Table S6. Extended description of enzymes, shown in Figure S8.

Full name of enzyme Short name of enzyme ATP-binding cassette (ABC) Superfamily ABC superfamily Arsenite-Antimonite (ArsAB) Efflux family ArsAB family The F-type/V-type/A-type (F-ATPase) Superfamily F-ATPase superfamily The P-type ATPase (P-ATPase) Superfamily P-ATPase superfamily The ATP:ADP Antiporter (AAA) Family AAA family The /Auxin Permease (AAAP) Family AAAP family The Aspartate:Alanine Exchanger (AAE) Family AAE family The p-Aminobenzoyl-glutamate Transporter (AbgT) Family AbgT family The Arsenical Resistance-3 (ACR3) Family ACR3 family The Anion Exchanger (AE) Family AE family The Alanine or Glycine:Cation Symporter (AGCS) Family AGCS family The Amino Acid-Polyamine-Organocation (APC) Family APC family The Arsenite-Antimonite (ArsB) Efflux Family ArsB Family The Bile Acid:Na+ Symporter (BASS) Family BASS family The Betaine/Carnitine/Choline Transporter (BCCT) Family BCCT family The Benzoate:H+ Symporter (BenE) Family BenE family The Ca2+:Cation Antiporter (CaCA) Family CaCA family The Cadmium Resistance (CadD) Family CadD family The Cation-Chloride Cotransporter (CCC) Family CCC family The Cation Diffusion Facilitator (CDF) Family CDF family The Chromate Ion Transporter (CHR) Family CHR family The Citrate-Mg2+:H+Citrate-Ca2+:H+ Symporter (CitMHS) Family CitMHS family The Concentrative Nucleoside Transporter (CNT) Family CNT family The Monovalent Cation:Proton Antiporter-1 (CPA1) Family CPA1 family The Monovalent Cation:Proton Antiporter-2 (CPA2) Family CPA2 family The Monovalent Cation (K+/Na+):Proton Antiporter-3 (CPA3) Family CPA3 family The Dicarboxylate/Amino Acid:Cation (Na+/H+) Symporter (DAACS) DAACS family Family The Divalent Anion:Na+ Symporter (DASS) Family DASS family The C4-Dicarboxylate Uptake (Dcu) Family Dcu family The C4-Dicarboxylate Uptake C (DcuC) Family DcuC family The Drug/Metabolite Transporter (DMT) Superfamily DMT superfamily The Glutamate:Na+ Symporter (ESS) Family ESS family The Folate-Biopterin Transporter (FBT) Family FBT family The Formate-Nitrite Transporter (FNT) Family FNT family The Gluconate:H+ Symporter (GntP) Family GntP family The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family GPH Family The Hydroxy/Aromatic Amino Acid Permease (HAAAP) Family HAAAP family The 2-Keto-3-Deoxygluconate Transporter (KDGT) Family KDGT family The K+ Uptake Permease (KUP) Family KUP family The Lysosomal Cystine Transporter (LCT) Family LCT family The Lactate Permease (LctP) Family LctP family The Branched Chain Amino Acid:Cation Symporter (LIVCS) Family LIVCS family The L- Exporter (LysE) Family LysE family The Mitochondrial Carrier (MC) Family MC family The Major Facillitator Family (MFS) MFS family The Multidrug/Oligosaccharidyl-/Polysaccharide (MOP) Flippase MOP superfamily Superfamily The Malonate:Na+ Symporter (MSS) Family MSS family The Nucleobase:Cation Symporter-1 (NCS1) Family NCS1 family The Nucleobase:Cation Symporter-2 (NCS2) Family NCS2 family The NhaA Na+:H+ Antiporter (NhaA) Family NhaA family The NhaB Na+:H+ Antiporter (NhaB) Family NhaB family The NhaC Na+:H+ Antiporter (NhaC) Family NhaC family The NhaD Na+:H+ Antiporter (NhaD) Family NhaD family The Ni2+-Co2+ Transporter (NiCoT) Family NiCoT family The Metal Ion (Mn2+-iron) Transporter (Nramp) Family Nramp family The Neurotransmitter:Sodium Symporter (NSS) Family NSS family The Oligopeptide Transporter (OPT) Family OPT family The Cytochrome Oxidase Biogenesis (Oxa1) Family Oxa1 family The Inorganic Phosphate Transporter (PiT) Family PiT family The Phosphate:Na+ Symporter (PNaS) Family PNaS family The Proton-dependent Oligopeptide Transporter (POT) Family POT family The Resistance to Homoserine/Threonine (RhtB) Family RhtB family The Resistance-Nodulation-Cell Division (RND) Superfamily RND superfamily The Na+-dependent Bicarbonate Transporter (SBT) Family SBT family The Solute:Sodium Symporter (SSS) Family SSS family The Sulfate Permease (SulP) Family SulP family The Twin Targeting (Tat) Family Tat family The Telurite-resistance/Dicarboxylate Transporter (TDT) Family TDT family The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family TRAP-T family The K+ Transporter (Trk) Family Trk family The Tricarboxylate Transporter (TTT) Family TTT family The Zinc (Zn2+)-Iron (Fe2+) Permease (ZIP) Family ZIP family The Ammonia Transporter Channel (Amt) Family Amt family The Chloride Carrier/Channel (ClC) Family ClC family The Major Intrinsic Protein (MIP) Family MIP family The CorA Metal Ion Transporter (MIT) Family MIT family The Large Conductance Mechanosensitive Ion Channel (MscL) Family MscL family The Small Conductance Mechanosensitive Ion Channel (MscS) Family MscS family The Urea/Amide Channel (UAC) Family UAC family The Urea Transporter (UT) Family UT family The Voltage-gated Ion Channel (VIC) Superfamily VIC superfamily General phosphotransferase (GPTS) GPTS Sugar specific phosphotransferase (SSPTS) SSPTS