Cancer Facts & Figures 2019
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Genetic Markers in Lung Cancer Diagnosis: a Review
International Journal of Molecular Sciences Review Genetic Markers in Lung Cancer Diagnosis: A Review Katarzyna Wadowska 1 , Iwona Bil-Lula 1 , Łukasz Trembecki 2,3 and Mariola Sliwi´ ´nska-Mosso´n 1,* 1 Department of Medical Laboratory Diagnostics, Division of Clinical Chemistry and Laboratory Haematology, Wroclaw Medical University, 50-556 Wroclaw, Poland; [email protected] (K.W.); [email protected] (I.B.-L.) 2 Department of Radiation Oncology, Lower Silesian Oncology Center, 53-413 Wroclaw, Poland; [email protected] 3 Department of Oncology, Faculty of Medicine, Wroclaw Medical University, 53-413 Wroclaw, Poland * Correspondence: [email protected]; Tel.: +48-71-784-06-30 Received: 1 June 2020; Accepted: 25 June 2020; Published: 27 June 2020 Abstract: Lung cancer is the most often diagnosed cancer in the world and the most frequent cause of cancer death. The prognosis for lung cancer is relatively poor and 75% of patients are diagnosed at its advanced stage. The currently used diagnostic tools are not sensitive enough and do not enable diagnosis at the early stage of the disease. Therefore, searching for new methods of early and accurate diagnosis of lung cancer is crucial for its effective treatment. Lung cancer is the result of multistage carcinogenesis with gradually increasing genetic and epigenetic changes. Screening for the characteristic genetic markers could enable the diagnosis of lung cancer at its early stage. The aim of this review was the summarization of both the preclinical and clinical approaches in the genetic diagnostics of lung cancer. The advancement of molecular strategies and analytic platforms makes it possible to analyze the genome changes leading to cancer development—i.e., the potential biomarkers of lung cancer. -
Iudaea Capta Vs. Mother Zion: the Flavian Discourse on Judaeans and Its Delegitimation in 4 Ezra
Journal for the Study of Judaism 49 (2018) 498-550 Journal for the Study of Judaism brill.com/jsj Iudaea Capta vs. Mother Zion: The Flavian Discourse on Judaeans and Its Delegitimation in 4 Ezra G. Anthony Keddie1 Assistant Professor, University of British Columbia, Vancouver, BC, Canada [email protected] Abstract This study proposes that the empire-wide Iudaea capta discourse should be viewed as a motivating pressure on the author of 4 Ezra. The discourse focused on Iudaea capta, Judaea captured, was pervasive across the Roman empire following the First Revolt. Though initiated by the Flavians, it became misrecognized across the Mediterranean and was expressed in a range of media. In this article, I examine the diverse evidence for this discourse and demonstrate that it not only cast Judaeans as barbaric enemies of Rome using a common set of symbols, but also attributed responsibility for a minor provincial revolt to a transregional ethnos/gens. One of the most distinctive symbols of this discourse was a personification of Judaea as a mourning woman. I argue that 4 Ezra delegitimates this Iudaea capta discourse, with its mourning woman, through the counter-image of a Mother Zion figure who transforms into the eschatological city. Keywords Iudaea capta/Judaea capta − Flavian dynasty − 4 Ezra − Roman iconography − Jewish-Roman relations − Mother Zion − apocalyptic discourse − First Jewish Revolt 1 I would like to thank Steven Friesen and L. Michael White for their helpful feedback and insightful suggestions on earlier versions of this study. © koninklijke brill nv, leiden, 2018 | doi:10.1163/15700631-12494235Downloaded from Brill.com10/06/2021 11:31:49PM via free access Iudaea Capta vs. -
Medical Oncology and Breast Cancer
The Breast Center Smilow Cancer Hospital 20 York Street, North Pavilion New Haven, CT 06510 Phone: (203) 200-2328 Fax: (203) 200-2075 MEDICAL ONCOLOGY Treatment for breast cancer is multidisciplinary. The primary physicians with whom you may meet as part of your care are the medical oncologist, the breast surgeon, and often the radiation oncologist. A list of these specialty physicians will be provided to you. Each provider works with a team of caregivers to ensure that every patient receives high quality, personalized, breast cancer care. The medical oncologist specializes in “systemic therapy”, or medications that treat the whole body. For women with early stage breast cancer, systemic therapy is often recommended to provide the best opportunity to prevent breast cancer from returning. SYSTEMIC THERAPY Depending on the specific characteristics of your cancer, your medical oncologist may prescribe systemic therapy. Systemic therapy can be hormone pills, IV chemotherapy, antibody therapy (also called “immunotherapy”), and oral chemotherapy; sometimes patients receive more than one type of systemic therapy. Systemic therapy can happen before surgery (called “neoadjuvant therapy”) or after surgery (“adjuvant therapy”). If appropriate, your breast surgeon and medical oncologist will discuss the benefits of neoadjuvant and adjuvant therapy with you. As a National Comprehensive Cancer Network (NCCN) Member Institution, we are dedicated to following the treatment guidelines that have been shown to be most effective. We also have a variety of clinical trials that will help us find better ways to treat breast cancer. Your medical oncologist will recommend what treatment types and regimens are best for you. The information used to make these decisions include: the location of the cancer, the size of the cancer, the type of cancer, whether the cancer is invasive, the grade of the cancer (a measure of its aggressiveness), prognostic factors such as hormone receptors and HER2 status, and lymph node involvement. -
Exposure to Carcinogens and Work-Related Cancer: a Review of Assessment Methods
European Agency for Safety and Health at Work ISSN: 1831-9343 Exposure to carcinogens and work-related cancer: A review of assessment methods European Risk Observatory Report Exposure to carcinogens and work-related cancer: A review of assessment measures Authors: Dr Lothar Lißner, Kooperationsstelle Hamburg IFE GmbH Mr Klaus Kuhl (task leader), Kooperationsstelle Hamburg IFE GmbH Dr Timo Kauppinen, Finnish Institute of Occupational Health Ms Sanni Uuksulainen, Finnish Institute of Occupational Health Cross-checker: Professor Ulla B. Vogel from the National Working Environment Research Centre in Denmark Project management: Dr Elke Schneider - European Agency for Safety and Health at Work (EU-OSHA) Europe Direct is a service to help you find answers to your questions about the European Union Freephone number (*): 00 800 6 7 8 9 10 11 (*) Certain mobile telephone operators do not allow access to 00 800 numbers, or these calls may be billed. More information on the European Union is available on the Internet ( 48TU http://europa.euU48T). Cataloguing data can be found on the cover of this publication. Luxembourg: Publications Office of the European Union, 2014 ISBN: 978-92-9240-500-7 doi: 10.2802/33336 Cover pictures: (clockwise): Anthony Jay Villalon (Fotolia); ©Roman Milert (Fotolia); ©Simona Palijanskaite; ©Kari Rissa © European Agency for Safety and Health at Work, 2014 Reproduction is authorised provided the source is acknowledged. European Agency for Safety and Health at Work – EU-OSHA 1 Exposure to carcinogens and work-related cancer: -
(2007) 30 International Journal of Law and Psychiatry 201-212
Deakin Research Online Deakin University’s institutional research repository DDeakin Research Online Research Online This is the authors final peer reviewed version of the item published as: Mendelson, Danuta 2007, Roman concept of mental capacity to make end-of-life decisions, International journal of law and psychiatry, vol. 30, no. 3, pp. 201-212. Copyright : 2007, Elsevier Ltd (2007) 30 IJLP 201 Danuta Mendelsona, ”Roman concept of mental capacity to make end-of-life decisions” (2007) 30 International Journal of Law and Psychiatry 201-212 aSchool of Law, Deakin University, Melbourne, Australia Abstract When assessing decisional competence of patients, psychiatrists have to balance the patients' right to personal autonomy, their condition and wishes against principles of medical ethics and professional discretion. This article explores the age-old legal and ethical dilemmas posed by refusal of vital medical treatment by patients and their mental capacity to make end-of-life decisions against the background of philosophical, legal and medical approaches to these issues in the time of the Younger Pliny (c62–c113 CE). Classical Roman discourse regarding mental competency and "voluntary death" formed an important theme of the vast corpus of Greco-Roman writings, which was moulded not only by legal permissibility of suicide but also by philosophical (in modern terms, moral or ethical) considerations. Indeed, the legal and ethical issues of evaluating the acceptability of end of life decisions discussed in the Letters are as pertinent today as they were 2000 years ago. We may gain valuable insights about our own methodologies and frames of reference in this area of the law and psychiatry by examining Classical Roman approaches to evaluating acceptability of death-choices as described in Pliny's Letters and the writings of some of his peers. -
Cancer Survival in Qidong Between 1972 and 2011: a Population‑Based Analysis
944 MOLECULAR AND CLINICAL ONCOLOGY 6: 944-954, 2017 Cancer survival in Qidong between 1972 and 2011: A population‑based analysis JIAN-GUO CHEN1,2, JIAN ZHU1, YONG-HUI ZHANG1, YI-XIN ZHANG2, DENG-FU YAO3, YONG-SHENG CHEN1, JIAN-HUA LU1, LU-LU DING1, HAI-ZHEN CHEN2, CHAO-YONG ZHU2, LI-PING YANG2, YUAN-RONG ZHU1 and FU-LIN QIANG2 1Qidong Cancer Registry, Qidong Liver Cancer Institute, Qidong, Jiangsu 226200; 2Nantong University Tumour Hospital/Institute, Nantong, Jiangsu 226361; 3Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, P.R. China Received May 17, 2016; Accepted March 7, 2017 DOI: 10.3892/mco.2017.1234 Abstract. Population-based cancer survival is an improved lung, colon and rectum, oesophagus, female breast and bladder index for evaluating the overall efficiency of cancer health cancer, as well as leukaemia and NHL. The observations of services in a given region. The current study analysed the the current study provide the opportunity for evaluation of observed survival and relative survival of leading cancer sites the survival outcomes of frequent cancer sites that reflects the from a population‑based cancer registry between 1972 and 2011 changes and improvement in a rural area in China. in Qidong, China. A total of 92,780 incident cases with cancer were registered and followed‑up for survival status. The main Introduction sites of the cancer types, based on the rank order of incidence, were the liver, stomach, lung, colon and rectum, oesophagus, Cancer survival is an index for evaluating the effect of treatment breast, pancreas, leukaemia, brain and central nervous system of patients in specific settings, whether used to define outcomes (B and CNS), bladder, blood [non‑Hodgkin's lymphoma in clinical trials or as an indicator of the overall efficiency of (NHL)] and cervix. -
Causes of Death of Cancer Patients in a Referral Hospital in Northern Iran Between 2013 and 2016
WCRJ 2017; 4 (3): e909 CAUSES OF DEATH OF CANCER PATIENTS IN A REFERRAL HOSPITAL IN NORTHERN IRAN BETWEEN 2013 AND 2016 F. BOZORGI, A. HEDAYATIZADEH-OMRAN, R. ALIZADEH-NAVAEI, G. JANBABAEI, S. MORADI, N. SAMADAEI Gastrointestinal Cancer Research Center, Mazandaran University of Medical Sciences, Sari, Iran Abstract – Objective: Cancer is a major cause of death worldwide. The first step in planning to in- crease the survival rate of cancer patients is to know the cause of death of these patients. This study aimed to investigate the causes of death in cancer patients hospitalized in Imam Khomeini hospital of Sari, Iran (a referral hospital in northern Iran). Patients and Methods: This cross-sectional study was conducted by collecting data on the caus- es of death in cancer patients who were hospitalized and passed away in Imam Khomeini hospital between 2013 and 2016 with a clinical diagnosis of cancer by an oncologist and confirmation of a pathologist. Data were collected using a questionnaire and were then analyzed by SPSS 21. Results: The most prevalent cancers were gastric, lung, breast and colon cancers and the most frequent causes of death among patients were sepsis (45.3%), carcinomatosis (16.4%), IHD (10.8%), internal bleeding (9.6%), other infections (6%) and pneumonia (3.8%). Conclusions: Infection is the most important cause of cancer deaths, while the importance of sepsis cannot be neglected. Bleeding, carcinomatosis and cardiovascular problems are also of par- ticular importance in the deaths of cancer patients. Most of cancers were related to the digestive tract, blood, and respiratory tract. A majority of these patients died from curable causes, including infection and bleeding, meaning that a large proportion of the deaths can be avoided by taking technical clinical precautions. -
DCIS): Pathological Features, Differential Diagnosis, Prognostic Factors and Specimen Evaluation
Modern Pathology (2010) 23, S8–S13 S8 & 2010 USCAP, Inc. All rights reserved 0893-3952/10 $32.00 Ductal carcinoma in situ (DCIS): pathological features, differential diagnosis, prognostic factors and specimen evaluation Sarah E Pinder Breast Research Pathology, Research Oncology, Division of Cancer Studies, King’s College London, Guy’s Hospital, London, UK Ductal carcinoma in situ (DCIS) is a heterogeneous, unicentric precursor of invasive breast cancer, which is frequently identified through mammographic breast screening programs. The lesion can cause particular difficulties for specimen handling in the laboratory and typically requires even more diligent macroscopic assessment and sampling than invasive disease. Pitfalls and tips for macroscopic handling, microscopic diagnosis and assessment, including determination of prognostic factors, such as cytonuclear grade, presence or absence of necrosis, size of the lesion and distance to margins are described. All should be routinely included in histopathology reports of this disease; in order not to omit these clinically relevant details, synoptic reports, such as that produced by the College of American Pathologists are recommended. No biomarkers have been convincingly shown, and validated, to predict the behavior of DCIS till date. Modern Pathology (2010) 23, S8–S13; doi:10.1038/modpathol.2010.40 Keywords: ductal carcinoma in situ (DCIS); breast cancer; histopathology; prognostic factors Ductal carcinoma in situ (DCIS) is a malignant, lesions, a good cosmetic result can be obtained by clonal proliferation of cells growing within the wide local excision. Recurrence of DCIS generally basement membrane-bound structures of the breast occurs at the site of previous excision and it is and with no evidence of invasion into surrounding therefore better regarded as residual disease, as stroma. -
PCHHAX Overview of Flaxseed Patent
Available online a t www.derpharmachemica.com ISSN 0975-413X Der Pharma Chemica, 2016, 8(14):33-38 CODEN (USA): PCHHAX (http://derpharmachemica.com/archive.html) Overview of Flaxseed Patent Applications for the prevention and treatment of human cancer Sepideh Miraj Infertility Fellowship, Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran _____________________________________________________________________________________________ ABSTRACT Flaxseed, Linum usitatissimum, is a member of the genus Linum in the family Linaceae. It is a food and fiber crop cultivated in cooler regions of the world. The aim of this study is to overview its anti-cancer and anti-tumor effects. This review article was carried out by searching studies in PubMed, Medline, Web of Science, and IranMedex databases up to 2016.totally, of 1 08 found articles, 41 articles were included. The search terms were “Flaxseed. ”, “therapeutic”, “pharmacological”, anticancer, anti-tumor. Various studies have shown that Flaxseed. Possess Anti-Breast Cancer properties, Anti-Breast tumors properties , Anti-Ovary cancer properties, Gut-associated diseases properties, Lung tumor properties, Inflammation properties, Anti-Skin Carcinogenesis properties, Pro- carcinogenic, Mastalgia properties, Aortic remodeling ,Anti-mammary Cancer effect ,Antioxidant and Antiproliferative ,Colon cancer properties, Esophagitis properties, Apoptosis properties. Flaxseed possess lots of therapeutic and pharmacological effects.in this study, its anticancer, anti-tumor effects was overviewed. Keywords : Flaxseed, therapeutic, pharmacological, anticancer, anti-tumor. _____________________________________________________________________________________________ INTRODUCTION It is proved that herbal medicine is effective in the treatment of many diseases [1-10].Flax, Linum usitatissimum , is a member of the genus Linum in the family Linaceae. It is a food and fiber crop cultivated in cooler regions of the world. -
Cancers Unequal Burden
The reality behind improving cancer survival rates April 2014 Cancer’s unequal burden – The reality behind improving cancer survival rates • Foreword • Executive summary • The reality behind improving cancer survival rates • Improving survival outcomes • Conclusion • References 3 Cancer’s unequal burden – The reality behind improving cancer survival rates in these areas has the potential to significantly reduce the overall cost of cancer care as well as greatly improving the lives of those with cancer. Routes from Diagnosis, developed in Survival rates for some cancers have soared over the past 40 years in England. partnership with strategy consultancy In the early 1970s, overall median survival time for all cancer types – the time Monitor Deloitte and Public Health by which half of people with cancer have died and half have survived – was just England’s National Cancer Intelligence i ii Network (NCIN), also shows us one year . Now it is predicted to be nearly six years , testament to the good work the value of linking and analysing of the NHS and advances in diagnosis, treatment and care. But there is a grim routinely collected NHS data. Only by reality hidden behind these numbers. combining data from cancer registries with hospital records have we been able to produce such a powerful picture of what happens to people New research led by Macmillan These new figures are taken from our after they are diagnosed with cancer Cancer Support reveals what happens groundbreaking Routes from Diagnosis and which groups of people in to people in England after they are research programme, which links particular need more support. -
A Bibliometric Analysis
787 Original Article Page 1 of 9 The 100 most cited articles on lung cancer screening: a bibliometric analysis Meng Li1,2, Qiang Cai2,3, Jing-Wen Ma1, Li Zhang1,2, Claudia I. Henschke2 1Department of Diagnostic Radiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; 2Department of Radiology, Mount Sinai Health System, New York, NY, USA; 3Department of Radiology, Shanxi Provincial People’s Hospital, Taiyuan, China Contributions: (I) Conception and design: M Li, CI Henschke; (II) Administrative support: CI Henschke; (III) Provision of study materials or patients: M Li, CI Henschke; (IV) Collection and assembly of data: M Li, L Zhang; (V) Data analysis and interpretation: M Li, Q Cai, JW Ma; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Claudia I. Henschke. Department of Radiology, Mount Sinai Health System, 1 Gustave Levy Place, New York, NY 10029, USA. Email: [email protected]. Background: The number of citations of an article reflects its impact on the scientific community. The aim of this study was to identify and characterize the 100 most cited articles on lung cancer screening. Methods: The 100 most cited articles on lung cancer screening published in all scientific journals were identified using the Web of Science database. Relevant data, including the number of citations, publication year, publishing journal and impact factor (IF), authorship and country of origin, article type and study design, screening modality, and main topic, were collected and analyzed. Results: The 100 most cited articles were all English and published between 1973 and 2017, with 81 published after 2000. -
Cancer Treatment and Survivorship Facts & Figures 2019-2021
Cancer Treatment & Survivorship Facts & Figures 2019-2021 Estimated Numbers of Cancer Survivors by State as of January 1, 2019 WA 386,540 NH MT VT 84,080 ME ND 95,540 59,970 38,430 34,360 OR MN 213,620 300,980 MA ID 434,230 77,860 SD WI NY 42,810 313,370 1,105,550 WY MI 33,310 RI 570,760 67,900 IA PA NE CT 243,410 NV 185,720 771,120 108,500 OH 132,950 NJ 543,190 UT IL IN 581,350 115,840 651,810 296,940 DE 55,460 CA CO WV 225,470 1,888,480 KS 117,070 VA MO MD 275,420 151,950 408,060 300,200 KY 254,780 DC 18,750 NC TN 470,120 AZ OK 326,530 NM 207,260 AR 392,530 111,620 SC 143,320 280,890 GA AL MS 446,900 135,260 244,320 TX 1,140,170 LA 232,100 AK 36,550 FL 1,482,090 US 16,920,370 HI 84,960 States estimates do not sum to US total due to rounding. Source: Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute. Contents Introduction 1 Long-term Survivorship 24 Who Are Cancer Survivors? 1 Quality of Life 24 How Many People Have a History of Cancer? 2 Financial Hardship among Cancer Survivors 26 Cancer Treatment and Common Side Effects 4 Regaining and Improving Health through Healthy Behaviors 26 Cancer Survival and Access to Care 5 Concerns of Caregivers and Families 28 Selected Cancers 6 The Future of Cancer Survivorship in Breast (Female) 6 the United States 28 Cancers in Children and Adolescents 9 The American Cancer Society 30 Colon and Rectum 10 How the American Cancer Society Saves Lives 30 Leukemia and Lymphoma 12 Research 34 Lung and Bronchus 15 Advocacy 34 Melanoma of the Skin 16 Prostate 16 Sources of Statistics 36 Testis 17 References 37 Thyroid 19 Acknowledgments 45 Urinary Bladder 19 Uterine Corpus 21 Navigating the Cancer Experience: Treatment and Supportive Care 22 Making Decisions about Cancer Care 22 Cancer Rehabilitation 22 Psychosocial Care 23 Palliative Care 23 Transitioning to Long-term Survivorship 23 This publication attempts to summarize current scientific information about Global Headquarters: American Cancer Society Inc.