Drug repurposing and polypharmacology to ght SARS-CoV-2 through the inhibition of the main protease Luca Pinzi Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy Annachiara Tinivella Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy Fabiana Caporuscio Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy Giulio Rastelli (
[email protected] ) Department of Life Sciences, University of Modena and Reggio Emilia, Via Giuseppe Campi 103, 41125 Modena, Italy Research Article Keywords: COVID-19, SARS-2-CoV-2, Drug repurposing, Polypharmacology, Structure-Based, Molecular docking, BEAR Posted Date: December 1st, 2020 DOI: https://doi.org/10.21203/rs.3.rs-27222/v2 License: This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License Drug repurposing and polypharmacology to fight SARS-CoV-2 through inhibition of the main protease Luca Pinzi1, Annachiara Tinivella1, 2, Fabiana Caporuscio1, Giulio Rastelli1* 1 Molecular Modelling and Drug Design Lab, Life Sciences Department, University of Modena and Reggio Emilia, Modena, Italy. 2 Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy. * Correspondence: Prof. Giulio Rastelli, Life Sciences Department, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.
[email protected] Keywords: COVID-19, SARS-2-CoV-2, Drug repurposing, Polypharmacology, Structure-Based, Molecular docking, BEAR. Abstract Therapeutic options are urgently needed to fight the outbreak of a novel coronavirus (SARS-CoV-2), which causes the COVID-19 disease and is spreading rapidly around the world.