Anopheles Stephensi
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Assessment and an Updated List of the Mosquitoes of Saudi Arabia Azzam M
Alahmed et al. Parasites Vectors (2019) 12:356 https://doi.org/10.1186/s13071-019-3579-4 Parasites & Vectors RESEARCH Open Access Assessment and an updated list of the mosquitoes of Saudi Arabia Azzam M. Alahmed1, Kashif Munawar1*, Sayed M. S. Khalil1,2 and Ralph E. Harbach3 Abstract Background: Mosquito-borne pathogens are important causes of diseases in the Kingdom of Saudi Arabia. Knowl- edge of the mosquito fauna is needed for the appropriate control of the vectors that transmit the pathogens and prevent the diseases they cause. An important frst step is to have an up-to-date list of the species known to be present in the country. Original occurrence records were obtained from published literature and critically scrutinized to compile a list of the mosquito species that occur within the borders of the Kingdom. Results: Fifty-one species have been recorded in the Kingdom; however, the occurrence of two of these species is unlikely. Thus, the mosquito fauna of the Kingdom comprises 49 species that include 18 anophelines and 31 culicines. Published records are provided for each species. Problematic records based on misidentifcations and inappropriate sources are discussed and annotated for clarity. Conclusion: Integrated morphological and molecular methods of identifcation are needed to refne the list of spe- cies and accurately document their distributions in the Kingdom. Keywords: Culicidae, Mosquitoes, Saudi Arabia, Vectors Background Mosquito-borne pathogens, including Plasmodium Te Arabian Peninsula (c.3 million km2) includes the species, dengue virus, Rift Valley fever virus and micro- Kingdom of Saudi Arabia (KSA), Oman, Qatar, United flariae, cause diseases in the KSA [9–11]. -
Profile of Janet Hemingway
PROFILE PROFILE Profile of Janet Hemingway Ann Griswold grandfather worked in the mines. At around Science Writer age five, Hemingway’s grandfather presented her with a pair of retired “pit” ponies that had pulled coal trucks in the mine but had Asthewheelsofabiplaneapproachadesolate resistance, and helped develop life-saving never been ridden. “I was kind of plopped airfield in the Solomon Islands, a man wear- quinolone antimalarial drugs (1). In her In- on top of one, and off we went,” she recalls. ing only a loincloth breaks through the brush, augural Article (2), Hemingway explores Much of the next few years was spent brandishing a spear and a flail. From behind the increasing challenge of insecticide re- outdoors “running riot” with ponies Cap- the plane’s windows four biologists watch sistance in Anopheles gambiae and Anoph- tain and Blaze, a Labrador-sheep dog cross with wary eyes and silently map an escape eles funestus mosquitoes, malaria vectors named Rinty, and a growing menagerie of route. “You’re thinking, ‘What am I sup- prevalent in the southern African country birds, frogs, and animals that family and posed to do here?’” recalls Janet Hemingway, fi of Malawi. The ndings reveal that pyreth- neighbors left in her care. “It was every Director of the Liverpool School of Tropical roids, the most effective antimalarial insec- girl’s dream, I suppose, trying to sort out Medicine, International Director of the Joint ticides known to date, are under siege by Centre for Infectious Disease Research, and these two little ponies and everything re- resistant variants of Anopheles, and in- lated to animals and the outdoors.” a recently elected member of the National creased monitoring in the impoverished “ Soon, Hemingway’s family moved and Academy of Sciences. -
Comparative Assessment of An. Gambiae and An. Stephensi Mosquitoes to Determine Transmission-Reducing Activity of Antibodies Against P
Eldering et al. Parasites & Vectors (2017) 10:489 DOI 10.1186/s13071-017-2414-z RESEARCH Open Access Comparative assessment of An. gambiae and An. stephensi mosquitoes to determine transmission-reducing activity of antibodies against P. falciparum sexual stage antigens Maarten Eldering1†, Anaïs Bompard2†, Kazutoyo Miura3, Will Stone1, Isabelle Morlais4, Anna Cohuet4, Geert-Jan van Gemert1, Patrick M. Brock2,6, Sanna R. Rijpma1, Marga van de Vegte-Bolmer1, Wouter Graumans1, Rianne Siebelink-Stoter1, Dari F. Da5, Carole A. Long3, Merribeth J. Morin7, Robert W. Sauerwein1, Thomas S. Churcher2 and Teun Bousema1,8* Abstract Background: With the increasing interest in vaccines to interrupt malaria transmission, there is a demand for harmonization of current methods to assess Plasmodium transmission in laboratory settings. Potential vaccine candidates are currently tested in the standard membrane feeding assay (SMFA) that commonly relies on Anopheles stephensi mosquitoes. Other mosquito species including Anopheles gambiae are the dominant malaria vectors for Plasmodium falciparum in sub-Saharan Africa. Methods: Using human serum and monoclonal pre-fertilization (anti-Pfs48/45) and post-fertilization (anti-Pfs25) antibodies known to effectively inhibit sporogony, we directly compared SMFA based estimates of transmission- reducing activity (TRA) for An. stephensi and An. gambiae mosquitoes. Results: In the absence of transmission-reducing antibodies, average numbers of oocysts were similar between An. gambiae and An. stephensi. Antibody-mediated TRA was strongly correlated between both mosquito species, and absolute TRA estimates for pre-fertilisation monoclonal antibodies (mAb) showed no significant difference between the two species. TRA estimates for IgG of naturally exposed individuals and partially effective concentrations of anti-Pfs25 mAb were higher for An. -
A New Malaria Vector in Africa: Predicting the Expansion Range of Anopheles Stephensi and Identifying the Urban Populations at Risk
A new malaria vector in Africa: Predicting the expansion range of Anopheles stephensi and identifying the urban populations at risk M. E. Sinkaa,1, S. Pirononb, N. C. Masseyc, J. Longbottomd, J. Hemingwayd,1, C. L. Moyesc,2, and K. J. Willisa,b,2 aDepartment of Zoology, University of Oxford, Oxford, United Kingdom, OX1 3SZ; bBiodiversity Informatics and Spatial Analysis Department, Royal Botanic Gardens Kew, Richmond, Surrey, United Kingdom, TW9 3DS; cBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom, OX3 7LF; and dDepartment of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, L3 5QA Edited by Nils Chr. Stenseth, University of Oslo, Norway, and approved July 27, 2020 (received for review March 26, 2020) In 2012, an unusual outbreak of urban malaria was reported from vector species in the published literature and found an equal Djibouti City in the Horn of Africa and increasingly severe out- number of studies (5:5) reported An. arabiensis in polluted, turbid breaks have been reported annually ever since. Subsequent inves- water as were found in clear, clean habitats, with a similar result tigations discovered the presence of an Asian mosquito species; for An. gambiae (4:4). Nonetheless, urban Plasmodium falciparum Anopheles stephensi, a species known to thrive in urban environ- transmission rates are repeatedly reported as significantly lower ments. Since that first report, An. stephensi has been identified in than those in peri-urban or rural areas (7, 10). Hay et al. (10) Ethiopia and Sudan, and this worrying development has prompted conducted a meta-analysis in cities from 22 African countries and the World Health Organization (WHO) to publish a vector alert reported a mean urban annual P. -
Yourthe Magazine for Alumni and Friends 2011 – 2012
UNIVERSITY yourTHE MAGAZINE FOR ALUMNI AND FRIENDS 2011 – 2012 A celebration of excellence HIGHLIGHTS FROM THE ROYAL VISIT HM The Queen is seen here wearing a pair of virtual reality glasses during the ground-breaking ceremony at the University’s Advanced Manufacturing Research Centre page 6 Alumni merchandise Joe Scarborough prints University tie In 2005, to celebrate the University’s Centenary, Sheffield artist Joe Scarborough In 100% silk with multiple (Hon LittD 2008) painted Our University, generously funded by the Sheffield University University shields Association of former students. Sales of the limited edition signed prints raised over Price: £18 (incl VAT) £18,000 for undergraduate scholarships. The University has now commissioned Joe Delivery: £1.00 UK; to paint a sister work entitled Our Students’ Journey which hangs in the Students’ Union. £1.30 Europe; £18 It depicts all aspects of student life including the RAG boat race and parade, student £1.70 rest of world (INCL VAT) officer elections and summer activities in Weston Park. We are delighted to be offering 500 limited edition signed prints. All proceeds will again provide scholarships for gifted students in need of financial support, £40 and to help the University’s Alumni Foundation which distributes grants (INCL VAT) to student clubs and societies. Our Students’ Journey Limited edition signed prints, measuring 19” x 17”, are unframed and packed in protective cardboard tubes and priced at £40.00 (incl VAT). Our University A very limited number of these prints (unsigned) are still available. Measuring 19” x 17”, they are unframed and packed in protective cardboard tubes and priced at £15.00 (incl VAT). -
Anopheles Stephensi Invasion and Spread Horn of Africa, the Republic of the Sudan and Surrounding Geographical Areas, and Sri Lanka
Global Malaria Programme Vector alert: Anopheles stephensi invasion and spread Horn of Africa, the Republic of the Sudan and surrounding geographical areas, and Sri Lanka AUGUST 2019 (UPDATED DECEMBER 2019) INFORMATION NOTE IDENTIFIED THREAT Anopheles stephensi, a highly competent vector of Plasmodium falciparum and P. vivax, is considered an efficient vector of urban malaria. In parts of India, two biological forms of An. stephensi – “type” and “intermediate” – have also emerged as efficient vectors in rural areas, due to changing agricultural and water storage practices and urbanization. The third form – “mysorensis” – is considered to be a poor vector, although it has been involved in malaria transmission in certain rural areas in Afghanistan and Iran. Until 2011, the reported distribution of An. stephensi was confined to certain countries in South-East Asia and large parts of the Arabian Peninsula. Since then, the vector has been reported from Djibouti (2012), Ethiopia (2016), Sri Lanka (2017) and most recently from the Republic of the Sudan (2019). In the Horn of Africa, the vector seems to be spreading from its first site of detection (Djibouti) to neighbouring countries. An. stephensi typically breeds in containers or cisterns with clean water, and the vector appears to quickly adapt itself to the local environment (including cryptic habitats such as deep wells); it also survives extremely high temperatures during the dry season, when malaria transmission usually reaches a seasonal low. In addition, the genetic background of introduced An. stephensi seems to confer resistance to multiple insecticide classes, posing potential challenges to its control. The World Health Organization (WHO) considers the spread of An. -
Speculation on the Possibility for Introducing Anopheles Stephensi As
Firooziyan et al. Malar J (2018) 17:366 https://doi.org/10.1186/s12936-018-2523-y Malaria Journal RESEARCH Open Access Speculation on the possibility for introducing Anopheles stephensi as a species complex: preliminary evidence based on odorant binding protein 1 intron I sequence Samira Firooziyan1,2, Navid Dinparast Djadid3 and Saber Gholizadeh1,2* Abstract Background: Anopheles stephensi is considered an important malaria vector in Iran, Asia, and recently in the Horn of Africa. Recently, Ansteobp1 intron I sequence has been introduced a new molecular marker for identifcation of its biological forms including, mysorensis, intermediate and type, using insectary colony specimens. Methods: In the current study, new marker ability in molecular identifcation of biological forms has been evaluated with An. stephensi specimens collected from Iran and Afghanistan malarious provinces. Following DNA extraction and PCR amplifcation, sequence analysis and constructed phylogenetic tree revealed that type and intermediate forms are distributed in Iran. Results: The specimens collected from Afghanistan identifed as intermediate and mysorensis forms. Therefore, intermediate form is sympatric species in both countries. Based on the results of Ansteobp1 intron I sequences, An. stephensi could be suggested as new Anopheles complex species including An. stephensi sibling A (type form), An. stephensi sibling B (intermediate form) and An. stephensi sibling C (mysorensis form). This is the frst report on the pres- ence of An. stephensi biological forms in Afghanistan. Conclusions: Iran is going to eliminate malaria transmission from the country, precise species identifcation, espe- cially in complex species will be helpful in the prevention of malaria resurgence in the country, mainly because of common fauna of Anopheles species and through border malaria and population movement within Afghanistan, Pakistan, and Iran. -
Smutty Alchemy
University of Calgary PRISM: University of Calgary's Digital Repository Graduate Studies The Vault: Electronic Theses and Dissertations 2021-01-18 Smutty Alchemy Smith, Mallory E. Land Smith, M. E. L. (2021). Smutty Alchemy (Unpublished doctoral thesis). University of Calgary, Calgary, AB. http://hdl.handle.net/1880/113019 doctoral thesis University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. Downloaded from PRISM: https://prism.ucalgary.ca UNIVERSITY OF CALGARY Smutty Alchemy by Mallory E. Land Smith A THESIS SUBMITTED TO THE FACULTY OF GRADUATE STUDIES IN PARTIAL FULFILMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY GRADUATE PROGRAM IN ENGLISH CALGARY, ALBERTA JANUARY, 2021 © Mallory E. Land Smith 2021 MELS ii Abstract Sina Queyras, in the essay “Lyric Conceptualism: A Manifesto in Progress,” describes the Lyric Conceptualist as a poet capable of recognizing the effects of disparate movements and employing a variety of lyric, conceptual, and language poetry techniques to continue to innovate in poetry without dismissing the work of other schools of poetic thought. Queyras sees the lyric conceptualist as an artistic curator who collects, modifies, selects, synthesizes, and adapts, to create verse that is both conceptual and accessible, using relevant materials and techniques from the past and present. This dissertation responds to Queyras’s idea with a collection of original poems in the lyric conceptualist mode, supported by a critical exegesis of that work. -
ASTMH 65Th Annual Meeting Atlanta Marriott Marquis and Hilton Atlanta Atlanta, GA Pre-Registration List As of October 27, 2016
ASTMH 65th Annual Meeting Atlanta Marriott Marquis and Hilton Atlanta Atlanta, GA Pre-Registration List as of October 27, 2016 *John Aaskov, PhD FRCPath Denise Abud Oladokun Adedamola Adesunloye, Queensland University of Technology Sanofi Pastuer Federal Ministry of Health(FMC) Australia USA Nigeria Neetu Abad Manfred M K Accrombessi Grace Adeya CDC Benin GHSC-PSM/Chemonics United States USA *Jane Winnie Achan, Clinical *Tochukwu Abadom MRC Unit, The Gambia Bwaka Mpia Ado Blackpool Victoria Hospital, United Gambia McKIng Consulting Corporation/ EPI Kingdom DRC Nigeria *Nicole L. Achee, PhD Dem. Republic of Congo Univ of Notre Dame *Shaymaa Abdalal, MD USA Joseph Ado-Yobo Tulane School of Public Hlth Ghana USA Salissou Adamou Bathiri Onchocerciasis & Lymphatic *Valentine Adolphe *Agatha Aboe, MBChB; DO Niger PSI Sightsavers USA Ghana *David P. Adams, PhD MPH MSc Dept of Community Medicine, Mercer Yaw Asare Afrane *Ayokunle Abogan Univ Sch of Medicine Kenya Medical Research Institute Natl Malaria Programme USA Kenya Botswana *John H. Adams, PhD Suneth Agampodi, MBBS MSc *Melanie Abongwa, MSc University of South Florida Coll of Pub Univ of Sri Lanka Iowa State University Hlth Sri Lanka USA USA *Kokila Agarwal, DRPH MBBS MPH *Ahmed Abd El Wahed Abou El Nasr, *Matthew Adams MCHIP/JHPIEGO Georg August University Goettingen Univ of Maryland Baltimore USA Germany USA Kodjovi D. Agbodjavou *Jennifer Abrahams, MD Marc Adamy Jhpiego Corp University of Miami/Jackson Memorial Medicines for Malaria Venture Togo Hospital Switzerland USA Rakesh Aggarwal, MD DM *David Addiss, MD MPH Sanjay Gandhi Postgraduate Inst of Lauren Abrams, GA Task Force for Global Hlth Med Sciences Children Without Worms USA India United States *Ahmed Adeel, MD MPH PhD *Selidji Todagbe AGNANDJI Marcelo Claudio Abril United States CERMEL Fundación Mundo Sano Gabon Argentina *Adeshina Israel Adekunle UNSW *Peter C. -
Breeding of Anopheles Mosquitoes in Irrigated Areas of South Punjab, Pakistan
Medical and Veterinary Entomology (2001) 15, 236±248 Breeding of Anopheles mosquitoes in irrigated areas of South Punjab, Pakistan N. HERREL, F. P. AMERASINGHE*, J. ENSINK, M. MUKHTAR, W. VAN DER HOEK* and F. KONRADSEN* International Water Management Institute, Lahore, Pakistan and *IWMI, Colombo, Sri Lanka Abstract. As part of investigations on potential linkages between irrigation and malaria transmission, all surface water bodies in and around three villages along an irrigation distributary in South Punjab, Pakistan, were surveyed for anopheline mosquito larvae (Diptera: Culicidae) from April 1999 to March 2000. Samples were characterized according to exposure to sunlight, substratum, presence of vegetation, fauna, inorganic matter and physical water condition (clear/turbid/foul). Also water temperature, dissolved oxygen (DO), electroconductivity (EC) and pH of sites were recorded. A total of 37 982 Anopheles larvae of six morphological types were collected from 2992 samples taken from irrigation/agricultural and village/domestic aquatic habitats. Anopheles subpictus Grassi sensu lato was by far the most abundant (74.3%), followed by An. culicifacies Giles s.l. (4.1%), An. stephensi Liston s.l. (2.6%), An. pulcherrimus Theobald (1.8%), An. peditaeniatus Leicester (0.3%) and An. nigerrimus Giles (0.1%). The four most abundant species were signi®cantly associated with waterlogged ®elds and communal village drinking- water tanks. Habitat characteristics most correlated with occurrence of anophelines were the physical water condition and the absence/presence of fauna, particularly predators. Occurrence and abundance of Anopheles immatures were not signi®cantly correlated with water temperature, DO, EC or pH. Malaria vectors of the Anopheles culicifacies complex occurred at relatively low densities, mainly in irrigated and waterlogged ®elds. -
Knockout of Anopheles Stephensi Immune Gene LRIM1 by CRISPR-Cas9 Reveals Its Unexpected Role in Reproduction and Vector Competen
bioRxiv preprint doi: https://doi.org/10.1101/2021.07.02.450840; this version posted July 2, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Knockout of Anopheles stephensi immune gene LRIM1 by CRISPR-Cas9 reveals 2 its unexpected role in reproduction and vector competence 3 Ehud Inbar1, Abraham G. Eappen1, Robert T. Alford2, William Reid1*, Robert A. Harrell2, Maryam 4 Hosseini1, Sumana Chakravarty 1, Tao Li1, B. Kim Lee Sim1, Peter F. Billingsley1 and Stephen L. Hoffman1& 5 1Sanaria Inc. Rockville, MD 20850. 2Insect Transformation Facility, Institute for Bioscience and 6 Biotechnology Research, University of Maryland, Rockville, MD 20850. 7 *Current address: Dept. Veterinary Pathobiology, University of Missouri, Columbia MO 65211. 8 &Correspondence and requests for materials should be addressed to Stephen L. Hoffman 9 10 Abstract 11 PfSPZ Vaccine against malaria is composed of Plasmodium falciparum (Pf) sporozoites (SPZ) 12 manufactured using aseptically reared Anopheles stephensi mosquitoes. Immune response 13 genes of Anopheles mosquitoes such as Leucin-Rich protein (LRIM1), inhibit Plasmodium SPZ 14 development (sporogony) in mosquitoes by supporting melanization and phagocytosis of 15 ookinetes. With the aim of increasing PfSPZ infection intensities, we generated an A. stephensi 16 LRIM1 knockout line, Δaslrim1, by embryonic genome editing using CRISPR-Cas9. Δaslrim1 17 mosquitoes had a significantly increased midgut bacterial load and an altered microbiome 18 composition, including elimination of commensal acetic acid bacteria. -
Testimony for “Science of Zika: the DNA of an Epidemic” House of Representatives Committee on Science, Space, and Technology
Testimony for “Science of Zika: The DNA of an Epidemic” House of Representatives Committee on Science, Space, and Technology Dr. Daniel Neafsey Associate Director, Genomic Center for Infectious Disease Broad Institute of MIT and Harvard Cambridge, MA SUMMARY The Zika epidemic has caught the world off guard. We lack fundamental understanding of how the virus moves from person to person via mosquitoes, information that is crucial for an effective response to the epidemic. Though the virus was little studied prior to the recent epidemic that began in Brazil, the Aedes mosquito that spreads it is better known, because Aedes mosquitoes also spread the viruses that cause Yellow Fever, Chikungunya, and Dengue Fever. Despite the mosquito’s importance, we lack foundational resources to pursue DNA-based studies of the biology and transmission of Zika. This resource is gap is critical. Infectious disease epidemiology has been transformed by DNA during the last 10 years into a rich digital information science, allowing biologists and public health agencies track the spread of outbreaks over time and space, and learn about what mosquito and human factors contribute to disease spread. We can now tackle emergent infectious diseases like Zika using efficient and innovative genetic tools, and the scientific community stands ready to develop and apply these tools to Zika to protect vulnerable populations within our borders and around the world. RATIONALE FOR DNA-BASED EPIDEMIOLOGY Insight into the biology of how Aedes mosquitoes are able to spread disease can be gained through sequencing and mapping the Aedes genome (the entirety of its DNA), by studying the DNA of mosquitoes collected across time and space during the outbreak, and by looking for DNA factors that impact interventions and Zika transmission.