determined by intravascular ultrasound. Catheter Cardiovasc Interv. 2005;65:233-9. 122. Hoffmann R, Guagliumi G, Musumeci G, Reimers B, Petronio AS, Disco C, Amoroso G, Moses JW, Fitzgerald PJ, Schofer J, Leon MB and Breithardt G. Vascular response to sirolimus-eluting stents delivered with a nonaggressive implantation technique: Comparison of intravascular ultrasound results from the multicenter, randomized E-SIRIUS, and SIRIUS trials. Catheter Cardiovasc Interv. 2005;66:499-506. 123. Hou D, Youssef EA, Brinton TJ, Zhang P, Rogers P, Price ET, Yeung AC, Johnstone BH, Yock PG and March KL. Radiolabeled cell distribution after intramyocardial, intracoronary, and interstitial retrograde coronary venous delivery: implications for current clinical trials. Circulation. 2005;112:I150-6. 124. Kaneda H, Ako J and Fitzgerald PJ. Peripartum dissection of the right coronary artery. N Engl J Med. 2005;352:1048- 9; author reply 1048-9. 125. Kaneda H, Ako J, Honda Y, Terashima M, Morino Y, Yock PG, Popma JJ, Leon MB, Moses JW and Fitzgerald PJ. Impact of asymmetric stent expansion on neointimal hyperplasia following sirolimus-eluting stent implantation. Am J Cardiol. 2005;96:1404-7. 126. Kaneda H, Ako J, Kataoka T, Miyazawa A, Terashima M, Ikeno F, Sonoda S, Shimada Y, Morino Y, Honda Y, Yock PG and Fitzgerald PJ. Effect of lumen narrowing within coronary stents on proximal and distal vessel segments following bare metal stent implantation. Am J Cardiol. 2005;96:376-8. 127. Kaneda H, Koizumi T, Ako J, Terashima M, Morino Y, Honda Y, Yock PG, Leon MB, Moses JW and Fitzgerald PJ. Impact of intravascular ultrasound lesion characteristics on neointimal hyperplasia following sirolimus-eluting stent implantation. Am J Cardiol. 2005;96:1237-41. 128. Kaplan AV, Harvey ED, Kuntz RE, Shiran H, Robb JF and Fitzgerald P. Humanitarian Use Devices/Humanitarian Device Exemptions in cardiovascular medicine. Circulation. 2005;112:2883-6. 129. Meredith IT, Ormiston J, Whitbourn R, Kay IP, Muller D, Bonan R, Popma JJ, Cutlip DE, Fitzgerald P, Prpic R and Kuntz RE. First-in-human study of the Endeavor ABT-578-eluting phosphorylcholine-encapsulated stent system in de novo native coronary artery lesions: Endeavor I Trial. EuroInterv. 2005;1:157-164. 130. Sakurai R, Ako J, Morino Y, Sonoda S, Kaneda H, Terashima M, Hassan AH, Leon MB, Moses JW, Popma JJ, Bonneau HN, Yock PG, Fitzgerald PJ and Honda Y. Predictors of edge stenosis following sirolimus-eluting stent deployment (a quantitative intravascular ultrasound analysis from the SIRIUS trial). Am J Cardiol. 2005;96:1251-3.

18 131. Yokoyama M, Komiyama N, Courtney BK, Nakayama T, Namikawa S, Kuriyama N, Koizumi T, Nameki M, Fitzgerald PJ and Komuro I. Plasma low-density lipoprotein reduction and structural effects on coronary atherosclerotic plaques by atorvastatin as clinically assessed with intravascular ultrasound radio-frequency signal analysis: a randomized prospective study. Am Heart J. 2005;150:287. 132. Ako J, Sudhir K, Farouque HM, Honda Y and Fitzgerald PJ. Transient left ventricular dysfunction under severe stress: brain-heart relationship revisited. Am J Med. 2006;119:10-7. 133. Costa RA, Sousa JE, Abizaid A, Chaves A, Feres F, Sousa AGMR, Musumeci G, Mehran R, Fitzgerald PJ, Lansky AJ, Leon MB, Shiran A, Halon DA, Lewis BS and Guagliumi G. The randomised study of the double dose versus single dose sirolimus-eluting stent for the treatment of diabetic patients with de novo coronary lesions. EuroInterv. 2006;2:295-301. 134. Fajadet J, Wijns W, Laarman GJ, Kuck KH, Ormiston J, Munzel T, Popma JJ, Fitzgerald PJ, Bonan R and Kuntz RE. Randomized, double-blind, multicenter study of the Endeavor zotarolimus-eluting phosphorylcholine-encapsulated stent for treatment of native coronary artery lesions: clinical and angiographic results of the ENDEAVOR II trial. Circulation. 2006;114:798-806. 135. Fearon WF. Physiologic assessment of renal artery stenosis: will history repeat itself? J Am Coll Cardiol. 2006;48:1856-8. 136. Fearon WF, Hirohata A, Nakamura M, Luikart H, Lee DP, Vagelos RH, Hunt SA, Valantine HA, Fitzgerald PJ, Yock PG and Yeung AC. Discordant changes in epicardial and microvascular coronary physiology after cardiac transplantation: Physiologic Investigation for Transplant Arteriopathy II (PITA II) study. J Heart Lung Transplant. 2006;25:765-71. 137. Hirohata A, Honda Y and Fitzgerald P. Axial plaque redistribution after coronary stent deployment. J Invasive Cardiol. 2006;18:E225-6. 138. Hirohata A, Morino Y, Ako J, Sakurai R, Buchbinder M, Caputo RP, Karas SP, Mishkel GJ, Mooney MR, O'Shaughnessy C D, Raizner AE, Wilensky RL, Williams DO, Wong SC, Yock PG, Honda Y, Moses JW and Fitzgerald PJ. Comparison of the efficacy of direct coronary stenting with sirolimus-eluting stents versus stenting with predilation by intravascular ultrasound imaging (from the DIRECT trial). Am J Cardiol. 2006;98:1464-7. 139. Holmes DR, Jr., Teirstein P, Satler L, Sketch M, O'Malley J, Popma JJ, Kuntz RE, Fitzgerald PJ, Wang H, Caramanica E and Cohen SA. Sirolimus-eluting stents vs vascular brachytherapy for in-stent restenosis within bare-metal stents: the SISR randomized trial. Jama. 2006;295:1264-73. 140. Ikeno F, Kim YH, Luna J, Condado JA, Colombo A, Grube E, Fitzgerald PJ, Park SJ and Yeung AC. Acute and long- term outcomes of the novel side access (SLK-View) stent for bifurcation coronary lesions: a multicenter nonrandomized feasibility study. Catheter Cardiovasc Interv. 2006;67:198-206. 141. Kandzari DE, Leon MB, Popma JJ, Fitzgerald PJ, O'Shaughnessy C, Ball MW, Turco M, Applegate RJ, Gurbel PA, Midei MG, Badre SS, Mauri L, Thompson KP, LeNarz LA and Kuntz RE. Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial. J Am Coll Cardiol. 2006;48:2440-7. 142. Kaneda H, Ako J, Kataoka T, Takahashi T, Terashima M, Waseda K, Miyazawa A, Hassan A, Honda Y, Yock PG and Fitzgerald PJ. Heterogeneity of neointimal distribution of in-stent restenosis in patients with diabetes mellitus. Am J Cardiol. 2006;97:340-2. 143. Kaneda H, Honda Y, Morino Y, Fox T, Crocker I, Lansky AJ, Yock PG, Bonan R and Fitzgerald PJ. Safety of beta radiation exposure to the non-target segment: an intravascular ultrasound dosimetric analysis. J Invasive Cardiol. 2006;18:309-12. 144. Kaneda H, Honda Y, Morino Y, Lansky AJ, Yock PG, Bonan R and Fitzgerald PJ. Predictors of recurrent in-stent restenosis after beta-radiation: an analysis from the START 40/20 trial. J Interv Cardiol. 2006;19:376-80. 145. Kaneda H, Ikeno F, Lyons J, Rezaee M, Yeung AC and Fitzgerald PJ. Long-term histopathologic and IVUS evaluations of a novel coiled sheet stent in porcine carotid arteries. Cardiovasc Intervent Radiol. 2006;29:413-9. 146. Kaneda H, Terashima M, Takahashi T, Iversen S, Felderhoff T, Grube E, Yock PG, Honda Y and Fitzgerald PJ. Mechanisms of lumen narrowing of saphenous vein bypass grafts 12 months after implantation: an intravascular ultrasound study. Am Heart J. 2006;151:726-9. 147. Kern MJ, Lerman A, Bech JW, De Bruyne B, Eeckhout E, Fearon WF, Higano ST, Lim MJ, Meuwissen M, Piek JJ, Pijls NH, Siebes M and Spaan JA. Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation. 2006;114:1321-41.

19 148. Koizumi T, Wilson AM, Clark DA and Fitzgerald PJ. Latent plaque rupture in a patient undergoing stenting for acute coronary syndrome and diffuse coronary disease: a case report and review of literature. Catheter Cardiovasc Interv. 2006;67:241-5. 149. Koizumi T, Yokoyama M, Namikawa S, Kuriyama N, Nameki M, Nakayama T, Kaneda H, Sudhir K, Yock PG, Komiyama N and Fitzgerald PJ. Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris. Am J Cardiol. 2006;97:1322-5. 150. Krummel TM, Gertner M, Makower J, Milroy C, Gurtner G, Woo R, Riskin DJ, Binyamin G, Connor JA, Mery CM, Shafi BM and Yock PG. Inventing our future: training the next generation of surgeon innovators. Semin Pediatr Surg. 2006;15:309-18. 151. Lerner AL, Kenknight BH, Rosenthal A and Yock PG. Design in BME: challenges, issues, and opportunities. Ann Biomed Eng. 2006;34:200-8. 152. Miyazawa A, Webster MW, Fitzgerald PJ and Ormiston JA. Novel stent system for bifurcation lesions: examination by intravascular ultrasound. Catheter Cardiovasc Interv. 2006;67:900-3. 153. Munoz-Pinedo C, Guio-Carrion A, Goldstein JC, Fitzgerald P, Newmeyer DD and Green DR. Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in duration. Proc Natl Acad Sci U S A. 2006;103:11573-8. 154. Ng MK, Tremmel J, Fitzgerald PJ and Fearon WF. Selective renal arterial infusion of fenoldopam for the prevention of contrast-induced nephropathy. J Interv Cardiol. 2006;19:75-9. 155. Ng MK, Yeung AC and Fearon WF. Invasive assessment of the coronary microcirculation: superior reproducibility and less hemodynamic dependence of index of microcirculatory resistance compared with coronary flow reserve. Circulation. 2006;113:2054-61. 156. Potena L, Holweg CT, Chin C, Luikart H, Weisshaar D, Narasimhan B, Fearon WF, Lewis DB, Cooke JP, Mocarski ES and Valantine HA. Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection. Transplantation. 2006;82:398-405. 157. Shimada Y, Courtney BK, Nakamura M, Hongo Y, Sonoda S, Hassan AH, Yock PG, Honda Y and Fitzgerald PJ. Intravascular ultrasonic analysis of atherosclerotic vessel remodeling and plaque distribution of stenotic left anterior descending coronary arterial bifurcation lesions upstream and downstream of the side branch. Am J Cardiol. 2006;98:193-6. 158. Shimada Y, Kataoka T, Courtney BK, Morino Y, Bonneau HN, Yock PG, Grube E, Honda Y and Fitzgerald PJ. Influence of plaque calcium on neointimal hyperplasia following bare metal and drug-eluting stent implantation. Catheter Cardiovasc Interv. 2006;67:866-9. 159. Tsuchiya Y, Lansky AJ, Costa RA, Mehran R, Pietras C, Shimada Y, Sonoda S, Cristea E, Negoita M, Dangas GD, Moses JW, Leon MB, Fitzgerald PJ, Muller R, Storger H, Hauptmann KE and Grube E. Effect of everolimus-eluting stents in different vessel sizes (from the pooled FUTURE I and II trials). Am J Cardiol. 2006;98:464-9. 160. Tu W, Potena L, Stepick-Biek P, Liu L, Dionis KY, Luikart H, Fearon WF, Holmes TH, Chin C, Cooke JP, Valantine HA, Mocarski ES and Lewis DB. T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease. Circulation. 2006;114:1608-15. 161. Yock A, Isbill JM and King SB, 3rd. Bare-metal stent outcomes in an unselected patient population. Clin Cardiol. 2006;29:352-6. 162. Abizaid A, Lansky AJ, Fitzgerald PJ, Tanajura LF, Feres F, Staico R, Mattos L, Abizaid A, Chaves A, Centemero M, Sousa AG, Sousa JE, Zaugg MJ and Schwartz LB. Percutaneous coronary revascularization using a trilayer metal phosphorylcholine-coated zotarolimus-eluting stent. Am J Cardiol. 2007;99:1403-8. 163. Ako J, Bonneau HN, Honda Y and Fitzgerald PJ. Design criteria for the ideal drug-eluting stent. Am J Cardiol. 2007;100:3M-9M. 164. Biadi O, Potena L, Fearon WF, Luikart HI, Yeung A, Ferrara R, Hunt SA, Mocarski ES and Valantine HA. Interplay between systemic inflammation and markers of insulin resistance in cardiovascular prognosis after heart transplantation. J Heart Lung Transplant. 2007;26:324-30. 165. Engel G, Cho S, Ghayoumi A, Yamazaki T, Chun S, Fearon WF and Froelicher VF. Prognostic significance of PVCs and resting heart rate. Ann Noninvasive Electrocardiol. 2007;12:121-9. 166. Fajadet J, Wijns W, Laarman GJ, Kuck KH, Ormiston J, Munzel T, Popma JJ, Fitzgerald PJ, Bonan R and Kuntz RE. Randomized, double-blind, multicenter study of the Endeavor zotarolimus-eluting phosphorylcholine-encapsulated stent for treatment of native coronary artery lesions. Clinical and angiographic results of the ENDEAVOR II Trial. Minerva Cardioangiol. 2007;55:1-18.

20 167. Fearon WF, Potena L, Hirohata A, Sakurai R, Yamasaki M, Luikart H, Lee J, Vana ML, Cooke JP, Mocarski ES, Yeung AC and Valantine HA. Changes in coronary arterial dimensions early after cardiac transplantation. Transplantation. 2007;83:700-5. 168. Fearon WF, Tonino PA, De Bruyne B, Siebert U and Pijls NH. Rationale and design of the Fractional Flow Reserve versus Angiography for Multivessel Evaluation (FAME) study. Am Heart J. 2007;154:632-6. 169. Gershlick A, Kandzari DE, Leon MB, Wijns W, Meredith IT, Fajadet J, Popma JJ, Fitzgerald PJ and Kuntz RE. Zotarolimus-eluting stents in patients with native coronary artery disease: clinical and angiographic outcomes in 1,317 patients. Am J Cardiol. 2007;100:45M-55M. 170. Grube E, Buellesfeld L, Neumann FJ, Verheye S, Abizaid A, McClean D, Mueller R, Lansky A, Mehran R, Costa R, Gerckens U, Trauthen B and Fitzgerald PJ. Six-month clinical and angiographic results of a dedicated drug-eluting stent for the treatment of coronary bifurcation narrowings. Am J Cardiol. 2007;99:1691-7. 171. Hasegawa T, Ako J, Ikeno F, Waseda K, Suzuki Y, Honda Y and Fitzgerald PJ. Comparison of nonuniform strut distribution between two drug-eluting stent platforms. J Invasive Cardiol. 2007;19:244-6. 172. Hirohata A, Nakamura M, Waseda K, Honda Y, Lee DP, Vagelos RH, Hunt SA, Valantine HA, Yock PG, Fitzgerald PJ, Yeung AC and Fearon WF. Changes in coronary anatomy and physiology after heart transplantation. Am J Cardiol. 2007;99:1603-7. 173. Hur SH, Hassan AH, Rekhi R, Ako J, Shimada Y, Nakamura M, Yamasaki M, Bonneau HN, Sudhir K, Yock PG, Honda Y and Fitzgerald PJ. Serial intravascular ultrasonic study of outcomes of coronary culprit lesions with plaque rupture following bare metal stent implantation in patients with angina pectoris. Am J Cardiol. 2007;99:1394-8. 174. Kaneda H, Ako J, Kataoka T, Takahashi T, Terashima M, Waseda K, Miyazawa A, Hassan AH, Honda Y, Yock PG and Fitzgerald PJ. Impact of gender on neointimal hyperplasia following coronary artery stenting. Am J Cardiol. 2007;99:491-3. 175. Meredith IT, Ormiston J, Whitbourn R, Kay IP, Muller D, Popma JJ, Cutlip DE and Fitzgerald PJ. Four-year clinical follow-up after implantation of the endeavor zotarolimus-eluting stent: ENDEAVOR I, the first-in-human study. Am J Cardiol. 2007;100:56M-61M. 176. Miyazawa A, Ako J, Hassan A, Hasegawa T, Abizaid A, Verheye S, McClean D, Neumann FJ, Grube E, Honda Y and Fitzgerald PJ. Analysis of bifurcation lesions treated with novel drug-eluting dedicated bifurcation stent system: intravascular ultrasound results of the AXXESS PLUS trial. Catheter Cardiovasc Interv. 2007;70:952-7. 177. Miyazawa A, Tsujino I, Ako J, Shimada Y, Courtney BK, Sakurai R, Nakamura M, Okura H, Waseda K, Honda Y and Fitzgerald PJ. Characterization of late incomplete stent apposition: a comparison among bare-metal stents, intracoronary radiation and sirolimus-eluting stents. J Invasive Cardiol. 2007;19:515-8. 178. Moses JW, Weisz G, Mishkel G, Caputo R, O'Shaughnessey C, Wong SC, Fischell TA, Mooney M, Williams DO, Popma JJ, Fitzgerald P, Smith S, Kuntz RE, Collins M, Cohen SA and Leon MB. The SIRIUS-DIRECT trial: A multi- center study of direct stenting using the sirolimus-eluting stent in patients with de novo native coronary artery lesions. Catheter Cardiovasc Interv. 2007;70:505-512. 179. Nakamura M, Abizaid A, Hirohata A, Honda Y, Sousa JE and Fitzgerald PJ. Efficacy of reduced-dose sirolimus- eluting stents in the human coronary artery: Serial IVUS analysis of neointimal hyperplasia and luminal dimension. Catheter Cardiovasc Interv. 2007. 180. Sakakura K, Kubo N, Ako J, Ikeda N, Funayama H, Hirahara T, Sugawara Y, Yasu T, Kawakami M and Momomura S. Determinants of in-hospital death and rupture in patients with a Stanford B aortic dissection. Circ J. 2007;71:1521- 4. 181. Sakurai R, Ako J, Hassan AH, Bonneau HN, Neumann FJ, Desmet W, Holmes DR, Jr., Yock PG, Fitzgerald PJ and Honda Y. Neointimal progression and luminal narrowing in sirolimus-eluting stent treatment for bare metal in-stent restenosis: a quantitative intravascular ultrasound analysis. Am Heart J. 2007;154:361-5. 182. Sakurai R, Bonneau HN, Honda Y and Fitzgerald PJ. Intravascular ultrasound findings in ENDEAVOR II and ENDEAVOR III. Am J Cardiol. 2007;100:71M-76M. 183. Sakurai R, Hongo Y, Yamasaki M, Honda Y, Bonneau HN, Yock PG, Cutlip D, Popma JJ, Zimetbaum P, Fajadet J, Kuntz RE, Wijns W and Fitzgerald PJ. Detailed intravascular ultrasound analysis of Zotarolimus-eluting phosphorylcholine-coated cobalt-chromium alloy stent in de novo coronary lesions (results from the ENDEAVOR II trial). Am J Cardiol. 2007;100:818-23. 184. Sakurai R, Yamasaki M, Nakamura M, Hirohata A, Honda Y, Bonneau HN, Luikart H, Yock PG, Fitzgerald PJ, Yeung AC, Valantine HA and Fearon WF. Determinants of lumen loss between years 1 and 2 after cardiac transplantation. Transplantation. 2007;84:1097-102.

21 185. Shimohama T, Honda Y and Fitzgerald PJ. The risks and benefits of drug-eluting stents. Am Heart Hosp J. 2007;5:146-50. 186. Tsujino I, Ako J, Honda Y and Fitzgerald PJ. Drug delivery via nano-, micro and macroporous coronary stent surfaces. Expert Opin Drug Deliv. 2007;4:287-295. 187. Waseda K, Ako J, Shimada Y, Morino Y, Tsujino I, Hongo Y, Sudhir K, Yock PG, Fitzgerald PJ and Honda Y. Comparison of vessel response following sirolimus-eluting stent implantation as assessed by serial 3-D intravascular ultrasound study. J Invasive Cardiol. 2007;19:171-3. 188. Whitbourn R, Fitzgerald P, Popma J, Cutlip D, Worthley S, Meredith I and Walters D. The next-generation Endeavor Resolute stent: 4-month clinical and angiographic results from the Resolute first-in-man trial EuroInterv. 2007;3:50- 53. 189. Ako J, Radke PW, Schunkert H and Kurowski V. Apical and Midventricular Transient Left Ventricular Dysfunction Syndrome (Tako-tsubo Cardiomyopathy). Chest. 2008;133:1052-3. 190. Chevalier B, Mario CD, Neumann F-J, Ribichini F, Urban P, Popma JJ, Fitzgerald PJ, Cutlip DE, Williams DO, Ormiston J, Grube E, Whitbourn R and Schwartz LB. A randomized, controlled, multicenter trial to evaluate the safety and efficacy of zotarolimus- versus paclitaxel-eluting stents in de novo occlusive lesions in coronary arteries: the ZoMaxx I trial. J Am Coll Cardiol Intv. 2008;1:524-532. 191. Costa JR, Jr., Abizaid A, Feres F, Costa R, Seixas AC, Maia F, Tanajura LF, Staico R, Siqueira D, Meredith L, Bhat V, Yan J, Ormiston J, Sousa AG, Fitzgerald P and Sousa JE. EXCELLA First-in-Man (FIM) study: safety and efficacy of novolimus-eluting stent in de novo coronary lesions. EuroIntervention. 2008;4:53-8. 192. Fearon WF, Shah M, Ng M, Brinton T, Wilson A, Tremmel JA, Schnittger I, Lee DP, Vagelos RH, Fitzgerald PJ, Yock PG and Yeung AC. Predictive value of the index of microcirculatory resistance in patients with ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2008;51:560-5. 193. Fitzgerald PJ and Otake H. Evaluation of vessel response to percutaneous coronary intervention. Rev Esp Cardiol. 2008;61:1001-6. 194. Grube E, Sievert H, Hauptmann KE, Mueller R, Gerckens U, Buellesfeld L, Ako J, Shimohama T, Costa M and Fitzgerald P. Novel drug eluting stent system for customised treatment of coronary lesions: CUSTOM I feasibility trial 24 month results. EuroIntervention. 2008;4:71-6. 195. Hoffmann R, Morice MC, Moses JW, Fitzgerald PJ, Mauri L, Breithardt G, Schofer J, Serruys PW, Stoll HP and Leon MB. Impact of late incomplete stent apposition after sirolimus-eluting stent implantation on 4-year clinical events: intravascular ultrasound analysis from the multicentre, randomised, RAVEL, E-SIRIUS and SIRIUS trials. Heart. 2008;94:322-8. 196. Honda Y and Fitzgerald PJ. Frontiers in intravascular imaging technologies. Circulation. 2008;117:2024-37. 197. Hur SH, Ako J, Shimada Y, Tsujino I, Hassan AH, Abizaid A, Shiran A, Lewis BS, Guagliumi G, Cohen SA, Honda Y, Fitzgerald PJ and Sousa JE. Two-year intravascular ultrasound observations in diabetic patients treated with single and double dose sirolimus-eluting stents: results of the double dose diabetes (3D) study. J Invasive Cardiol. 2008;20:411-6. 198. Kaneda H, Honda Y and Fitzgerald PJ. Impact of additional ballooning on plaque prolapse after stent implantation in patients with acute myocardial infarction. J Am Coll Cardiol Img. 2008;1:815. 199. Kaneda H, Kataoka T, Ako J, Honda Y, Yock PG and Fitzgerald PJ. Coronary risk factors and coronary atheroma burden at severely narrowing segments. Int J Cardiol. 2008;124:124-6. 200. Kereiakes DJ, Petersen JL, Batchelor WB, Fitzgerald PJ, Mehran R, Lansky A, Tsujino I, Schofer J, Dubois C, Verheye S, Cristea E, Garg J, Wijns W and Krucoff MW. Clinical and angiographic outcomes in diabetic patients following single or multivessel stenting in the COSTAR II randomized trial. J Invasive Cardiol. 2008;20:335-41. 201. Koo BK, Yamasaki M, Ako J, Waseda K, Honda Y, Fitzgerald PJ, Abizaid A and Whitbourn RJ. Intravascular ultrasound analysis of small-vessel lesions treated with novel ultra-low profile, guidewire-based self-expanding stent system. J Invasive Cardiol. 2008;20:647-50. 202. Krucoff MW, Kereiakes DJ, Petersen JL, Mehran R, Hasselblad V, Lansky AJ, Fitzgerald PJ, Garg J, Turco MA, Simonton CA, 3rd, Verheye S, Dubois CL, Gammon R, Batchelor WB, O'Shaughnessy CD, Hermiller JB, Jr., Schofer J, Buchbinder M and Wijns W. A novel bioresorbable polymer paclitaxel-eluting stent for the treatment of single and multivessel coronary disease: primary results of the COSTAR (Cobalt Chromium Stent With Antiproliferative for Restenosis) II study. J Am Coll Cardiol. 2008;51:1543-52. 203. Miyazawa A, Ako J, Hongo Y, Hur SH, Tsujino I, Courtney BK, Hassan AH, Kandzari DE, Honda Y and Fitzgerald PJ. Comparison of vascular response to zotarolimus-eluting stent versus sirolimus-eluting stent: intravascular ultrasound results from ENDEAVOR III. Am Heart J. 2008;155:108-13.

22 204. Ratner RE, Cannon CP, Gerstein HC, Nesto RW, Serruys PW, Van Es GA, Kolatkar NS, Kravitz BG, Zalewski A and Fitzgerald PJ. Assessment on the Prevention of Progression by Rosiglitazone on Atherosclerosis in diabetes patients with Cardiovascular History (APPROACH): study design and baseline characteristics. Am Heart J. 2008;156:1074-9. 205. Rodriguez-Porcel M, Brinton TJ, Chen IY, Gheysens O, Lyons J, Ikeno F, Willmann JK, Wu L, Wu JC, Yeung AC, Yock P and Gambhir SS. Reporter gene imaging following percutaneous delivery in swine moving toward clinical applications. J Am Coll Cardiol. 2008;51:595-7. 206. Stone GW, Midei M, Newman W, Sanz M, Hermiller JB, Williams J, Farhat N, Mahaffey KW, Cutlip DE, Fitzgerald PJ, Sood P, Su X and Lansky AJ. Comparison of an everolimus-eluting stent and a paclitaxel-eluting stent in patients with coronary artery disease: a randomized trial. Jama. 2008;299:1903-13. 207. Suzuki Y, Ikeno F, Koizumi T, Tio F, Yeung AC, Yock PG, Fitzgerald PJ and Fearon WF. In vivo comparison between optical coherence tomography and intravascular ultrasound for detecting small degrees of in-stent neointima after stent implantation. J Am Coll Cardiol Intv. 2008;1:168-173. 208. Waseda K, Ako J, Kaneda H, Miyazawa A, Shimada Y, Morino Y, Honda Y and Fitzgerald PJ. Effect of lumen narrowing within sirolimus-eluting stents on proximal and distal vessel segments. Circ J. 2008;72:534-7. 209. Waseda K, Fitzgerald PJ and Takahashi M. Intraoperative assessment of coronary grafts with fluorescent angiography. Heart. 2008;94:64. 210. Yamada KP, Koizumi T, Yamaguchi H, Kaneda H, Bonneau HN, Honda Y and Fitzgerald PJ. Serial angiographic and intravascular ultrasound analysis of late stent strut fracture of sirolimus-eluting stents in native coronary arteries. Int J Cardiol. 2008;130:255-9. 211. Yamasaki M, Ako J, Honda Y, Hassan A, Koo B, Abizaid A, Fitzgerald P and Whitbourn R. Novel guidewire-based stent delivery system: examination by intravascular ultrasound. Catheter Cardiovasc Interv. 2008. 212. Arrow K, Auerbach A, Bertko J, Brownlee S, Casalino LP, Cooper J, Crosson FJ, Enthoven A, Falcone E, Feldman RC, Fuchs VR, Garber AM, Gold MR, Goldman D, Hadfield GK, Hall MA, Horwitz RI, Hooven M, Jacobson PD, Jost TS, Kotlikoff LJ, Levin J, Levine S, Levy R, Linscott K, Luft HS, Mashal R, McFadden D, Mechanic D, Meltzer D, Newhouse JP, Noll RG, Pietzsch JB, Pizzo P, Reischauer RD, Rosenbaum S, Sage W, Schaeffer LD, Sheen E, Silber BM, Skinner J, Shortell SM, Thier SO, Tunis S, Wulsin L, Jr., Yock P, Nun GB, Bryan S, Luxenburg O and van de Ven WP. Toward a 21st-century health care system: recommendations for health care reform. Ann Intern Med. 2009;150:493-5. 213. Chang H, Hassan AH, Kim YL, Lloyd LJ, Koo BK, Ako J, Honda Y, Davidson CJ and Fitzgerald PJ. A novel technique for endovascular detection and removal of radiographic contrast during angiography. J Invasive Cardiol. 2009;21:314- 8. 214. Chang H, Kim YL, Hassan A and Fitzgerald PJ. Whole blood reflectance for assessment of hematologic condition and detection of angiographic contrast media. Appl Opt. 2009;48:2435-43. 215. Hasegawa T, Ako J, Koo BK, Miyazawa A, Sakurai R, Chang H, Dens J, Verheye S, Grube E, Honda Y and Fitzgerald PJ. Analysis of left main coronary artery bifurcation lesions treated with biolimus-eluting DEVAX AXXESS plus nitinol self-expanding stent: intravascular ultrasound results of the AXXENT trial. Catheter Cardiovasc Interv. 2009;73:34-41. 216. Honda Y. Drug-eluting stents: insights from invasive imaging technologies. Circ J. 2009;73:1371-1380. 217. Honda Y and Fitzgerald PJ. Stent expansion as a mechanical parameter to predict late stent patency: back to the basics. J Am Coll Cardiol Interv. 2009;2:1276-1278. 218. Hur SH, Ako J, Honda Y, Sudhir K and Fitzgerald PJ. Late-acquired incomplete stent apposition: morphologic characterization. Cardiovasc Revasc Med. 2009;10:236-46. 219. Kaneda H, Ako J, Terashima M, Waseda K, Yock PG and Fitzgerald PJ. Distribution pattern of neointimal hyperplasia following sirolimus-eluting stent implantation assessed by 3-dimensional intravascular ultrasound. Int J Cardiol. 2009;135:243-5. 220. Kirtane AJ, Patel R, O'Shaughnessy C, Overlie P, McLaurin B, Solomon S, Mauri L, Fitzgerald P, Popma JJ, Kandzari DE and Leon MB. Clinical and angiographic outcomes in diabetics from the ENDEAVOR IV trial: randomized comparison of zotarolimus- and paclitaxel-eluting stents in patients with coronary artery disease. JACC Cardiovasc Interv. 2009;2:967-76. 221. Meredith IT, Worthley S, Whitbourn R, Walters DL, McClean D, Horrigan M, Popma JJ, Cutlip DE, DePaoli A, Negoita M and Fitzgerald PJ. Clinical and angiographic results with the next-generation resolute stent system: a prospective, multicenter, first-in-human trial. JACC Cardiovasc Interv. 2009;2:977-85.

23 222. Nakatani D, Ako J, Yamasaki M, Shimohama T, Hasegawa T, Otake H, Waseda K, Tsujino I, Sakurai R, Koo BK, Chang H, Yock PG, Sudhir K, Pierson W, Stone GW, Saito S, Honda Y and Fitzgerald PJ. Preprocedural inflammation does not affect neointimal hyperplasia following everolimus-eluting stent implantation. J Invasive Cardiol. 2009;21:613-7. 223. Otake H, Shite J, Ako J, Shinke T, Tanino Y, Ogasawara D, Sawada T, Miyoshi N, Kato H, Koo BK, Honda Y, Fitzgerald PJ and Hirata K. Local determinants of thrombus formation following sirolimus-eluting stent implantation assessed by optical coherence tomography. J Am Coll Cardiol Interv. 2009;2:459-66. 224. Russo RJ, Silva PD, Teirstein PS, Attubato MJ, Davidson CJ, DeFranco AC, Fitzgerald PJ, Goldberg SL, Hermiller JB, Leon MB, Ling FS, Lucisano JE, Schatz RA, Wong SC, Weissman NJ, Zientek DM and Investigators A. A randomized controlled trial of angiography versus intravascular ultrasound-directed bare-metal coronary stent placement (the AVID Trial). Circ Cardiovasc Interv. 2009;2:113-23. 225. Takagi T, Okura H, Kobayashi Y, Kataoka T, Taguchi H, Toda I, Tamita K, Yamamuro A, Sakanoue Y, Ito A, Yanagi S, Shimeno K, Waseda K, Yamasaki M, Fitzgerald PJ, Ikeno F, Honda Y, Yoshiyama M and Yoshikawa J. A prospective, multicenter, randomized trial to assess efficacy of pioglitazone on in-stent neointimal suppression in type 2 diabetes: POPPS (Prevention of In-Stent Neointimal Proliferation by Pioglitazone Study). JACC Cardiovasc Interv. 2009;2:524-31. 226. Verheye S, Agostoni P, Dawkins KD, Dens J, Rutsch W, Carrie D, Schofer J, Lotan C, Dubois CL, Cohen SA, Fitzgerald PJ and Lansky AJ. The GENESIS (randomized, multicenter study of the pimecrolimus-eluting and pimecrolimus/paclitaxel-eluting coronary stent system in patients with de novo lesions of the native coronary arteries) trial. J Am Coll Cardiol Intv. 2009;2:205-214. 227. Verheye S, Agostoni P, Dubois CL, Dens J, Ormiston J, Worthley S, Trauthen B, Hasegawa T, Koo BK, Fitzgerald PJ, Mehran R and Lansky AJ. 9-month clinical, angiographic, and intravascular ultrasound results of a prospective evaluation of the Axxess self-expanding biolimus A9-eluting stent in coronary bifurcation lesions: the DIVERGE (Drug-Eluting Stent Intervention for Treating Side Branches Effectively) study. J Am Coll Cardiol. 2009;53:1031-9. 228. Waseda K, Ako J, Hasegawa T, Shimada Y, Ikeno F, Ishikawa T, Demura Y, Hatada K, Yock PG, Honda Y, Fitzgerald PJ and Takahashi M. Intraoperative fluorescence imaging system for on-site assessment of off-pump coronary artery bypass graft. J Am Coll Cardiol Img. 2009;2:604-12. 229. Waseda K, Miyazawa A, Ako J, Hasegawa T, Tsujino I, Sakurai R, Yock PG, Honda Y, Kandzari DE, Leon MB and Fitzgerald PJ. Intravascular ultrasound results from the ENDEAVOR IV trial: randomized comparison between zotarolimus- and paclitaxel-eluting stents in patients with coronary artery disease. JACC Cardiovasc Interv. 2009;2:779-84. 230. Willmann JK, Paulmurugan R, Rodriguez-Porcel M, Stein W, Brinton TJ, Connolly AJ, Nielsen CH, Lutz AM, Lyons J, Ikeno F, Suzuki Y, Rosenberg J, Chen IY, Wu JC, Yeung AC, Yock P, Robbins RC and Gambhir SS. Imaging gene expression in human mesenchymal stem cells: from small to large animals. . 2009. 231. Chamie D, Costa JR, Jr., Abizaid A, Feres F, Staico R, Devito F, Costa RA, Tanajura LF, Sousa AG, Fitzgerald PJ, Whitbourn RJ and Sousa JE. Serial angiography and intravascular ultrasound: results of the SISC registry (Stents In Small Coronaries). JACC Cardiovasc Interv. 2010;3:191-202. 232. Gerstein HC, Ratner RE, Cannon CP, Serruys PW, Garcia-Garcia HM, van Es GA, Kolatkar NS, Kravitz BG, Miller DM, Huang C, Fitzgerald PJ and Nesto RW. Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cardiovascular history trial. Circulation. 2010;121:1176-87. 233. Hassan AH, Ako J, Waseda K, Honda Y, Zeller T, Leon MB and Fitzgerald PJ. Mechanism of lumen gain with a novel rotational aspiration atherectomy system for peripheral arterial disease: examination by intravascular ultrasound. Cardiovasc Revasc Med. 2010;11:155-158. 234. Hassan AH, Luna J, Davidson CJ and Fitzgerald PJ. Endovascular detection and removal of radiographic contrast. Cardiovasc Revasc Med. 2010;11:114-5. 235. Kaneda H, Ako J, Terashima M, Morino Y, Honda Y, Yock PG, Leon MB, Moses JW and Fitzgerald PJ. Sirolimus- eluting stent implantation in small coronary arteries: a three dimensional intravascular ultrasound study from the SIRIUS trial. Int J Cardiol. 2010;138:126-30. 236. Kawarada O, Yokoi Y, Honda Y and Fitzgerald PJ. Awareness of anatomical variations for infrapopliteral intervention. Catheter Cardiovasc Interv. 2010;76:888-94. 237. Kimura T, Morimoto T, Kozuma K, Honda Y, Kume T, Aizawa T, Mitsudo K, Miyazaki S, Yamaguchi T, Hiyoshi E, Nishimura E and Isshiki T. Comparisons of baseline demographics, clinical presentation, and long-term outcome among patients with early, late, and very late stent thrombosis of sirolimus-eluting stents: Observations from the Registry of Stent Thrombosis for Review and Reevaluation (RESTART). Circulation. 2010;122:52-61.

24 238. Koizumi T, Fitzgerald PJ, Honda Y, Ellis SG, Kent K, Martin SL, Brown CL, Masud AR, Patterson JB, Greenberg J, Friedman M, Uchida T and Stone GW. Vascular responses to the multiple overlapped paclitaxel-eluting stents for the treatment of bare-metal in-stent restenotic lesions: angiographic and intravascular ultrasound analysis from the TAXUS-V ISR Trial. Cardiovasc Revasc Med. 2010;11:140-148. 239. Koo BK, Waseda K, Ako J, Hasegawa T, Shimohama T, Nakatani D, Otake H, Yamasaki M, Sakurai R, Tsujino I, Honda Y and Fitzgerald PJ. Incidence of diffuse and focal chronic stent recoil after implantation of current generation bare-metal and drug-eluting stents. Int J Cardiol. 2010;144:132-4. 240. Koo BK, Waseda K, Kang HJ, Kim HS, Nam CW, Hur SH, Kim JS, Choi D, Jang Y, Hahn JY, Gwon HC, Yoon MH, Tahk SJ, Chung WY, Cho YS, Choi DJ, Hasegawa T, Kataoka T, Oh SJ, Honda Y, Fitzgerald PJ and Fearon WF. Anatomic and functional evaluation of bifurcation lesions undergoing percutaneous coronary intervention. Circ Cardiovasc Interv. 2010;3:113-9. 241. Leon MB, Mauri L, Popma JJ, Cutlip DE, Nikolsky E, O'Shaughnessy C, Overlie PA, McLaurin BT, Solomon SL, Douglas JS, Jr., Ball MW, Caputo RP, Jain A, Tolleson TR, Reen BM, 3rd, Kirtane AJ, Fitzgerald PJ, Thompson K and Kandzari DE. A randomized comparison of the ENDEAVOR zotarolimus-eluting stent versus the TAXUS paclitaxel-eluting stent in de novo native coronary lesions 12-month outcomes from the ENDEAVOR IV trial. J Am Coll Cardiol. 2010;55:543-54. 242. Ormiston JA, Abizaid A, Spertus J, Fajadet J, Mauri L, Schofer J, Verheye S, Dens J, Thuesen L, Dubois C, Hoffmann R, Wijns W, Fitzgerald PJ, Popma JJ, Macours N, Cebrian A, Stoll HP, Rogers C, Spaulding C and Investigators NR- I. Six-month results of the NEVO Res-Elution I (NEVO RES-I) trial: a randomized, multicenter comparison of the NEVO sirolimus-eluting coronary stent with the TAXUS Liberte paclitaxel-eluting stent in de novo native coronary artery lesions. Circ Cardiovasc Interv. 2010;3:556-64. 243. Otake H, Ako J, Waseda K, Sakurai R, Hirohata A, Kaneda H, Hasegawa T, Honda Y and Fitzgerald PJ. Neointimal hyperplasia in a thin-strut cobalt-chromium stent: insights from detailed 3-D intravascular ultrasound analysis. Int J Cardiol. 2010;145:125-6. 244. Otake H, Ako J, Yamasaki M, Tsujino I, Shimohama T, Hasegawa T, Sakurai R, Waseda K, Honda Y, Sood P, Sudhir K, Stone GW and Fitzgerald PJ. Comparison of everolimus- versus paclitaxel-eluting stents implanted in patients with diabetes mellitus as evaluated by three-dimensional intravascular ultrasound analysis. Am J Cardiol. 2010;106:492-497. 245. Otake H, Honda Y, Yamasaki M, Tsujino I, Shimohama T, Sakurai R, Hasegawa T, Waseda K, Ako J and Fitzgerald PJ. Vascular response to overlapping everolimus-eluting stents. - Comparison with paclitaxel-eluting stents. Circ J. 2010;74:1023-5. 246. Serruys PW, Garg S, Abizaid A, Ormiston J, Windecker S, Verheye S, Dubois C, Stewart J, Hauptmann KE, Schofer J, Stangl K, Witzenbichler B, Wiemer M, Barbato E, de Vries T, den Drijver AM, Otake H, Meredith L, Toyloy S and Fitzgerald P. A randomised comparison of novolimus-eluting and zotarolimus-eluting coronary stents: 9-month follow- up results of the EXCELLA II study. EuroIntervention. 2010;6:195-205. 247. Shimohama T, Ako J, Yamasaki M, Otake H, Tsujino I, Hasegawa T, Nakatani D, Sakurai R, Chang H, Kusano H, Waseda K, Honda Y, Stone GW, Saito S, Fitzgerald PJ and Sudhir K. SPIRIT III JAPAN versus SPIRIT III USA: a comparative intravascular ultrasound analysis of the everolimus-eluting stent. Am J Cardiol. 2010;106:13-7. 248. Teramoto T, Ikeno F, Otake H, Lyons JK, van Beusekom HM, Fearon WF and Yeung AC. Intriguing peri-strut low- intensity area detected by optical coherence tomography after coronary stent deployment. Circ J. 2010;74:1257-9. 249. Waksman R, Torguson R, Kent KM, Pichard AD, Suddath WO, Satler LF, Martin BD, Perlman TJ, Maltais JA, Weissman NJ, Fitzgerald PJ and Brewer HB, Jr. A first-in-man, randomized, placebo-controlled study to evaluate the safety and feasibility of autologous delipidated high-density lipoprotein plasma infusions in patients with acute coronary syndrome. J Am Coll Cardiol. 2010;55:2727-35. 250. Waseda K, Ako J, Yamasaki M, Koizumi T, Ormiston J, Worthley SG, Whitbourn RJ, Walters DL, Honda Y, Meredith IT and Fitzgerald PJ. Short- and mid-term intravascular ultrasound analysis of the new zotarolimus-eluting stent with durable polymer – results from the RESOLUTE trial –. Circ J. 2010;74:2097-2102. 251. Waseda K, Hasegawa T, Ako J, Honda Y, Grube E, Whitbourn R, Ormiston J, O'Shaughnessy CD, Henry TD, Overlie P, Schwartz LB, Sudhir K, Chevalier B, Gray WA, Yeung AC and Fitzgerald PJ. Comparison of vascular response to zotarolimus-eluting stent vs paclitaxel-eluting stent implantation: pooled IVUS results from the ZoMaxx I and II trials. Circ J. 2010;74:2334-9. 252. Williams AR, Koo BK, Gundert TJ, Fitzgerald PJ and LaDisa JF, Jr. Local hemodynamic changes caused by main branch stent implantation and subsequent virtual side branch balloon angioplasty in a representative coronary bifurcation. J Appl Physiol. 2010;109:532-40.

25 253. Ellwein LM, Otake H, Gundert TJ, Koo B-K, Shinke T, Honda Y, Shite J and LaDisa JF. Optical coherence tomography for patient-specific 3D artery reconstruction and evaluation of wall shear stress in a left circumflex coronary artery. Cardiovascular Engineering and Technology. 2011;2:212-227. 254. Kandzari DE, Mauri L, Popma JJ, Turco MA, Gurbel PA, Fitzgerald PJ and Leon MB. Late-term clinical outcomes with zotarolimus- and sirolimus-eluting stents. 5-year follow-up of the ENDEAVOR III (A Randomized Controlled Trial of the Medtronic Endeavor Drug [ABT-578] Eluting Coronary Stent System Versus the Cypher Sirolimus-Eluting Coronary Stent System in De Novo Native Coronary Artery Lesions). JACC Cardiovasc Interv. 2011;4:543-50. 255. Kawarada O, Yokoi Y, Higashimori A, Waratani N, Fujihara M, Kume T, Sakata K, Honda Y and Fitzgerald PJ. Assessment of macro- and microcirculation in contemporary critical limb ischemia. Catheter Cardiovasc Interv. 2011;78:1051-8. 256. Kawarada O, Yokoi Y, Higashimori A, Waratani N, Waseda K, Honda Y and Fitzgerald PJ. Stent-assisted below- the-ankle angioplasty for limb salvage. J Endovasc Ther. 2011;18:32-42. 257. Ko YG, Kim BK, Lee BK, Kang WC, Choi SH, Kim SW, Lee JH, Lee M, Honda Y, Fitzerald PJ, Shim WH and Investigators S. Study design and rationale of "Synergistic effect of combination therapy with cilostazol and ProbUcol on plaque stabilization and lesion REgression (SECURE)" study: a double-blind randomised controlled multicenter clinical trial. Trials. 2011;12:10. 258. Meredith IT, Worthley S, Whitbourn R, Webster M, Fitzgerald PJ and Ormiston J. First-in-human experience with the Medtronic Bifurcation Stent System. EuroIntervention. 2011;7:662-9. 259. Nakatani D, Ako J, Tremmel JA, Waseda K, Otake H, Koo BK, Miyazawa A, Hongo Y, Hur SH, Sakurai R, Yock PG, Honda Y and Fitzgerald PJ. Sex differences in neointimal hyperplasia following endeavor zotarolimus-eluting stent implantation. Am J Cardiol. 2011;108:912-7. 260. Otake H, Honda Y, Courtney BK, Shimohama T, Ako J, Waseda K, Macours N, Rogers C, Popma JJ, Abizaid A, Ormiston JA, Spaulding C, Cohen SA and Fitzgerald PJ. Intravascular ultrasound results from the NEVO ResElution- I trial: a randomized, blinded comparison of sirolimus-eluting NEVO stents with paclitaxel-eluting TAXUS Liberte stents in de novo native coronary artery lesions. Circ Cardiovasc Interv. 2011;4:146-54. 261. Saatchi S, Azuma J, Wanchoo N, Smith SJ, Yock PG, Taylor CA and Tsao PS. Three-Dimensional Microstructural Changes in Murine Abdominal Aortic Aneurysms Quantified Using Immunofluorescent Array Tomography. J Histochem Cytochem. 2011. 262. Shin DH, Koo BK, Waseda K, Park KW, Kim HS, Corral M, Lansky A, Honda Y, Fearon WF and Fitzgerald PJ. Discrepancy in the assessment of jailed side branch lesions by visual estimation and quantitative coronary angiographic analysis: comparison with fractional flow reserve. Catheter Cardiovasc Interv. 2011;78:720-6. 263. Tremmel JA, Koizumi T, O'Loughlin A and Yeung AC. Images in intervention. Intramural hematoma appearing as a new lesion after coronary stenting. JACC Cardiovasc Interv. 2011;4:129-30. 264. Waseda K, Ako J, Yamasaki M, Koizumi T, Sakurai R, Hongo Y, Koo BK, Ormiston J, Worthley SG, Whitbourn RJ, Walters DL, Meredith IT, Fitzgerald PJ and Honda Y. Impact of polymer formulations on neointimal proliferation after zotarolimus-eluting stent with different polymers: insights from the RESOLUTE trial. Circ Cardiovasc Interv. 2011;4:248-55. 265. Yamasaki M, Sakurai R, Hirohata A, Honda Y, Bonneau HN, Luikart H, Yock PG, Fitzgerald PJ, Yeung AC, Valantine HA and Fearon WF. Impact of donor-transmitted atherosclerosis on early cardiac allograft vasculopathy: new findings by three-dimensional intravascular ultrasound analysis. Transplantation. 2011;91:1406-11. 266. Yeung AC, Leon MB, Jain A, Tolleson TR, Spriggs DJ, Mc Laurin BT, Popma JJ, Fitzgerald PJ, Cutlip DE, Massaro JM and Mauri L. Clinical evaluation of the Resolute zotarolimus-eluting coronary stent system in the treatment of de novo lesions in native coronary arteries: the RESOLUTE US clinical trial. J Am Coll Cardiol. 2011;57:1778-83. 267. Yock PG, Brinton TJ and Zenios SA. Teaching biomedical technology innovation as a discipline. Sci Transl Med. 2011;3:92cm18. 268. Gray WA, Yeung AC, Cutlip DE, Popma JJ, Fitzgerald PJ, Williams DO, Heuer H, O'Shaughnessy CD, Overlie PA, Mann JT, Cannon LA, Hermiller JB, Henry TD, Whitbourn R, Stuckey TD, Midei MG, Coe J and Schwartz LB. A randomized, controlled, multi-center trial comparing the safety and efficacy of zotarolimus-eluting and paclitaxel- eluting stents in de novo lesions in coronary arteries: final results of the ZoMaxx II trial. Int J Cardiol. 2012;157:96- 101. 269. Hong SJ, Hou D, Brinton TJ, Johnstone B, Feng D, Rogers P, Fearon WF, Yock P and March KL. Intracoronary and retrograde coronary venous myocardial delivery of adipose-derived stem cells in swine infarction lead to transient myocardial trapping with predominant pulmonary redistribution. Catheter Cardiovasc Interv. 2012. 270. Kawarada O, Fujihara M, Higashimori A, Yokoi Y, Honda Y and Fitzgerald PJ. Predictors of adverse clinical outcomes after successful infrapopliteal intervention. Catheter Cardiovasc Interv. 2012;80:861-71.

26 271. Kume T, Waseda K, Ako J, Sakata K, Yamasaki M, Shimohama T, Tsujino I, Hasegawa T, Fitzgerald PJ and Honda Y. Intravascular ultrasound assessment of postprocedural incomplete stent apposition. J Invasive Cardiol. 2012;24:13-6. 272. Kume T, Waseda K, Koo BK, Botelho R, Verheye S, Whitbourn R, Meredith I, Worthley S, Hai KT, Yock PG, Azevedo de Oliveira FR, Abizaid A, Fitzgerald PJ and Honda Y. Intravascular ultrasound comparison of small coronary lesions between novel guidewire-based sirolimus-eluting stents and conventional sirolimus-eluting stents. J Invasive Cardiol. 2012;24:489-93. 273. Otake H, Shite J, Ikeno F, Shinke T, Teramoto T, Miyoshi N, Ako J, Honda Y, Fitzgerald PJ and Hirata K. Evaluation of the peri-strut low intensity area following sirolimus- and paclitaxel-eluting stents implantation: insights from an optical coherence tomography study in humans. Int J Cardiol. 2012;157:38-42. 274. Saito S, Nakamura S, Fujii K, Nakamura M, Isshiki T, Hirayama H, Kikuchi T, Fujita H, Nonogi H, Mitsudo K, Kimura T, Igarashi K, Saito K, Lansky AJ, Stone GW, Honda Y, Waseda K, Fitzgerald PJ and Sudhir K. Mid-term results of everolimus-eluting stent in a Japanese population compared with a US randomized cohort: SPIRIT III Japan Registry with harmonization by doing. J Invasive Cardiol. 2012;24:444-50. 275. Sakata K, Waseda K, Kume T, Otake H, Nakatani D, Yock PG, Fitzgerald PJ and Honda Y. Impact of diabetes mellitus on vessel response in the drug-eluting stent era: pooled volumetric intravascular ultrasound analyses. Circ Cardiovasc Interv. 2012;5:763-71. 276. Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG, Bouma B, Bruining N, Cho JM, Chowdhary S, Costa MA, de Silva R, Dijkstra J, Di Mario C, Dudek D, Falk E, Feldman MD, Fitzgerald P, Garcia-Garcia HM, Gonzalo N, Granada JF, Guagliumi G, Holm NR, Honda Y, Ikeno F, Kawasaki M, Kochman J, Koltowski L, Kubo T, Kume T, Kyono H, Lam CC, Lamouche G, Lee DP, Leon MB, Maehara A, Manfrini O, Mintz GS, Mizuno K, Morel MA, Nadkarni S, Okura H, Otake H, Pietrasik A, Prati F, Raber L, Radu MD, Rieber J, Riga M, Rollins A, Rosenberg M, Sirbu V, Serruys PW, Shimada K, Shinke T, Shite J, Siegel E, Sonoda S, Suter M, Takarada S, Tanaka A, Terashima M, Thim T, Uemura S, Ughi GJ, van Beusekom HM, van der Steen AF, van Es GA, van Soest G, Virmani R, Waxman S, Weissman NJ, Weisz G and International Working Group for Intravascular Optical Coherence T. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol. 2012;59:1058-72. 277. Tsujino I, Koizumi T, Shimohama T, Ako J, Waseda K, Krucoff M, Honda Y and Fitzgerald PJ. Intravascular ultrasound insights from the Cobalt Chromium Stent With Antiproliferative for Restenosis II (COSTAR II) trial comparing CoStar and Taxus paclitaxel-eluting stents. Cardiovasc Revasc Med. 2012;13:111-8. 278. Yamasaki M, Tsujino I, Lima-Filho MO, Ako J, Shimohama T, Hasegawa T, Sakurai R, Sudhir K, Stone GW, Waseda K, Honda Y and Fitzgerald PJ. Comparison of vascular response to the everolimus-eluting stent versus the paclitaxel-eluting stent: intravascular ultrasound results from the SPIRIT III trial. EuroIntervention. 2012;8:724-31. 279. Abnousi F, Waseda K, Kume T, Otake H, Kawarada O, Yong CM, Fitzgerald PJ, Honda Y, Yeung AC and Fearon WF. Variability in quantitative and qualitative analysis of intravascular ultrasound and frequency domain optical coherence tomography. Catheter Cardiovasc Interv. 2013;82:E192-9. 280. Hibi K, Honda Y, Kimura K and Umemura S. Atherosclerosis: progress in diagnosis and treatments. Topics: III. Progress in diagnosis of atherosclerosis; 5. IVUS (intravascular ultrasound). Nihon Naika Gakkai Zasshi. 2013;102:344-53. 281. Kawarada O, Higashimori A, Noguchi M, Waratani N, Yoshida M, Fujihara M, Yokoi Y, Honda Y and Fitzgerald PJ. Duplex criteria for in-stent restenosis in the superficial femoral artery. Catheter Cardiovasc Interv. 2013;81:E199- 205. 282. Kozuma K, Kimura T, Suzuki N, Miyazawa A, Waseda K, Honda Y, Morimoto T, Aizawa T, Mitsudo K, Miyazaki S, Yamaguchi T and Isshiki T. Peri-stent contrast staining and very late stent thrombosis after sirolimus-eluting stent implantation: an observation from the RESTART (REgistry of Stent Thrombosis for review And Re-evaluaTion) angiographic substudy. EuroIntervention. 2013;9:831-40. 283. Kume T, Kim BK, Waseda K, Sathyanarayana S, Li W, Teo TJ, Yock PG, Fitzgerald PJ and Honda Y. Improved automated lumen contour detection by novel multifrequency processing algorithm with current intravascular ultrasound system. Catheter Cardiovasc Interv. 2013;81:E173-7. 284. Lin S, Tremmel JA, Yamada R, Rogers IS, Yong CM, Turcott R, McConnell MV, Dash R and Schnittger I. A novel stress echocardiography pattern for myocardial bridge with invasive structural and hemodynamic correlation. J Am Heart Assoc. 2013;2:e000097. 285. Ormiston J, Webster M, Stewart J, Vrolix M, Whitbourn R, Donohoe D, Knape C, Lansky A, Attizzani GF, Fitzgerald P, Kandzari DE and Wijns W. First-in-human evaluation of a bioabsorbable polymer-coated sirolimus-eluting stent: imaging and clinical results of the DESSOLVE I Trial (DES with sirolimus and a bioabsorbable polymer for the treatment of patients with de novo lesion in the native coronary arteries). JACC Cardiovasc Interv. 2013;6:1026-34.

27 286. Buysschaert I, Sanidas E, Hasegawa T, Koo BK, Honda Y, Fitzgerald PJ and Verheye S. Baseline and 9 months IVUS analysis of the bifurcation-dedicated biolimus A9-eluting Axxess stent system: the DIVERGE IVUS substudy. Catheter Cardiovasc Interv. 2014;84:1062-70. 287. Calderas C, Condado JF, Condado JA, Flores A, Mueller A, Thomas J, Nakatani D, Honda Y, Waseda K and Fitzgerald P. Safety and efficacy of low-dose paclitaxel utilizing the cobra-P drug-eluting stent system with a novel biodegradable coating in de novo coronary lesions: the PLUS-ONE first-in-man study. Cardiovasc Revasc Med. 2014;15:18-22. 288. Kawarada O, Yasuda S, Huang J, Honda Y, Fitzgerald PJ, Ishihara M and Ogawa H. Contemporary infrapopliteal intervention for limb salvage and wound healing: harmonization of revascularization and wound management. Circ J. 2014;78:1540-9. 289. Kobayashi Y and Fearon WF. Invasive coronary microcirculation assessment--current status of index of microcirculatory resistance. Circ J. 2014;78:1021-8. 290. Kume T, Waseda K, Koo BK, Yock PG, Botelho R, Verheye S, Whitbourn R, Meredith I, Worthley S, Hai KT, Honda Y, Abizaid A and Fitzgerald PJ. Intravascular ultrasound analysis of small vessel lesions treated with the Sparrow coronary stent system: results of the CARE II trial. Catheter Cardiovasc Interv. 2014;83:19-24. 291. Nakatani D, Waseda K, Ako J, Calderas C, Condado JA, Condado JF, Honda Y and Fitzgerald PJ. First-in-man study of the low-dose paclitaxel using the COBRA-P drug-eluting coronary stent system with a novel biodegradable coating in de novo coronary lesions. Catheter Cardiovasc Interv. 2014;84:1101-1109. 292. Yamada R, Turcott RG, Connolly AJ, Ikeno F, McConnell MV, Schnittger I, Fitzgerald PJ and Honda Y. Histological characteristics of myocardial bridge with an ultrasonic echolucent band. Comparison between intravascular ultrasound and histology. Circ J. 2014;78:502-4. 293. Iqbal J, Verheye S, Abizaid A, Ormiston J, de Vries T, Morrison L, Toyloy S, Fitzgerald P, Windecker S and Serruys PW. DESyne novolimus-eluting coronary stent is superior to Endeavor zotarolimus-eluting coronary stent at five-year follow-up: final results of the multicentre EXCELLA II randomised controlled trial. EuroIntervention. 2015;11. 294. Kereiakes DJ, Ellis SG, Popma JJ, Fitzgerald PJ, Samady H, Jones-McMeans J, Zhang Z, Cheong WF, Su X, Ben- Yehuda O and Stone GW. Evaluation of a fully bioresorbable vascular scaffold in patients with coronary artery disease: design of and rationale for the ABSORB III randomized trial. Am Heart J. 2015;170:641-651 e3. 295. Kobayashi Y, Fearon WF, Honda Y, Tanaka S, Pargaonkar V, Fitzgerald PJ, Lee DP, Stefanick M, Yeung AC and Tremmel JA. Effect of sex differences on invasive measures of coronary microvascular dysfunction in patients with angina in the absence of obstructive coronary artery disease. JACC Cardiovasc Interv. 2015;8:1433-41. 296. Kobayashi Y, Tremmel JA, Kobayashi Y, Amsallem M, Tanaka S, Yamada R, Rogers IS, Haddad F and Schnittger I. Exercise Strain Echocardiography in Patients With a Hemodynamically Significant Myocardial Bridge Assessed by Physiological Study. J Am Heart Assoc. 2015;4. 297. Lee BK, Lim HS, Fearon WF, Yong AS, Yamada R, Tanaka S, Lee DP, Yeung AC and Tremmel JA. Invasive evaluation of patients with angina in the absence of obstructive coronary artery disease. Circulation. 2015;131:1054- 60. 298. Nakatani S, Sotomi Y, Ishibashi Y, Grundeken MJ, Tateishi H, Tenekecioglu E, Zeng Y, Suwannasom P, Regar E, Radu MD, Raber L, Bezerra H, Costa MA, Fitzgerald P, Prati F, Costa RA, Dijkstra J, Kimura T, Kozuma K, Tanabe K, Akasaka T, Di Mario C, Serruys PW and Onuma Y. Comparative analysis method of permanent metallic stents (XIENCE) and bioresorbable poly-L-lactic (PLLA) scaffolds (Absorb) on optical coherence tomography at baseline and follow-up. EuroIntervention. 2015;11. 299. Okada K, Hibi K, Gohbara M, Kataoka S, Takano K, Akiyama E, Matsuzawa Y, Saka K, Maejima N, Endo M, Iwahashi N, Tsukahara K, Kosuge M, Ebina T, Fitzgerald PJ, Honda Y, Umemura S and Kimura K. Association between blood glucose variability and coronary plaque instability in patients with acute coronary syndromes. Cardiovasc Diabetol. 2015;14:111. 300. Okada K, Kitahara H, Yang HM, Tanaka S, Kobayashi Y, Kimura T, Luikart H, Yock PG, Yeung AC, Valantine HA, Fitzgerald PJ, Khush KK, Honda Y and Fearon WF. Paradoxical vessel remodeling of the proximal segment of the left anterior descending artery predicts long-term mortality after heart transplantation. JACC Heart Fail. 2015;3:942-52. 301. Sakata K, Koo BK, Waseda K, Nakatani D, Yock PG, Whitbourn R, Worthley SG, Ormiston J, Webster M, Wilkins GT, Honda Y, Meredith IT and Fitzgerald PJ. A Y-shaped bifurcation-dedicated stent for the treatment of de novo coronary bifurcation lesions: an IVUS analysis from the BRANCH trial. EuroIntervention. 2015;10:e1-8. 302. Schwartz JG, Tanaka S, Schnittger I and Tremmel JA. Invasive physiologic and anatomic multimodality assessment of myocardial bridging. Coron Artery Dis. 2015;26 Suppl 1:e38-40.

28 303. Tremmel JA, Fearon WF, Lee BK, Lim HS, Yong AS, Yamada R, Tanaka S, Lee DP and Yeung AC. Response to Letters Regarding Article, "Invasive Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease". Circulation. 2015;132:e244. 304. Iqbal J, Verheye S, Abizaid A, Ormiston J, de Vries T, Morrison L, Toyloy S, Fitzgerald P, Windecker S and Serruys PW. DESyne novolimus-eluting coronary stent is superior to Endeavor zotarolimus-eluting coronary stent at five-year follow-up: final results of the multicentre EXCELLA II randomised controlled trial. EuroIntervention. 2016;12:e1336- e1342. 305. Kitahara H, Okada K, Tanaka S, Yang HM, Miki K, Kobayashi Y, Kimura T, Luikart H, Yock PG, Yeung AC, Fitzgerald PJ, Khush KK, Fearon WF and Honda Y. Association of periarterial neovascularization with progression of cardiac allograft vasculopathy and long-term clinical outcomes in heart transplant recipients. J Heart Lung Transplant. 2016;35:752-9. 306. Kitahara H, Waseda K, Yamada R, Otagiri K, Tanaka S, Kobayashi Y, Okada K, Kume T, Nakagawa K, Teramoto T, Ikeno F, Yock PG, Fitzgerald PJ and Honda Y. Acute stent recoil and optimal balloon inflation strategy: an experimental study using real-time optical coherence tomography. EuroIntervention. 2016;12:e190-8. 307. Kitahara H, Waseda K, Yamada R, Sakamoto K, Yock PG, Fitzgerald PJ and Honda Y. Relative dose and vascular response after drug-eluting stent implantation: A dosimetric 3D-intravascular ultrasound study. Int J Cardiol. 2016;204:211-7. 308. Kobayashi Y, Kitahara H, Tanaka S, Okada K, Kimura T, Ikeno F, Yock PG, Fitzgerald PJ and Honda Y. Quantitative precision of optical frequency domain imaging: direct comparison with frequency domain optical coherence tomography and intravascular ultrasound. Cardiovasc Interv Ther. 2016;31:79-88. 309. Miki K, Fujii K, Kawasaki D, Shibuya M, Fukunaga M, Imanaka T, Tamaru H, Sumiyoshi A, Nishimura M, Horimatsu T, Saita T, Okada K, Kimura T, Honda Y, Fitzgerald PJ, Masuyama T and Ishihara M. Intravascular ultrasound- derived stent dimensions as predictors of angiographic restenosis following nitinol stent implantation in the superficial femoral artery. J Endovasc Ther. 2016;23:424-32. 310. Nakatani S, Sotomi Y, Ishibashi Y, Grundeken MJ, Tateishi H, Tenekecioglu E, Zeng Y, Suwannasom P, Regar E, Radu MD, Raber L, Bezerra H, Costa MA, Fitzgerald P, Prati F, Costa RA, Dijkstra J, Kimura T, Kozuma K, Tanabe K, Akasaka T, Di Mario C, Serruys PW and Onuma Y. Comparative analysis method of permanent metallic stents (XIENCE) and bioresorbable poly-L-lactic (PLLA) scaffolds (Absorb) on optical coherence tomography at baseline and follow-up. EuroIntervention. 2016;12:1498-1509. 311. Okada K, Fearon WF, Luikart H, Kitahara H, Otagiri K, Tanaka S, Kimura T, Yock PG, Fitzgerald PJ, Yeung AC, Valantine HA, Khush KK and Honda Y. Attenuated-signal plaque progression predicts long-term mortality after heart transplantation: IVUS assessment of cardiac allograft vasculopathy. J Am Coll Cardiol. 2016;68:382-92. 312. Perl L, Daniels D, Schwartz J, Tanaka S, Yeung A, Tremmel JA and Schnittger I. Myocardial Bridge and Acute Plaque Rupture. J Investig Med High Impact Case Rep. 2016;4:2324709616680227. 313. Waseda K, Ako J, Kume T, Fitzgerald PJ and Honda Y. Characteristics of late-acquired incomplete stent apposition: a comparison with first-generation and second-generation drug-eluting stents. J Invasive Cardiol. 2016;28:323-9. 314. Yamada R, Tremmel JA, Tanaka S, Lin S, Kobayashi Y, Hollak MB, Yock PG, Fitzgerald PJ, Schnittger I and Honda Y. Functional versus anatomic assessment of myocardial bridging by intravascular ultrasound: impact of arterial compression on proximal atherosclerotic plaque. J Am Heart Assoc. 2016;5:e001735. 315. Yang HM, Khush K, Luikart H, Okada K, Lim HS, Kobayashi Y, Honda Y, Yeung AC, Valantine H and Fearon WF. Invasive assessment of coronary physiology predicts late mortality after heart transplantation. Circulation. 2016;133:1945-50. 316. Boyd JH, Pargaonkar VS, Scoville DH, Rogers IS, Kimura T, Tanaka S, Yamada R, Fischbein MP, Tremmel JA, Mitchell RS and Schnittger I. Surgical Unroofing of Hemodynamically Significant Left Anterior Descending Myocardial Bridges. Ann Thorac Surg. 2017;103:1443-1450. 317. Fearon WF, Felix R, Hirohata A, Sakurai R, Jose PO, Yamasaki M, Nakamura M, Fitzgerald PJ, Valantine HA, Yock PG and Yeung AC. The effect of negative remodeling on fractional flow reserve after cardiac transplantation. Int J Cardiol. 2017;241:283-287. 318. Fearon WF, Okada K, Kobashigawa JA, Kobayashi Y, Luikart H, Sana S, Daun T, Chmura SA, Sinha S, Cohen G, Honda Y, Pham M, Lewis DB, Bernstein D, Yeung AC, Valantine HA and Khush K. Angiotensin-converting enzyme inhibition early after heart transplantation. J Am Coll Cardiol. 2017;69:2832-2841. 319. Forsdahl SH, Rogers IS, Schnittger I, Tanaka S, Kimura T, Pargaonkar VS, Chan FP, Fleischmann D, Tremmel JA and Becker HC. Myocardial Bridges on Coronary Computed Tomography Angiography- Correlation With Intravascular Ultrasound and Fractional Flow Reserve. Circ J. 2017;81:1894-1900.

29 320. Kitahara H, Okada K, Kimura T, Yock PG, Lansky AJ, Popma JJ, Yeung AC, Fitzgerald PJ and Honda Y. Impact of stent size selection on acute and long-term outcomes after drug-eluting stent implantation in de novo coronary lesions. Circ Cardiovasc Interv. 2017;10:e004795. 321. Kitahara H, Waseda K, Sakamoto K, Yamada R, Huang CC, Nakatani D, Sakata K, Kawarada O, Yock PG, Matsuyama Y, Yokoi H, Nakamura M, Muramatsu T, Nanto S, Fitzgerald PJ and Honda Y. Impact of attenuated- signal plaque observed by intravascular ultrasound on vessel response after drug-eluting stent implantation. Atherosclerosis. 2017;259:68-74. 322. Lee JH, Okada K, Khush K, Kobayashi Y, Sinha S, Luikart H, Valantine H, Yeung AC, Honda Y and Fearon WF. Coronary endothelial dysfunction and the index of microcirculatory resistance as a marker of subsequent development of cardiac allograft vasculopathy. Circulation. 2017;135:1093-1095. 323. Miki K, Fujii K, Kawasaki D, Shibuya M, Fukunaga M, Imanaka T, Tamaru H, Sumiyoshi A, Nishimura M, Horimatsu T, Saita T, Kobayashi Y, Honda Y, Fitzgerald PJ, Masuyama T and Ishihara M. Impact of analysis interval size on the quality of optical frequency domain imaging assessments of stent implantation for lesions of the superficial femoral artery. Catheter Cardiovasc Interv. 2017;89:735-745. 324. Miki K, Fujii K, Shibuya M, Fukunaga M, Imanaka T, Kawai K, Tamaru H, Sumiyoshi A, Nishimura M, Horimatsu T, Saita T, Yoshihara N, Kimura T, Honda Y, Fitzgerald PJ, Masuyama T and Ishihara M. Impact of stent diameter on vascular response after self-expanding paclitaxel-eluting stent implantation in the superficial femoral artery. J Cardiol. 2017;70:346-352. 325. Choi DH, Chmura SA, Ramachandran V, Dionis-Petersen KY, Kobayashi Y, Nishi T, Luikart H, Dimbil S, Kobashigawa J, Khush K, Lewis DB and Fearon WF. The ratio of circulating regulatory cluster of differentiation 4 T cells to endothelial progenitor cells predicts clinically significant acute rejection after heart transplantation. J Heart Lung Transplant. 2018;37:496-502. 326. Choi DH, Kobayashi Y, Nishi T, Luikart H, Dimbil S, Kobashigawa J, Khush K and Fearon WF. Change in lymphocyte to neutrophil ratio predicts acute rejection after heart transplantation. Int J Cardiol. 2018;251:58-64. 327. Fearon WF, Nishi T, De Bruyne B, Boothroyd DB, Barbato E, Tonino P, Juni P, Pijls NHJ, Hlatky MA and Investigators FT. Clinical outcomes and cost-effectiveness of fractional flow reserve-guided percutaneous coronary intervention in patients with stable coronary artery disease: three-year follow-up of the FAME 2 trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation). Circulation. 2018;137:480-487. 328. Kobayashi Y, Kobayashi Y, Yang HM, Bouajila S, Luikart H, Nishi T, Choi DH, Schnittger I, Valantine HA, Khush KK, Yeung ACY, Haddad F and Fearon WF. Long-term prognostic value of invasive and non-invasive measures early after heart transplantation. Int J Cardiol. 2018;260:31-35. 329. Kobayashi Y, Lonborg J, Jong A, Nishi T, De Bruyne B, Hofsten DE, Kelbaek H, Layland J, Nam CW, Pijls NHJ, Tonino PAL, Warnoe J, Oldroyd KG, Berry C, Engstrom T, Fearon WF, Danami-3-Primulti F and Investigators F-NS. Prognostic value of the residual SYNTAX score after functionally complete revascularization in ACS. J Am Coll Cardiol. 2018;72:1321-1329. 330. Maeda K, Schnittger I, Murphy DJ, Tremmel JA, Boyd JH, Peng L, Okada K, Pargaonkar VS, Hanley FL, Mitchell RS and Rogers IS. Surgical unroofing of hemodynamically significant myocardial bridges in a pediatric population. J Thorac Cardiovasc Surg. 2018;156:1618-1626. 331. Nishi T and Fearon WF. Fractional flow reserve derived from routine coronary angiography. Int J Cardiol. 2018;271:51-52. 332. Nishi T, Piroth Z, De Bruyne B, Jagic N, Mobius-Winkler S, Kobayashi Y, Derimay F, Fournier S, Barbato E, Tonino P, Juni P, Pijls NHJ and Fearon WF. Fractional flow reserve and quality-of-life improvement after percutaneous coronary intervention in patients with stable coronary artery disease. Circulation. 2018;138:1797-1804. 333. Okada K, Honda Y, Kitahara H, Otagiri K, Tanaka S, Hollak MB, Yock PG, Popma JJ, Kusano H, Cheong WF, Sudhir K, Fitzgerald PJ and Kimura T. Bioresorbable scaffold for treatment of coronary artery lesions: intravascular ultrasound results from the ABSORB Japan trial. JACC Cardiovasc Interv. 2018;11:648-661. 334. Okada K, Kitahara H, Mitsutake Y, Tanaka S, Kimura T, Yock PG, Fitzgerald PJ, Ikeno F and Honda Y. Assessment of bioresorbable scaffold with a novel high-definition 60 MHz IVUS imaging system: Comparison with 40-MHz IVUS referenced to optical coherence tomography. Catheter Cardiovasc Interv. 2018;91:874-883. 335. Shah SV, Zimmermann FM, Johnson NP, Nishi T, Kobayashi Y, Witt N, Berry C, Jeremias A, Koo BK, Esposito G, Rioufol G, Park SJ, Oldroyd KG, Barbato E, Pijls NHJ, De Bruyne B, Fearon WF and Investigators CS. Sex differences in adenosine-free coronary pressure indexes: a CONTRAST substudy. JACC Cardiovasc Interv. 2018;11:1454-1463. 336. Choi DH, Kobayashi Y, Nishi T, Kim HK, Ki YJ, Kim SS, Park KH, Song H and Fearon WF. Combination of mean platelet volume and neutrophil to lymphocyte ratio predicts long-term major adverse cardiovascular events after percutaneous coronary intervention. . 2019;70:345-351.

30 337. Derimay F, Rioufol G, Nishi T, Kobayashi Y, Fearon WF, Veziers J, Guerin P and Finet G. Optimal balloon positioning for the proximal optimization technique? An experimental bench study. Int J Cardiol. 2019;292:95-97. 338. Kawarada O, Kume T, Zen K, Nakamura S, Hozawa K, Akimitsu T, Asano H, Ando H, Yamamoto Y, Yamashita T, Shinozaki N, Odashiro K, Sato T, Yuba K, Sakanoue Y, Uzu T, Okada K, Fitzgerald PJ, Honda Y and Yasuda S. Cardiac function response to stenting in atherosclerotic renal artery disease with and without heart failure: results from the Carmel study. ESC Heart Fail. 2019;6:319-327. 339. Matsushita K, Hibi K, Okada K, Sakamaki K, Akiyama E, Kimura Y, Matsuzawa Y, Maejima N, Iwahashi N, Tsukahara K, Kosuge M, Ebina T, Fitzgerald PJ, Honda Y, Tamura K and Kimura K. Comparison between instantaneous wave-free ratio versus morphometric assessments by intracoronary imaging. Heart Vessels. 2019;34:926-935. 340. Nishi T and Fearon WF. FFR-guided PCI in STEMI. EuroIntervention. 2019;15:134-136. 341. Okada K, Hibi K, Matsushita K, Yagami H, Tamura K, Honda Y and Kimura K. Intravascular ultrasound radiofrequency signal analysis of blood speckles: physiological assessment of intermediate coronary artery stenosis. Catheter Cardiovasc Interv. 2019. 342. Okada K, Honda Y, Luikart H, Yock PG, Fitzgerald PJ, Yeung AC, Valantine HA, Khush KK and Fearon WF. Early invasive assessment of the coronary microcirculation predicts subsequent acute rejection after heart transplantation. Int J Cardiol. 2019;290:27-32. 343. Pargaonkar VS, Kobayashi Y, Kimura T, Schnittger I, Chow EKH, Froelicher VF, Rogers IS, Lee DP, Fearon WF, Yeung AC, Stefanick ML and Tremmel JA. Accuracy of non-invasive stress testing in women and men with angina in the absence of obstructive coronary artery disease. Int J Cardiol. 2019;282:7-15. 344. Parikh RV, Khush K, Pargaonkar VS, Luikart H, Grimm D, Yu M, Okada K, Honda Y, Yeung AC, Valantine H and Fearon WF. Association of endothelin-1 with accelerated cardiac allograft vasculopathy and late mortality following heart transplantation. J Card Fail. 2019;25:97-104. 345. Arashi H, Sato T, Kobashigawa J, Luikart H, Kobayashi Y, Okada K, Sinha S, Honda Y, Yeung AC, Khush K and Fearon WF. Long-term clinical outcomes with use of an angiotensin-converting enzyme inhibitor early after heart transplantation. Am Heart J. 2020;222:30-37. 346. Kumar A, Gogas BD, Thompson EW, Burnett GM, Molony D, Hosseini H, Chandran K, Lefieux A, Honda Y, Lee JM, Serruys PW, Kereiakes DJ, Stone GW, Samady H and Collaborators. Absorb bioresorbable vascular scaffold is associated with low wall shear stress compared to Xience V: a biomechanical analysis of the ABSORB III Imaging Study. EuroIntervention. 2020. 347. Okada K, Hibi K, Honda Y, Fitzgerald PJ, Tamura K and Kimura K. Association between abdominal fat distribution and coronary plaque instability in patients with acute coronary syndrome. Nutr Metab Cardiovasc Dis. 2020;30:1169- 1178. 348. Okada K, Honda Y, Kitahara H, Ikutomi M, Kameda R, Hollak MB, Yock PG, Popma JJ, Kusano H, Cheong W- F, Sudhir K, Fitzgerald PJ and Kimura T. Scaffold underexpansion and late lumen loss after bioresorbable scaffold implantation: insights from ABSORB JAPAN trial (in press). Int J Cardiol Heart Vasc. 2020. 349. Onuma Y, Honda Y, Asano T, Shiomi H, Kozuma K, Ozaki Y, Namiki A, Yasuda S, Ueno T, Ando K, Furuya J, Hanaoka KI, Tanabe K, Okada K, Kitahara H, Ono M, Kusano H, Rapoza R, Simonton C, Popma JJ, Stone GW, Fitzgerald PJ, Serruys PW and Kimura T. Randomized comparison between everolimus-eluting bioresorbable scaffold and metallic stent: multimodality imaging through 3 years. JACC Cardiovasc Interv. 2020;13:116-127. 350. Sonoda S, Hibi K, Okura H, Fujii K, Honda Y and Kobayashi Y. Current clinical use of intravascular ultrasound imaging to guide percutaneous coronary interventions. Cardiovasc Interv Ther. 2020;35:30-36. 351. Tanaka S, Okada K, Kitahara H, Luikart H, Yock PG, Yeung AC, Schnittger I, Fitzgerald PJ, Khush KK, Fearon WF and Honda Y. Impact of myocardial bridging on coronary artery plaque formation and long-term mortality after heart transplantation (in press). J Heart Lung Transplant. 2020.

31 CCVT Bibliography 2000-2020

Book Chapters and Textbooks

1. Honda Y and Kobayashi Y. Intravascular ultrasound. In: J. Yoshikawa, ed. Diagnosis of Coronary Artery Disease: Chugai Igaku Co.; 2000: 104-115. 2. Okura H, Benneau HN, Yock PG and Fitzgerald PJ. Intravascular ultrasound: practical use in the cardiac catheterization laboratory. In: S. G. Ellis and J. David R. Holmes, eds. Strategic Approaches in Coronary Intervention. Second ed.: Lippincott Williams & Wilkins; 2000: 78-93. 3. Yock PG and Fitzgerald PJ. Intravascular ultrasound. In: J. T. Willerson and J. N. Cohn, eds. Cardiovascular Medicine. Second ed.: Churchill Livingstone; 2000: 1454-1459. 4. Abernethy WB, Fitzgerald PJ and Yeung AC. Novel revascularization strategies: PMR, TMR, and percutaneous in situ coronary venous arterialization. In: G. S. Abela, ed. Myocardial Revascularization: Novel Percutaneous Approaches New York: John Wiley and Sons Ltd; 2001: 125-136. 5. Chou T, Fitzgerald PJ and Yock PG. Intravascular ultrasound. In: S. B. Donald and W. Grossman, eds. Intravascular Ultrasound for Cardiac Catheterization, Angioplasty and Intervention. Sixth ed.: Lippincott Williams & Wilkins; 2001. 6. Honda Y. The role of intravascular ultrasound in clinical trials. In: J. Yoshikawa, ed. Clinical Echocardiography. Second ed.: Bunkodo; 2001: 265-267. 7. Honda Y. Stanford university. Journal of Clinical Echocardiography. 2001. 8. Honda Y and Kabayashi Y. Future direction of intravascular ultrasound. In: J. Yoshikawa, ed. Clinical Echocardiography. Second ed.: Bunkodo; 2001: 267-275. 9. Honda Y and Kobayashi Y. Principles of intravascular ultrasound. In: J. Yoshikawa, ed. Clinical Echocardiography. Second ed.: Bunkodo; 2001: 252-259. 10. Knopf WD, Fitzgerald PJ and Takagi A. Long Segments. In: N. Curzen and M. T. Rothman, eds. Coronary Artery Stenting: A Case-Oriented Approach: Martin Dunitz; 2001: 7-18. 11. Morino Y, Takagi A, Honda Y and Fitzgerald PJ. Vascular brachytherapy: from theory to practice. In: S. Jani, E. Minar, P. Serruys and P. Tripuraneni, eds. Coronary Angioplasty and Intravascular Ultrasound for Brachytherapy: Remedica Publishing; 2001: 121-141. 12. Shimodozono S, Honda Y, Bonneau HN and Fitzgerald PJ. The role of IVUS in the prevention and treatment of restenosis. In: D. P. Faxon, ed. Restenosis: A Guide to Therapy London, UK: Martin Dunitz Ltd; 2001: 77-95. 13. Honda Y. New technology for the treatment of acute myocardial infarction: how to protect coronary microcirculation and myocardium. Coronary Intervention. 2002;1:99-105. 14. Honda Y, Fitzgerald PJ and Yock PG. Intravascular ultrasound. In: E. J. Topol, ed. Textbook of Interventional Cardiology. Fourth ed.: W.B. Saunders; 2002: 893-917. 15. Hur S-H, Honda Y, Bonneau HN, Yock PG and Fitzgerald PJ. Intravascular ultrasound observations for stented and non-stented procedures. In: R. Waksman, ed. Vascular Brachytherapy. Third ed. Armonk, NY: Futura Publishing Company, Inc.; 2002: 581-603. 16. Jeremias A, Fitzgerald PJ and Yock PG. Intravascular ultrasonography to diagnose vulnerable plaque. In: D. L. Brown, ed. Cardiovascular Plaque Rapture: Marcel dekker, Inc.; 2002: 245-268. 17. Kitamura K, Yock PG and Fitzgerald PJ. Intravascular ultrasound: histologic correlation and clinical applications. In: C. M. Otto, ed. The Practice of Clinical Echocardiography. Second ed. Philadelphia: W.B. Saunders; 2002: 349-365. 18. Morino Y, Kataoka T, Honda Y and Fitzgerald PJ. Prevention of restenosis: sonotheraphy, photoangioplasty and cryotherapy. In: T. Yamaguchi, ed. Cardiology New Trends: New Trends in Coronary Intervention Tokyo: Medical View; 2002. 19. Silber S, Grube E and Fitzgerald PJ. The Quanam QuaDDS-QP2 stent. In: P. W. Serruys and B. J. Rensing, eds. Handbook of Coronary Stents. Fourth ed.: Martin Dunitz; 2002: 343-347. 20. Staehr P, Honda Y, Fitzgerald PJ and Yock PG. Coronary intravascular ultrasonography. In: P. Lanzer and E. J. Topol, eds. PanVascular Medicine: Integrated Clinical Management: Springer-Verlag Berlin Heidelberg; 2002: 667-678. 21. Fearon WF and Yeung AC. Evaluating intermediate coronary lesions in the cardiac catheterization laboratory. Rev Cardiovasc Med. 2003;4:1-7.

32 22. Fitzgerald PJ. Diagnostic and therapeutic ultrasound application for interventional cardiology: from current practice to future potential. In: F. Alfonso and J. Botas, eds. Intracoronary Diagnostic Techniques madrid, Spain: McGraw- Hill/Interamericana; 2003: 229-238. 23. Honda Y. New technologies for the treatment of acute myocardial infarction: ongoing clinical trials in the United States and Europe. In: K. Kimura, ed. Cardioangiology Tokyo: Kagaku Hyoronsha Ltd.; 2003(54): 70-79. 24. Honda Y and Hayase M. Percutaneous intervention by the coronary venous route. Heart View. 2003;7:58-64. 25. Kaneda H, Honda Y and Fitzgerald PJ. What do cardiologists want from vascular ultrasound? In: Y. Saijo and A. F. W. v. d. Steen, eds. Vascular Ultrasound Tokyo: Springer-Verlag Tokyo; 2003: 3-27. 26. Sakurai R, Honda Y, Bonneau HN and Fitzgerald PJ. IVUS guided stenting - optimizing outcomes. Coronary Intervention. 2003;2:26-30. 27. Ako J, Honda Y and Fitzgerald PJ. Drug-eluting stent: basic components. In: T. Yamaguchi and T. Tamura, eds. Drug- Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 40-50. 28. Courtney BK and Fitzgerald PJ. Intravascular ultrasound and tissue characterization. In: P. W. Serruys and R. Waksman, eds. Handbook of the Vulnerable Plaque London: Taylor & Francis; 2004. 29. Honda Y. Thrombectomy and distal protection: protection of coronary microcirculation and myocardium. In: M. Hori, ed. Coronary Intervention Tokyo, Japan: Medical Sense; 2004: 199-206. 30. Honda Y and Fitzgerald PJ. IVUS observations of drug-eluting stents. In: T. Yamaguchi and T. Tamura, eds. Drug- Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 128-138. 31. Hongo Y, Honda Y and Fitzgerald PJ. ABT-578-eluting stent. In: T. Yamaguchi and T. Tamura, eds. Drug-Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 98-100. 32. Kaneda H, Honda Y and Fitzgerald PJ. Other drug-eluting stents. In: T. Yamaguchi and T. Tamura, eds. Drug-Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 105-110. 33. Kataoka T, Honda Y and Fitzgerald PJ. Drug-eluting stent for the treatment of in-stent restenosis. In: T. Yamaguchi and T. Tamura, eds. Drug-Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 116-122. 34. Morino Y, Honda Y and Fitzgerald PJ. Sirolimus-eluting stent (CYPHER™). In: T. Yamaguchi and T. Tamura, eds. Drug-Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 63-73. 35. Morino Y, Nakamura M, Kataoka T, Honda Y and Fitzgerald PJ. Paclitaxel-eluting stent. Jpn J Cardiovasc Ther. 2004;4:148-153. 36. Nakamura M, Honda Y and Fitzgerald PJ. Paclitaxel-eluting stent. In: T. Yamaguchi and T. Tamura, eds. Drug- Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 74-82. 37. Sakurai R, Honda Y and Fitzgerald PJ. Dexamethasone-eluting stent (Dexamet™). In: T. Yamaguchi and T. Tamura, eds. Drug-Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 83-88. 38. Sakurai R, Honda Y and Fitzgerald PJ. Estradiol-eluting stent. In: T. Yamaguchi and T. Tamura, eds. Drug-Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 101-104. 39. Shimada Y and Honda Y. Left main coronary disease: an IVUS perspective. Coronary Intervention. 2004;3:16-22. 40. Sonoda S, Honda Y and Fitzgerald PJ. Lessons from failed drug-eluting stents. In: T. Yamaguchi and T. Tamura, eds. Drug-Eluting Stent Tokyo: Igaku-Shoin Ltd.; 2004: 111-115. 41. Honda Y. Future directions of drug-eluting stent technology. In: H. Nishikawa, ed. Coronary Intervention Tokyo, Japan: Medialfa; 2005(1): 96-101. 42. Hongo Y and Honda Y. New treatment technologies for coronary artery disease: other techniques. In: K. Kimura and K. Haze, eds. Practical Cardiology: Coronary Artery Disease II Tokyo: Bunkodo; 2005(5): 158-164. 43. Ikeno F, Honda Y, Bonneau HN, Hassan AHM and Fitzgerald PJ. Percutaneous coronary sinus repair of mitral regurgitation. In: H. C. Herrmann, ed. Interventional Cardiology Totowa, NJ: Humana Press Inc; 2005: 69-86. 44. Ako J. Long-term follow-up of drug-eluting stent: incomplete stent apposition. In: T. Yamaguchi, ed. Drug-Eluting Stent 2 Tokyo: Igaku-Shoin Ltd.; 2006: 199-204. 45. Ako J, Hassan A, Honda Y and Fitzgerald PJ. Available transcatheter mitral valve repair techniques: CS method. In: Z. Hijazi, P. Bonhoeffer, T. E. Feldman and C. Ruiz, eds. Transcathter Valve Repair London: Taylor & Francis Books Ltd; 2006: 285-294. 46. Brinton TJ, Hassan A and Yeung AC. Procedures. Coronary vein device insertion. In: S. B. King, 3rd and A. C. Yeung, eds. Interventional Cardiology: McGraw-Hill; 2006: 519-526.

33 47. Fearon WF. Knowledge foundation. Cardiac chamber anatomy. In: S. B. King, 3rd and A. C. Yeung, eds. Interventional Cardiology: McGraw-Hill; 2006: 13-17. 48. Fearon WF, Nakamura M and Fitzgerald PJ. Procedures. Adjunctive diagnostic techniques. In: S. B. King, 3rd and A. C. Yeung, eds. Interventional Cardiology: McGraw-Hill; 2006: 291-302. 49. Fearon WF and Stewart RE. Knowledge foundation. Coronary artery anatomy for the interventionalise. In: S. B. King, 3rd and A. C. Yeung, eds. Interventional Cardiology: McGraw-Hill; 2006: 3-12. 50. Honda Y. Next generation drug-eluting stents. In: T. Yamaguchi, ed. Drug-Eluting Stent 2 Tokyo: Igaku-Shoin Ltd.; 2006: 100-105. 51. Honda Y, Fitzgerald PJ and Yock PG. Intravascular imaging techniques. In: S. B. Donald and W. Grossman, eds. Cardiac Catheterization, Angioplasty and Intervention. Seventh ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2006: 371-394. 52. Miyazawa A. Cypher and TAXUS in complex lesions: results in bifurcation and left main lesions. In: T. Yamaguchi, ed. Drug-Eluting Stent 2 Tokyo: Igaku-Shoin Ltd.; 2006: 52-58. 53. Overall WR and Yock PG. Principles of innovation. Innovation and interventional cardiology: looking back, thinking ahead. In: S. B. King, 3rd and A. C. Yeung, eds. Interventional Cardiology: McGraw-Hill; 2006: 795-804. 54. Tsujino I. Cypher and TAXUS in complex lesions: results in diabetic patients. In: T. Yamaguchi, ed. Drug-Eluting Stent 2 Tokyo: Igaku-Shoin Ltd.; 2006: 32-37. 55. Waseda K. ABT578-eluting stent: Zomaxx. In: T. Yamaguchi, ed. Drug-Eluting Stent 2 Tokyo: Igaku-Shoin Ltd.; 2006: 73-76. 56. Yamasaki M. Controversy in drug-eluting stent: overseas reports of stent thrombosis. In: T. Yamaguchi, ed. Drug- Eluting Stent 2 Tokyo: Igaku-Shoin Ltd.; 2006: 139-145. 57. Honda Y, Fitzgerald PJ and Yock PG. Intravascular ultrasound. In: E. J. Topol, ed. Textbook of Interventional Cardiology. Fifth ed. Philadelphia: Saunders Elsevier; 2007: 1115-1142. 58. Hur S-H, Honda Y, Fitzgerald PJ and Yock PG. Intravascular ultrasound. In: J. T. Willerson, J. N. Cohn, H. J. J. Wellens and J. David R. Holmes, eds. Cardiovasuclar Medicine. Third ed. Philadelphia, PA: Churchill Livingstone, A Harcourt Health Sciences Company; 2007: 1797-1810. 59. Waseda K and Honda Y. Future directions of drug-eluting stents in the treatment of acute coronary syndrome. Coronary Intervention. 2007;3:94-99. 60. Ako J, Yamasaki M, Honda Y and Fitzgerald PJ. Cardiovascular imaging: intravascular ultrasound. Interventional Cardiology: Current Best Practice. 2009:206-211. 61. Kume T and Honda Y. Primary PCI for STEMI: hypothermia and myocardial regeneration therapy. Evidence Based Medicine: Treatment of Cardiovascular Disease 2010-2011. 2009:39-43. 62. Nakatani D and Honda Y. Drug-euting stents: current developments and future directions. Journal of Clinical an Experimental Medicine. 2009;231:727-731. 63. Sakata K and Honda Y. Future directions of intravascular ultrasound. The Lipid. 2009;20:90-99. 64. Sakata K and Honda Y. Stent designs for bifurcation lesions: dedicated bifurcation stents. Coronary Intervention. 2009;5:33-40. 65. Sakata K and Honda Y. IB-IVUS, Virtual Histology. Journal of Clinical Echocardiography. 2009;10:792-802. 66. Waseda K and Honda Y. Scieitific support for clinical trials: the role and system of core laboratories in clinical research. Coronary Intervention. 2009;5:25-28. 67. Zenios S, Makower J, Yock PG, Brinton TJ, N. KU, Denend L, Krummel TM and Kurihara C. Biodesign: the process of innovating medical technologies. 2009. 68. Otake H, Honda Y and Fitzgerald PJ. The role of intravascular ultrasound in percutaneous coronary intervention. In: S. Redwood, N. Curzen and M. Thomas, eds. Oxford Textbook of Interventional Cardiology Oxford, UK: Oxford University Press; 2010: 147-174. 69. Sakata K, Honda Y and Yamagishi M. Plaque characterization - IVUS, OCT. Current Therapy. 2010;28:26-32. 70. Honda Y. World Report: Up-to-Date. Stanford University. Circulation Up-to-Date. 2011;7:58-60. 71. Honda Y, Fitzgerald PJ and Yock PG. Intravascular ultrasound. In: E. J. Topol and P. Teirstein, eds. Textbook of Interventional Cardiology. Sixth ed. Philadelphia, PA: Saunders Elsevier; 2011: 793-808.

34 72. Koo B-K, Honda Y and Fitzgerald PJ. Coronary artery physiology: intracoronary ultrasonography, coronary flow velocity and pressure measurements. In: R. R. Baliga, ed. McGraw-Hill Specialty Board Review Cardiology New York, NY: McGraw Hill; 2011: 419-429. 73. Hahn J-Y, Honda Y and Fitzgerald PJ. Intravascular ultrasound. In: P. Lanzer, ed. Catheter-based Cardiovascular Interventions; Knowledge-based Approach New York, NY: Springer; 2012: 325-345. 74. Honda Y. Intravascular ultrasound. 2012. 75. Honda Y. World Report: Up-to-Date. Stanford University. Circulation Up-to-Date. 2012;7:164-166. 76. Kume T, Honda Y and Fitzgerald PJ. Intravascular coronary ultrasound and beyond. In: K. Chatterjee, ed. Cardiology - An Illustrated Textbook London: Mosby-wolfe; 2012: 349-380. 77. Sakamoto K, Honda Y and Fitzgerald PJ. Intravascular ultrasound: role in diagnosis and management. In: C. Arampatzis, E. P. McFadden, L. Κ. Michalis, R. Virmani and P. W. Serruys, eds. Coronary Atherosclerosis: Current Management and Treatment London, UK: Informa Healthcare; 2012: 152-165. 78. Yamada R and Honda Y. Cardiovascular imaging for percutaneous coronary interventions. Evidence Based Medicine: Treatment of Cardiovascular Disease 2012-2013. 2012. 79. Honda Y, Fitzgerald PJ and Yock PG. Intravascular imaging techniques. In: M. Moscucci, ed. Cardiac Catheterization, Angioplasty and Intervention. Eighth ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013: 545-575. 80. Kitahara H, Fitzgerald PJ, Yock PG and Honda Y. Basic concepts and clinical applications of intravascular imaging. In: J. Ramalho and M. Castillo, eds. Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications and Emerging Techniques New Jersey: Wiley-Blackwell; 2014: 345-370. 81. Kobayashi Y, Hollak BM and Honda Y. Conference Scene: American Heart Association Scientific Sessions 2013. Interventional Cardiology. 2014;6:21-23. 82. Okada K and Honda Y. Near-infrared spectroscopy for plaque assessment. Cardioangiology. 2014;76:579-584. 83. Honda Y, Fitzgerald PJ and Yock PG. Intravascular ultrasound. In: E. J. Topol and P. Teirstein, eds. Textbook of Interventional Cardiology. Seventh ed. Philadelphia, PA: Saunders Elsevier; 2015: 932-951. 84. Kitahara H, Honda Y and Fitzgerald PJ. Intravascular ultrasound. In: P. Lanzer, ed. PanVascular Medicine II: Integrated Vascular Approach for 21st Century: Springer-Verlag GmbH; 2015: 1379-1418. 85. Okada K, Hibi K and Honda Y. High-definition intravascular ultrasound. Shinzo. 2015;47:782-788. 86. Honda Y and Koo B-K. Clinical evaluation of myocardial ischemia: CT-FFR. In: M. Nakamura and N. Tanaka, eds. Handbook of Ischema Evaluation Tokyo, Japan: Nankodo; 2016: 177-180. 87. Kobayashi Y, Fitzgerald PJ and Honda Y. Adjunctive techniques: IVUS, OCT and Spectroscopy. In: H. Samady, W. Fearon, A. C. Yeung and S. B. King, 3rd, eds. Interventional Cardiology. Second ed. New York, NY: McGraw-Hill Education; 2017: 387-415. 88. Ikutomi M, Honda Y, Fitzgerald PJ and Yock PG. Intravascular imaging. In: M. Moscucci, M. G. Cohen and S. J. Chetcuti, eds. Atlas of Cardiac Catheterization and Interventional Cardiology Philadelphia, PA: Lippincott Williams & Wilkins; 2018: 297-362. 89. Okada K, Honda Y and Fitzgerald PJ. The role of intravascular ultrasound in percutaneous coronary intervention. In: S. Redwood, N. Curzen and M. Thomas, eds. Oxford Textbook of Interventional Cardiology. Second ed. Oxford, UK: Oxford University Press; 2018: 145-170. 90. Honda Y, Fitzgerald PJ and Yock PG. Intravascular ultrasound. In: E. J. Topol and P. Teirstein, eds. Textbook of Interventional Cardiology. Eighth ed. Philadelphia, PA: Elsevier, Inc.; 2019: 1018-1035. 91. Okada K, Fitzgerald PJ and Honda Y. Intravascular ultrasound. In: P. Lanzer, ed. Catheter-based Cardiovascular Interventions; Knowledge-based Approach. Second ed. New York, NY: Springer; 2019: 329-363. 92. Honda Y. Immediate post-PCI findings, including expansion, malappositions, dissections and stent deformation (in press). In: R. Petraco and S. Sen, eds. Oxford Specialist Handbook of Coronary Physiology and Imaging: Oxford University Press; 2020. 93. Honda Y, Fitzgerald PJ and Yock PG. Intravascular imaging techniques (in press). In: M. Moscucci, ed. Cardiac Catheterization, Angioplasty and Intervention. Nineth ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2020: 545-575. 94. Honda Y and Yock PG. A brief history of IVUS (in press). In: R. Petraco and S. Sen, eds. Oxford Specialist Handbook of Coronary Physiology and Imaging: Oxford University Press; 2020.

35 36

2021

CARDIOVASCULAR RESEARCH SCHOLARSHIP PROGRAM

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Stanford University

The Cardiovascular Medicine Division at Stanford University features diverse faculty and provides opportunities for research in many cardiovascular subspecialties. Stanford’s Center for Cardiovascular Technology (CCVT) facilities include animal laboratories, device development programs, and participation in multi-center cardiology trials, which are supported by Core Angiographic and Intravascular Ultrasound Laboratories. Visiting Scholars to Stanford’s CCVT represent many countries and a variety of research disciplines, resulting in a stimulating and productive research environment.

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