molecules Review Targeting Metabolism in Cancer Cells and the Tumour Microenvironment for Cancer Therapy Jiaqi Li 1, Jie Qing Eu 2, Li Ren Kong 2,3, Lingzhi Wang 2,4, Yaw Chyn Lim 2,5, Boon Cher Goh 2,4,6 and Andrea L. A. Wong 2,6,* 1 School of Clinical Medicine, University of Cambridge, Cambridge CB2 0SP, UK;
[email protected] 2 Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore;
[email protected] (J.Q.E.);
[email protected] (L.R.K.);
[email protected] (L.W.);
[email protected] (Y.C.L.);
[email protected] (B.C.G.) 3 Medical Research Council Cancer Unit, University of Cambridge, Cambridge CB2 0XZ, UK 4 Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore 5 Department of Pathology, National University Health System, Singapore 119074, Singapore 6 Department of Haematology-Oncology, National University Health System, Singapore 119228, Singapore * Correspondence:
[email protected]; Tel.: +65-6779-5555 Academic Editors: Jacinta Serpa and Sofia C. Nunes Received: 29 September 2020; Accepted: 16 October 2020; Published: 20 October 2020 Abstract: Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer treatment. The metabolic reprogramming that accompanies the development of malignancy creates targetable differences between cancer cells and normal cells, which may be exploited for therapy. There is also emerging evidence regarding the role of stromal components, creating an intricate metabolic network consisting of cancer cells, cancer-associated fibroblasts, endothelial cells, immune cells, and cancer stem cells.