bioRxiv preprint doi: https://doi.org/10.1101/705251; this version posted July 23, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The knockout effect of low doses of gamma radiation on hepatotoxicity induced by Echis Coloratus snake venom in rats Esraa M. Samya,*,1, Esmat A. Shaabana,2, Sanaa A. Kenawyb,3, Walaa H. Salamac,4 and Mai A. Abd El Fattahb,5 a Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt b Department of Pharmacology and Toxicology, Faculty of Pharmacy, Cairo University, Egypt c Department of Molecular Biology, Genetic engineering and biotechnology research division, National Research Centre, Cairo, Egypt 1
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[email protected] *Corresponding author: Esraa M. Samy Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt Tel: 01008371542 E-mail address:
[email protected] ABSTRACT Echis Coloratus is the most medically important viper in Egypt causing several pathological effects leading to death. Gamma radiation has been used as a venom detoxifying tool in order to extend the lifespan of the immunized animals used in antivenin production process. Thus, the aim of this study is to assess the effects of increasing doses of gamma radiation on Echis Coloratus in vivo through biochemical and histological studies. The results revealed a significant increase in the levels of AST, ALT, ALP and glucose of sera collected from the rats injected with native Echis Coloratus venom compared with the non-envenomed group.