HONGXIU JI, MD, PHD BOARD CERTIFICATION CYTOPATHOLOGY / GYNECOLOGIC PATHOLOGY • Anatomic & Clinical Pathology

FELLOWSHIP Dr. Ji has been a pathologist at Incyte professor in the Department of Radiology • Gynecologic Pathology Diagnostics since 2007. She is currently at the University of Washington in Seattle, Johns Hopkins Hospital serving as the medical director of Incyte WA. Baltimore, MD Diagnostics’ Bellevue laboratory. Dr. Ji is Dr. Ji has been an active participant in RESIDENCY board certified in anatomic and clinical the Puget Sound medical community • Anatomic & Clinical Pathology pathology. Johns Hopkins Hospital and is currently licensed in the states of Baltimore, MD Dr. Ji received her medical degree from Washington and Maryland, as well as Shanghai Medical University (now Fudan London, England and Helsinki, Finland. MEDICAL/DOCTORATE DEGREE University) in Shanghai, China. During her She served as interim medical director • Fudan University School of Medicine final year of medical school, she completed of clinical laboratories and pathology at Shanghai, China an internship in internal medicine, surgery, the Evergreen Hospital Medical Center in HOSPITAL AFFILIATIONS obstetrics/gynecology, pediatrics, Kirkland, WA, in 2010. • Overlake Hospital Medical Center dermatology, radiology, and traditional Dr. Ji serves as the medical director of the • UW Valley Medical Center Chinese medicine at Peking Union Medical Overlake outpatient coagulation laboratory, College Hospital. PROFESSIONAL SOCIETIES & the interventional radiation point of care ASSOCIATIONS Dr. Ji was a resident in the gynecologic laboratory and the Overlake oncology • American College of Physician oncology department of the Gynecologic laboratory. She is also a member of the Executives • Association for Molecular Pathology Oncology Tumor Hospital, Chinese Overlake cancer comittee. • College of American Pathologists Academy of Medical Sciences in Beijing, • International Society of Gynecologic China. Pathologists • United States & Canadian Academy of Following this, Dr. Ji completed her Ph.D. in Pathology gynecologic pathology at Kuopio University in Kuopio, Finland, and then served as a resident physician in the department of obstetrics & gynecology at Kuopio University Hospital in Kuopio, Finland.

Dr. Ji completed a postdoctoral research fellowship in the tumor immunology division of the gynecologic pathology department at Johns Hopkins Medical Institutions in Baltimore, MD. Dr. Ji also completed her anatomic and clinical pathology residency and a fellowship in gynecologic pathology at Johns Hopkins Hospital.

Dr. Ji remained as a faculty member at Johns Hopkins Hospital, teaching gynecologic pathology for the next three years until she moved to the Seattle area in 2007. She continues to teach as an affiliated-assistant HONGXIU JI, MD CYTOPATHOLOGY

PUBLICATIONS International Journal of Gynecological immunotherapy for liver tumors. Journal of • Yemelyanova, A., Ji, H., Shih, I-M, Pathology, (24), 67-72. Hepatology, (86), 725-730. Wang, T-L, Wu, L-S-F, & Ronnett, B. • Peng, S., Ji, H., Trimble, C., He, L., Tsai, • Chang, E., Chen, C., Ji, H., Wang, T., (2009). Utility of p16 expression for Y-C, Yeatermeyer, J., Boyd, D., Hung, Hung, K., Lee, B., Huang, A., Kurman, distinction from endometrial endometrioid C-F, & Wu, T-C. (2004). Development R., Pardoll, D., & Wu, T-C. (2000). and endocervical adenocarcinoma: of a DNA vaccine targeting HPV-16 Antigen-specific cancer immunotherapy Immunohistochemical analysis of 201 oncoprotein E6. Journal of Virology, (78), using GM-CSF secreting allogeneic tumor cases. American Journal of Surgical 8468-8476. cell-based vaccine. International Journal of Pathology, (33),1504-1514. Cancer, (86), 725-730. • Rangel, L., Agrawal, R., Sherman-Baust, • Honda, H., Pazin, M., D’Souza, T., Ji, C., de Mello-Coelho, V., Pizer, E., Ji, H., • Chen, C-H, Ji, H., Suh, K., Choti, M., H., & Morin P. (2007). Regulation of the Taub, D., & Morin, P. (2004). Anomalous Pardoll, D., & Wu, T-C. (1999). Gene CLDN3 gene in ovarian cancer cells. expression of the HLA-DR a and b chains gun-mediated DNA vaccination induces Cancer Biology & Therapy, (11),1733- in ovarian and other cancer. Cancer antitumor immunity against human 1742. Biology & Therapy, (10), 69-75. papillomavirus type 16 E7-expressing • Honda, H., Pazin, M., Ji, H., Mernyj, murine tumor metastases in the liver and • Ji, H., & Yardley, J. (2004). Iron- R., & Morin PJ. (2006). Crucial roles lungs. Gene Therapy, (6),1972-1981. medication associated gastric mucosal of SP1 and epigenetic modifications in injury. Archives of Pathology and • Ji, H., Wang, T-L, Chen, C-H, Hung, the regulation of the CLDN4 promoter Laboratory Medicine, (128), 821-822. C-F, Lin, K-Y, Kurman, R., Pardoll DM, in ovarian cancer cells. The Journal of & Wu T-C. (1999). Targeting human Biological Chemistry, (281), 21433- • Yang, X., Yeung, C., Ji, H., Serfaty, papillomavirus type 16 E7 to the 21444. J., & Atalar, E. (2002). Thermal effect endosomal/lysosomal compartment of intravascular imaging using an MR • Sheridan, T., Askin, F., & Ji, H. (2005). enhances the antitumor immunity of imaging-guidewire: An in vivo laboratory Multinucleated foreign-body giant cells DNA vaccines against murine human and histopathological evaluation. Medical in placental membrane. Pediatric and papillomavirus type 16 E7-expressing Science Monitor, (8), 113-117. Developmental Pathology, (8), 493-496. tumors. Human Gene Therapy, (10), • Ji, H., Isacson, C., Seidman, J., Kurman, 2727-2740. • Diaz-Montes, T., Ji, H., Smith-Sehdev, R., & Ronnett, B. (2002). Cytokeratins A., Zahurak, M., Kurman, R., Armstrong, • Anttila, M., Syrjanen, S., Ji, H., 7 and 20, Dpc4, and MUC5AC in D., & Bristow, R. (2005). Clinical Saarikoski, S., & Syrjanen, K. the distinction of metastatic mucinous significance of Her-2/neu overexpression (1999). Failure to demonstrate human carcinomas in the ovary from primary in uterine serous carcinoma. Gynecologic papillomavirus DNA in epithelial ovarian mucinous tumors: dpc4 assists Oncology, (100), 139-144. ovarian cancer by general primer PCR. in identifying metastatic pancreatic Gynecological Pathology, (72), 337- • Peng, S., Trimble, C., Ji, H., He, L., Tsai, carcinomas. International Journal of 341. Y-C, Macaes, B., Hung, C-F & Wu, T-C. Gynecological Pathology, (21), 391- (2005). Characterization of HPV16-E6 400. • Anttila, M., Ji, H., & Kosma, V-M. (1999). DNA vaccines employing intracellular P21/WAF1 expression as related to • Chen, C-H, Wang, T-L, Ji, H., Hung, targeting and intercellular spreading p53, cell proliferation and prognosis in C-F, Pardoll, D., Ling, M., & Wu, T-C. strategies. Journal of Biomedical Science, epithelial ovarian cancer. British Journal of (2001). Recombinant DNA vaccines (12), 689-700. Cancer, (79),1870-1878. protect animals against tumors that • Cao, D., Ji, H., & Ronnett, B. (2005). are resistant to recombinant vaccinia • Anttila, M., Ji, H., Juhola, M., Saarikoski, Expression of mesothelin, fascin, and vaccines containing the same gene. Gene S., & Syrjanen, K. (1999). The prostate stem cell antigen in primary Therapy, (8), 128-138. prognostic significance of p53 expression ovarian mucinous tumors and their utility in quantitated by computerized image • Chen, C-H, Suh, K., Ji, H., Choti, M., differentiating primary ovarian mucinous analysis in epithelial ovarian cancer. Huang, C-C, Pardoll, D., & Wu, T-C. tumors from metastatic pancreatic International Journal of Gynecological (2000). Successful antigen-specific mucinous carcinomas in the ovary. Pathology, (18), 42-51. Rev 3/2015 ID000021

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