Description: Uniprot:Q13769 Alternative Names： Specificity

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Description: Uniprot:Q13769 Alternative Names： Specificity

TD8426 THOC5 Antibody Order 021-34695924 [email protected] Support 400-6123-828 50ul [email protected] 100 uL √ √ Web www.ab-mart.com.cn Description: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma- associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development. Uniprot:Q13769 Alternative Names： C22orf19; Chromosome 22 open reading frame 19; Fmip; Fms interacting protein; fSAP79; Functional spliceosome-associated protein 79; hTREX90; KIAA0983; LOC400922; NF2/meningioma region protein pK1.3; PK1.3; Placental protein 39.2; PP39.2; THO complex 5; THO complex subunit 5; THO complex subunit 5 homolog; thoc5; THOC5_HUMAN; Specificity: THOC5 Antibody detects endogenous levels of total THOC5. Reactivity:Human Source:Rabbit Mol.Wt.: 79kD; 79kDa(Calculated). Storage Condition: Store at -20 °C. Stable for 12 months from date of receipt. Application: WB 1:1000-1:2000；IHC/IF 1:50-1:500.

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Produktinformation Diagnostik & molekulare Diagnostik Laborgeräte & Service Zellkultur & Verbrauchsmaterial Forschungsprodukte & Biochemikalien Weitere Information auf den folgenden Seiten! See the following pages for more information! Lieferung & Zahlungsart Lieferung: frei Haus Bestellung auf Rechnung SZABO-SCANDIC Lieferung: € 10,- HandelsgmbH & Co KG Erstbestellung Vorauskassa Quellenstraße 110, A-1100 Wien T. +43(0)1 489 3961-0 Zuschläge F. +43(0)1 489 3961-7 [email protected] • Mindermengenzuschlag www.szabo-scandic.com • Trockeneiszuschlag • Gefahrgutzuschlag linkedin.com/company/szaboscandic • Expressversand facebook.com/szaboscandic WDR58 monoclonal antibody (M01), clone 1F6 Catalog # : H00079228-M01 規格 : [ 100 ug ] List All Specification Application Image Product Mouse monoclonal antibody raised against a partial recombinant Western Blot (Cell lysate) Description: WDR58. Immunogen: WDR58 (NP_077315, 71 a.a. ~ 180 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. Sequence: TFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAEMLKKGCKELWRRQ PPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGH enlarge TDYIHCLALRERS Western Blot (Cell lysate) Host: Mouse Reactivity: Human, Rat Isotype: IgG1 Kappa enlarge Quality Control Antibody Reactive Against Recombinant Protein. Testing: Western Blot (Transfected lysate) enlarge Western Blot (Recombinant protein) Immunohistochemistry Western Blot detection against Immunogen (37.84 KDa) . (Formalin/PFA-fixed paraffin- embedded sections) Storage Buffer: In 1x PBS, pH 7.4 Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. Instruction: MSDS: Download enlarge Datasheet: Download Sandwich ELISA (Recombinant protein) Publication Reference 1. Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I. Katahira J, Okuzaki D, Inoue H, Yoneda Y, Maehara K, Ohkawa YNucleic Acids Res. 2013 Aug;41(14):7060-72. doi: 10.1093/nar/gkt414.
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