Publikationsliste Reinhard Büttner

Original papers 1989-2017

(1) Handt S., R. Büttner, R. Knüchel, H. Rübben, F. Hofstädter, and C. Wagener: Investigations for a point mutation in the c-Ha-ras 1 oncogene in the genome of bladdercarcinomas by Southern blot analysis. Invest. Urolog. 3: 125-128 (1989).

(2) Buettner R., S. Yim, Y. Hong, E. Boncinelli, and M.A. Tainsky: Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cell. Mol. Cell. Biol. 11: 3573-3583 (1991).

(3) Tainsky M.A., S. Yim, D.B. Krizman, P. Kannan, P. Chiao, T. Mukhopadhyay, and R. Buettner: Modulation of differentiation in PA-1 human teratocarcinoma cells by an N-ras oncogene. Oncogene 6: 1575-1582 (1991).

(4) Kannan P., R. Buettner, D.R. Pratt, and M.A. Tainsky: Identification of a retinoic acid inducible endogenous retrovirus in the human teratocarcinoma-derived cell line PA-1. J. Virol. 65: 6343-6348 (1991).

(5) Le-Ruppert K., J.R.W. Masters, R. Knuechel, S. Seegers, M.A. Tainsky, F. Hofstaedter, and R. Buettner: The effect of retinoic acid on chemosensitivity of PA-1 human teratocarcinoma cells and its modulation by an activated N-ras oncogene. Int. J. Cancer 51: 646-651 (1992).

(6) Meyer S., R. Buettner, P. Sauer und L. Rupprecht: Akuter arterieller Extremitätenverschluß durch Tumorembolus (Case report and review of literature). Der Chirurg 64: 424-26 (1993).

(7) Rohrer L., F.Raulf, C.Bruns, F. Hofstaedter, R. Buettner and R Schuele: Cloning and characterization of a fourth human somatostatin receptor. Proc. Natl. Acad. Sci. USA 90: 4196-4200 (1993).

(8) R. Buettner, R. Bauer, A. Imhof, M.A. Tainsky und F. Hofstaedter: AP-2: a nuclear effector of malignant transformation by ras-oncogenes. Verh. Dtsch. Ges. Pathol. 77: 271-275 (1993).

(9) Buettner R., P. Kannan, A. Imhof, R. Bauer, S.O. Yim, R. Glockshuber, M.W. Van Dyke, and M.A. Tainsky: An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2. Mol. Cell. Biol. 13: 4174-4185 (1993).

(10) Moser M., A. Pscherer, R. Bauer, A. Imhof, S.Seegers, M. Kerscher and R. Buettner: The complete murine cDNA sequence of the transcription factor AP-2. Nucl. Acids Res. 21: 4844 (1993).

(11) Kopp H., J.R. Masters, W. Wieland, F. Hofstaedter und R. Buettner: Differential regulation of androgen receptor promoter in hormone-sensitive and -insensitive prostate carcinoma cells. Verh. Dtsch. Ges. Pathol. 77: 129-133 (1993).

(12) Rüschoff J., T. Bocker, R. Buettner, A. Bittinger, W. Wieland und F. Hofstädter: In vitro und ex vivo expression of nuclear proliferation-associated antigens (p120, B23) in the prostate. Verh. Dtsch. Ges. Pathol. 77: 103-106 (1993).

(13) Dermietzel R., T.K. Hwang, R. Buettner, A. Hofer, E. Dotzler, M. Kremer, F.P. Thinnes, D. Siemen: Cloning of a brain-derived porin and its in situ identification in astrocytic plasma membranes. Proc. Natl. Acad. Sci. USA 91: 499-503 (1994).

(14) Kannan P., R. Buettner, P.J. Chiao, S.O. Yim, M. Sarkiss and M.A. Tainsky: N-ras oncogene causes AP-2 transcriptional self-interference, which leads to transformation. Genes Dev. 8: 1258-1269 (1994).

(15) Schuster U., R. Buettner, F. Hofstaedter, R. Knuechel: An in vitro coculture system to study interaction between bladder cancer cells and stromal cells. J. Urol. 151: 1707-1711 (1994).

(16) Bauer R., A. Pscherer, A. Imhof, M. Moser, S. Seegers, M.A. Tainsky, F. Hofstaedter and R. Buettner: The genomic structure of the human gene coding for the transcription factor AP-2. Nucl. Acids Res. 22: 1413-1420 (1994).

(17) Buettner R., M. Moser, A. Pscherer, A. Imhof, R. Bauer, F. Hofstädter: Molecular cloning of a novel AP-2 transcription factor, AP-2ß, and its function in cell differentiation. Verh. Dtsch. Ges. Pathol. 78: 38-42 (1994).

(18) Blesch A., A.K. Boßerhoff, R. Apfel, C. Behl, B. Heßdörfer, A. Schmitt, P. Jachimczak, F. Lottspeich, R. Buettner and U. Bogdahn: Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Res. 54: 5695-5701 (1994).

(19) Bocker T., A. Bittinger, W. Wieland, R. Buettner, G. Fauser, F. Hofstädter and J. Rüschoff: In vitro and ex vivo expression of nucleolar proteins (B23, p120) in benign and malignant epithelial lesions of the prostate. Mod. Pathol. 8: 226-231 (1995).

(20) Jacob K., A.K. Boßerhoff, F. Wach, R. Knüchel, R. Hein, and R. Buettner: Selection of high- and low- invasive sublines of a primary melanoma cell line and isolation of subtractive cDNA clones. Int. J. Cancer 60: 668- 675 (1995).

(21) Messmann H., S. Hollerbach, V. Gross, A. Holstege, R. Büttner, J. Schmidt, W. Hohenberger und J. Schölmerich: Multiple Magenwandabszesse - eine seltene endosonographische Differentialdiagnose submuköser Magentumoren. Z. Gastroenterol. 33: 170-172 (1995).

(22) Moser M., A. Pscherer, A. Imhof, R. Bauer, M. Kerscher, W. Amselgruber, F. Sinowatz, F. Hofstaedter, R. Schüle and R. Buettner: Molecular cloning and characterization of a second AP-2 transcription activator gene, AP- 2ß. Development 121: 2779-2788 (1995).

(23) Gaubatz S., A. Imhof, R. Dosch, O. Werner, P. Mitchell, R. Buettner and M. Eilers: Transcription factor AP-2 negatively regulates gene activation by myc. EMBO J. 14: 1508-1519 (1995).

(24) Boßerhoff A.K., R. Hein, U. Bogdahn and R. Buettner: Structure and promoter analysis of the human MIA gene. J. Biol. Chem. 271: 490-495 (1996).

(25) Buettner R., B. Schleicher, P. Schleicher, J. Rüschoff and F. Hofstädter: The benign placental site nodule: Case report and review of diseases of the intermediate trophoblast. Geburtsh. Frauenheilk. 56: 257-261 (1996).

(26) Smith C.M., S.A. Ballard, N. Worman, R. Buettner, J.R.W. Masters: 5a-reductase expression by prostate cancer cell lines and benign prostatic hyperplasia in vitro. J. Clin. Endocrin. Metab. 81: 1361-1366 (1996).

(27) Pscherer A., U. Dörflinger, J. Kirfel, K. Gawlas, J. Rüschoff, R. Buettner and R. Schüle: The helix-loop- helix transcription factor SEF-2 regulates the activity of a novel initiator element in the promoter of the human somatostatin receptor II gene. EMBO J. 15: 6680-6690 (1996).

(28) Koehler M.R., A.K. Boßerhoff, G. von Beust, A. Bauer, A. Blesch, R. Buettner, J. Schlegel, U. Bogdahn, M. Schmid: Assignment of the human melanoma inhibitory activity gene (MIA) to 19q13.32-13.33 by flourescence in situ hybridization (FISH). Genomics 35: 265-267 (1996).

(29) Moser M., J. Rüschoff and R. Buettner: Comparative analysis of AP-2 gene expression during murine embryogenesis. Dev. Dynam. 208: 115-124 (1997).

(30) Bosserhoff A.K., S. Kondo, M. Moser, U.H. Dietz, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, R. Buettner and L. Sandell: Expression, structure and chromosomal localization of the mouse MIA/CD-RAP gene. Dev. Dynam. 208: 516-525 (1997).

(31) Dammer, R., J. Stavenow, P. Held, J. Schröder, H. Niederdellmann, F. Hofstädter and R. Buettner: Pigmented Schwannoma of the oral cavity. Oral Surg., Oral Med., Oral Pathol., Oral Radiol. Endodont. 84: 40- 44 (1997).

(32) Bogenrieder, T., D.P. Griese, R. Schiffner, R. Buettner, G.A. Riegger, U. Hohenleutner and M. Landthaler: Well's syndrome associated with idiopathic hypereosinophilic syndrome. Br. J. Dermatol. 137: 978-982 (1997).

(33) Moser, M., A. Pscherer, C. Roth, J. Becker, G. Mücher, K. Zerres, C. Dixkens, J. Weis, L. Guay-Woodford, R. Buettner and R. Fässler: Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2ß. Genes Dev. 11: 1938-1948 (1997).

(34) Bosserhoff A.K., M. Kaufmann, B. Kaluza, I. Bartke, H. Zirngibl, R. Hein, W. Stolz and R. Buettner: MIA, a novel serum marker for progression of malignant melanoma. Cancer Res. 57: 3149-3153 (1997).

(35) Bosserhoff, A.K., A. Gläßl, W. Stolz and R. Buettner: Detection of telomerase activity in skin, melanocytic nevi and melanoma by telomerase PCR ELISA. BM Biochemica 3: 16-18 (1997).

(36) Grether-Beck, S., R. Buettner and J. Krutmann: Ultraviolet A radiation-induced expression of human genes: molecular and photobiological mechanisms. Biol. Chem. 378: 1231-1236 (1997).

(37) Jacob K., F. Wach, U. Holzapfel, R. Hein, E. Lengyel, R. Buettner and A.K. Bosserhoff: In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid. Melanoma Res. 8: 1-9 (1998).

(38) Mücher G., J. Becker, M. Knapp, R. Buettner, M. Moser, S. Rudnik-Schöneborn, S. Somlo, G. Germino, L. Onuchic, E. Avner, L. Guay-Woodford, and K. Zerres: Fine mapping of the autosomal recessive polycystic kidney disease locus (PKHD1) and the genes MUT, RDS, CSNK2ß, and GSTA1 at 6p21.1-p12. Genomics 48: 40-45 (1998).

(39) Kroiss, M.M., A.K. Bosserhoff, T. Vogt, R. Buettner, T. Bogenrieder, M. Landthaler and W. Stolz: Loss of expression or mutation in the p73 tumour suppressor gene are not involved in the pathogenesis of malignant melanoma. Melanoma Res. 8: 504-509 (1998).

(40) Bosserhoff, A.K., M. Lederer, M. Kaufmann, R. Hein, W. Stolz, R. Apfel, U. Bogdahn and R. Buettner: MIA, a novel serum marker for progression of malignant melanoma. Anticancer Res. 19: 2691-3 (1999).

(41) Imhof A., M. Schuierer, O. Werner, M. Moser, C. Roth, R. Bauer and R. Buettner: Transcriptional regulation of the AP-2a promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor Mol. Cell. Biol. 19: 194-204 (1999).

(42) Bosserhoff, A.K., M. Moser, R. Hein, M. Landthaler and R. Buettner: In situ expression patterns of melanoma-inhibiting activity (MIA) in malignant melanomas and breast cancers. J. Pathol. 187: 446-454 (1999).

(43) Dörflinger, U., A. Pscherer, M. Moser, P. Rümmele, R. Schüle and R. Buettner: SSTR-2 expression in embryonic and adult tissues involves transcriptional activation by mib-1. Mol. Cell. Biol. 19: 3736-3747 (1999).

(44) Müller-Ladner, U., A.K. Bosserhoff, K Dreher, R. Hein, M. Neidhart, S. Gay, J. Schölmerich, R. Büttner and B. Lang: MIA (melanoma inhibitory activity), a potential serum marker for rheumatoid arthritis. Rheumatol. 38: 148-154 (1999).

(45) Dréau, D., A.K. Bosserhoff, R.L. White, R. Buettner and W.D. Holder: Melanoma-inhibitory activity protein, a useful marker to monitor melanoma patients treated with immunotherapy. Oncol. Res. 11: 55-61 (1999).

(46) Obermann, E.C., V. Bonkowsky, C. Mayr and R. Buettner: Cervical thymic cyst in the differential diagnosis of lateral neck tumors. HNO 47: 821-824 (1999).

(47) Glaessl, A., Bosserhoff, A.K., Buettner, R., Hohenleutner, U. and W. Stolz: Increase of telomerase activity during progression of melanocytic cells from melanocytic nevi to malignant melanoma. Arch. Dermtol. Res. 291: 81-87 (1999).

(48) Klebl, F.H., M. Merger, F.X. Hierlmeier, R. Buettner und K.D. Palitzsch: Ungewöhnlicher Fall einer disseminierten Sarkoidose mit führender gastrointestinaler Symptomatik. DMW 124: 39-44 (1999).

(49) Mühlbauer, M., N. Langenbach, W. Stolz, R. Hein, M. Landthaler, R. Buettner and A.K. Bosserhoff: Detection of melanoma cells in the blood of melanoma patients by MIA RT-PCR. Clin. Cancer Res. 5: 1099-1105 (1999).

(50) Bosserhoff, A.K., S. Seegers, C. Hellerbrand, J. Schölmerich and R. Buettner: Rapid genetic screening for hemochromatosis using automated SSCP-based capillary electrophoresis (SSCP-CE). BioTechniques 26: 1106-10 (1999).

(51) Takeuchi, S., I. Imafuku, M. Waragi, C. Roth, I. Kanazawa, R. Buettner M.M. Mouradian and H. Okazawa: AP-2ß represses D1A dopamine receptor gene transcription. Brain Res. Mol. Brain Res. 74: 208-216 (1999).

(52) Bretschneider, T., U. Dorenbeck , M. Strotzer, M. Roth, P. Rümmele and R. Buetter: Squamous cell carcinoma arising in an intradiploic epidermoid cyst. Neuroradiol. 41: 570-572 (1999).

(53) Moser, M., T. Stempfl, Y. Li, P. Glynn, R. Buettner and D. Kretzschmar. Cloning and expression of the murine SWS/NTE gene. MOD 90: 279-282 (2000).

(54) Bosserhoff, A.K., A. Hauschild, R. Hein, D. Schadendorf, E. Stockfleth, T. Bogenrieder, M. Landthaler, R. Buettner and W. Stolz. Elevated MIA serum levels are of relevance for management of metastasized malignant melanomas: results of a German multicenter study. J. Invest. Dermatol. 114: 395-396 (2000).

(55) Buettner, R., G. Paputsoglou, E. Scemes, Dacid C. Spray and Rolf Dermietzel: Genetic evidence for plasmalemmal translocation of VDAC-1 channel porins. PNAS 97: 3201-3206 (2000).

(56) Müller, J.M., U. Isele, E. Metzger, A. Rempel, M. Moser, A. Pscherer, T. Breyer, C. Holubarsch, R. Buettner and R. Schüle. FHL2, a tissue-specific coactivator of the androgen receptor. EMBO J. 19: 359-69 (2000).

(57) Merkelbach-Bruse, S, S. Köse, I. Losen, A.K. Bosserhoff, R. Buettner. High Throughput Genetic Screening for the Detection of Hereditary Non-polyposis Colon Cancer (HNPCC) Using Capillary Electrophoresis. Comb. Chem. High Throuput Screen. 3: 519-524 (2000).

(58) Roth, C., M. Schuierer, K. Günther and R. Buettner. Cloning and characterization of the human zinc finger transcriptional repressor, AP-2rep. Genomics 63: 384-390 (2000).

(59) Schaller, U.C., A.J. Mueller, A.K. Bosserhoff, S. Haraida, U. Lohrs, R. Buettner and A. Kampik: Melanoma inhibiting activity (MIA): Evaluation of a novel tumor associated antigen as a serum marker for uveal melanoma. Der Ophthalmologe 97: 429-432 (2000).

(60) Stahlecker, J., A. Gauger, A.K. Bosserhoff, D. Matzen, R. Buettner, J. Ring and R. Hein: MIA as a reliable tumor marker in the serum of patients with malignant melanoma. Anticancer Res. 20: 5041-4 (2000).

(61) Fritsche, J., M. Moser, S. Faust, A. Peuker, R. Buettner, A. Peuker, R. Andreesen and M. Kreutz: Molecular cloning and characterization of a human metalloprotease disintegrin - a novel marker for dendritic cell differentiation. Blood 96: 732-9 (2000).

(62) Dötsch, M., A. Brauers, R. Buettner, C. Nolte-Ernsting, M.J. Eble and G. Jakse: Malignant germ cell tumor of the contralateral testis following radiotherapy for testicular intraepithelial neoplasia. J. Urol. 164: 452-3 (2000).

(63) Stoll, R., C. Renner, D. Ambrosius, M. Golob, W. Voelter, R. Buettner, A.K. Bosserhoff and T.A. Holak.

Sequence-specific 1H, 13C, and 15N assignment of the human melanoma inhibitory activity (MIA) protein. J. Biomol. NMR 17: 87-88 (2000).

(64) Biederer, C., S. Ries, M. Moser, M. Florio, M. Israel and R. Buettner: The E-box motif is required for myogenin mediated skeletal muscle specific induction of the human Caveolin-3 gene. J. Biol. Chem. 275: 26245- 26251 (2000).

(65) Juergensen, A., U. Holzapfel, R. Hein, W. Stolz, R. Buettner and A.K. Bosserhoff: A comparison of two tumormarkers for malignant melanomas: MIA and S100. Tumor Biol. 22: 54-58 (2000).

(66) Golob, M., R. Buettner and A.K. Bosserhoff. Characterization of a transcription factor binding site, specifically activating MIA expression in malignant melanoma. J. Invest. Dermatol. 11: 42-47 (2000).

(67) Guba, M., A.K. Bosserhoff, M. Steinbauer, C. Abels, M. Anthuber, R. Buettner and K.W. Jauch: Over- expression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo. Br. J. Cancer 83: 1216-22 (2000).

(68) Brucherseifer, M., Nagel, M., Haring Bolivar, P., Kurz, H., A. Bosserhoff, and R. Buettner: Label-free probing of the binding state of DNA by time-domain THz sensing. Appl. Phys. Lett. 77: 4049-51 (2000).

(69) Perez, R., M. Abu-hadid, P. Zhang, A.K. Bosserhoff and R. Buettner: Expression of melanoma inhibitory activity (MIA) in melanoma and non-melanoma tissue specimens. Hum Pathol. 31: 1381-1388 (2000).

(70) Brauers, A., E. Manegold, R. Buettner, J.M. Baron, H.F. Merk and G. Jakse: Cytochrome P450 isoenzyme mRNA expression pattern in human urinary malignancies and normal urothelium. Cancer Detect. Prev. 24: 356-363 (2000).

(71) Bosserhoff, A.K., R. Buettner, C. Hellerbrand: Use of capillary electrophoresis for high throuput screening in biomedical applications. A Minireview. Comb. Chem. High Throuput Screen. 3: 455-466 (2000).

(72) Hilger-Eversheim, K., M. Moser, H. Schorle and R. Buettner: Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell cycle control. Gene 260: 1-12 (2000).

(73) Günther, K., A. Fleischer, R. Buettner and A.K. Bosserhoff: Detection of invasion-related chromosomal changes in highly and weakly invasive melanoma cell clones by a modified comparative genomic hybridization approach. Melanoma Res. 11: 105-15 (2001).

(74) Bosserhoff, A.K., D. Dreau, R. Hein, M. Landthaler, W.D. Holder and R. Buettner: MIA, a serological marker of malignant melanoma. Recent Res Cancer Res 158: 158-168 (2001).

(75) Stoll, R., C. Renner, M. Zweckstetter, M. Brüggert, D. Ambrosius, S. Palme, R.A. Engh, M. Golob, I. Breibach, R. Buettner, W. Voelter, T.A. Holak, and A.K. Bosserhoff: The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold. EMBO J. 20: 340-9 (2001).

(76) Schuierer, M., K. Hilger-Eversheim, T. Dobner, A.K. Bosserhoff, M. Moser, J. Turner, M. Crossley and R. Buettner. Induction of AP-2a expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1. J. Biol. Chem. 276: 27944-49 (2001).

(77) Bosserhoff, A.K., B. Echtenacher, R. Hein and R. Buettner: Functional role of melanoma inhibitory activity in regulating invasion and metastasis of malignant melanoma cells in vivo. Melanoma Res. 11: 417-421 (2001).

(78) Hermanns, B., A. Brunn, E.R. Schwarz, J.S. Sachweh, I. Seipelt, J.M. Schröder, U. Vogel, F.A. Schoendube and R. Buettner: Fulminant toxoplasmosis in a heart transplant recipient. Pathol. Res. Pract. 197: 211- 15 (2001).

(79) Neulen, J., D. Wenzel, C. Hornig, E. Wünsch, U. Weissenborn, R. Grunwald, R. Büttner, H. Weich: Poor responder - high responder: the importance of soluble vascular endothelial growth factor receptor 1 in ovarian stimulation protocols. Hum. Reprod. 16: 621-626 (2001).

(80) Brauers, A., R. Buettner and G. Jakse: Second resection and prognosis of primary high risk superficial bladder cancer: Is cystectomy often too early ? J. Urol. 165: 8080-810 (2001).

(81) Gütgemann, A., M. Golob, S. Müller, R. Buettner, A.K. Bosserhoff: Isolation of invasion-associated cDNAs in melanoma. Arch. Dermatol. Res. 293: 283-290 (2001).

(82) Rhode, H.T., K.P. Riesener, R. Büttner, V. Schumpelick. Leiomyosarcoma of the splenic artery. Chirurg 72: 844-6 (2001).

(83) Mumme, T., R. Büttner, C. Peiper, V. Schumpelick. Pancreatoblastoma: a rare malignant neoplasm in early adulthood. Chirurg 72: 806-11 (2001).

(84) Gabriel, H.D., B. Strobl, P. Hellmann, R. Buettner and E. Winterhager: Organization and regulation of the rat Cx31 gene. Implication for a crucial role of the intron region. Eur. J. Biochem. 268: 1749-59 (2001).

(85) Poser, I., D. Domínguez A.G. de Herreros, A. Varnai, R. Buettner and A.K. Bosserhoff: Loss of E-Cadherin expression in melanoma cells involves up-regulation of the transcriptional repressor Snail. J. Biol. Chem. 276: 24661-6 (2001).

(86) Hellerbrand, C., A.K. Bosserhoff, S. Seegers, G. Lingner, C. Wrede, G. Lock, J. Schölmerich and R. Buettner: Mutation analysis of the HFE gene in German hemochromatosis patients and controls using automated SSCP-based capillary electrophoresis and a new PCR-ELISA technique. Scand. J. Gastroenterol. 36: 1211-16 (2001).

(87) Gerhards, F., R. Buettner and S. Jänicke: Aberrant salivary gland tissue as a differential diagnosis of branchiogenic cysts: A case report. HNO 49: 476-78 (2001).

(88) Zhou, X.H., C. Brakebusch, H. Matthies, T. Oohashi, E. Hirsch, M. Moser, M. Krug, C.I. Seidenbecher, T.M. Boeckers, U. Rauch, R. Buettner, E.D. Gundelfinger and R. Fässler. Neurocan is dispensible for brain development. Mol. Cell. Biol. 21: 5970-78 (2001).

(89) Rudlowski, C., W. Rath, A.J. Becker, O.D. Wiestler, R. Buttner: Trastuzumab and breast cancer (correspondence). N. Engl. J. Med. 345: 997-8 (2001).

(90) Weiskirchen, R., M. Moser, S. Weiskirchen, M. Erdel, S. Dahmen, R. Büttner and A.M. Gressner: LIM- domain protein cysteine- and glycine-rich protein 2 (CRP2) is a novel marker of hepatic stellate cells and binding partner of the protein inhibitor of activated Stat1. Biochem J. 359: 485-96 (2001).

(91) Moser, M., A.K. Bosserhoff, E. Hunziker, L. Sandell, R. Fässler and R. Buettner: Ultrastructural cartilage abnormalities in MIA/CD-RAP-deficient mice. Mol. Cell. Biol. 22: 1438-45 (2002).

(92) Dobrowolski, R., R. Hein, R. Buettner and A.K. Bosserhoff: Loss of p14ARF expression in melanoma. Arch. Dermatol. Res. 293: 545-51 (2002).

(93) Müller, A.G., M. Moser, R. Kluge, S. Leder, M. Blum, R. Buettner, H.G. Joost, and A. Schürmann. Embryonic lethality caused by apoptosis during gastrulation in mice lacking the gene of the ADP-ribosylation factor- related protein 1. Mol. Cell. Biol. 22: 1488-94 (2002).

(94) Müller, J.M., E. Metzger, H. Greschik, A.K. Bosserhoff, L. Mercep, R. Büttner and R. Schüle. The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. EMBO J. 21: 736- 746 (2002).

(95) Schaller, U.C., A.K. Bosserhoff, A.S. Neubauer, R. Buettner, A. Kampik, A.J. Mueller: Melanoma inhibitory activity: a novel serum marker for uveal melanoma. Melanoma Res. 12: 593-9 (2002).

(96) Nagel, M., P. Haring Bolivar, M. Bruchseifer, H. Kurz, A. Bosserhoff, and R. Buettner: Integrated THz technology for label-free diagnostics. Appl. Phys. Lett. 80: 154-156 (2002).

(97) Mahnken, A.H., J. Tacke, P. Wolter, R. Büttner, J.S. Haller and R.W. Günther: Cross-sectional imaging of primary osseous hemangiopericytoma. Eur. Radiol. 12: 85-89 (2002).

(98) Nagel, M., P. Haring Bolivar, M. Bruchseifer, H. Kurz, A. Bosserhoff, and R. Buettner: Integrated planar terahertz resonators for femtomolar sensitivity label-free detection of DNA hybridization. Appl. Opt. 14: 2074-8 (2002).

(99) Haring Bolivar, P., M. Bruchseifer, M. Nagel, H. Kurz, A. Bosserhoff, and R. Buettner: Label-free probing of the binding state of DNA by time-domain terahertz sensing. Materials Science Forum 384/5: 253-258 (2002).

(100) Nagasawa, Y, S. Matthiesen, L.F. Onuchic, X. Hou, C. Bergmann, E. Esquivel, J. Senderek, Z. Ren, R. Zeltner, L. Furu, E. Avner, M. Moser, S. Somlo, L. Guay-Woodford, R. Buettner, K. Zerres and G.G. Germino. Identification and characterization of Pkhd1, the mouse orthologue of the human ARPKD gene. JASN 13: 2246-58 (2002).

(101) Friedrichs, N., R. Vorreuther, C. Poremba, K.L. Schafer, A. Böcking, R. Buettner, and H. Zhou. Primitive neuroectodermal tumor (PNET) in the differential diagnosis of malignant kidney tumors. Pathol. Res. Pract. 198: 563-69 (2002).

(102) Poser, I., M. Golob, M. Weidner, R. Buettner, and A.K. Bosserhoff. Downregulation of COOH-terminal binding protein expression in malignant melanomas leads to induction of MIA expression. Cancer Res. 62: 5962-6 (2002).

(103) Zhou-Stache, J., R. Buettner, G. Artmann, C. Mittermayer, and A.K. Bosserhoff. Inhibition of TNF-alpha induced cell death in human umbilical vein endothelial cells and Jurkat cells by protocatechuic acid. Med. Biol. Eng. Comput. 40: 698-703 (2002).

(104) Haring Bolivar, P., M. Bruchseifer, M. Nagel, H. Kurz, A. Bosserhoff, and R. Buettner: Label-free probing of genes by time-domain terahertz sensing. Phys. Med. Biol. 47: 3815-21 (2002).

(105) Bosserhoff, A.K. and R. Buettner: Expression, function and clinical relevance of MIA (melanoma inhibitory activity). Histol. Histopathol. 17: 289-300 (2002).

(106) Bergmann, C., J. Senderek, B. Sedlacek, I. Pegiazoglou, P. Puglia, T. Eggermann, S. Rudnik-Schöneborn, L. Furu, L.F. Onuchic, M. de Baca, G.G. Germino, L. Guay-Woodford, S. Somlo, M. Moser, R. Buettner and K. Zerres. Spectrum of mutations in the gene for autosomal recessive polycystic kidney disease (ARPKD/PKHD1). JASN 14: 76-89 (2003)

(107) Poser, I., M. Golob, R. Buettner, and A.K. Bosserhoff. Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype. Mol. Cell. Biol. 23: 2991-8 (2003).

(108) Metzger, E., J.M. Müller, S. Ferrari, R. Buettner and R. Schüle: A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer. EMBO J. 22: 270-80 (2003).

(109) Senderek, J. C. Bergmann, S. Weber, U.P. Ketelsen, H. Schorle, S. Rudnik-Schöneborn, R. Büttner, E. Buchheim and K. Zerres: Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. Hum. Mol. Genet. 12: 349-56 (2003).

(110) Heukamp, L.C., D.W. Schröder, D. Plassmann, J. Homann and R. Buttner: Marked clinical and histological improvement in a patient with type-1 Gaucher´s disease following long-term glucocerebroside substitution. Pathol. Res. Pract. 199: 159-63 (2003).

(111) Wardelmann, E., I. Losen, V. Hans, I. Neidt, N. Speidel, E. Bierhoff, T. Heinicke, T. Pietsch, R. Buttner and S. Merkelbach-Bruse: Deletion of Trp-557 and Lys-558 in the juxtamembrane domain of the c-kit protooncogene is associated with metastatic behavior of gastrointestinal stromal tumors. Int. J. Cancer 106: 887-95 (2003).

(112) Bosserhoff, A.K., M. Moser, J. Schölmerich, R. Buettner and C. Hellerbrand: Specific expression and regulation of the new melanoma inhibitory activity-related gene MIA2 in hepatocytes. J. Biol. Chem. 278: 15225-31 (2003).

(113) Stoll, R., C. Renner, R. Buettner, W. Voelter, A.K. Bosserhoff and T.A. Holak: Backbone dynamics of the human MIA protein studied by (15)N NMR relaxation: implications for extended interactions of SH3 domains. Protein Sci. 12: 510-9 (2003).

(114) Moser, M., S. Dahmen, R. Kluge, H. Gröne, J. Dahmen, D. Kunz, H. Schorle and R. Buettner: Terminal renal failure in mice lacking trancription factor AP-2beta. Lab. Invest. 83: 571-8 (2003).

(115) Bosserhoff, A.K. and R. Buettner: Establishing the protein MIA (melanoma inhibitory activity) as a marker for chondrocyte differentiation. Biomaterials 24: 3229-34 (2003).

(116) Friedrichs, N., R. Vorreuther, H.P. Fischer, O.D. Wiestler, R. Buettner: Neurocytoma arising in the pelvis (case report). Virchows Arch. 443: 217-9 (2003).

(117) Behrmann, I., S. Wallner, W. Komyod, P.C. Heinrich, M. Schuierer, R. Buettner and A.K. Bosserhoff: Characterization of methyladenosin phosphorylase (MTAP) expression in malignant melanoma. Am. J. Pathol. 163: 683-90 (2003).

(118) Bierhoff, E., K. Appel, T. appel, R. Buettner and E. Wardelmann : Comparative morphometric analysis of primary versus recurrent basal cell carcinoma and of histological subtypes. Significance of morphometry of the nuclei. Anticancer Res. 23: 2697-700 (2003).

(119) Rudlowski, C., A.J Becker, W. Schröder, W. Rath, R. Büttner, M. Moser. GLUT 1 mRNA and protein induction relates to the malignant transformation of cervical cancer. Am. J. Clin. Pathol. 120: 691-8 (2003).

(120) Friedrichs, N., A.M. Eis-Hübinger, A. Heim, E. Platen., H. Zhou, R. Buettner. Acute adenoviral infection of a graft by serotype 35 following renal transplantation. Patho. Res. Pract. 199: 565-70 (2003).

(121) Arias, M., S. Sauer-Lehnen, J. Treptau, N. Janoschek, I. Theuerkauf, R. Buettner, A.M. Gressner, and R. Weiskirchen: Adenoviral expression of a transforming grpwth factor-beta1 antisense mRNA is effective in preventing liver fibrosis in bile-duct ligated rats. BMC Gastroenterology 3: 29 (2003).

(122) Senderek, J., C. Bergmann, C. Stendel,J. Kirfel, N. Verpoorten, P. De Jonghe, V. Timmerman, R. Chrast, M. H G Verheijen, G. Lemke, E. Battaloglu, Y. Parman, S. Erdem, E. Tan, H. Topaloglu, A. Hahn, W. Muller- Felber, N. Rizzuto, G.M. Fabrizi, M. Stuhrmann, S. Rudnik-Schoneborn, S. Zuchner, J. M. Schroder, E. Buchheim V. Straub, J. Klepper, K. Huehne, B. Rautenstrauss, R. Buttner, E. Nelis, K. Zerres: Mutations in a Gene Encoding a Novel SH3/TPR Domain Protein Cause Autosomal Recessive Charcot-Marie-Tooth Type 4C Neuropathy. Am J Hum Genet. 73: 1106-19 (2003).

(123) Hohlweg, U., M. Hosel, A. Dorn, D. Webb, K. Hilger-Eversheim, R. Remus, B. Schmitz, R. Buettner, A. Schramme, L. Corzilius, A. Niemann and W. Doerfler. Intraperitoneal dissemination of Ad12-induced undifferentiated neuroectodermal hamster tumors: de novo methylation and transcription patterns of integrated viral and cellular genes. Virus Res. 98: 45-56 (2003).

(124) Bosserhoff, A.K., R. Stoll, J.P. Sleeman, F. Bataille, R. Buettner, T.A. Holak. Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity. Lab. Invest. 83: 1583-1594 (2003).

(125) Merkelbach-Bruse, S., E. Wardelmann, P. Behrens, I. Losen, R. Buettner, and N. Friedrichs: Current diagnostic methods of HER2/neu-detection in breast cancer with special regard to real-time PCR. Am. J. Surg. Pathol. 27: 1565-1570 (2003).

(126) Park, T.W., O. Zivanovic, I. Theuerkauf, B. Dürkop, J.J. Hernando, M. Simon, R. Buttner, W. Kuhn: The diagnostic utility of human papillomavirus (HPV)-testing in combination with immunohistochemistry in advanced gynaecologic pelvic tumors: A new diagnostic approach. Int. J. Oncol. 24: 829-36 (2004).

(127) Merkelbach-Bruse, S., V. Hans, M. Mathiak, R. Sanguedolce, R. Alessandro, J. Ruschoff, R. Buettner, R. Houshdaran, and L. Gullotti: Associations between polymorphisms in the thymidilate synthase gene, the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal cancer. Oncol. Rep. 11: 839-43 (2004).

(128) Rudlowski, C., N. Friedrichs, A. Faridi, L. Füzesi, R. Moll, G. Bastert, W. Rath, and R Büttner: HER-2/neu Gene Amplification and Protein Expression in Primary Male Breast Cancer. Breast Cancer Res. Treat. 84: 215-223 (2004).

(129) Müller, A., T. Bocker-Edmonston, W. Dietmaier, R. Büttner, R. Fishel and J. Rüschoff: MSI-Testing in Hereditary Non-Polyposis Colorectal Carcinoma (HNPCC). Disease Markers 20: 225-236 (2004).

(130) Bergmann, C., J. Senderek, F. Küpper, F. Schneider, Chr. Dornia, E. Windelen, T. Eggermann, S. Rudnik- Schöneborn, J. Kirfel, L. Furu, L. F. Onuchic, S. Rossetti, P.C. Harris, S. Somlo, L. Guay-Woodford, G.G. Germino, M. Moser, R. Büttner, K. Zerres. PKHD1 mutations in autosomal recessive polycystic kidney disease (ARPKD). Hum. Mutation 23: 453-63 (2004).

(131) Bergmann, C., J. Senderek, F. Schneider, Chr. Dornia, F. Küpper, T. Eggermann, S. Rudnik-Schöneborn, J. Kirfel , M. Moser, R. Büttner, K. Zerres: PKHD1 mutations in families requesting prenatal diagnosis for autosomal recessive polycystic kidney disease (ARPKD). Hum. Mutation 23: 487-95 (2004).

(132) Moser, M., Y. Li, K. Vaupel, D. Kretzschmar, R. Kluge, P. Glynn and R. Buettner: Placental failure and impaired vasculogenesis result in embryonic lethality for neuropathy target esterase-deficient mice Mol. Cell. Biol. 24: 1667-1679 (2004).

(133) Wrede, C.E., S. Hutzler, L.C. Bollheimer, R. Buettner, C. Hellerbrand, J. Schoelmerich and K.D. Palitzsch: Correlation between iron status and genetic hemochromatosis (codon C282Y) in a large German population. Isr. Med. Assoc. J. 6: 30-3 (2004).

(134) Hohlweg, U., A. Dorn, M. Hosel, D. Webb, R. Buettner, W. Doerfler: Tumorigenesis by adenovirus type 12 in newborn Syrian hamsters. Curr. Top. Microbiol. Immunol. 273: 215-44 (2004).

(135) Wang, H.V., K. Vaupel, R. Buettner, A.K. Bosserhoff and M. Moser: Identification and embryonic expression of a new AP-2 transcription factor, AP-2epsilon. Dev. Dyn. 231: 128-135 (2004).

(136) Wardelmann, E., A. Hrychyk, S. Merkelbach-Bruse, K. Pauls, J. Goldstein, P. Hohenberger, I. Losen, C. Mangold, R. Büttner and T. Pietsch. Association of platelet-derived growth factor receptor mutations with gastric primary site and epitheliod or mixed cell morphology in gastrointestinal stromal tumors. J. Mol. Diagn. 6: 197-204 (2004).

(137) Haferkamp, A., B. Schurch, A. Reitz, U. Krengel, J. Grosse, G. Kramer, S. Schumacher, P.J. Bastian, R. Büttner, S.C. Mueller and M. Stoehrer. Lack of ultrastructural detrusor changes following endoscopic injection of Botulinum Toxin Type A in overactive neurogenic bladder. Eur. Urol. 46: 784-791 (2004).

(138) Haferkamp, A., J. Mundhenk, P.J. Bastian, A. Reitz, J. Dorsam, J. Pannek, S. Schumacher, B. Schurch, R. Büttner and S.C. Müller: Increased expression of connexin 43 in the overactive neurogenic detrusor. Eur. Urol. 46: 799-805 (2004).

(139) Bosserhoff, A.K., M. Moser, and R. Buettner: Characterization and expression pattern of the novel MIA homolog TANGO. Gene Expr. Patterns 4: 473-9 (2004).

(140) Zerres, K., J. Senderek, S. Rudnik-Schoneborn, T. Eggermann, J. Kunze, T. Mononen, H. Kaariainen, J. Kirfel, M. Moser, R. Buettner and C. Bergmann. New options for prenatal diagnosis in autosomal recessive polycystic kidney disease by mutation analysis of the PKHD1 gene. Clin. Genet. 66: 53-57 (2004).

(141) Müller, A., G. Guiffre, T. Bocker-Edmonston, M. Mathiak, B. Roggendorf, E. Heinmoller, T. Brodegger, G. Tuccari, E. Mangold, R. Buettner, and J. Rüschoff. Challenges and pitfalls in HNPCC screening by microsatellite analysis and immunhistochemistry. J. Mol. Diagn. 6: 308-15 (2004).

(142) Haring Bolivar, P., M. Nagel, F. Richter, M. Bruchseifer, H. Kurz, A. Bosserhoff, R. Büttner. Label-free THz sensing of genetic sequences: towards THz biochips. Philos. Transact. Ser. A. Math. Phys. Eng. Sci. 362: 323-35 (2004).

(143) Rudlowski, C., M. Moser, A.J. Becker, W. Rath, R. Büttner, W. Schröder and A. Schürmann. GLUT1 mRNA and protein expression in ovarian borderline tumors and cancer. Oncology 66: 404-10 (2004).

(144) Pauls, K., E. Wardelmann, S. Merkelbach-Bruse, R. Büttner and H. Zhou. C-kit codon 816 mutation in a recurrent and metastatic dysgerminoma of a 14-year-old girl: case study. Virchows Arch. 445: 651-54 (2004).

(145) Calascibetta A., L. Rausa, L. Gullotti, R. Buettner, R. Sanguedolce. Thymidylate synthase polymorphism and microsatellite instability: association in colorectal cancer. Nucleosides Nucleotides Nucleic Acids, 23: 1377-79 (2004).

(146) Friedrichs, N., R. Jäger, E. Paggen, C. Rudlowski, S. Merkelbach-Bruse, H. Schorle and R. Buettner: Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. Mod. Pathol. 18: 431-438 (2005).

(147) Moser, M., S. Matthiesen, J. Kirfel,, H. Schorle, C. Bergmann, J. Senderek, S. Rudnik-Schöneborn, K. Zerres and R. Buettner. A mouse model for congenital liver fibrosis in autosomal recessive polycystic kidney disease (ARPKD). Hepatology 41: 1113-1121 (2005).

(148) Mangold, E., C. Pagenstecher, W. Friedl, M. Mathiak, R. Buettner, C. Engel, M. Loeffler, E. Holinski- Feder, Y. Mueller-Koch, G. Keller, J. Plaschke, S. Krueger, T. Goecke, G. Moeslein, M. Kloor, J. Gebert, E. Kunstmann, K. Schulmann, J. Rueschoff, P. Propping, and the German HNPCC Consortium. Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1721 German families suspected of hereditary nonpolyposis colorectal cancer . Int. J. Cancer 116: 692-702 (2005).

(149) Wardelmann, E., N. Thomas, S. Merkelbach-Bruse, K. Pauls, T. Heinicke, N. Speidel, X. Palmedo, T. Pietsch, R. Büttner, D. Pink, P. Reichardt, P. Hohenberger: Acquired resistance to imatinib in progressive gastrointestinal stromal tumors due to multiple kinase-domain mutations of c-Kit. Lancet Oncol. 6: 249-51 (2005).

(150) Tasci, S., A. Kovacs, C. Leutner, O. Zivanovic, B. Lüderitz, R. Büttner, U. Mey. Patients with malignancy requiring urgent therapy: Case 1. Central airway obstruction as first presentation of ovarian cancer. JCO 23: 6791- 93 (2005).

(151) Jäger, R., N. Friedrichs, I. Heim, R. Büttner and H. Schorle. Dual role of AP-2g in c-erbB-2-induced mammary tumorigenesis. Breast Cancer Res. Treatment 90: 273-80 (2005).

(152) Woerner, S.M., M. Kloor, A. Mueller, J. Rueschoff, N. Friedrichs, R. Buettner, M. Buzello, P. Kienle, H.P. Knaebel, E. Kunstmann, C. Pagenstecher, H.K. Schackert, G. Möslein, H. Vogelsang, M. von Knebel Doeberitz, J.F. Gebert, and the German HNPCC Consortium. Microsatellite instability of candidate real common target genes in colon adenomas. Oncogene 24: 2525-2535 (2005).

(153) Pauls, K., R. Jäger, S. Weber, E. Wardelmann, A. Koch, R. Buettner and H. Schorle. Transcription factor AP-2 gamma, a novel marker of gonocytes and seminomatous germ cell tumors. Int. J. Cancer 115: 470-477 (2005).

(154) Pauls, K., S. Merkelbach-Bruse, D. Thal, R. Buettner and E. Wardelmann. Histological and immunological characteristics of PDGFRa- and c-KIT-mutated Gastrointestinal Stromal Tumors. Histopathology 46: 166-175 (2005).

(155) Giuffrè, G., A. Müller, T. Brodegger, T. Bocker-Edmonston, J. Gebert, M. kloor, W. Dietmaier, F. Kullmann, R. Büttner, G. Tuccari, J. Rüschoff: Microsatellite analysis of HNPCC-associated colorectal adenomas by laser-assisted microdissection: correlation with mismatch repair protein analysis provides new insights in early steps of tumorigenesis. J. Mol. Diagn. 7: 160-70 (2005).

(156) Hartmann, K., E. Wardelmann, Y. Ma, S. Merkelbach-Bruse, L.M. Preussner, C. Woolery, S.E. Baldus, T. Heinicke, J. Thiele, R. Buettner and B.J. Longley. Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis. Gastroenterology 129: 1042-46 (2005).

(157) Mühlig-Versen, M., A.B. da Cruz, J.A. Tschäpe, M. Moser, R. Büttner, K. Athenstaedt, P. Glynn and D. Kretzschmar. Loss of Swiss Cheese/Neuropathy Target Esterase activity causes disruption of phophatidylcholine homeostasis and neuronal and glial death in adult Drosophila. J. Neurosciences 25: 2865-2873 (2005).

(158) Bergmann, C., J. Senderek, E. Windelen, F. Kupper, I. Middeldorf, F. Schneider, C. Dornia, S. Rudnik- Schöneborn, M. Konrad, C.P. Schmitt, T. Seeman, T.J. Neuhaus, U. Vester, J. Kirfel, R. Büttner, K. Zerres; members of the APN. Clinical consequences of PKHD1 mutations in 164 patients with autosomal-recessive polycystic kidney disease (ARPKD). Kidney Int. 67: 829-48 (2005).

(159) Haas, S., T.W. Park, E. Voigt, R. Büttner and S. Merkelbach-Bruse. Detection of HPV 52, 58 and 87 in cervicovaginal intraepithelial lesions of HIV infected women. Int. J. Mol. Medicine 16 : 815-9 (2005).

(160) Hellerbrand, C., F. Bataille, J. Schlegel, A. Hartmann, M. Mühlbauer, J. Schölmerich, R. Büttner, F. Hofsädter and A.K. Bosserhoff. In situ expression patterns of melanoma inhibitory activity 2 in healthy and diseased livers. Liver International 25: 357-66 (2005).

(161) Stelzner, F., N. Friedrichs, R. Büttner, N. Wernert, D. von Mallek, J. Rühlmann, H.U. Steinau. Lymph vascularity and lymph node metastases on PET and PET-CT: immunohistological and clinical observations. Chirurg 76: 493-500 (2005).

(162) Pauls, K., F.E. Franke, R. Buettner and H. Zhou. Gonadoblastoma: evidence for a stepwise progression to dysgerminoma in a dysgenetic ovary. Virchows Arch. 447: 603-9 (2005).

(163) Friedrichs, N., M.A. Testi, L. Moiraghi, P. Modena, E. Paggen, A. Plotner, V. Wiechmann, L. Mantovani- Löffler, S. Merkelbach-Bruse, R. Buettner and E. Wardelmann: Clear cell sarcoma-like tumor with osteoclast-like giant cells in the small bowel: Further evidence for a new tumor entity. Int. J. Surg. Pathol. 13: 313-318 (2005).

(164) Hermanns-Sachweh, B., A, Stemper, B. Klosterhalfen, J. Senderek, R. Buttner and M. Weber. Light microscopical, immunhistochemical and ultrastructural findings in congenital fibular aplasia or hypoplasia (FAH). Pediatric. Dev. Pathol. 8: 474-82 (2005).

(165) Metzger, E., M. Wissmann, N. Yin, J.M. Müller, R. Schneider, A.H. Peters, T. Gunther, R. Buettner and R. Schuele. LSD1 demethylates repressive histone marks to promote androgen receptor-dependent transcription. Nature 437: 436-9 (2005).

(166) Pauls, K., E. Wardelmann, F.E. Franke, L.C. Heukamp, R. Büttner, U. Mey, H. Zhou. Primary extragonadal germ cell tumor: unusual localization of a c-kit mutated retroperitoneal seminoma in the gastric wall. Histopathology 47: 112-14 (2005).

(167) Patil, M.A., I. Gütgemann, J. Zhang, C. Ho, S.T. Ceung, D. Ginzinger, R. Li, K.J. Dykema, S. So, S.T. Fan, S. Kakar, K.A. Furge, R. Büttner and X. Chen. Array-based comparative genomic hybridization reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma. Carcinogenesis 26: 2050-57 (2005).

(168) Hermanns-Sachweh, B., J. Senderek, J. Alfer, B. Klosterhalfen, R. Buettner, L. Fuzesi and M. Weber. Vascular changes in the periosteum of congenital pseuarthrosis of the tibia. Path. Res. Pract. 201: 305-12 (2005).

(169) Omram, H., H. Schmidt, D. Hardung, C. Hammerstingl, G. von der Recke, S. Haas, R. Büttner and B. Lüderitz. Post mortem analysis of a left atrial appendage occlusion device (PLAATO) in a patient with permanent atrial fibrillation. J. Interv. Card. Electrophysiol. 14: 17-20 (2005).

(170) Mangold, E., C. Pagenstecher, W. Friedl, H.-P. Fischer, S. Merkelbach-Bruse, M. Ohlendorf, N. Friedrich, S. Aretz, R. Buettner, P. Propping and M. Mathiak. Tumors from MSH2 mutation carriers show loss of MSH2 expression but many tumors from MLH1 muation carriers exhibit weak positive MLH1 staining.. J. Pathol. 207: 385-395 (2005).

(171) Wagener, N., A. Reitz, J. Pfitzenmaier, J. Pannek, P.J. Bastian, R. Büttner, S.C. Müller, M. Hohenfellner and A. Haferkamp. Adherens junctions of the human detrusor. BJU Int. 96: 843-7 (2005).

(172) Merkelbach-Bruse, S., E. Wardelmann, L. Heukamp, N. Friedrichs, R. Büttner. Moleclar targets for diagnostics and therapy – new challenges for pathologists. Verh. Dtsch. Ges. Pathol. 89: 111-5 (2005).

(173) Pagenstecher, C., M. Wehner, W. Friedl, N. Rahner, N. Friedrichs, S. Aretz, M. Senteller, R. Büttner, P. Propping and E. Mangold. Aberrant splicing in MLH1 and MSH2 genes due to exonic and intronic variants in common. Human Genet. 119: 9-22 (2006).

(174) Pauls K., H. Schorle, W. Jeske, R. Brehm, K. Steger, N. Wernert, R. Büttner and H. Zhou. Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunhistochemical study. Hum. Reprod. 21: 397-404 (2006).

(175) Engel, C., J. Forberg, E. Holinski-Feder, C. Pagenstecher, J. Plachke, M. Kloor, C. Poremba, C.P. Pox, J. Rüschoff, G. Keller, W. Dietmaier, P. Rümmele, N. Friedrichs, E. Mangold, R. Büttner H.K. Schackert, P. Kienle, S. Stemmler, G. Möslein, M. Loeffler and the German HNPCC Consortium. Novel strategy for optimal application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer. Int. J. Cancer 118: 115-122 (2006).

(176) Wardelmann, E., S. Merkelbach-Bruse, K. Pauls, N. Thomas, H.U. Schildhaus, T. Heinicke, N. Speidel, T. Pietsch, R. Büttner, D. Pink, P. Reichardt, P. Hohenberger. Polyclonal evolution of multiple secondary KIT mutations in gastrointestinal stromal tumors under treatment with imatinib mesylate. Clin. Cancer Res. 12: 1743-9 (2006).

(177) Domeier, E., R. Büttner, F.G. Holz, K.U. Löffler. Plötzlich auftretender Tumor der Conjunctiva bulbi bei einem 7-jährigen Jungen. Opthalmologe 103: 616-9 (2006).

(178) Friedrichs, N., L. Kriegl, C. Poremba, K.L. Schäfer, A. Shimomura, E. Paggen, S. Merkelbach-Bruse and R. Buettner: Pitfalls in the detection of t(11;22) translocation by fluorescence in-situ hybridization and PCR: A single blinded study. Diagn. Mol. Pathol. 15: 83-89 (2006).

(179) Heukamp, L.C., H.P. Fischer, P. Schirmacher, X. Chen, K. Breuhahn, C. Nicolay, R. Büttner, I. Gütgemann. Podocalyxin-like protein 1 expression in primary human hepatic tumours and tumour-like lesions. Histopathology 49: 242-7 (2006).

(180) Mueller, A., C. Beckmann, G. Westphal, T. Bocker-Edmonston, N. Friedrichs, W. Dietmaier, F.E. Brasch, M. Kloor, C. Poremba, G. Keller, D. Aust, J. Faß, R. Büttner, H. Becker, J. Rüschoff and the German HNPCC Consortium. Prevalence of mismatch repair-insufficient phenotype in HNPCC adenomas: Results of a five year follow-up study. Int. J. Colorectal Dis. 21: 632-41 (2006).

(181) Kirfel, J., J. Senderek, M. Moser, C. Bermann, K. Zerres and R. Buettner. Cloning, expression and characterization of the murine orthologue of Sbf2, the gene mutated in Charcot-Marie-Tooth type 4B2. Gene Expr. Patterns 6: 978-84 (2006).

(182) Friedrichs, N., J.C. Hahne, M.S. Peper, U. Rommerscheidt-Fuss, R. Buettner, F. Stelzner and N. Wernert. Immunohistochemical quantification of lymph vessels, VEGF-C and VEGF receptor-3 in human sarcomas. Histopathology 49: 87-101 (2006).

(183) Gütgemann, I., S. Haas, J.P. Berg, H. Zhou, R. Büttner, H.P. Fischer. CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions. Virchows Archiv 448: 407-11 (2006).

(184) Biermann, K., D. Klingmüller, A. Koch, T. Pietsch, H. Schorle, R. Büttner, and H. Zhou. Diagnostic value of markers M2A, OCT3/4, AP-2g, PLAP and c-KIT in the detection of extragonadal seminomas. Histopathology 49: 290-7 (2006).

(185) Haferkamp, A., T. Freund, N. Wagener, A. Reitz, B. Schurch, J. Doesam, S. Schumacher, P.J. Bastian, R. Buettner, S.C. Mueller, M. Hohenfellner. Distribution of neuropeptide-Y containing nerves in the neurogenic and non-neurogenic detrusor. BJU Int. 97: 393-9 (2006).

(186) Tormo, D., A. Ferrer, E. Gaffal, J. Wenzel, E. Basner-Tschakarjan, J. Steitz, L.C. Heukamp, I. Gütgemann, R. Buettner, M. Malumbres, M. Barbacid, G. Merino, T. Tüting. Rapid growth of invasive metastatic melanoma in carcinogen-treated HGF/SF-transgenic mice carrying an oncogenic CDK4 mutation. Am. J. Pathol. 169: 665-72 (2006).

(187) Bergmann, C., V. Frank, F. Kupper, D. Kamitz, J. Hanten, P. Berges, S. Mager, M. Moser, J. Kirfel, R. Buettner, J. Senderek and K. Zerres. Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease. Mol. Diagn. Ther. 10: 163-74 (2006).

(188) Lamberti, C., E. Mangold, C. Pagenstecher, M. Jungck, D. Schwering, M. Bollmann, J. Vogel, D. Kindermann, R. Nikorowitsch, N. Friedrichs, B. Schneider, F. Houshdaran, I.G.H. Schmidt-Wolf, W. Friedl, P. Propping, T. Sauerbruch, R. Büttner, M. Mathiak. Frequency of hereditary non-polyposis colorectal cancer (HNPCC) among unselected patients with colorectal cancer in Germany. Digestion 74: 58-67 (2006).

(189) Wardelmann, E., K. Biermann, S. Merkelbach-Bruse, H.U. Schildhaus, N. Thomas, R. Buettner, T. Pietsch, T. Heinicke, N. Speidel, D. Pink, P. Reichardt, P. Hohenberger. Polyclonal resistance in GIST treated with sequential kinase inhibitors. Clin. Cancer Res. 12: 6206 (2006) correspondence.

(190) Kahl, P., L. Gullotti, L.C. Heukamp, S. Wolf, N. Friedrichs, R. Vorreuther, G. Solleder, P.J. Bastian, J. Ellinger, E. Metzger, R. Schuele and R. Buettner. Androgen receptor coactivators LSD1 and FHL2 predict risk of prostate cancer recurrence. Cancer Res. 66: 11341-11347 (2006).

(191) Bosserhoff, A.K., E.I. Grussendorf-Conen, A. Rubben, S. Rudnik-Schoneborn, K. Zerres, R. Buettner, S. Merkelbach-Bruse. Multiple colon carcinoma in a patient with Cowden syndrome. Int. J. Mol. Med. 18: 643-7 (2006).

(192) Wardelmann, E, H.U. Schildhaus, S. Merkelbach-Bruse, R. Buttner. Therapeutic targets in gastrointestinal stromal tumors. Verh. Dtsch. Ges. Pathol. 90: 73-9 (2006).

(193) Ney, J.T., H. Zhou, B. Sipos, R. Buttner, X. Chen, G. Klöppel, I. Gütgemann. Podocalyxin-like protein 1 expression is useful to differentiate pancreatic ductal adenocarcinomas from adenocarcinomas of the biliary and gastrointestinal tracts. Hum. Pathol. 38: 359-64 (2007).

(194) Lamberti, C., S. Lundin, M. Bogdanow, C. Pagenstecher, N. Friedrichs, R. Büttner, T. Sauerbruch. Microsatellite instability did not predict individual survival of unselected patients with colorectal cancer. Int. J. Colorectal Dis. 22: 145-52 (2007).

(195) Hata, K., R.H. Tolba, L. Wei, B.M. Doorschodt, R. Büttner, Y. Yamamoto, T. Minor. Impact of polysol, a newly developed preservation solution, on cold storage of steatotic rat livers. Liver Transpl. 13: 114-21 (2007).

(196) Wissmann, M., N. Yin, J.M. Muller, H. Greschik, B.D. Fodor, T. Jenuwein, C. Vogler, R. Schneider, T. Günther, R. Buettner, E. Metzger and R. Schüle. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 9: 347-53 (2007).

(197) Kahl, P., L. Heukamp, R. Buettner, N. Friedrichs, B. Roesing, G. Knöpfle. Orofacialdigital syndrome type IV (Mohr-Majewski-Syndrome). Pediatr. Dev. Pathol. 10: 239-43 (2007).

(198) Wixler, V., S. Hirner, J. M. Müller, L. Gullotti, C. Will, J. Kirfel, T. Günther, H. Schneider, A.K. Bosserhoff, H. Schorle, J. Park, R. Schüle and R. Buettner. Deficency in the LIM-only protein FHL2 impairs skin wound healing. J. Cell Biol. 177: 163-72 (2007).

(199) Mangold, E., N. Rahner, N. Friedrichs, R. Buettner, C. Pagenstecher, S. Aretz, W. Friedl, T. Ruzicka, P. Propping, A. Rutten, P. Kruse. MSH6 mutation in Muir-Torre syndrome: could this be a rare finding ? Br. J. Dermatol. 156: 158-162 (2007).

(200) Berg, J.P., Q. Zhou, K. Breuhahn, P. Schirmacher, M.A. Patil, X. Chen, N. Schäfer, T.T. Holler, H.P. Fischer, R. Büttner and I. Gütgemann. Inverse expression of Jun activation domain-binding protein 1 and cell cycle inhibitor p27(kip1): influence on proliferation in hepatocellular carcinoma. Hum. Pathol. 38: 1621-7 (2007).

(201) Alessandro, R., G. Seidita, A.M. Flugy, F. Damiani, A. Russo, C. Corrado, P. Colomba, L. Gullotti, R. Buettner, L. Bruno and G. De Leo. Role of S128R polymorphism of E-selectin in colon metastasis formation. Int. J. Cancer 121: 528-35 (2007).

(202) Rahner, N., N. Friedrichs, M. Wehner, V. Steinke, S. Aretz, W. Friedl, R. Buettner, E. Mangold, P. Propping, C. Walldorf. Nine Novel Pathogenic Germline Mutations in MLH1, MSH2, MSH6 and PMS2 in Families with Lynch Syndrome. Acta Oncologica 46: 763-9 (2007).

(203) Heukamp, L.C., A. Knoblich, E. Rausch, N. Friedrichs, H.U. Schildhaus,, P. Kahl, R. Tismer, B. Schneider, R. Büttner and F. Houshdaran. Extraosseous osteosarcoma arising from the small intestinal mesentery. Path. Res. Pract. 203: 473-7 (2007).

(204) Kloor, M., S. Michel, B. Buckowitz, J. Rüschoff, R. Büttner, E. Holinski-Feder, W. Dippold, R. Wagner, M. Tariverdian, A. Benner, Y. Schwitalle, B. Kuchenbuch, and M. von Kebel Doeberitz. Beta2-microglobulin mutations in microsatellite unstable colorectal tumors. Int. J. Cancer 121: 454-8 (2007).

(205) Kahl, P., R. Buettner, N. Friedrichs, S. Merkelbach-Bruse, J Wenzel, and L.C. Heukamp. Kaposi´s sarcoma of the gastrointestinal tract. Report of two cases and review of the literature. Path. Res. Pract. 203: 227-31 (2007).

(206) Pantelis, A., D. Pantelis, P. Ruemmele, A. Hartmann, F. Hofstaedter, R. Büttner, F. Bootz, R. Stoehr. P53 codon 72 polymorphisms, loss of heterozygosity and high-risk human papillomavirus infection in a low-incidence German esophageal squamous cell carcinoma patient cohort. Oncol. Rep. 17: 1243-8 (2007).

(207) Friedrichs, N., S. Steiner, R. Buettner, G. Knoepfle,. Immunohistochemical expression patterns of AP- 2alpha and AP-2gamma in the developing fetal human breast. Histopathology 51: 814-23 (2007).

(208) Biermann, K., F. Göke, D. Nettersheim, D. Eckert, H. Zhou, P. Kahl, I Gashaw, H. Schorle and R. Buettner. c-KIT is frequently mutated in bilateral germ cell tumors and down-regulated during progression from intratubular germ cell neoplasia to seminoma. J. Pathol. 213: 311-8 (2007).

(209) Biermann, K., L.C. Heukamp, D. Nettersheim, K. Steger, H. Zhou, F.E. Franke, I. Guetgemann, V. Sonnack, R. Brehm, J. Berg, P.J. Bastian, S.C. Müller, L. Wang-Eckert, H. Schorle, R. Buettner. Embryonal germ cells and germ cell tumors. Verh Dtsch Ges Pathol 91: 39-48 (2007).

(210) Karsak, M., E. Gaffal, R. Date, L. Wang-Eckhardt, J. Rehnelt, S. Petrosino, K. Starowicz, R. Steuder, E. Schlicker, B. Cravatt, R. Mechoulam, R. Buettner, S. Werner, V. di Marzo, T. Tüting and A. Zimmer. Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 316: 1494-97 (2007).

(211) Demant, A.W., A. Schmiedel, R. Büttner, T. Lewalter, C. Reichel. Heart failure and malignant ventricular tachyarrhythmias due to hereditary hemochromatosis with ironoverload cardiomyopathy. Clin. Res. Cardiol. 96: 900-03 (2007).

(212) Wei, L., K. Hata, B.M. Doorschodt, R. Büttner, T. Minor, R.H. Tolba. Experimental small bowel preservation using polysol: A new alternative to University of Wisconsin solution, Celsior and histidine-tryptophan- ketoglutarate solution. World J. Gastroenterol. 13: 3684-91 (2007).

(213) Adam A., C. Grohé, S. Stier, S. Gattenlöhner, Z. Balta, R. Büttner und I. Gütgemann. Hodgkin´s lymphoma in a patient with Jo-1 syndrome. Virchows Arch. 451: 101-4 (2007).

(214) Mikeska, T., C. Bock, O. El-Maarri, A. Hübner, D. Ehrentraut, J. Schramm, J. Felsberg, P. Kahl, R. Büttner, T. Pietsch, and A. Waha. Optimization of quantitative MGMT promoter methylation analysis using pyrosequencing and combined bisulfite restriction analysis. J. Mol. Diagn. 9: 368-81 (2007).

(215) Riehm, K., U. Flucke, C. Engel, B. Wappenschmidt, A. Reinecke-Lüthge, R. Büttner, R.K. Schmutzler. Association of the BRCA1 missense variant R1699W with a malignant phylloides tumour of the breast. Cancer Genet. Cytogenet. 176: 76-9 (2007).

(216) Wardelmann, E., R. Buettner, S. Merkelbach-Bruse, H.U. Schildhaus. Mutation analysis of gastrointestinal stromal tumors: increasing significance for risk assessment and effective targeted therapy. Virchows Arch. 451: 743- 9 (2007).

(217) Simon, A., S. Völz, S.M. Reiffert, H. Bölefahr, H. Marklein, R. Büttner, N. Hepping, U. Bode, G. Fleischhack. Protracted cervical lymphadenitis with Mycobacterium avium and Methylobacterium mesophilicum. Pediatr. Infect. Dis. J. 26: 971 (2007).

(218) Wardelmann, E., S. Merkelbach-Bruse, R. Buttner, H.U. Schildhaus. Activating mutations in receptor tyrosine kinases with relevance for treatment of gastrointestinal stromal tumors. Verh. Dt. Ges. Pathol. 91: 165-8 (2007).

(219) Biermann, K., L.C. Heukamp, K. Steger, H. Zhou, F.E. Franke, I. Guetgemann, V. Sonnack, R. Brehm, J. Berg, P.J. Bastian, S.C. Mueller, L. Wang-Eckert H. Schorle, and R. Buettner: Gene expression profiling identifies new biological markers of neoplastic germ cells. Anticancer Res. 27: 3091-100 (2007).

(220) Biermann, K., L.C. Heukamp, K. Steger, H. Zhou, F.E. Franke, I. V. Sonnack, R. Brehm, J. Berg, P.J. Bastian, S.C. Müller, L. Wang-Eckert, R. Buettner. Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors. Cancer Genomics Proteomics 4: 359-368 (2007).

(221) Albers, R., F. Honeckers, J. Rüschoff, G. Sauter, S.C. Müller, R. Büttner, C. Bokemeyer. Molecular studies of late relapse of testicular cancer. Cochrane Database Syst. Rev. 46: 1185-6 (2007).

(222) Ellinger, J., P.J. Bastian, K.I. Haan, L.C. Heukamp, R. Buettner, R. Fimmers, S.C. Müller, A. von Ruecker. Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and pronostic indicators. Int. J. Cancer 122: 138-43 (2008).

(223) Ellinger, J., K.I. Haan, L.C. Heukamp, P. Kahl, R. Buettner, S.C. Müller, A. von Rücker, P.J. Bastian. CpG island hypermethylation in cell-free serum DNA identifies patients with locakized prostate cancer. Prostate 68: 42-9 (2008).

(224) Gottschling S., H. Reinhard, C. Pagenstecher, S. Kruger, J. Raedle, G. Plotz, W. Henn, R. Buettner, S. Meyer, N. Graf. Hypothesis: Possibile role of retinoic acid therapy in patients with biallelic mismatch repair gene defects. Eur. J. Pediatr. 167: 225-9 (2008).

(225) Krüger, S., M. Kinzel, C. Walldorf, S. Gottschling,, A. Bier, S. Tinschert, A. von Stackelberg, W. Henn, H. Görgens, S. Boue, K. Kölble, R. Büttner and H.K. Schackert. Homozygous PMS2 germline mutation in two families with early onset haematological malignancy, brain tumours, HNPCC associated tumours, and signs of neurofibromatosis type I. Eur. J. Hum Genet. 16: 62-72 (2008).

(226) Grünhage, F., M. Jungck, C. Lamberti, C. Berg, U. Becker, H. Schulte-Witte, D. Plassmann, N. Rahner, S. Aretz, N. Friedrichs, R. Buettner, T. Sauerbruch and F. Lammert. Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes. Int. J. Colorect. Dis. 23: 147-54 (2008).

(227) Grünhage, F., M. Jungck, C. Lamberti, H. Schulte-Witte, D. Plassmann, U. Becker, N. Rahner, S. Aretz, N. friedrichs, R. Buettner, T. Sauerbruch and F. Lammert. Contribution of common monoallelic MUTYH gene variants in German patients with familial colorectal cancer. Cancer Biomark. 4: 55-61 (2008).

(228) Shimomura, A., M.V. Lilienfeld-Toal, Z. Balta, E. Schroers, I.G. Schmidt-Wolf, R. Büttner, A.von Rücker, I. Gütgemann. Absent immunoglobulins in HIV-related Burkitt lymphoma/leukaemia. Ann. Hematol. 87: 255-6 (2008).

(229) Hofmann, M., O. Stoss, D. Shi, R. Büttner, M. van de Vjiver, W. Kim, A. Ochiai, J. Rüschoff, T. Henkel. Assessment of a Her2 scoring system for gastric cancer: results from a validation study. Histopathology 52: 797-805 (2008).

(230) Biermann, K., L.C. Heukamp, R. Büttner and H. Zhou. Uterine tumor resembling an ovarian sex-cord tumor associated with metastasis. Int J Gynecological Pathol. 27: 58-60 (2008).

(231) Rahner, N., N. Friedrichs, V. Steinke, S. Aretz, W. Friedl, R. Buettner, E. Mangold, P. Propping, C. Walldorf. Coexisting somatic promoter hypermethylation and pathogenic MLH1 germline mutation in Lynch syndrome. J. Pathol. 214: 10-16 (2008).

(232) Schulte, J.H., S. Horn, T. Otto, B. Samans, L.C. Heukamp, U.C. Eilers, M. Krause, K. Astrahantseff, L. Klein-Hitpass, R. Buettner, A. Schramm, H. Christiansen, M. Eilers, A. Eggert and B. Berwanger. MYCN regulates oncogenic microRNAs in neuroblastoma. Int. J. Cancer 122: 699-704 (2008).

(233) Metzger, E., N. Yin, M. Wissmann, N. Kunowska, K. Fischer, N. Friedrichs, D. Patnaik, J.M. Higgins, N. Poitier, K.H. Scheidtmann, R. Buettner, R. Schüle. Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nature Cell Biol 10: 53-60 (2008).

(234) Park, J., C. Will, B. Martin, L. Gullotti, N. Friedrichs, R. Buettner, H. Schneider, S. Ludwig and V. Wixler. Deficiency in the LIM-only protein FHL2 impairs assembly of extracellular matrix proteins. FASEB J. 7: 2508-20 (2008).

(235) Speel, E.J.M., A.J. van de Wouw, S.M.H. Claessen, A. Haesevoets, A.H.N. Hopman, A.A.M. va der Wurff, R. Osieka, R. Buettner, H.F.P. Hillen, F.C.S. Ramaekers. Molecular evidence for a clonal relationship between multiple lesions in patients with unknown primary adenocarcinoma. Int. J. Cancer 123: 1292-1300 (2008).

(236) Braun, M., U. Flucke, M. Debald, G. Walgenbach-Bruenagel, K.J. Walgenbach, T. Höller, M. Pölcher, M. Wolfgarten, A. Sauerwald, M. Keyver-Paik, M. Kühr, R.Büttner, W. Kuhn. Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin) – a clinically useful predictor for axillary lymph node metastases. Breast Cancer Res. Treat. 112: 503-11 (2008).

(237) Sagave, J.F., M. Moser, E. Ehler, S. Weiskirchen, D. Stoll, K. Günther, R. Büttner, and R. Weiskirchen. Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine rich LIM domain protein CRP2 results in subtle ulteration of the cardiac ultrastructure. BMC Dev. Biol. 8: 80 (2008).

(238) Schildhaus, H.U., T. Cavlar, E. Binot, R. Buettner, E. Wardelmann, S. Merkelbach-Bruse. Inflammatory fibroid polyps harbor mutations in the PDGFRA gene. J. Pathol. 216: 176-82 (2008).

(239) Ellinger, J., P.J. Bastian, N. Ellinger, P. Kahl, F.G. Perabo, R. Büttner, S.C. Müller, A. v. Ruecker. Apoptotic DNA fragments in the serum of patients with muscle invasive bladder cancer: A prognostic entity. Cancer Letters 264: 274-80 (2008).

(240) Hong, S.J., T. Lardaro, M.S. Oh, Y Huh, Y. Ding, U.J. Kang, J. Kirfel, R. Buettner and K.S. Kim. Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP2ß. J. Biol. Chem. 283: 16860-67 (2008)

(241) Koch, L.K., H. Zhou, J. Ellinger, K. Biermann, T. Höller, A. von Rücker, R. Büttner, I. Gütgemann. Stem cell marker expression in small cell lung carcinoma and developing lung tissue. Human Pathol. (Epub July23, 2008).

(242) Müller, A., D. Zielinski, N. Friedrichs, B. Oberschmid, S. Merkelbach-Bruse, W. Dietmaier, H. Zöltzer, K. Schulmann, H.K. Schackert, M. Linnebacher, M. von Knebel-Döberitz, R. Buettner, J. Rüschoff and the German HNPCC Consortium. Reduced mRNA expression in paraffin-embedded tissues identifies MLH1 and MSH2-deficient colorectal tumors and potential mutation carriers. Virchows Arch. 453: 9-16 (2008).

(243) Thalheimer, A., M. Schlemmer, M. Bueter, S. Merkelbach-Bruse, H.U. Schildhaus, R. Buettner, E. Hartung, A. Thiede, D. Meyer, M. Fein, J. Maroske, E. Wardelmann. Familial gastrointestinal stromal tumors caused by the novel KIT exon 17 germline mutation N822Y. Am. J. Surg. Pathol. 32: 1560-5 (2008).

(244) Friedrichs, N., J. Küchler, E. Endl, A. Koch, J. Czerwitzki, P. Wurst, J.H. Schulte, M. Holst, L.C. Heukamp, O. Lasson, S. Tanaka, A. Kawai, E. Wardelmann, R. Büttner, T. Pietsch and W. Hartmann. Insulin-like growth factor-I receptor-I acts as a growth regulator in synovial sarcoma. J. Path. 216: 428-39 (2008).

(245) Ellinger, J., A. von Rücker, N. Wernert, R. Büttner, P.J. Bastian, Stefan C. Müller. Prostate cancer research: Biomarkers as promising options for optimized diagnosis and treatment. Urologe A. 47: 1190-2 (2008).

(246) Frank, B., B. Burwinkel, J.L. Bermejo, A. Försti, K. Hemminki, R. Houlston, E. Mangold, N. Rahner, W. Friedl, N. Friedrichs, R. Buettner, C. Engel, M. Loeffler, E. Holinski-Feder, M. Morak, Y. Müller-Koch, G. Keller, H.K. Schackert, S. Krüger, T. Goecke, G. Moeslein, M. Kloor, J. Gebert, E. Kunstmann, K. Schulmann, J. Rüschoff, P. Propping, and the German HNPCC Consortium. Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families. Cancer Letters 271: 153-7 (2008).

(247) Schulte, J.H., J. Kirfel, S. Lim, A. Schramm, N. Friedrichs, H. Deubtzer, O. Witt, A. Eggert, R. Buettner. Transcription factor AP2alpha (TFAP2a) regulates differentiation and proliferation of neuroblastoma cells. Cancer Letters 271: 56-63 (2008).

(248) Grünhage, F., M. Jungck, Chr. Lamberti, H. Keppeler, U. Becker, H. Schulte-Witte, D. Plassmann, N. Fiedrichs, R. Buettner, S. Aretz, T. Sauerbruch, F. Lammert. Effects of common haplotypes of the ileal sodium dependent bile acid transporter gene on the development of sporadic and familial colorectal cancer: a case control study. BMC Med. Genet. 9: 70 (2008).

(249) Kirfel, J., D. Pantelis, M. Kabba, P. Kahl, A. Röper, J.C. Kalff, and R. Buettner. A functional role of the FHL2 signal transducer in anastomotic wound healing after bowel surgery. Exp. Cell Res. 314: 3684-91 (2008).

(250) Schulte, J.H., S.Y. Lim, A. Schramm, N. Friedrichs, I. Ora, K. Pajtler, L. Klein-Hitpass, S. Kuhfittig-Kulle, E. Metzger, R. Schüle, A. Eggert, R. Buettner and J. Kirfel. LSD1 histone demethylase is strongly expressed in poorly differentiated neuroblastoma: Implications for therapy. Cancer Res. 69: 2065-71 (2009).

(251) Schulte, J.H., S. Horn, S. Schlierf, A. Schramm, L.C. Heukamp, H. Christiansen, R. Buettner, B. Berwanger and A. Eggert. MicroRNAs in the pathogenesis of neuroblastoma. Minireview. Cancer Letters 274: 10-15 (2009).

(252) Ney, J.T., T. Schmidt, C. Kurts, Q. Zhou, D. Eckert, D. Felsher, H. Schorle, P. Knolle, T. Tüting, W. Barchet, R. Büttner, A. Limmer, I. Gütgemann. Autochthonous liver tumors induce systemic T-cell tolerance associated with T-cell receptor down-modulation. Hepatology 49: 471-81(2009).

(253) Huneburg, R., F. Lammert, C. Rabe, N. Rahner, P. Kahl, R. Büttner, P. Propping, T. Sauerbruch, C. Lamberti. Chromocolonoscopy detects more adenomas than white light colonoscopy or narrow band imaging colonoscopy in hereditary nonpolyposis colorectal cancer screening. Endoscopy 41: 316-322 (2009).

(254) Schulte, J.H., F. Pentek, W. Hartmann, A. Schramm, N. Friedrichs, I. Ora, J. Koster, R. Versteeg, J. Kirfel, R. Buettner and A. Eggert. The low-affinity neurotrophin receptor, p75, is upreglated in ganglioneuroblastoma / ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo. Int. J. Cancer 124: 2488-94 (2009).

(255) Kahl, P., S. Wolf, L.C. Heukamp, R. Vorreuther, G. Solleder, R. Buettner. Saturation biopsy improves preoperative Gleason scoring of prostate cancers. Path Res Pract 205: 259-64 (2009)

(256) Haas, S., H. Gevensleben, S. Rabstein, V. Harth, B. Pesch, T. Brüning, C. Justenhoven, H. Brauch, U. Hamann, Y. Ko, C. Baisch, H.P. Fischer, R. Büttner. Expression of heregulin, phosphorylated HER-2, HER-3 and HER4 in HER-2 negtative breast cancers Oncol. Rep. 21: 299-304 (2009).

(257) Zimmer, S., P. Kahl, T.M. Buhl, S. Steiner, E. Wardelmann, S. Merkelbach-Bruse, R. Buettner, L.C. Heukamp. Epidermal Growth Factor Receptor Mutations in Non Small Cell Lung Cancer influence downstream Akt, MAPK and Stat3 Signalling. J. Cancer Res. Clin. Oncol. 135: 723-30 (2009).

(258) Wei, L., A. Wedeking, R. Büttner, J.C. Kalff, R.H. Tolba, G. van Echten-Deckert. A natural tetrahydropyrimidine protects small bowel from cold ischemia and subsequent warm in vitro reperfusion injury. Pathobiology 76: 212-20 (2009).

(259) Hartmann, W., J. Küchler, J., A. Koch, N. Friedrichs, A. Waha, E. Endl, J. Czerwitzki, D. Metzger, S. Steiner, P. Wurst, I. Leuschner, D. von Schweinitz, R. Buettner, T. Pietsch. Activation of phosphatidylinositol-3’- kinase/AKT signalling is essential in hepatoblastoma survival. Clin. Cancer Res. 15: 4538-45 (2009).

(260) Braun, M., E. Wardelmann, M. Debald, G. Walgenbach-Bruenagel, T. Höller, M. Wolfgarten, A. Sauerwald, C. Rudlowski, R. Büttner, W. Kuhn, M. Pölcher. Detection of lymphovascular invasion in vulvar cancer by D2-40 (podoplanin) as a predictor for inguinal lymph node metastases. Onkologie 32: 732-8 (2009)

(261) Morawietz, L., A. Floore, L. Stork-Sloots, G. Folprecht, R. Buettner, A. Rieger, M. Dietel, G. Huebner. Comparison of histopathological and gene expression-based typing of cancer of unknown primary. Virchows Arch. 456: 23-9 (2010).

(262) Ellinger, J., P. Kahl, J. v.d.Gathen, S. Rogenhofer, L.C. Heukamp, I. Gütgemann, B. Walter, F. Hofstädter, R. Büttner, S.C. Müller, P.J. Bastian, , A. v.Ruecker. Global levels of histone modifications predict prostate cancer recurrence. Prostate 70: 61-9 (2010).

(263) Engel, C., N. Rahner, K. Schulmann, E. Holinski-Feder, T.O. Goecke, H.K. Schackert, M. Kloor, V. Steinke, H. Vogelsang, G. Möslein, H. Görgens, S. Dechant, M. von Knebel Doeberitz, J. Rüschoff, N. Friedrichs, R. Büttner, M. Loeffler, P. Propping, W. Schmiegel. German HNPCC Consortium. Efficacy of annual colonoscopic surveillance in individuals with hereditary nonpolyposis colorectal cancer. Clin. Gastroenterol. Hepatol. 8: 174-82 (2010).

(264) Magerl, C., J. Ellinger, T. Braunschweig, E. Kremmer, L.K. Koch, T. Höller, R. Büttner, B. Lüscher, I. Gütgemann. H3K4 dimethylation in hepatocellular carcinoma is rare compared to other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1. Hum. Pathol. 41: 181-9 (2010).

(265) Lim, S., A. Janzer, A. Becker, A. Zimmer, R. Schüle, R. Buettner, J. Kirfel. Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology. Carcinogenesis 31: 512-20 (2010).

(266) Mirchev, M.B., P. Kahl, N. Friedrichs, I.A. Kotzev, R. Buettner. DNA methylation in patients with colorectal cancer – correlation with some clinical and morphological features and with local tumour invasion. Folia Med. 52: 22-30 (2010).

(267) Metzger, E., A. Imhof, D. Patel, P. Kahl, , K. Hoffmeyer, N. Friedrichs, J.M. Müller, H. Greschik, J. Kirfel, S. Ji, N. Kunowska, C. Beisenherz-Huss, T. Günther, R. Buettner, R. Schüle. Phosphorylation of histone H3T6 by PKCbeta (I) controls demethylation at histone H3K4. Nature 464: 792-6 (2010).

(268) Pölcher, M, C. Rudlowski, N. Friedrichs, M. Mielich, T. Höller, M. Wolfgarten, K. Kübler, R. Büttner, W. Kuhn, M. Braun. In vivo intratumor angiogenic treatment effects during taxane-based neoadjuvant chemotherapy of ovarian cancer. BMC Cancer 10: 137 (2010).

(269) Pölcher, M., N. Friedrichs, C. Rudlowski, R. Fimmers, M.D. Keyver-Paik, K. Kübler, A. Sauerwald, R. Büttner, W. Kuhn, M. Braun. Changes in Ki-67 labelling indices during neoadjuvant chemotherapy for advanced ovarian cancer are associated with survival. Int. J. Gynecol. Cancer 20: 555-60 (2010).

(270) Flucke, U., M.T. Flucke, L. Hoy, H. Winzenried, E. Breuer, R. Goebbels, K. Rhiem, R. Schmutzler, M. Braun, S. Steiner, R. Buettner, H. Gevensleben. Distinguishing medullary carcinoma of the breast from high-grade invasive ductal carcinoma with medullary features. Histopathology 56: 852-9 (2010).

(271) Pölcher, M., M. Braun, N. Friedrichs, C. Rudlowski, E. Bercht, R. Fimmers, A. Sauerwald, M.D. Keyver- Paik, K. Kübler, R. Büttner, W.C. Kuhn, J.J. Hernando. Foxp3+ cell infiltration and granzyme B (+)/Foxp3 (+) cell ratio are associated with outcome in neoadjuvant chemotherapy-treated ovarian carcinoma. Cancer Immunol. Immunother. 59: 909-19 (2010).

(272) Huss, S., J. Schmitz, D. Goltz, H.P. Fischer, R. Büttner and R. Weiskirchen. Development and evaluation of an open source Delphi-based software for morphometric quantification of liver fibrosis. Fibrogenesis Tissue Repair 3: 10 (2010).

(273) Pantelis, D., M.S. Kabba, J. Kirfel, P. Kahl, S. Wehner, R. Buettner, A. Hirner, J.C. Kalff. Transient perioperative pharmacologic inhibition of muscularis macrophages as a target for prophylaxis of postoperative ileus does not affect anastomotic healing in mice. Surgery 148: 59-70 (2010).

(274) Debald, M., M. Pölcher, U. Flucke, G. Walgenbach-Brünagel, K.J. Walgenbach, T. Höller, M. Wolfgarten, C. Rudlowski, R. Büttner, H. Schild, W. Kuhn, M. Braun. Increased detection of lymphatic vessel invasion by D2-40 (podoplanin) in early breast cancer: possible influence on patient selection for accelerated partial breast irradiation (APBI). Int. J. Radiat. Oncol. Biol. Phys. 77: 1128-33 (2010).

(275) König, K., L. Diehl, U. Rommerscheidt-Fuss, C. Golletz, T. Quast, P. Kahl, W. Kolanus, P. Knolle, R. Buettner, L.C. Heukamp. Four-and-a-half LIM domain protein 2 is a novel regulator of sphingosine 1-phosphate receptor 1 in CCL19-induced dendritic cell migration. J. Immunol. 185: 1466-75 ( 2010).

(276) Lascorz, J., A. Försti, B. Chen, S. Buch, V. Steinke, N. Rahner, E. Holinski-Feder, M. Morak, H.K. Schackert, H. Görgens, K. Schulmann, T. Goecke, M. Kloor, C. Engel, R. Büttner, N. Kunkel, M. Weires, M. Hoffmeister, B. Pardini, A. Naccarati, L. Vodickova, J. Novotny, S. Schreiber, M. Krawczak, C.D. Bröring, H. Völzke, C. Schafmayer, P, Vodicka, J. Chang-Claude, H. Brenner, B. Burwinkel, P. Propping, J. Hampe K. Hemminki. Genome-wide association study for colorectal cancer identifies risk polymorphisms in German familial cases and implicates MAPK signalling pathways in disease susceptibility. Carcinogenesis 31: 1612-9 (2010).

(277) Campa, D., B. Pardini, A. Naccarati, L. Vodickova, J. Novotny, V. Steinke, N. Rahner, E. Holinski-Feder, M. Morak, H.K. Schackert, H. Görgens, J. Kotting, B. Betz, M. Kloor, C. Engel, R. Buttner, P. Propping, A. Forsti, K. Hemminki, R. Barale, P. Vodicka, F. Canzian. Polymorphisms of genes coding for ghrelin and its receptor in relation to colorectal cancer risk: a two-step gene-wide case-control study. BMC Gastroenterol. 10: 112 (2010).

(278) Wardelmann, E., H.U. Schildhaus, S. Merkelbach-Bruse, W. Hartmann, P. Reichardt, P. Hohenberger, R. Büttner. Soft tissue sarcoma: from molecular diagnosis to selection of treatment. Pathological diagnosis of soft tissue sarcoma amid molecular biology and targeted therapies. Ann. Oncol. 21 Suppl 7: vii265-9 (2010).

(279) Lim S., E. Metzger, R. Schüle, J. Kirfel, R. Buettner. Epigenetic regulation of cancer growth by histone demethylases. Int. J. Cancer 127: 1991-8 (2010).

(280) Tolba, R.H., F.A. Schildberg, D. Decker, Z. Abdullah, R. Büttner, T. Minor, A. von Rücker. Mechanisms of improved wound healing in Murphy Roths Large (MRL) mice after skin transplantation. Wound Repair Regen. 18: 662-70 (2010).

(281) Ellinger, J., P. Kahl, C. Mertens, S. Rogenhofer, S. Hauser, W. Hartmann, P.J. Bastian, R. Büttner, S.C. Müller, A. v.Rücker. Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation levels in renal cell carcinoma. Int. J. Cancer 127: 2360-60 (2010).

(282) Mosashvilli, D., P. Kahl, C. Mertens, S. Holzapfel, S. Rogendorfer, S. Hauser, R. Büttner, A.von Rücker, S.C. Müller, J. Ellinger. Global histone acetylation levels: prognostic relevance in patients with renal cell carcinoma. Cancer Sci. 101: 2664-9 (2010)

(283) Gevensleben, H., U.J. Göhring, R. Büttner, L.C. Heukamp, G. Kunz, T. Dimpfl, C. Jackisch, O. Ortmann, U.S.Albert, R. Bender, F. de Snoo, O. Krijgsman, A.M. Glas, Y.H. Ergönenc, C. Vogel, A. Dykgers, C. Langwieder, M. Rees, T. Anzeneder. Comparison of MammaPrint and TargetPrint results with clinical parameters in German patients with early stage breast cancer. Int. J. Mol. Med. 26: 837-43 (2010).

(284) Weiss, J., M.L. Sos, D. Seidel, M. Peifer, T. Zander, J.M. Heuckmann, R.T. Ullrich, R. Menon, S. Maier, A. Soltermann, H. Moch, P. Wagener, F. Fischer, S. Heynck, M. Koker, J. Schöttle, F. Leenders, F. Gabler, I. Dabow, S. Querings, L.C. Heukamp, H. Balke-Want, S. Ansén, D. Rauh, I. Baessmann, J. Altmüller, Z. Wainer, M. Conron, G. Wright, P. Russell, B. Solomon, E. Brambilla, C. Brambilla, P. Lorimier, S. Sollberg, O.T. Brustugun, W. Engel- Riedel, C. Ludwig, I. Petersen, J. Sänger, J. Clement, H. Groen, W. Timens, H. Sietsma, E. Thunnissen, E. Smit, D. Heideman, F. Cappuzzo, C. Ligorio, S. Damiani, M. Hallek, R. Beroukhim, W. Pao, B. Klebl, M. Baumann, R. Buettner, K. Ernestus, E. Stoelben, J. Wolf, P. Nürnberg, S. Perner, R.K. Thomas. Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer. Sci. Transl. Med. 2: 62-93 (2010.)

(285) Fassunke, J., M.C. Blum, H.U. Schildhaus, M. Zapatka, B. Brors, H. Künstlinger, R. Büttner, E. Wardelmann, S. Merkelbach-Bruse. qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL. BMC Mol. Biol. 11: 100 (2010).

(286) Carrai, M., V. Steinke, P. Vodicka, B. Pardini, N. Rahner, E. Holinski-Feder, M. Morak, H.K. Schackert, H. Görgens, S. Stemmler, B. Betz, M. Kloor, C. Engel, R. Büttner, A. Naccarati, L. Vodickova, J. Novotny, A. Stein, K. Hemminki, P. Propping, A. Försti, F. Canzian, et al. Association between TAS2R38 gene polymorphisms and colorectal cancer risk: a case-control study in two independent populations of Caucasian origin. PLoS One 6: e20464 (2011).

(287) Huhn, S., D. Ingelfinger, J.L. Bermejo, M. Bevier, B. Pardini, A. Naccarati, V. Steinke, N. Rahner, E. Holinski-Feder, M. Morak, H.K. Schackert, H. Görgens, C.P. Pox, T. Goecke, M. Kloor, M. Loeffler, R. Büttner, L. Vodickova, J. Novotny, K. Demir, C. Cruciat, R. Renneberg, W. Huber, C. Niehrs, M. Boutros, P. Propping, P. Vodicka, K. Hemminki, A. Försti. Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications. Int. J. Epidemiol Genet. 2: 36-50 (2011).

(288) Kempers, M.J., R.P. Kuiper, C.W. Ockeloen, P.O. Chappuis, P. Hutter, N. Rahner, H.K. Schackert, V. Steinke, E. Holinski-Feder, M. Morak, M. Kloor, R. Büttner, E.T. Verwiel, J.H. van Krieken, I.D. Nagtegaal, M. Goossens, R.S. van der Post, R.C. Niessen, R.H. Sijmons, I. Kluijt, F.B. Hogervorst, E.M. Leter, et al. Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study. Lancet. Oncol. 12: 49-55 (2011).

(289) Hesse, K., K. Vaupel, S. Kurt, R. Buettner, J. Kirfel, M. Moser. AP-2δ is a crucial transcriptional regulator of the posterior midbrain. PLoS One 6: e23483.

(290) Zhao, F., A.K. Bosserhoff, R. Buettner, M. Moser. A heart-hand syndrome gene: Tfap2b plays a critical role in the development and remodeling of mouse ductus arteriosus and limb patterning. Plos. One. 6: e22908 (2011).

(291) Penzel, R., C. Sers, Y. Chen, U. Lehmann-Mühlenhoff, S. Merkelbach-Bruse, A. Jung, T. Kirchner, R. Büttner, H.H. Kreipe, I. Petersen, M. Dietel, P. Schirmacher. EGFR mutation detection in NSCLC--assessment of diagnostic application and recommendations of the German Panel for Mutation Testing in NSCLC. Virchows Arch. 458: 95-8 (2011).

(292) Hong, S.J., Y.H. Huh, A. Leung, H.J. Choi, Y. Ding, U.J.Kang, S.H. Yoo, R. Buettner, K.S. Kim. Transcription factor AP-2β regulates the neurotransmitter phenotype and maturation of chromaffin cells. Mol. Cell. Neurosci. 46: 245-51(2010).

(293) Rhiem, K., D. Foth, B. Wappenschmidt, H. Gevensleben, R. Büttner, U. Ulrich, R.K. Schmutzler. Risk- reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers. Arch. Gynecol. Obstet. 283: 623-7 (2011).

(294) Huss, S., F. Fronhoffs, R. Büttner, L.C. Heukamp. Web-based database for the management of tissue specimens in a transregional histological research facility. Diagn. Pathol. 6:17 (2011).

(295) Shaikhibrahim, Z., B., Langer, A. Lindstrot, A. Florin, A. Bosserhoff, R. Buettner, N. Wernert. Ets-1 is implicated in the regulation of androgen co-regulator FHL2 and reveals specificity for migration, but not invasion, of PC3 prostate cancer cells. Oncol. Rep. 25: 1125-9 (2011).

(296) Küchler, J., W. Hartmann, A. Waha, A. Koch, E. Endl, P. Wurst, D. Kindler, T. Mikeska, A. Waha, C.G. Goodyer, R. Büttner, K. Schilling, T. Pietsch. P75 (NTR) induces apoptosis in medulloblastoma cells. Int. J. Cancer 128: 18047-12 (2011).

(297) Zander, T., M. Scheffler, L. Nogova, C. Kobe, W. Engel-Riedel, M. Hellmich, I. Papachristou, K. Toepelt, A. Draube, L. Heukamp, R. Buettner, Y.D. Ko, R.T. Ullrich, E. Smit, R. Boellaard, A.A. Lammertsma, M. Hallek, A.H. Jacobs, A. Schlesinger, K. Schulte, S. Querings, E. Stoelben, B. Neumaier, R.K. Thomas, M. Dietlein, J Wolf. Early prediction of nonprogression in advanced non-samll cell lung cancer treated with erlotinib by using [(18)F] fluorodeoxyglucose and [(18)F] fluorothymidine positron emission tomography. J. Clin. Oncol. 29: 1701-8 (2011).

(298) Shaikhibrahim, Z., A. Lindstrot, B. Langer, R. Buettner, N. Wernert. Comprehensive gene expression microarray analysis of Ets-1 blockade in PC3 prostate cancer cells and correlations with prostate cancer tissues: Insights into genes involved in the metastatic cascade. Int. J. Mol. Med. 27: 811-9 (2011).

(299) Shaikhibrahim, Z., A. Lindstrot , B. Langer, R. Buettner, N. Wernert. Differential expression of ETS family members in prostate cancer tissues and androgen-sensitive and insensitive prostate cancer cell lines. Int. J. Mol. Med. 28: 89-93 (2011).

(300) Friedrichs, N., M. Trautmann, E. Endl, E. Sievers, D. Kindler, P. Wurst, J. Czerwitzki, S. Steiner, M. Renner, R. Penzel, A. Koch, O. Larsson, S. Tanaka, A. Kawai, P. Schirmacher, G. Mechtersheimer, E. Wardelmann, R. Buettner, W. Hartmann. Phosphatidylinositol-3'-kinase/AKT signaling is essential in synovial sarcoma. Int. J. Cancer 129: 1564-75 (2011).

(301) Shaikhibrahim, Z., A. Lindstrot, R. Buettner, N. Wernert. Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers. Int. J. Mol. Med. 28: 605-11 (2011).

(302) Schildhaus, H.U., R. Riegel, W. Hartmann, S. Steiner, E. Wardelmann, S. Merkelbach-Bruse, S. Tanaka, H. Sonobe, R. Schüle, R. Buettner, J. Kirfel. Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumours, synovial sarcomas, rhabdomyosarcomas, desmoplastic small round cell tumours, and malignant peripheral nerve sheath tumours. Human Pathol. 42: 1667-75 (2011).

(303) Shaikhibrahim, Z., A. Lindstrot, J. Ellinger, S. Rogenhofer, R. Buettner, N. Wernert. Identification of immunity-related genes in prostate cancer and potential role of the ETS family of transcription factors in their regulation. Int. J. Mol. Med. 28: 799-807 (2011).

(304) Bergmann, C., J. von Bothmer, N. Ortiz Brüchle, A. Venghaus, V. Frank, H. Fehrenbach, T. Hempel, L. Pape, A. Buske, J. Jonsson, N. Sarioglu, A. Santos, J.C. Ferreira, J.U. Becker, R. Cremer, J. Hoefele, M.R. Benz, L.T. Weber, R. Buettner, K. Zerres. Mutations in multiple PKD genes may explain early and severe polycystic kidney disease. J. Am. Soc. Nephrol. 22: 2047-56 (2011).

(305) Bachmann, H.S., L.C. Heukamp, K.J. Schmitz, C.F. Hilburn, P. Kahl, R. Buettner, H. Nückel, A. Eisenhardt, H. Rübben, K.W. Schmid, W. Siffert, A. Eggert, A. Schramm, J.H. Schulte. Regulatory BCL2 promoter polymorphism (-938C>A) is associated with adverse outcome in patients with prostate carcinoma. Int. J. Cancer 129: 2390-9 (2011).

(306) Gullotti, L., J. Czerwitzki, J. Kirfel, P. Propping, N. Rahner, V. Steinke, P. Kahl, C. Engel, R. Schüle, R. Buettner, N. Friedrichs. FHL2 expression in peritumoural fibroblasts correlates with lymphatic metastasis in sporadic but not in HNPCC-associated colon cancer. Lab. Invest. 91: 1695-705 (2011).

(307) Ozretić, L., K. Rhiem, S. Huss, B. Wappenschmidt, B. Markiefka, P. Sinn, R.K. Schmutzler, R. Buettner. High nuclear poly(adenosine diphosphate-ribose) polymerase expression is predictive for BRCA1- and BRCA2- deficient breast cancer. J. Clin. Oncol. 29: 4586-8 (2011).

(308) Kahl, P., R. Buettner, K. Tchatcheva, R. Stressig, U. Gembruch, T. Kohl. Macroscopic and histopathologic findings in a laparoschisis model in fetal sheep – comparisons with gastroschisis in human fetuses and implications for prenatal interventions. Arch. Gynecol. Obstet. 285: 15-9 (2012).

(309) Mentzel, T., H.U. Schildhaus, G. Palmedo, R. Büttner, H. Kutzner. Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases. Mod. Pathol. 25: 75-85 (2012).

(310) Ozretić, L., L.C. Heukamp, M. Odenthal, R. Buettner. The role of molecular diagnostics in cancer diagnosis and treatment. Onkologie. 35 Suppl. 1: 8:12 (2012).

(311) Shaikhibrahim, Z., A. Lindstrot, J. Ellinger, S. Rogenhofer, R. Buettner, N. Wernert. Genes differentially expressed in the peripheral zone compared to the transitional zone of the normal human prostate and their potential regulation by ETS factors. Mol. Med. Report 5: 32-6 (2012).

(312) Rogenhofer, S., P. Kahl, C. Mertens, S. Hauser, W. Hartmann, R. Büttner, S.C. Müller, A. von Rücker, J. Ellinger. Global histone H3 lysine 27 (H3K27) methylation levels and their prognostic relevance in renal cell carcinoma. BJU Int. 109: 459-65 (2012).

(313) Shaikhibrahim, Z., A. Lindstrot, J. Ellinger, S. Rogenhofer, R. Buettner, S. Perner, N. Wernert. The peripheral zone of the prostate is more prone to tumor development than the transitional zone: is the ETS family the key? Mol. Med. Report 5: 313-6 (2012).

(314) Shaikhibrahim, Z., A. Lindstrot, R. Buettner, N. Wernert. Regulation of prostate cancer immunity-related genes in PC3 prostate cancer cells by ETS-1. Oncol Lett. 3: 513-516 (2012).

(315) Bassett, E.A., A. Korol, P.A. Deschamps, R. Buettner, V.A. Wallace, T. Williams, J.A. West-Mays. Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina. Dev Dyn. 241: 814-29 (2012).

(316) Kamieniarz, K., A. Izzo, M. Dundr, P. Tropberger, L. Ozretic, J. Kirfel, E. Scheer, P. Tropel, J.R. Wisniewski, L. Tora, S. Viville, R. Buettner, R. Schneider. A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation. Genes Dev. 26: 797-802 (2012).

(317) Drexler, J.F., V.M. Corman, M.A. Müller, G.D. Maganga, P. Vallo, T. Binger, F. Gloza-Rausch, A. Rasche, S. Yordanov, A. Seebens, S. Oppong, Y. Adu Sarkodie, C. Pongombo, A.N. Lukashev, J. Schmidt-Chanasit, A. Stöcker, A.J. Carneiro, S. Erbar, A. Maisner, F. Fronhoffs, R. Buettner, E.K. Kalko et al. Bats host major mammalian paramyxoviruses. Nat Commun. 3: 796 (2012).

(318) Janzer, A., S. Lim, F. Fronhoffs, N. Niazy, R. Buettner, J. Kirfel. Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components. Biochem Biophys Res Commun. 421: 665-70 (2012).

(319) Michels, G., T. Topalidis, R. Büttner, M. Engels, R. Pfister. Usefulness of imprint and brushing cytology in diagnosis of lung diseases with flexible bronchoscopy. J Clin Pathol.65: 649-53 (2012).

(320) Huss, S., E. Wardelmann, D. Goltz, E. Binot, W. Hartmann, S. Merkelbach-Bruse, R. Büttner, H.U. Schildhaus. Activating PDGFRA mutations in inflammatory fibroid polyps occur in exons 12, 14 and 18 and are associated with tumour localization. Histopathology. 61: 59-68 (2012).

(321) Heukamp, L.C., T. Thor, A. Schramm, K. De Preter, C. Kumps, B. De Wilde, A. Odersky , M. Peifer, S. Lindner, A. Spruessel, F. Pattyn, P. Mestdagh, B. Menten, S. Kuhfittig-Kulle, A. Künkele, K. König, L. Meder, S. Chatterjee, R.T. Ullrich, S. Schulte, J. Vandesompele, F. Speleman et al. Targeted expression of mutated ALK induces neuroblastoma in transgenic mice. Sci Transl Med. 4: 141ra91 (2012).

(322) Serce, N., A. Gnatzy, S. Steiner, H. Lorenzen, J. Kirfel, R. Buettner. Elevated expression of LSD1 (Lysine- specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast. BMC Clin Pathol. 12: 13 (2012).

(323) Ney JT, S. Froehner, A. Roesler, R. Buettner, S. Merkelbach-Bruse. High-resolution melting analysis as a sensitive prescreening diagnostic tool to detect KRAS, BRAF, PIK3CA, and AKT1 mutations in formalin-fixed, paraffin-embedded tissues. Arch Pathol Lab Med. 136: 983-92 (2012).

(324) Sprüssel, A., J.H. Schulte, S. Weber, M. Necke, K. Händschke, T. Thor, K.W. Pajtler, A. Schramm, K. König, L. Diehl, P. Mestdagh, J. Vandesompele, F. Speleman, H. Jastrow, L.C. Heukamp, R. Schüle, U. Dührsen, R. Buettner, A. Eggert, J.R. Göthert. Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation. Leukemia. 26: 2039-51 (2012).

(325) Rabenhorst, A., M. Schlaak, L.C. Heukamp, A. Förster, S. Theurich, M. von Bergwelt-Baildon, R. Büttner, P. Kurschat, C. Mauch, A. Roers, K. Hartmann. Mast cells play a protumorigenic role in primary cutaneous lymphoma. Blood. 120: 2042-54 (2012).

(326) Janzer, A., K. Stamm, A. Becker, A. Zimmer, R. Buettner, J. Kirfel. The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts. J Biol Chem. 287: 30984-92 (2012).

(327) Peifer, M., L. Fernández-Cuesta, M.L. Sos, J. George, D. Seidel, L.H. Kasper, D. Plenker, F. Leenders, R. Sun, T. Zander, R. Menon, M. Koker, I. Dahmen, C. Müller, V. Di Cerbo, H.U. Schildhaus, J. Altmüller, I. Baessmann, C. Becker, B. de Wilde, J. Vandesompele, D. Böhm et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet. 44: 1104-10 (2012).

(328) Sos, M.L., F. Dietlein, M. Peifer, J. Schöttle, H. Balke-Want, C. Müller, M. Koker, A. Richters, S. Heynck, F. Malchers, J.M. Heuckmann, D. Seidel, P.A. Eyers, R.T. Ullrich, A.P. Antonchick, V.V. Vintonyak, P.M. Schneider, T. Ninomiya, H. Waldmann, R. Büttner, D. Rauh, L.C. Heukamp et al. A framework for identification of actionable cancer genome dependencies in small cell lung cancer. Proc Natl Acad Sci U S A. 109: 17034-9 (2012).

(329) Adam, A.C., V. Faudou, S.A. Paschen, O.M. Adam, P. Kahl, U. Drebber, H.P. Fischer, R. Büttner. Hepatocarcinogenesis in non-cirrhotic liver is associated with a reduced number of clonal hepatocellular patches in non-tumorous liver parenchyma. J Pathol. 228: 333-40 (2012)

(330) Renner, M., E. Czwan, W. Hartmann, R. Penzel, B. Brors, R. Eils, E. Wardelmann, R. Büttner, P. Lichter, P. Schirmacher, G. Mechtersheimer. MicroRNA profiling of primary high-grade soft tissue sarcomas. Genes Chromosomes Cancer. 51: 982-96 (2012).

(331) Schildhaus, H.U., L.C. Heukamp, S. Merkelbach-Bruse, K. Riesner, K. Schmitz, E. Binot, E. Paggen, K. Albus, W. Schulte, Y.D. Ko, A. Schlesinger, S. Ansén, W. Engel-Riedel, M. Brockmann, M. Serke, U. Gerigk, S. Huss, F. Göke, S. Perner, K. Hekmat, K.F. Frank, M. Reiser et al. Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer. Mod Pathol. 25: 1473-80 (2012).

(332) Willmann, D., S. Lim, S. Wetzel, E. Metzger, A. Jandausch, W. Wilk, M. Jung, I. Forne, A. Imhof, A. Janzer, J. Kirfel, H. Waldmann, R. Schüle, R. Buettner. Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer. 131: 2704-9 (2012).

(333) Engel, C., M. Loeffler, V. Steinke, N. Rahner, E. Holinski-Feder, W. Dietmaier, H.K. Schackert, H. Goergens, M von Knebel Doeberitz, T.O. Goecke, W. Schmiegel, R. Buettner, G. Moeslein, T.G. Letteboer, E.G. García, F.J. Hes, N. Hoogerbrugge, F.H. Menko, T.A. van Os, R.H. Sijmons, A. Wagner, I. Kluijt et al. Risks of Less Common Cancers in Proven Mutation Carriers With Lynch Syndrome. J Clin Oncol. 30: 4409-15 (2012).

(334) Scheffler, M., T. Zander, L. Nogova, C. Kobe, D. Kahraman, M. Dietlein, I. Papachristou, L. Heukamp, R. Büttner, R. Boellaard, A.A. Lammertsma, S. Querings, E. Stoelben, W. Engel-Riedel, B. Neumaier, J. Wolf. Prognostic impact of [18F]fluorothymidine and [18F]fluoro-D-glucose baseline uptakes in patients with lung cancer treated first-line with erlotinib. PLoS One. 8: e53081 (2013).

(335) König, K., L. Meder, C. Kröger, L. Diehl, A. Florin, U. Rommerscheidt-Fuss, P. Kahl, E. Wardelmann, T.M. Magin, R. Buettner, L.C. Heukamp. Loss of the keratin cytoskeleton is not sufficient to induce epithelial mesenchymal transition in a novel KRAS driven sporadic lung cancer mouse model. PLoS One. 8: e57996 (2013).

(336) Huss, S., J. Nehles, E. Binot, E. Wardelmann, J. Mittler, M.A. Kleine, H. Künstlinger, W. Hartmann, P. Hohenberger, S. Merkelbach-Bruse, R. Buettner, H.U. Schildhaus. β-Catenin (CTNNB1) mutations and clinicopathological features of mesenteric desmoid-type fibromatosis. Histopathology. 62: 294-304 (2013).

(337) Göke, F., A. Göke, A. von Mässenhausen, A. Franzen, R. Sharma, R. Kirsten, D. Böhm, G. Kristiansen, A. Stenzinger, M. Wynes, F.R. Hirsch, W. Weichert, L. Heasley, R. Buettner, S. Perner. Fibroblast growth factor receptor 1 as a putative therapy target in colorectal cancer. Digestion. 88: 172-81 (2013).

(338) Huss, S., C. Stellmacher, D. Goltz, I. Khlistunova, A.C. Adam, J, Trebicka, J. Kirfel, R. Büttner, R. Weiskirchen. Deficiency in four and one half LIM domain protein 2 (FHL2) aggravates liver fibrosis in mice. BMC Gastroenterol. 13: 8 (2013)

(339) Noetel, A, N. Elfimova, J. Altmüller, C. Becker, D. Becker, W. Lahr, P. Nürnberg, H. Wasmuth, A. Teufel, R. Büttner, H.P. Dienes, M. Odenthal. Next generation sequencing of the Ago2 interacting transcriptome identified chemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells. J Hepatol. 58: 335-41 (2013).

(340) Chatterjee, S., L.C. Heukamp, M. Siobal, J. Schöttle, C. Wieczorek, M. Peifer, D. Frasca, M. Koker, K. König, L. Meder, D. Rauh, R. Buettner, J. Wolf, R.A. Brekken, B. Neumaier, G. Christofori, R.K. Thomas, R.T. Ullrich . Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer. J Clin Invest. 123: 3183 (2013).

(341) Schlaak, M., A. Bajah, T. Podewski, N. Kreuzberg, W. von Bartenwerffer, E. Wardelmann, S. Merkelbach- Bruse, R. Büttner, C. Mauch, P. Kurschat. Assessment of clinicalparameters associated with mutational status in metastatic malignant melanoma: a single-centre investigation of 141 patients. Br J Dermatol. 168: 708-16 (2013).

(342) Michels, S., M. Trautmann, E. Sievers, D. Kindler, S. Huss, M. Renner, N. Friedrichs, J. Kirfel, S. Steiner, E. Endl, P. Wurst, L. Heukamp, R. Penzel, O. Larsson, A. Kawai, S. Tanaka, H. Sonobe, P. Schirmacher, G. Mechtersheimer, E. Wardelmann, R. Büttner, W. Hartmann. SRC signaling is crucial in the growth of synovial sarcoma cells. Cancer Res. 73: 2518-28 (2013).

(343) Elfimova, N., E. Sievers, H. Eischeid, M. Kwiecinski, A. Noetel, H. Hunt, D. Becker, P. Frommolt, M. Quasdorff, H.M. Steffen, P. Nürnberg, R. Büttner, A. Teufel, H.P. Dienes, U. Drebber, M. Odenthal.Control of mitogenic and motogenic pathways by miR-198, diminishing hepatoma cell growth and migration. Biochim Biophys Acta. 1833: 1190-1198 (2013).

(344) Buettner, R., J. Wolf, R.K. Thomas. Lessons learned from lung cancer genomics: the emerging concept of individualized diagnostics and treatment. J Clin Oncol. 31: 1858-65 (2013).

(345) Pajtler, K.W., C. Weingarten, T. Thor, A. Künkele, L.C. Heukamp, R. Büttner, T. Suzuki, N. Miyata, M. Grotzer, A. Rieb, A. Sprüssel, A. Eggert, A. Schramm, J.H. Schulte. The KDM1A histone demethylase is a promising new target for the epigenetic therapy of medulloblastoma. Acta Neuropathol Commun. 1: 19 (2013).

(346) Lim, S., A. Becker, A. Zimmer, J. Lu, R. Buettner, J. Kirfel. SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance. PLoS One. 8:e66558 (2013).

(347) Huss, S., H. Künstlinger, E. Wardelmann, M.A. Kleine, E. Binot, S. Merkelbach-Bruse, T. Rüdiger, J. Mittler, W. Hartmann, R. Büttner, H.U. Schildhaus. A subset of gastrointestinal stromal tumors previously regarded as wild-type tumors carries somatic activating mutations in KIT exon 8 (p.D419del). Mod Pathol. 26: 1004-12 (2013).

(348) Bos, M., M. Gardizi, H.U. Schildhaus, L.C. Heukamp, T. Geist, B. Kaminsky, T. Zander, L. Nogova, M. Scheffler, M. Dietlein, C. Kobe, A. Holstein, D. Maintz, R. Büttner, J. Wolf. Complete metabolic response in a patient with repeatedly relapsed non-small cell lung cancer harboring ROS1 gene rearrangement after treatment with crizotinib. Lung Cancer. 81: 142-3 (2013).

(349) V Laffert, M., A. Warth, R. Penzel, P. Schirmacher, D. Jonigk, H. Kreipe, H.U. Schildhaus, S. Merkelbach- Bruse, R. Büttner, S. Reu, R. Kerler, A. Jung, T. Kirchner, C. Wölfel, I. Petersen, R. Rodriguez, W. Jochum, H. Bartsch, A. Fisseler-Eckhoff, E. Berg, D. Lenze, M. Dietel, M. Hummel. Anaplastic lymphoma kinase (ALK) gene rearrangement in non-small cell lung cancer (NSCLC): results of a multi-centre ALK-testing. Lung Cancer. 81: 200-6 (2013).

(350) Kreppel, M., M. Scheer, M. Meyer, M. Stenner, I. Wedemeyer, U. Drebber, R. Semrau, M. Odenthal, J.E. Zöller, O. Guntinas-Lichius, R. Büttner, D. Beutner. Comparison of TNM-based stage grouping versus UICC/AJCC stage grouping (7th edition) in malignant parotid gland tumors. Oral Oncol. 49: 903-10 (2013).

(351) Becker, K., C. Vollbrecht, U. Koitzsch, K. Koenig, J. Fassunke, S. Huss, P. Nuernberg, L.C. Heukamp, R. Buettner, M. Odenthal, J. Altmueller, S. Merkelbach-Bruse. Deep ion sequencing of amplicon adapter ligated libraries: a novel tool in molecular diagnostics of formalin fixed and paraffin embedded tissues. J Clin Pathol. 66: 803-6 (2013).

(352) Loeser, H., M. Wittersheim, K. Puetz, J. Friemann, R. Buettner, J.W. Fries. Potential complications of transcatheter aortic valve implantation (TAVI)-an autopsy perspective. Cardiovasc Pathol. 22: 319-23 (2013)

(353) Rüschoff, J., K.M. Kerr, H.J. Grote, P. Middel, A. von Heydebreck, V.A. Alves, S.E. Baldus, R. Büttner, L. Carvalho, L. Fink, W. Jochum, A.W. Lo, F. López-Ríos, A. Marx, T.J. Molina, W.T. Olszewski, R.J. Rieker, M. Volante, E. Thunnissen, F. Wrba, I. Celik, S. Störkel. Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test. Arch Pathol Lab Med. 137: 1255- 61 (2013).

(354) Clinical Lung Cancer Genome Project (CLCGP); Network Genomic Medicine (NGM). A genomics-based classification of human lung tumors. Sci Transl Med. 5: 209ra153 (2013).

(355) Schildhaus, H.U., K.F. Deml, K. Schmitz, M. Meiboom, E. Binot, S. Hauke, S. Merkelbach-Bruse, R. Büttner. Chromogenic in situ hybridization is a reliable assay for detection of ALK rearrangements in adenocarcinomas of the lung. Mod Pathol. 26: 1468-77 (2013).

(356) Künstlinger, H., S. Huss, S. Merkelbach-Bruse, E. Binot, M.A. Kleine, H. Loeser, J. Mittler, W. Hartmann, P. Hohenberger, P. Reichardt, R. Büttner, E. Wardelmann, H.U. Schildhaus. Gastrointestinal stromal tumors with KIT exon 9 mutations: Update on genotype-phenotype correlation and validation of a high-resolution melting assay for mutational testing. Am J Surg Pathol. 37: 1648-59 (2013).

(357) Schildhaus, H.U., L. Schroeder, S. Merkelbach-Bruse, E. Binot, R. Büttner, W. Kuhn, C. Rudlowski. Therapeutic strategies in male breast cancer: Clinical implications of chromosome 17 gene alterations and molecular subtypes. Breast. 22: 1066-71 (2013).

(358) Renner, M., T. Wolf, H. Meyer, W. Hartmann, R. Penzel, A. Ulrich, B. Lehner, V. Hovestadt, E. Czwan, G. Egerer, T. Schmitt, I. Alldinger, E.K. Renker, V. Ehemann, R. Eils, E. Wardelmann, R. Büttner, P. Lichter, B. Brors, P. Schirmacher, G. Mechtersheimer. Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas. Genome Biol. 14: r137 (2013).

(359) Kurakula, K., M. Vos, I. Otermin Rubio, G. Marinković, R. Buettner, L.C. Heukamp, J. Stap, W. de Waard, C.M. van Tiel, C.J. de Vries. The LIM-Only Protein FHL2 ReducesVascular Lesion Formation Involving Inhibition of Proliferation and Migration of Smooth Muscle Cells. PLoS One. 9:e94931 (2014).

(360) Ihle, M.A., J. Fassunke, K. König, I. Grünewald, M. Schlaak, N. Kreuzberg, L. Tietze, H.U. Schildhaus, R. Büttner, S. Merkelbach-Bruse. Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non- p.V600E BRAF mutations. BMC Cancer. 14:13 (2014).

(361) Schultheis, A.M., M. Bos, K. Schmitz, L. Wilsberg, E. Binot, J. Wolf, R. Büttner, H.U. Schildhaus. Fibroblast growth factor receptor 1 (FGFR1) amplification is a potential therapeutic target in small-cell lung cancer. Mod Pathol. 27: 214-21 (2014).

(362) Yang, R., B. Chen, K. Pfütze, S. Buch, V. Steinke, E. Holinski-Feder, S. Stöcker, W. von Schönfels, T. Becker, H.K. Schackert, B. Royer-Pokora, M. Kloor, W.H. Schmiegel, R. Büttner, C. Engel, J. Lascorz Puertolas, A. Försti, N. Kunkel, P. Bugert, S. Schreiber, M. Krawczak, C. Schafmayer, P. Propping, J. Hampe, K. Hemminki, B. Burwinkel. Genome-wide analysis associates familial colorectal cancer with increases in copynumber variations and a rare structural variation at 12p12.3. Carcinogenesis. 35: 315-23 (2014).

(363) Malchers, F., F. Dietlein, J. Schöttle, X. Lu, L. Nogova, K. Albus, L. Fernandez-Cuesta, J.M. Heuckmann, O. Gautschi, J. Diebold, D. Plenker, M. Gardizi, M. Scheffler, M. Bos, D. Seidel, F. Leenders, A. Richters, M. Peifer, A. Florin, P.S. Mainkar, N. Karre, S. Chandrasekhar, J. George, S. Silling, D. Rauh, T. Zander, R. Ullrich, H.C. Reinhardt, F. Ringeisen, R. Buttner, L.C. Heukamp, J. Wolf, R.K. Thomas. Cell-autonomous and non-cell- autonomous mechanisms of transformation by amplified FGFR1 in lung cancer. Cancer Discov. 4: 246-57 (2014).

(364) Buettner, R. Just another brick in the wall: unravelling the epigenetic mechanism underlying tumour initiation of testicular germ cell cancer. Br JCancer. 110: 549-50 (2014).

(365) Künstlinger, H., E. Binot, S. Merkelbach-Bruse, S. Huss, E. Wardelmann, R. Buettner, H.U. Schildhaus. High-resolution melting analysis is a sensitive diagnostic tool to detect imatinib-resistant and imatinib-sensitive PDGFRA exon 18 mutations in gastrointestinal stromal tumors. Hum Pathol. 45: 573-82 (2014).

(366) Fuchs, A., K. König, L.C. Heukamp, J. Fassunke, J. Kirfel, S. Huss, A.J. Becker, R. Büttner, M. Majores. Tuberous-sclerosis complex-related cell signaling in thepathogenesis of lung cancer. Diagn Pathol. 9:48 (2014).

(367) Fernandez-Cuesta, L., M. Peifer, X. Lu, R. Sun, L. Ozretić, D. Seidel, T. Zander, F. Leenders, J. George, C. Müller, I. Dahmen, B. Pinther, G. Bosco, K. Konrad, J. Altmüller, P. Nürnberg, V. Achter, U. Lang, P.M. Schneider, M. Bogus, A. Soltermann, O.T. Brustugun, Â. Helland, S. Solberg, M. Lund-Iversen, S. Ansén, E. Stoelben, G.M. Wright, P. Russell, Z. Wainer, B. Solomon, J.K. Field, R. Hyde, M.P. Davies, L.C. Heukamp, I. Petersen, S. Perner, C.M. Lovly, F. Cappuzzo, W.D. Travis, J. Wolf, M. Vingron, E. Brambilla, S.A. Haas, R. Buettner, R.K. Thomas. Frequent mutations in chromatin-remodelling genes inpulmonary carcinoids. Nat Commun. 5:3518 (2014).

(368) Schütte, U., S. Bisht, L.C. Heukamp, M. Kebschull, A. Florin, J. Haarmann, P. Hoffmann, G. Bendas, R. Buettner, P. Brossart, G. Feldmann. Hippo signaling mediatesproliferation, invasiveness, and metastatic potential of clear cell renal cellcarcinoma. Transl Oncol. 7:309-21 (2014).

(369) Wedemeyer, I., M. Kreppel, M. Scheer, J.E. Zöller, R. Büttner, U. Drebber.Histopathological assessment of tumour regression, nodal stage and status ofresection margins determines prognosis in patients with oral squamous cellcarcinoma treated with neoadjuvant radiochemotherapy. Oral Dis. 20:e81-9 (2014).

(370) Broekaert, S.M., J. Ehrchen, R. Büttner, H.J. Pfister, D. Metze. Acquired epidermodysplasia verruciformis in an HIV-infected patient. J Dtsch Dermatol Ges. 12:353-5 (2014).

(371) Fernandez-Cuesta, L., D. Plenker, H. Osada, R. Sun, R. Menon, F. Leenders, S. Ortiz-Cuaran, M. Peifer, M. Bos, J. Dabler, F. Malchers, J. Schottle, W. Vogel, I. Dahmen, M. Koker, R.T. Ullrich, G.M. Wright, P.A. Russell, Z. Wainer, B. Solomon, E. Brambilla, H. Nagy-Mignotte, D. Moro-Sibilot, C.G. Brambilla, S. Lantuejoul, J. Altmuller, C. Becker, P. Nurnberg, J.M. Heuckmann, E. Stoelben, I. Petersen, J.H. Clement, J. Sanger, L.A. Muscarella, A. la Torre, V.M. Fazio, I. Lahortiga, T. Perera, S. Ogata, M. Parade, D. Brehmer, M. Vingron, L.C. Heukamp, R. Buettner, T. Zander, J. Wolf, S. Perner, S. Ansen, S.A. Haas, Y. Yatabe, R.K. Thomas. CD74-NRG1 fusions in lung adenocarcinoma. Cancer Discov. 4:415-22 (2014).

(372) Kloth, M., R. Buettner. Changing histopathological diagnostics by genome-basedtumor classification. Genes (Basel). 5:444-59 (2014).

(373) Duteil, D., E. Metzger, D. Willmann, P. Karagianni, N. Friedrichs, H. Greschik, T. Günther, R. Buettner, I. Talianidis, D. Metzger, R. Schüle. LSD1 promotes oxidativemetabolism of white adipose tissue. Nat Commun. 5:4093 (2014).

(374) Steinke, V., S. Holzapfel, M. Loeffler, E. Holinski-Feder, M. Morak, H.K. Schackert, H. Görgens, C. Pox, B. Royer-Pokora, M. von Knebel-Doeberitz, R. Büttner, P. Propping, C. Engel. On behalf of the German HNPCC Consortium. Evaluating the performance of clinical criteria for predicting mismatch repair gene mutations in Lynch syndrome: A comprehensive analysis of 3671 families. Int J Cancer. 135:69-77 (2014).

(375) Schultheis, A.M., G.P. Nguyen, M. Ortmann, W. Kruis, R. Büttner, H.U. Schildhaus, B. Markiefka. Squamous Cell Carcinoma of the Pancreas in a Patient with Germline BRCA2 Mutation-Response to Neoadjuvant Radiochemotherapy. Case Rep Oncol Med. Epub 2014:860532 (2014).

(376) Gevensleben, H., V. Bossung, A. Meindl, B. Wappenschmidt, N. de Gregorio, A. Osorio, A. Romero, R. Buettner, B. Markiefka, R.K. Schmutzler. Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers. Virchows Arch. 465:365-9 (2014).

(377) Heydt, C., J. Fassunke, H. Künstlinger, M.A. Ihle, K. König, L.C. Heukamp, H.U. Schildhaus, M. Odenthal, R. Büttner, S. Merkelbach-Bruse. Comparison of pre-analytical FFPE sample preparation methods and their impact on massively parallel sequencing in routine diagnostics. PLoS One. 9:e104566 (2014).

(378) Lovly, C.M., N.T. McDonald, H. Chen, S. Ortiz-Cuaran, L.C. Heukamp, Y. Yan, A. Florin, L. Ozretić, D. Lim, L. Wang, Z. Chen, X. Chen, P. Lu, P.K. Paik, R. Shen, H. Jin, R. Buettner, S. Ansén, S. Perner, M. Brockmann, M. Bos, J. Wolf, M. Gardizi, G.M. Wright, B. Solomon, P.A. Russell, T.M. Rogers, Y. Suehara, M. Red-Brewer, R. Tieu, E. de Stanchina, Q. Wang, Z. Zhao, D.H. Johnson, L. Horn, K.K. Wong, R.K. Thomas, M. Ladanyi, W. Pao. Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer. Nat Med. 20:1027-34 (2014).

(379) Elbelt, U., A. Trovato, M. Kloth, E. Gentz, R. Finke, J. Spranger, D. Galas, S. Weber, C. Wolf, K. König, W. Arlt, R. Büttner, P. May, B. Allolio, J.G. Schneider. Molecular and Clinical Evidence for an ARMC5 Tumor Syndrome: Concurrent Inactivating Germline and Somatic Mutations are Associated with both Primary Macronodular Adrenal Hyperplasia and Meningioma. J Clin Endocrinol Metab. 100(1):E119-28 (2015).

(380) Trautmann, M., E. Sievers, S. Aretz, D. Kindler, S. Michels, N. Friedrichs, M. Renner, J. Kirfel, S. Steiner, S. Huss, A. Koch, R. Penzel, O. Larsson, A. Kawai, S. Tanaka, H. Sonobe, A. Waha, P. Schirmacher, G. Mechtersheimer, E. Wardelmann, R. Büttner, W. Hartmann. SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma. Oncogene. 33:5006-16 (2014).

(381) V Laffert, M., A. Warth, R. Penzel, P. Schirmacher, K.M. Kerr, G. Elmberger, H.U. Schildhaus, R. Büttner, F. Lopez-Rios, S. Reu, T. Kirchner, P. Pauwels, K. Specht, E. Drecoll, H. Höfler, D. Aust, G. Baretton, L. Bubendorf, S. Stallmann S, A. Fisseler-Eckhoff, A. Soltermann, V. Tischler, H. Moch, F. Penault-Llorca, H. Hager, F. Schäper, D. Lenze, M. Hummel, M. Dietel. Multicenter Immunohistochemical ALK-Testing of Non-Small-Cell Lung Cancer Shows High Concordance after Harmonization of Techniques and Interpretation Criteria. J Thorac Oncol. 9:1685-92 (2014).

(382) Scheffler, M., M. Bos, M. Gardizi, K. König, S. Michels, J. Fassunke, C. Heydt, H. Künstlinger, M. Ihle, F. Ueckeroth, K. Albus, M. Serke, U. Gerigk, W. Schulte, K. Töpelt, L. Nogova, T. Zander, W. Engel-Riedel, E. Stoelben, Y.D. Ko, W. Randerath, B. Kaminsky, J. Panse, C. Becker, M. Hellmich, S. Merkelbach-Bruse, L.C. Heukamp, R. Büttner, J. Wolf. PIK3CA mutations in non-small cell lung cancer (NSCLC): Genetic heterogeneity, prognostic impact and incidence of prior malignancies. Oncotarget 6(2):1315-26 (2015).

(383) Odenthal, M., J. Hee, I. Gockel, L. Sisic, J. Schmitz, N.H. Stoecklein, C. Driemel, B. Möhlendick, T. Schmidt, W.T. Knoefel, H. Lang, R. Büttner, K. Ott, D. Vallböhmer. Serum microRNA profiles as prognostic/predictive markers in the multimodality therapy of locally advanced adenocarcinomas of the gastroesophageal junction. Int J Cancer 137(1):230-7 (2015).

(384) Friedrichs, J., D. Fink, C. Mauch, D. Kindler, W. Hartmann, R. Schüle, R. Buettner, N. Friedrichs. TGF-β1- dependent induction and nuclear translocation of FHL2 promotes keratin expression in pilomatricoma. Virchows Arch. 466(2):199-208 (2015).

(385) Schildhaus, H., A.M. Schultheis, J. Ruschoff, E. Binot, S. Merkelbach-Bruse, J. Fassunke, W. Schulte, Y. Ko, A. Schlesinger, M. Bos, M. Gardizi, W. Engel-Riedel, M. Brockmann, M. Serke, U. Gerigk, K. Hekmat, K.F. Frank, M. Reiser, H. Schulz, S. Kruger, E. Stoelben, T. Zander, J. Wolf, R. Buettner. MET amplification status in therapy-naïve adeno-and squamous cell carcinomas of the lung. Clin Cancer Res. 21(4):907-15 (2015).

(386) Westphal P, Mauch C, Florin A, Czerwitzki J, Olligschläger N, Wodtke C, Schüle R, Büttner R, Friedrichs N. Enhanced FHL2 and TGF-?1 Expression Is Associated With Invasive Growth and Poor Survival in Malignant Melanomas. Am J Clin Pathol. 143(2): 248-56 (2015).

(387) Loeser H, von Brandenstein M, Herschung A, Schlosser M, Büttner R, Fries JW. ET-1 Induced Downregulation of MRP2 via miRNA 133a - A Marker for Tubular Nephrotoxicity? Am J Nephrol. 41(3): 191-9 (2015).

(388) Adam AC, Scriba A, Ortmann M, Huss S, Kahl P, Steiner S, Störkel S, Büttner R. Immunohistochemical analysis of cytochrome C oxidase facilitates differentiation between oncocytoma and chromophobe renal cell carcinoma. Appl Immunohistochem Mol Morphol. 23(1): 54-9 (2015).

(389) Heydt C, Kumm N, Fassunke J, Künstlinger H, Ihle MA, Scheel A, Schildhaus HU, Haller F, Büttner R, Odenthal M, Wardelmann E, Merkelbach-Bruse S. Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy. BMC Cancer 15: 291 (2015).

(390) Ebner K, Feldkoetter M, Ariceta G, Bergmann C, Buettner R, Doyon A, Duzova A, Goebel H, Haffner D, Hero B, Hoppe B, Illig T, Jankauskiene A, Klopp N, König J, Litwin M, Mekahli D, Ranchin B, Sander A, Testa S, Weber LT, Wicher D, Yuzbasioglu A, Zerres K, Dötsch J, Schaefer F, Liebau MC, ESCAPE Study Group , GPN Study Group , Cachat F, Seeman T, Bruechle N, Querfeld U, Kirschstein M, Benz K, Buescher R, Latta K, Pohl M, Gross O, Patzer L, Kemper M, Pape L, Bernhardt W, Wuehl E, Beck B, Benzing T, Wygoda S, Wiemann D, Klaus G, Fehrenbach H, Wallot M, Lange-Sperandio B, Uetz B, Kranz B, Boeswald M, Staude H, Leichter HE, Billing H, Beringer O, Ilmoja ML, Lara L, Sallay P, Ardissino G, Emma F, Cerkauskiene R, Drozdz D, Niemirska A, Szczepanska M, Zaniew M, Paripovi D, Anarat A, Baskin E, Caliskan S, Candan C, Emre S, Dursun I, Ekinci Z, Delibas A, Kerecuk L, Guay-Woodford L. Rationale, design and objectives of ARegPKD, a European ARPKD registry study. BMC Nephrol. 16: 22 (2015).

(391) Wittersheim M, Büttner R, Markiefka B. Genotype/Phenotype correlations in patients with hereditary breast cancer. Breast Care OR. 10(1): 22-6 (2015).

(392) Thewes V, Simon R, Schroeter P, Schlotter M, Anzeneder T, Büttner R, Benes V, Sauter G, Burwinkel B, Nicholson RI, Sinn HP, Schneeweiss A, Deuschle U, Zapatka M, Heck S, Lichter P .Reprogramming of the ERR and ER target gene landscape triggers tamoxifen resistance in breast cancer. Cancer Res. 75(4): 720-31 (2015).

(393) Dietlein F, Kalb B, Jokic M, Noll EM, Strong A, Tharun L, Ozreti? L, Künstlinger H, Kambartel K, Randerath WJ, Jüngst C, Schmitt A, Torgovnick A, Richters A, Rauh D, Siedek F, Persigehl T, Mauch C, Bartkova J, Bradley A, Sprick MR, Trumpp A, Rad R, Saur D, Bartek J, Wolf J, Büttner R, Thomas RK, Reinhardt HC. A Synergistic Interaction between Chk1- and MK2 Inhibitors in KRAS-Mutant Cancer. Cell. 162(1): 146-59 (2015).

(394) Goltz D, Huss S, Ramadori E, Büttner R, Diehl L, Meyer R. Immunomodulation by splenectomy or by FTY720 protects the heart against ischemia reperfusion injury. Clin Exp Pharmacol Physiol. 42(11): 1168-77 (2015).

(395) Leifeld L, Rogler G, Stallmach A, Schmidt C, Zuber-Jerger I, Hartmann F, Plauth M, Drabik A, Hofstädter F, Dienes HP, Kruis W, Detect Dysplasia Study Group , Büttner R, Löser H, Drebber U, Dignass A, Terjung B, Sauerbruch T, Schreiber S, Lanyi B, Pfuetzer R, Morgenstern J, Böhm S, Böcker U, Rupf AK, Appenroth B, Biecker E, Walldorf J. White-Light or Narrow-Band Imaging Colonoscopy in Surveillance of Ulcerative Colitis: A Prospective Multicenter Study. Clin Gastroenterol Hepatol. 13(10): 1776-1781 (2015).

(396) von Brandenstein M, Puetz K, Schlosser M, Löser H, Kallinowski JP, Gödde D, Buettner R, Störkel S, Fries JW. Vimentin 3, the new hope, differentiating RCC versus oncocytoma. Dis Markers. 2015: 368534 (2015).

(397) Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schöttle J, Ullrich RT, Altmüller J, Becker C, Nürnberg P, Seidel H, Böhm D, Göke F, Ansén S, Russell PA, Wright GM, Wainer Z, Solomon B, Petersen I, Clement JH, Sänger J, Brustugun OT, Helland Å, Solberg S, Lund-Iversen M, Buettner R, Wolf J, Brambilla E, Vingron M, Perner S, Haas SA, Thomas RK. Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biol. 16: 7 (2015).

(398) Sievers E, Trautmann M, Kindler D, Huss S, Gruenewald I, Dirksen U, Renner M, Mechtersheimer G, Pedeutour F, Åman P, Nishio J, Schildhaus HU, Kirfel J, Schirmacher P, Wardelmann E, Buettner R, Hartmann W. SRC inhibition represents a potential therapeutic strategy in liposarcoma. Int J Cancer. 137(11): 2578-88 (2015).

(399) Ouladan S, Trautmann M, Orouji E, Hartmann W, Huss S, Büttner R, Wardelmann E. Differential diagnosis of solitary fibrous tumors: A study of 454 soft tissue tumors indicating the diagnostic value of nuclear STAT6 relocation and ALDH1 expression combined with in situ proximity ligation assay. Int. J. Oncol. 46(6): 2595-605 (2015).

(400) Ladang A, Rapino F, Heukamp LC, Tharun L, Shostak K, Hermand D, Delaunay S, Klevernic I, Jiang Z, Jacques N, Jamart D, Migeot V, Florin A, Göktuna S, Malgrange B, Sansom OJ, Nguyen L, Büttner R, Close P, Chariot A. Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. J. Exp. Med. 212(12): 2057-75 (2015).

(401) König K, Peifer M, Fassunke J, Ihle MA, Künstlinger H, Heydt C, Stamm K, Ueckeroth F, Vollbrecht C, Bos M, Gardizi M, Scheffler M, Nogova L, Leenders F, Albus K, Meder L, Becker K, Florin A, Rommerscheidt- Fuss U, Altmüller J, Kloth M, Nürnberg P, Henkel T, Bikár SE, Sos ML, Geese WJ, Strauss L, Ko YD, Gerigk U, Odenthal M, Zander T, Wolf J, Merkelbach-Bruse S, Buettner R, Heukamp LC . Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients. J. Thorac. Oncol. 10(7): 1049-57 (2015).

(402) Scheffler M, Merkelbach-Bruse S, Bos M, Fassunke J, Gardizi M, Michels S, Groneck L, Schultheis AM, Malchers F, Leenders F, Kobe C, König K, Heukamp LC, Sos ML, Thomas RK, Büttner R, Wolf J. Spatial Tumor Heterogeneity in Lung Cancer with Acquired Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance: Targeting High-Level MET-Amplification and EGFR T790M Mutation Occurring at Different Sites in the Same Patient. J Thorac Oncol. 10(6): e40-3 (2015).

(403) Ihle MA, Trautmann M, Kuenstlinger H, Huss S, Heydt C, Fassunke J, Wardelmann E, Bauer S, Schildhaus HU, Buettner R, Merkelbach-Bruse S miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours. Mol Oncol. 9(7): 1421-33 (2015).

(404) Peifer M, Hertwig F, Roels F, Dreidax D, Gartlgruber M, Menon R, Krämer A, Roncaioli JL, Sand F, Heuckmann JM, Ikram F, Schmidt R, Ackermann S, Engesser A, Kahlert Y, Vogel W, Altmüller J, Nürnberg P, Thierry-Mieg J, Thierry-Mieg D, Mariappan A, Heynck S, Mariotti E, Henrich KO, Gloeckner C, Bosco G, Leuschner I, Schweiger MR, Savelyeva L, Watkins SC, Shao C, Bell E, Höfer T, Achter V, Lang U, Theissen J, Volland R, Saadati M, Eggert A, de Wilde B, Berthold F, Peng Z, Zhao C, Shi L, Ortmann M, Büttner R, Perner S, Hero B, Schramm A, Schulte JH, Herrmann C, O'Sullivan RJ, Westermann F, Thomas RK, Fischer M. Telomerase activation by genomic rearrangements in high-risk neuroblastoma. Nature 526(7575): 700-4 (2015).

(405) Gautschi O, Stadelmann C, Aebersold-Keller F, König K, Büttner R, Heukamp LC, Betticher D, Baumann C, Buser K, Calderoni A, Casty A, D'Addario G, Irlé C, Mamot C, Morant R, Trojan A, Pellicioli E, Jehle- Schwertfeger S, Aebi S, Diebold J.Mutation Profiling of Lung Cancers with Long-Term Response to Gefitinib Therapy. Oncol Res Treat. 38(11): 560-9 (2015).

(406) Franz H, Greschik H, Willmann D, Ozreti? L, Jilg CA, Wardelmann E, Jung M, Buettner R, Schüle R. The histone code reader SPIN1 controls RET signaling in liposarcoma. Oncotarget. 6(7): 4773-89 (2015).

(407) Grünewald I, Vollbrecht C, Meinrath J, Meyer MF, Heukamp LC, Drebber U, Quaas A, Beutner D, Hüttenbrink KB, Wardelmann E, Hartmann W, Büttner R, Odenthal M, Stenner M. Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity. Oncotarget. 6(20): 18224-37 (2015).

(408) Kübler K, Heinenberg S, Rudlowski C, Keyver-Paik MD, Abramian A, Merkelbach-Bruse S, Büttner R, Kuhn W, Schildhaus HU. c-myc copy number gain is a powerful prognosticator of disease outcome in cervical dysplasia. Oncotarget. 6(2): 825-35 (2015).

(409) Künstlinger H, Fassunke J, Schildhaus HU, Brors B, Heydt C, Ihle MA, Mechtersheimer G, Wardelmann E, Büttner R, Merkelbach-Bruse S. FGFR2 is overexpressed in myxoid liposarcoma and inhibition of FGFR signaling impairs tumor growth in vitro. Oncotarget. 6(24): 20215-30 (2015).

(410) Scheffler M, Schultheis A, Teixido C, Michels S, Morales-Espinosa D, Viteri S, Hartmann W, Merkelbach- Bruse S, Fischer R, Schildhaus HU, Fassunke J, Sebastian M, Serke M, Kaminsky B, Randerath W, Gerigk U, Ko YD, Krüger S, Schnell R, Rothe A, Kropf-Sanchen C, Heukamp L, Rosell R, Büttner R, Wolf J. ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability. Oncotarget. 6(12): 10577-85 (2015).

(411) Schmitz K, Koeppen H, Binot E, Fassunke J, Künstlinger H, Ihle MA, Heydt C, Wardelmann E, Büttner R, Merkelbach-Bruse S, Rüschoff J, Schildhaus HU. MET gene copy number alterations and expression of MET and hepatocyte growth factor are potential biomarkers in angiosarcomas and undifferentiated pleomorphic sarcomas. PLoS ONE. 10(4): e0120079 (2015).

(412) Vollbrecht C, Mairinger FD, Koitzsch U, Peifer M, Koenig K, Heukamp LC, Crispatzu G, Wilden L, Kreuzer KA, Hallek M, Odenthal M, Herling CD, Buettner R. Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing. PLoS ONE. 10(6): e0129544 (2015).

(413) Al-Nomani L, Friedrichs J, Schüle R, Büttner R, Friedrichs N. Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer. Pathol Res Pract. 211(2): 171-4 (2015).

(414) Friedrichs J, Fink D, Mauch C, Kindler D, Hartmann W, Schüle R, Buettner R, Friedrichs N. TGF-ß1- dependent induction and nuclear translocation of FHL2 promotes keratin expression in pilomatricoma. Virchows Arch. 466(2): 199-208 (2015).

(415) Schneider R, Schneider C, Büttner R, Reinacher-Schick A, Tannapfel A, Fürst. Colorectal Carcinoma with Suspected Lynch Syndrome: A Multidisciplinary Algorithm. Zentralbl Chir. 140(6): 591-9 (2015).

(416) George J, Lim JS, Jang SJ, Cun Y, Ozreti? L, Kong G, Leenders F, Lu X, Fernández-Cuesta L, Bosco G, Müller C, Dahmen I, Jahchan NS, Park KS, Yang D, Karnezis AN, Vaka D, Torres A, Wang MS, Korbel JO, Menon R, Chun SM, Kim D, Wilkerson M, Hayes N, Engelmann D, Pützer B, Bos M, Michels S, Vlasic I, Seidel D, Pinther B, Schaub P, Becker C, Altmüller J, Yokota J, Kohno T, Iwakawa R, Tsuta K, Noguchi M, Muley T, Hoffmann H, Schnabel PA, Petersen I, Chen Y, Soltermann A, Tischler V, Choi CM, Kim YH, Massion PP, Zou Y, Jovanovic D, Kontic M, Wright GM, Russell PA, Solomon B, Koch I, Lindner M, Muscarella LA, la Torre A, Field JK, Jakopovic M, Knezevic J, Castaños-Vélez E, Roz L, Pastorino U, Brustugun OT, Lund-Iversen M, Thunnissen E, Köhler J, Schuler M, Botling J, Sandelin M, Sanchez-Cespedes M, Salvesen HB, Achter V, Lang U, Bogus M, Schneider PM, Zander T, Ansén S, Hallek M, Wolf J, Vingron M, Yatabe Y, Travis WD, Nürnberg P, Reinhardt C, Perner S, Heukamp L, Büttner R, Haas SA, Brambilla E, Peifer M, Sage J, Thomas RK. Comprehensive genomic profiles of small cell lung cancer. Nature 524(7563): 47-53 (2015).

(417) Schultheis AM, Scheel AH, Ozretić L, George J, Thomas RK, Hagemann T, Zander T, Wolf J, Buettner R. PD-L1 expression in small cell neuroendocrine carcinomas. Eur J Cancer. 2015 Feb;51(3):421-6.

(418) Helbig D, Ihle MA, Pütz K, Tantcheva-Poor I, Mauch C, Büttner R, Quaas A. Oncogene and therapeutic target analyses in Atypical fibroxanthomas and pleomorphic dermal sarcomas. Oncotarget. 2016 Apr 19;7(16):21763-74.

(419) Goltz D, Hittetiya K, Gevensleben H, Kirfel J, Diehl L, Meyer R, Büttner R. Loss of the LIM-only protein Fhl2 impairs inflammatory reaction and scar formation after cardiac ischemia leading to better hemodynamic performance. Life Sci. 2016 S0024-3205(16)30132-1 (2016).

(420) Michels S, Scheel AH, Scheffler M, Schultheis AM, Gautschi O, Aebersold F, Diebold J, Pall G, Rothschild S, Bubendorf L, Hartmann W, Heukamp L, Schildhaus HU, Fassunke J, Ihle MA, Künstlinger H, Heydt C, Fischer R, Nogovà L, Mattonet C, Hein R, Adams A, Gerigk U, Schulte W, Lüders H, Grohé C, Graeven U, Müller- Naendrup C, Draube A, Kambartel KO, Krüger S, Schulze-Olden S, Serke M, Engel-Riedel W, Kaminsky B, Randerath W, Merkelbach-Bruse S, Büttner R, Wolf J. Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients. J Thorac Oncol. 2016 Jan;11(1):122-7 (2016).

(421) Castiglione R, Ihle MA, Heydt C, Schultheis AM, Merkelbach-Bruse S, Mauch C, Büttner R. The impact of sequencing on diagnosis and treatment of malignant melanoma.Expert Rev Mol Diagn. 2016.

(422) Ozretić L, Wagner S, Huebbers CU, Gattenlöhner S, Klussmann JP, Beutner D, Zander T, Buettner R, Quaas A. FGFR1 amplification and co-overexpression of c-MYC in oropharyngeal squamous cell carcinoma. Oral Oncol. 2016 Mar;54:e7-9. 2016.

(423) Scheel AH, Ansén S, Schultheis AM, Scheffler M, Fischer RN, Michels S, Hellmich M, George J, Zander T, Brockmann M, Stoelben E, Groen H, Timens W, Perner S, von Bergwelt-Baildon M, Büttner R, Wolf J. PD-L1 expression in non-small cell lung cancer: Correlations with genetic alterations. Oncoimmunology. 2016 Mar 16;5(5):e1131379.

(424) Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, Rüschoff J, Schildhaus HU, Schirmacher P, Tiemann M, Warth A, Weichert W, Fischer RN, Wolf J, Buettner R. Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas.Mod Pathol. 2016 Jul 8. doi: 10.1038/modpathol.2016.117.

(425) Gultekin SE, Senguven B, Gonul II, Okur B, Buettner R. Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature. J Oral Maxillofac Surg. 2016 Jun 12. pii: S0278-2391(16)30247-6.

(426) Tóth C, Meinrath J, Herpel E, Derix J, Fries J, Buettner R, Schirmacher P, Heikaus S. Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. J Cancer Res Clin Oncol. 2016 May;142(5):927-35.

(427) Kloth M, Ruesseler V, Engel C, Koenig K, Peifer M, Mariotti E, Kuenstlinger H, Florin A, Rommerscheidt- Fuss U, Koitzsch U, Wodtke C, Ueckeroth F, Holzapfel S, Aretz S, Propping P, Loeffler M, Merkelbach-Bruse S, Odenthal M, Friedrichs N, Heukamp LC, Zander T, Buettner R. Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer. Gut. 2016 Aug;65(8):1296-305.

(428) Schlößer HA, Drebber U, Kloth M, Thelen M, Rothschild SI, Haase S, Garcia-Marquez M, Wennhold K, Berlth F, Urbanski A, Alakus H, Schauss A, Shimabukuro-Vornhagen A, Theurich S, Warnecke-Ebertz U, Stippel DL, Zippelius A, Büttner R, Hallek M, Hölscher AH, Zander T, Mönig SP, von Bergwelt-Baildon M. Immune checkpoints programmed death 1 ligand 1 and cytotoxic T lymphocyte associated molecule 4 in gastric adenocarcinoma. Oncoimmunology. 2015 Nov 9;5(5):e1100789. doi: 10.1080/2162402X.2015.1100789. eCollection 2016 May.

(429) Ortiz-Cuaran S, Scheffler M, Plenker D, Dahmen I, Scheel A, Fernandez-Cuesta L, Meder L, Lovly CM, Persigehl T, Merkelbach-Bruse S, Bos M, Michels S, Fischer R, Albus K, König K, Schildhaus HU, Fassunke J, Ihle MA, Pasternack H, Heydt C, Becker C, Altmüller J, Ji H, Müller C, Florin A, Heuckmann JM, Nuernberg P, Ansén S, Heukamp LC, Berg J, Pao W, Peifer M, Büttner R, Wolf J, Thomas RK, Sos ML. Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors. Clin Cancer Res. 2016 Oct 1;22(19):4837-47.

(430) Walch-Rückheim B, Pahne-Zeppenfeld J, Fischbach J, Wickenhauser C, Horn LC, Tharun L, Büttner R, Mallmann P, Stern P, Kim YJ, Bohle RM, Rübe C, Ströder R, Juhasz-Böss I, Solomayer EF, Smola S. STAT3/IRF1 Pathway Activation Sensitizes Cervical Cancer Cells to Chemotherapeutic Drugs. Cancer Res. 2016 Jul 1;76(13):3872-83.

(431) Knittel G, Liedgens P, Korovkina D, Seeger JM, Al-Baldawi Y, Al-Maarri M, Fritz C, Vlantis K, Bezhanova S, Scheel AH, Wolz OO, Reimann M, Möller P, López C, Schlesner M, Lohneis P, Weber AN, Trümper L; German International Cancer Genome Consortium Molecular Mechanisms in Malignant Lymphoma by Sequencing Project Consortium, Staudt LM, Ortmann M, Pasparakis M, Siebert R, Schmitt CA, Klatt AR, Wunderlich FT, Schäfer SC, Persigehl T, Montesinos-Rongen M, Odenthal M, Büttner R, Frenzel LP, Kashkar H, Reinhardt HC. B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B- cell lymphoma in mice. Blood. 2016 Jun 2;127(22):2732-41.

(432) Endris V, Stenzinger A, Pfarr N, Penzel R, Möbs M, Lenze D, Darb-Esfahani S, Hummel M, Sabine- Merkelbach-Bruse, Jung A, Lehmann U, Kreipe H, Kirchner T, Büttner R, Jochum W, Höfler G, Dietel M, Weichert W, Schirmacher P. NGS-based BRCA1/2 mutation testing of high-grade serous ovarian cancer tissue: results and conclusions of the first international round robin trial. Virchows Arch. 2016 Jun;468(6):697-705.

(433) von Laffert M, Schirmacher P, Warth A, Weichert W, Büttner R, Huber RM, Wolf J, Griesinger F, Dietel M, Grohé C. [Statement of the German Society for Pathology and the working group thoracic oncology of the working group oncology/German Cancer Society on ALK testing in NSCLC: Immunohistochemistry and/or FISH?]. Pathologe. 2016 Mar;37(2):187-91.

(434) von Laffert M, Schirmacher P, Warth A, Weichert W, Büttner R, Huber RM, Wolf J, Griesinger F, Dietel M, Grohé Ch. [ALK-Diagnostics in NSCLC - Immunohistochemistry (IHC) and/or Fluorescence-in-situ Hybridisation (FISH)]. Pneumologie. 2016 Apr;70(4):277-81.

(435) Göktuna SI, Shostak K, Chau TL, Heukamp LC, Hennuy B, Duong HQ, Ladang A, Close P, Klevernic I, Olivier F, Florin A, Ehx G, Baron F, Vandereyken M, Rahmouni S, Vereecke L, van Loo G, Büttner R, Greten FR, Chariot A. The Prosurvival IKK-Related Kinase IKKε Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Res. 2016 May 1;76(9):2587-99.

(436) Adam R, Spier I, Zhao B, Kloth M, Marquez J, Hinrichsen I, Kirfel J, Tafazzoli A, Horpaopan S, Uhlhaas S, Stienen D, Friedrichs N, Altmüller J, Laner A, Holzapfel S, Peters S, Kayser K, Thiele H, Holinski-Feder E, Marra G, Kristiansen G, Nöthen MM, Büttner R, Möslein G, Betz RC, Brieger A, Lifton RP, Aretz S. Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. Am J Hum Genet. 2016 Jul 27. pii: S0002-9297(16)30219-1.

(437) HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat. Angelika Ihle M, Merkelbach-Bruse S, Hartmann W, Bauer S, Ratner N, Sonobe H, Nishio J, Larsson O, Åman P, Pedeutour F, Taguchi T, Wardelmann E, Buettner R, Schildhaus HU. J Pathol Clin Res. 2016 Feb 5;2(2):59-71. doi: 10.1002/cjp2.35.

(438) Implementing amplicon-based next generation sequencing in the diagnosis of small cell lung carcinoma metastases. Meder L, König K, Fassunke J, Ozretić L, Wolf J, Merkelbach-Bruse S, Heukamp LC, Buettner R. Exp Mol Pathol. 2015 Dec;99(3):682-6. doi: 10.1016/j.

(439) NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas. Meder L, König K, Ozretić L, Schultheis AM, Ueckeroth F, Ade CP, Albus K, Boehm D, Rommerscheidt-Fuss U, Florin A, Buhl T, Hartmann W, Wolf J, Merkelbach-Bruse S, Eilers M, Perner S, Heukamp LC, Buettner R. Int J Cancer. 2016 Feb 15;138(4):927-38. doi: 10.1002/ijc.29835.

(440) Elp3 links tRNA modification to IRES-dependent translation of LEF1 to sustain metastasis in breast cancer. Delaunay S, Rapino F, Tharun L, Zhou Z, Heukamp L, Termathe M, Shostak K, Klevernic I, Florin A, Desmecht H, Desmet CJ, Nguyen L, Leidel SA, Willis AE, Büttner R, Chariot A, Close P. J Exp Med. 2016 Oct 17;213(11):2503-2523.

(441) Testing for ROS1 in non-small cell lung cancer: a review with recommendations. Bubendorf L, Büttner R, Al-Dayel F, Dietel M, Elmberger G, Kerr K, López-Ríos F, Marchetti A, Öz B, Pauwels P, Penault-Llorca F, Rossi G, Ryška A, Thunnissen E. Virchows Arch. 2016 Nov;469(5):489-503. Review.

(442) Predictive PD-L1 immunohistochemistry for non-small cell lung cancer: Current state of the art and experiences of the first German harmonization study]. Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, Rüschoff J, Schildhaus HU, Schirmacher P, Tiemann M, Warth A, Weichert W, Fischer RN, Wolf J, Büttner R. Pathologe. 2016 Nov;37(6):557-567. German.

(443) ALK evaluation in the world of multiplex testing: Network Genomic Medicine (NGM): the Cologne model for implementing personalised oncology. Heydt C, Kostenko A, Merkelbach-Bruse S, Wolf J, Büttner R. Ann Oncol. 2016 Sep;27 Suppl 3:iii25-iii34. doi: 10.1093/annonc/mdw303. Review.

(444) MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas. Grünewald I, Trautmann M, Busch A, Bauer L, Huss S, Schweinshaupt P, Vollbrecht C, Odenthal M, Quaas A, Büttner R, Meyer MF, Beutner D, Hüttenbrink KB, Wardelmann E, Stenner M, Hartmann W. Oncotarget. 2016 Nov 15;7(46):75261-72.

(445) The tumour suppressor CYLD regulates the p53 DNA damage response. Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M. Nat Commun. 2016 Aug 26;7:12508. doi: 10.1038/ncomms12508.

(446) Ercc1 Deficiency Promotes Tumorigenesis and Increases Cisplatin Sensitivity in a Tp53 Context-Specific Manner. Jokić M, Vlašić I, Rinneburger M, Klümper N, Spiro J, Vogel W, Offermann A, Kümpers C, Fritz C, Schmitt A, Riabinska A, Wittersheim M, Michels S, Ozretić L, Florin A, Welcker D, Akyuz MD, Nowak M, Erkel M, Wolf J, Büttner R, Schumacher B, Thomale J, Persigehl T, Maintz D, Perner S, Reinhardt HC. Mol Cancer Res. 2016 Nov;14(11):1110-1123.

(447) Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. Adam R, Spier I, Zhao B, Kloth M, Marquez J, Hinrichsen I, Kirfel J, Tafazzoli A, Horpaopan S, Uhlhaas S, Stienen D, Friedrichs N, Altmüller J, Laner A, Holzapfel S, Peters S, Kayser K, Thiele H, Holinski-Feder E, Marra G, Kristiansen G, Nöthen MM, Büttner R, Möslein G, Betz RC, Brieger A, Lifton RP, Aretz S. Am J Hum Genet. 2016 Aug 4;99(2):337-51. doi: 10.1016/j.ajhg.2016.06.015.

(448) Reguart, N., C. Teixidó, A. Giménez-Capitán, L. Paré, P. Galván, S. Viteri, S. Rodríguez, V. Peg, E. Aldeguer, E. Ovalle, N. Viñolas, D. Morales-Espinosa, N. Karachaliou, E. Conde, F. Lopez-Rios, E. Nadal, S. Merkelbach-Bruse, R. Büttner, R. Rosell, M. A Molina-Vila, A. Prat. Identification of clinically relevant ALK, ROS1 and RET rearrangements by an automated, multiplexed nCounter-based assay in formalin-fixed, paraffin- embedded samples from advanced non-small-cell lung cancer patients. Clin. Chem., 2017 Mar 63(3):751-60.

(449) Thunnissen E, Borczuk AC, Flieder DB, Witte B, Beasley MB, Chung JH, Dacic S, Lantuejoul S, Russell PA, den Bakker M, Botling J, Brambilla E, de Cuba E, Geisinger KR, Hiroshima K, Marchevsky AM, Minami Y, Moreira A, Nicholson AG, Yoshida A, Tsao MS, Warth A, Duhig E, Chen G, Matsuno Y, Travis WD, Butnor K, Cooper W, Mino-Kenudson M, Motoi N, Poleri C, Pelosi G, Kerr K, Aisner SC, Ishikawa Y, Buettner RH, Keino N, Yatabe Y, Noguchi M.The Use of Immunohistochemistry Improves the Diagnosis of Small Cell Lung Cancer and Its Differential Diagnosis. An International Reproducibility Study in a Demanding Set of Cases. J Thorac Oncol. 2017 Feb;12(2):334-346.

(450) Nogova L, Sequist LV, Perez Garcia JM, Andre F, Delord JP, Hidalgo M, Schellens JH, Cassier PA, Camidge DR, Schuler M, Vaishampayan U, Burris H, Tian GG, Campone M, Wainberg ZA, Lim WT, LoRusso P, Shapiro GI, Parker K, Chen X, Choudhury S, Ringeisen F, Graus-Porta D, Porter D, Isaacs R, Buettner R, Wolf J. Evaluation of BGJ398, a Fibroblast Growth Factor Receptor 1-3 Kinase Inhibitor, in Patients With Advanced Solid Tumors Harboring Genetic Alterations in Fibroblast Growth Factor Receptors: Results of a Global Phase I, Dose- Escalation and Dose-Expansion Study. J Clin Oncol. 2017 Jan 10;35(2):157-165.

(451) Loeser H, Waldschmidt D, Kuetting F, Schallenberg S, Zander T, Bollschweiler E, Hoelscher A, Weckermann K, Plum P, Alakus H, Buettner R, Quaas A. Somatic BRCA1-associated protein 1 (BAP1) loss is an early and rare event in esophageal adenocarcinoma. Mol Clin Oncol. 2017 Aug;7(2):225-228.

(452) Knittel G, Rehkämper T, Korovkina D, Liedgens P, Fritz C, Torgovnick A, Al-Baldawi Y, Al-Maarri M, Cun Y, Fedorchenko O, Riabinska A, Beleggia F, Nguyen PH, Wunderlich FT, Ortmann M, Montesinos-Rongen M, Tausch E, Stilgenbauer S, P Frenzel L, Herling M, Herling C, Bahlo J, Hallek M, Peifer M, Buettner R, Persigehl T, Reinhardt HC. Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia. Nat Commun. 2017 Jul 28;8(1):153.

(453) Schallenberg S, Merkelbach-Bruse S, Buettner R. Lung cancer as a paradigm for precision oncology in solid tumours. Virchows Arch. 2017 Jul 20.

(454) Plenker D, Riedel M, Brägelmann J, Dammert MA, Chauhan R, Knowles PP, Lorenz C, Keul M, Bührmann M, Pagel O, Tischler V, Scheel AH, Schütte D, Song Y, Stark J, Mrugalla F, Alber Y, Richters A, Engel J, Leenders F, Heuckmann JM, Wolf J, Diebold J, Pall G, Peifer M, Aerts M, Gevaert K, Zahedi RP, Buettner R, Shokat KM, McDonald NQ, Kast SM, Gautschi O, Thomas RK, Sos ML. Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors. Sci Transl Med. 2017 Jun 14;9(394).

(455) Meyer MF, Kreppel M, Meinrath J, Grünewald I, Stenner M, Drebber U, Quaas A, Odenthal M, Semrau R, Huebbers CU, Zöller J, Huettenbrink KB, Buettner R, Beutner D. Prediction of outcome by lymph node ratio in patients with parotid gland cancer. Clin Otolaryngol. 2017 Feb;42(1):98-103.

(456) Porres D, Pfister D, Thissen A, Kuru TH, Zugor V, Buettner R, Knuechel R, Verburg FA, Heidenreich A.The role of salvage extended lymph node dissection in patients with rising PSA and PET/CT scan detected nodal recurrence of prostate cancer. Prostate Cancer Prostatic Dis. 2017 Mar 20(1):85-92.

(457) George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Büttner R, Harris CC, Yokota J, Thomas RK, Kohno T.Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin Cancer Res. 2017 Mar 1;23(5):1220-1226.

(458) Meyer MF, Meinrath J, Seehawer J, Lechner A, Odenthal M, Quaas A, Semrau R, Huebbers CU, Marnitz S, Büttner R, Beutner D. The relevance of the lymph node ratio as predictor of prognosis is higher in HPV-negative than in HPV-positive oropharyngeal squamous cell carcinoma. Clin Otolaryngol. 2017 Jul 17.

(459) Büttner R, Wolf J, Thomas RK, Sos ML. Resistance Mechanisms to AZD9291 and Rociletinib-Response. Clin Cancer Res. 2017 Jul 15;23(14):3967-3968.

(460) Hagmeyer L, Tharun L, Schäfer SC, Hekmat K, Büttner R, Randerath W. First case report of a curative wedge resection in epithelial-myoepithelial carcinoma of the lung. Gen Thorac Cardiovasc Surg. 2017 Sep;65(9):535-538.

(461) Ozretić L, Schwindowski A, Dienes HP, Büttner R, Drebber U, Fries JWU. [Consequences of autopsies for the living: Causes of death in the clinical diagnosis "septic and toxic shock"]. Pathologe. 2017 Sep;38(5):370-379.

(462) Koelsche C, Schrimpf D, Tharun L, Roth E, Sturm D, Jones DTW, Renker EK, Sill M, Baude A, Sahm F, Capper D, Bewerunge-Hudler M, Hartmann W, Kulozik AE, Petersen I, Flucke U, Schreuder HWB, Büttner R, Weber MA, Schirmacher P, Plass C, Pfister SM, von Deimling A, Mechtersheimer G. Histone 3.3 hotspot mutations in conventional osteosarcomas: a comprehensive clinical and molecular characterization of six H3F3A mutated cases. Clin Sarcoma Res. 2017 May 4;7:9.

(463) Wittersheim M, Heydt C, Hoffmann F, Büttner R. KRAS mutation in papillary fibroelastoma: a true cardiac neoplasm? J Pathol Clin Res. 2017 Mar 7;3(2):100-104.

(464) Grafen M, Hofmann TR, Scheel AH, Beck J, Emmert A, Küffer S, Danner BC, Schütz E, Büttner R, Ostendorf A, Ströbel P, Bohnenberger H. Optimized expression-based microdissection of formalin-fixed lung cancer tissue. Lab Invest. 2017 Jul;97(7):863-872.

(465) Koitzsch U, Heydt C, Attig H, Immerschitt I, Merkelbach-Bruse S, Fammartino A, Büttner RH, Kong Y, Odenthal M. Use of the GeneReader NGS System in a clinical pathology laboratory: a comparative study. J Clin Pathol. 2017 Aug;70(8):725-728.

(466) Schmitt A, Knittel G, Welcker D, Yang TP, George J, Nowak M, Leeser U, Büttner R, Perner S, Peifer M, Reinhardt HC. ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma. Cancer Res. 2017 Jun 1;77(11):3040-3056.

(467) Thewes V, Simon R, Hlevnjak M, Schlotter M, Schroeter P, Schmidt K, Wu Y, Anzeneder T, Wang W, Windisch P, Kirchgäßner M, Melling N, Kneisel N, Büttner R, Deuschle U, Sinn HP, Schneeweiss A, Heck S, Kaulfuss S, Hess-Stumpp H, Okun JG, Sauter G, Lykkesfeldt AE, Zapatka M, Radlwimmer B, Lichter P, Tönjes M. The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer. Oncogene. 2017 Jul 20;36(29):4124-4134.

(468) Löser H, Heydt C, Büttner R, Markiefka B. [BRCA diagnostics of ovarian cancer: Molecular tumor testing since the introduction of PARP inhibitor therapy]. Pathologe. 2017 Mar;38(2):117-126.

(469) Heindl LM, Koch KR, Hermann MM, Merkelbach-Bruse S, Schultheis AM, Wagener S, Büttner R, Mauch C, Schuler-Thurner B, Schuler G, Cursiefen C. Block Excision of Iridociliary Tumors Enables Molecular Profiling and Immune Vaccination. Ophthalmology. 2017 Feb;124(2):268-270.

(470) Huss S, Pasternack H, Ihle MA, Merkelbach-Bruse S, Heitkötter B, Hartmann W, Trautmann M, Gevensleben H, Büttner R, Schildhaus HU, Wardelmann E. (471) Shiraliyeva N, FriedriClinicopathological and molecular features of a large cohort of gastrointestinal stromal tumors (GISTs) and review of the literature: BRAF mutations in KIT/PDGFRA wild-type GISTs are rare events. Hum Pathol. 2017 Apr;62:206-214. Review.

(472) von Laffert M, Schirmacher P, Warth A, Weichert W, Büttner R, Huber RM, Wolf J, Griesinger F, Dietel M, Grohé C. ALK-Testing in non-small cell lung cancer (NSCLC): Immunohistochemistry (IHC) and/or fluorescence in-situ Hybridisation (FISH)?: Statement of the Germany Society for Pathology (DGP) and the Working Group Thoracic Oncology (AIO) of the German Cancer Society e.V. (Stellungnahme der Deutschen Gesellschaft für Pathologie und der AG Thorakale Onkologie der Arbeitsgemeinschaft Onkologie/Deutsche Krebsgesellschaft e.V.). Lung Cancer. 2017 Jan;103:1-5.

(473) Loeser H, Waldschmidt D, Kuetting F, Heydt C, Zander T, Plum P, Alakus H, Buettner R, Quaas A. Copy- number variation and protein expression of DOT1L in pancreatic adenocarcinoma as a potential drug target. Mol Clin Oncol. 2017 May;6(5):639-642.

(474) Capoluongo E, Ellison G, López-Guerrero JA, Penault-Llorca F, Ligtenberg MJL, Banerjee S, Singer C, Friedman E, Markiefka B, Schirmacher P, Büttner R, van Asperen CJ, Ray-Coquard I, Endris V, Kamel-Reid S, Percival N, Bryce J, Röthlisberger B, Soong R, de Castro DG. Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients. Semin Oncol. 2017 Jun;44(3):187-197.

(475) Büttner R, Wolf J, Thomas RK, Sos ML. Resistance Mechanisms to AZD9291 and Rociletinib-Response. Clin Cancer Res. 2017 Jul 15;23(14):3967-3968.

(476) Lim SY, Macheleidt I, Dalvi P, Schäfer SC, Kerick M, Ozretić L, Ortiz-Cuaran S, George J, Merkelbach- Bruse S, Wolf J, Timmermann B, Thomas RK, Schweiger MR, Buettner R, Odenthal M. LSD1 modulates the non- canonical integrin β3 signaling pathway in non-small cell lung carcinoma cells. Sci Rep. 2017 Aug 31;7(1):10292.

(477) Alidousty C, Brandes D, Heydt C, Wagener S, Wittersheim M, Schäfer SC, Holz B, Merkelbach-Bruse S, Büttner R, Fassunke J, Schultheis AM. Comparison of Blood Collection Tubes from Three Different Manufacturers for the Collection of Cell-Free DNA for Liquid Biopsy Mutation Testing. J Mol Diagn. 2017 Sep;19(5):801-804.

(478) Malchers F, Ercanoglu M, Schütte D, Castiglione R, Tischler V, Michels S, Dahmen I, Brägelmann J, Menon R, Heuckmann JM, George J, Ansén S, Sos ML, Soltermann A, Peifer M, Wolf J, Büttner R, Thomas RK. Mechanisms of Primary Drug Resistance in FGFR1-Amplified Lung Cancer. Clin Cancer Res. 2017 Sep 15;23(18):5527-5536.

(479) Amer W, Toth C, Vassella E, Meinrath J, Koitzsch U, Arens A, Huang J, Eischeid H, Adam A, Buettner R, Scheel A, Schaefer SC, Odenthal M. Evolution analysis of heterogeneous non-small cell lung carcinoma by ultra- deep sequencing of the mitochondrial genome. Sci Rep. 2017 Sep 11;7(1):11069.

(480) Brägelmann J, Dammert MA, Dietlein F, Heuckmann JM, Choidas A, Böhm S, Richters A, Basu D, Tischler V, Lorenz C, Habenberger P, Fang Z, Ortiz-Cuaran S, Leenders F, Eickhoff J, Koch U, Getlik M, Termathe M, Sallouh M, Greff Z, Varga Z, Balke-Want H, French CA, Peifer M, Reinhardt HC, Örfi L, Kéri G, Ansén S, Heukamp LC, Büttner R, Rauh D, Klebl BM, Thomas RK, Sos ML. Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma. Cell Rep. 2017 Sep 19;20(12):2833-2845.

(481) Binder H, Hopp L, Schweiger MR, Hoffmann S, Jühling F, Kerick M, Timmermann B, Siebert S, Grimm C, Nersisyan L, Arakelyan A, Herberg M, Buske P, Loeffler-Wirth H, Rosolowski M, Engel C, Przybilla J, Peifer M, Friedrichs N, Moeslein G, Odenthal M, Hussong M, Peters S, Holzapfel S, Nattermann J, Hueneburg R, Schmiegel W, Royer-Pokora B, Aretz S, Kloth M, Kloor M, Buettner R*, Galle J*, Loeffler M* (*corresponding authors). Genomic and transcriptomic heterogeneity of colorectal tumors arising in Lynch Syndrome. J Pathol. 2017 Oct;243(2):242-254.

(482) Fassunke J, Ihle MA, Lenze D, Lehmann A, Hummel M, Vollbrecht C, Penzel R, Volckmar AL, Stenzinger A, Endris V, Jung A, Lehmann U, Zeugner S, Baretton G, Kreipe H, Schirmacher P, Kirchner T, Dietel M, Büttner R, Merkelbach-Bruse S. EGFR T790M mutation testing of non-small cell lung cancer tissue and blood samples artificially spiked with circulating cell-free tumor DNA: results of a round robin trial. Virchows Arch. 2017 Oct;471(4):509-520.

(483) Doerr F, George J, Schmitt A, Beleggia F, Rehkämper T, Hermann S, Walter V, Weber JP, Thomas RK, Wittersheim M, Büttner R, Persigehl T, Reinhardt HC. Targeting a non-oncogene addiction to the ATR/CHK1 axis for the treatment of small cell lung cancer. Sci Rep. 2017 Nov 14;7(1):15511.

(484) Schiller J, Klein S, Engels M, Büttner R, Rybniker J, Fätkenheuer G, Scheid C, Wybranski C, Quaas A, Reinhardt HC, Flümann R. Case Report: A Cryptosporidium infection in a patient with relapsed T-lymphoblastic lymphoma undergoing allogeneic stem cell transplantation. Eur J Haematol. 2017 Nov 15. doi: 10.1111/ejh.12998.

(485) Helbig D, Quaas A, Mauch C, Merkelbach-Bruse S, Büttner R, Emberger M, Wobser M, Rüsseler V, Pütz K, Binot E, Rehker J, Budczies J, Ihle MA. Copy number variations in atypical fibroxanthomas and pleomorphic dermal sarcomas. Oncotarget. 2017 Nov 25;8(65):109457-109467.

(486) Horpaopan S, Kirfel J, Peters S, Kloth M, Hüneburg R, Altmüller J, Drichel D, Odenthal M, Kristiansen G, Strassburg C, Nattermann J, Hoffmann P, Nürnberg P, Büttner R, Thiele H, Kahl P, Spier I, Aretz S. Exome sequencing characterizes the somatic mutation spectrum of early serrated lesions in a patient with serrated polyposis syndrome (SPS). Hered Cancer Clin Pract. 2017 Nov 29;15:22.

(487) Petersen I, Dietel M, Geilenkeuser WJ, Mireskandari M, Weichert W, Steiger K, Scheel AH, Büttner R, Schirmacher P, Warth A, Lasitschka F, Schildhaus HU, Kirchner T, Reu S, Kreipe H, Länger F, Tiemann M, Schulte C, Jöhrens K. EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC - Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP®). Pathol Res Pract. 2017 Dec;213(12):1530-1535.

(488) Büttner R, Gosney JR, Skov BG, Adam J, Motoi N, Bloom KJ, Dietel M, Longshore JW, López-Ríos F, Penault-Llorca F, Viale G, Wotherspoon AC, Kerr KM, Tsao MS. Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non-Small-Cell Lung Cancer. J Clin Oncol. 2017 Dec 1;35(34):3867-3876.

(489) Meder L, Büttner R, Odenthal M. Notch signaling triggers the tumor heterogeneity of small cell lung cancer. J Thorac Dis. 2017 Dec;9(12):4884-4888. (490) Shiraliyeva N, Friedrichs J, Buettner R, Friedrichs N. PD-L1 expression in HNPCC-associated colorectal cancer. Pathol Res Pract. 2017 Dec;213(12):1552-1555.

(491) Plenker D, Bertrand M, de Langen AJ, Riedel R, Lorenz C, Scheel AH, Müller JN, Brägelmann J, Daßler- Plenker J, Kobe C, Persigehl T, Kluge A, Wurdinger T, Schellen P, Hartmann G, Zacherle T, Menon R, Thunnissen E, Büttner R, Griesinger F, Wolf J, Heukamp L, Heuckmann JM, Sos ML. Structural alterations of MET trigger response to MET kinase inhibition in lung adenocarcinoma patients. Clin Cancer Res. 2017 Dec 28. pii: clincanres.3001.2017.

(492) Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K. AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018 Jan 11. doi: 10.1038/s41388-017-0054-6. [Epub ahead of print]

(493) Scheel AH, Baenfer G, Baretton G, Dietel M, Diezko R, Henkel T, Heukamp LC, Jasani B, Jöhrens K, Kirchner T, Lasitschka F, Petersen I, Reu S, Schildhaus HU, Schirmacher P, Schwamborn K, Sommer U, Stoss O, Tiemann M, Warth A, Weichert W, Wolf J, Büttner R, Rüschoff J. Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer. Histopathology. 2018 Feb;72(3):449-459.