Federal Register/Vol. 86, No. 4/Thursday, January 7, 2021/Rules
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
A Quantum Chemical Study Involving Nitrogen Mustards
The Pharmaceutical and Chemical Journal, 2016, 3(4):58-60 Available online www.tpcj.org ISSN: 2349-7092 Research Article CODEN(USA): PCJHBA Formation enthalpy and number of conformers as suitable QSAR descriptors: a quantum chemical study involving nitrogen mustards Robson Fernandes de Farias Universidade Federal do Rio Grande do Norte, Cx. Postal 1664, 59078-970, Natal-RN, Brasil Abstract In the present work, a quantum chemical study (Semi-empirical,PM6 method) is performed using nitrogen mustards (HN1, HN2 and HN3) as subjects in order to demonstrate that there is a close relationship between pharmacological activity and parameters such as formation enthalpy and number of conformers, which could, consequently, be employed as reliable QSAR descriptors. To the studied nitrogen mustards, a very simple equation o o relating log P, ΔH f and the number of conformers (Nc) was found: log P = [(log -ΔH f + logNc)/2]-0.28. Keywords QSAR, Descriptors, Formation enthalpy, Conformers, Semi-empirical, Nitrogen mustards, Log P Introduction It is well known that lipophilicity is a very important molecular descriptor that often correlates well with the bioactivity of chemicals [1]. Hence, lipophilicity, measured as log P, is a key property in quantitative structure activity relationship (QSAR) studies. In this connection, in the pharmaceutical sciences it is a common practice to use log P (the partition coefficient between water and octanol), as a reliable indicator of the hydrophobicity or lipophilicity of (drug) molecules [1-2]. For example, relying primarily on the log P is a sensible strategy in preparing future 18-crown-6 analogs with optimized biological activity [3]. -
The Chemotherapy of Malignant Disease -Practical and Experimental Considerations
Postgrad Med J: first published as 10.1136/pgmj.41.475.268 on 1 May 1965. Downloaded from POSTGRAD. MED. J. (1965), 41,268 THE CHEMOTHERAPY OF MALIGNANT DISEASE -PRACTICAL AND EXPERIMENTAL CONSIDERATIONS JOHN MATTHIAS, M.D., M.R.C.P., F.F.A., R.C.S. Physician, The Royal Marsden Hospital, London, S.W.3. THE TERM chemotherapy was introduced by positively charged alkyl (CH2) radicles of Ehrlich to describe the specific and effective the agent. treatment of infectious disease by chemical (a) The nitrogen mustards: mustine (HN2 substances. It is currently also applied to the 'nitrogen mustard', mechlorethamine, treatment of malignant disease. Unfortunately mustargen), trimustine (Trillekamin no aspect of tumour metabolism has been HN3), chlorambucil (Leukeran, phenyl discovered which has allowed the development butyric mustard), melphalan (Alkeran, of drugs capable of acting specifically upon the phenyl alanine mustard), uramustine malignant cell, so that cytotoxic drugs also (Uracil mustard), cyclophosphamide affect normal cells to a greater or lesser degree. (Endoxan or Cytoxan), mannomustine The most susceptible or sensitive of the normal (DegranoO). tissues are those with the highest rates of cell (b) The ethylenamines: tretamine (trie- turnover and include the haemopoietic and thanomelamine, triethylene melamine, lympho-reticular tissues, the gastro-intestinal TEM), thiotepa (triethylene thiopho- the the testis and the hair epithelium, ovary, sphoramide), triaziquone (Trenimon).by copyright. follicles. (c) The epoxides: triethyleneglycoldigly- Cancer chemotherapy may be said to encom- cidyl ether (Epodyl). pass all treatments of a chemical nature (d) The sulphonic acid esters: busulphan administered to patients with the purpose of (Myleran), mannitol myleran. restricting tumour growth or destroying tumour 2. -
Information Data Sheet Detector Tube QUALITEST QL Part No. (US): 497665 Part No. D5085810
Information Data Sheet Detector Tube QUALITEST QL Part No. (US): 497665 Part No. D5085810 1. Application Detction of dangerous (toxic or combustible) gases and vapors in air.In particular fot testing the air in confined spaces such as fuel tanks, storage bins, cable vaults, sewers. Furthermore the tube QL can be used to detect or localize leaks, e.g. in pipelines. 2. General Description The detector tube QL does not have any calibration scale. The indication is non-specific and qualita- tive, i. e. only the presence resp. the absence of contaminants will be detected. The indication gives no information about type or concentration of contaminants detected. A special detector tube with quantitative indication shoud be used if the presence or the concentration of a known contaminant is to be determined. This applies also to substances which can not be indicated by the detector tube QL. The various contaminants are indicated with different sensitivity. However, the detector tube is sufficiently sensitive for all listed substances. Normally, concentrations of a few ppm are detectable. Among others, the following substances are indicated: Acetone, acetylene, benzene, 1.3-butadiene, butanes, butylenes, carbon disulfide, carbon monoxide, cyclohexane, diesel oil, ethanol (ethyl alcohol), ethylene, formic acid, fuel oil, gasoline (engine fuel),hydrogen chloride, hydrogen sulfide, kerosene, liquid petroleum gas (propane, butanes), methyl ethyl ketone (butanone), pentanes and other saturated hydrocarbons, phenol, propane, propanols (propyl alcohols), -
Nerve Agent - Lntellipedia Page 1 Of9 Doc ID : 6637155 (U) Nerve Agent
This document is made available through the declassification efforts and research of John Greenewald, Jr., creator of: The Black Vault The Black Vault is the largest online Freedom of Information Act (FOIA) document clearinghouse in the world. The research efforts here are responsible for the declassification of MILLIONS of pages released by the U.S. Government & Military. Discover the Truth at: http://www.theblackvault.com Nerve Agent - lntellipedia Page 1 of9 Doc ID : 6637155 (U) Nerve Agent UNCLASSIFIED From lntellipedia Nerve Agents (also known as nerve gases, though these chemicals are liquid at room temperature) are a class of phosphorus-containing organic chemicals (organophosphates) that disrupt the mechanism by which nerves transfer messages to organs. The disruption is caused by blocking acetylcholinesterase, an enzyme that normally relaxes the activity of acetylcholine, a neurotransmitter. ...--------- --- -·---- - --- -·-- --- --- Contents • 1 Overview • 2 Biological Effects • 2.1 Mechanism of Action • 2.2 Antidotes • 3 Classes • 3.1 G-Series • 3.2 V-Series • 3.3 Novichok Agents • 3.4 Insecticides • 4 History • 4.1 The Discovery ofNerve Agents • 4.2 The Nazi Mass Production ofTabun • 4.3 Nerve Agents in Nazi Germany • 4.4 The Secret Gets Out • 4.5 Since World War II • 4.6 Ocean Disposal of Chemical Weapons • 5 Popular Culture • 6 References and External Links --------------- ----·-- - Overview As chemical weapons, they are classified as weapons of mass destruction by the United Nations according to UN Resolution 687, and their production and stockpiling was outlawed by the Chemical Weapons Convention of 1993; the Chemical Weapons Convention officially took effect on April 291997. Poisoning by a nerve agent leads to contraction of pupils, profuse salivation, convulsions, involuntary urination and defecation, and eventual death by asphyxiation as control is lost over respiratory muscles. -
Section 2. Hazards Identification OSHA/HCS Status : This Material Is Considered Hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200)
SAFETY DATA SHEET Nonflammable Gas Mixture: Arsine / Helium / Phosgene Section 1. Identification GHS product identifier : Nonflammable Gas Mixture: Arsine / Helium / Phosgene Other means of : Not available. identification Product use : Synthetic/Analytical chemistry. SDS # : 006605 Supplier's details : Airgas USA, LLC and its affiliates 259 North Radnor-Chester Road Suite 100 Radnor, PA 19087-5283 1-610-687-5253 24-hour telephone : 1-866-734-3438 Section 2. Hazards identification OSHA/HCS status : This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200). Classification of the : GASES UNDER PRESSURE - Compressed gas substance or mixture ACUTE TOXICITY (inhalation) - Category 4 GHS label elements Hazard pictograms : Signal word : Warning Hazard statements : Contains gas under pressure; may explode if heated. May displace oxygen and cause rapid suffocation. Harmful if inhaled. Precautionary statements General : Read and follow all Safety Data Sheets (SDS’S) before use. Read label before use. Keep out of reach of children. If medical advice is needed, have product container or label at hand. Close valve after each use and when empty. Use equipment rated for cylinder pressure. Do not open valve until connected to equipment prepared for use. Use a back flow preventative device in the piping. Use only equipment of compatible materials of construction. Prevention : Use only outdoors or in a well-ventilated area. Avoid breathing gas. Response : IF INHALED: Remove person to fresh air and keep comfortable for breathing. Call a POISON CENTER or physician if you feel unwell. Storage : Protect from sunlight when ambient temperature exceeds 52°C/125°F. Store in a well- ventilated place. -
Kinetics of Coal Fly Ash Chlorination by Phosgene Douglas John Adelman Iowa State University
Iowa State University Capstones, Theses and Retrospective Theses and Dissertations Dissertations 1984 Kinetics of coal fly ash chlorination by phosgene Douglas John Adelman Iowa State University Follow this and additional works at: https://lib.dr.iastate.edu/rtd Part of the Chemical Engineering Commons Recommended Citation Adelman, Douglas John, "Kinetics of coal fly ash chlorination by phosgene " (1984). Retrospective Theses and Dissertations. 8971. https://lib.dr.iastate.edu/rtd/8971 This Dissertation is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Retrospective Theses and Dissertations by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. INFORMATION TO USERS This reproduction was made from a copy of a document sent to us for microfilming. While the most advanced technology has been used to photograph and reproduce this document, the quality of the reproduction is heavily dependent upon the quality of the material submitted. The following explanation of techniques is provided to help clarify markings or notations which may appear on this reproduction. 1.The sign or "target" for pages apparently lacking from the document photographed is "Missing Page(s)". If it was possible to obtain the missing page(s) or section, they are spliced into the film along with adjacent pages. This may have necessitated cutting through an image and duplicating adjacent pages to assure complete continuity. 2. When an image on the film is obliterated with a round black mark, it is an indication of either blurred copy because of movement during exposure, duplicate copy, or copyrighted materials that should not have been filmed. -
OSHA Method 61: Phosgene
PHOSGENE - (Organic Method #61) Page 1 of 20 U.S. Department of Labor Occupational Safety & Health Administration www.osha.gov Search Advanced Search | A Technical Links > Sampling & Analytical Methods > Index PHOSGENE Method no.: 61 Matrix: Air Target concentration: 100 ppb (0.4 mg/m3) (OSHA PEL) Procedure: Air samples are collected by drawing known volumes of air through sampling tubes containing XAD-2 adsorbent which has been coated with 2 (hydroxymethyl)piperidine. The samples are desorbed with toluene and then analyzed by gas chromatography using a nitrogen selective detector. Recommended air volume and sampling rate: 240 L at 1 L/min Reliable quantitation limit: 3.5 ppb (0.014 mg/m3) Standard error of estimate at the target concentration: 6.7% (Section 4.7.) Status of method: Evaluated method. This method has been subjected to the established evaluation procedures of the Organic Methods Evaluation Branch. Date: August 1986 Chemist: Warren Hendricks Organic Methods Evaluation Branch OSHA Analytical Laboratory Salt Lake City, Utah 1. General Discussion 1.1. Background 1.1.1. History http://www.osha.gov/dts/sltc/methods/organic/org061/org061.html 7/7/2008 PHOSGENE - (Organic Method #61) Page 2 of 20 The procedures that have been used by OSHA to monitor occupational exposure to phosgene include detector tubes, monitoring dosimeters and infrared gas analyzers. None of these procedures have proven to be completely adequate for use by OSHA. These methods lack either the desired precision and accuracy or they are awkward and inconvenient for field use. This procedure was developed after it was found that phosgene would react quantitatively with 2-(hydroxymethyl)piperidine (2-HMP) to form a stable derivative, 1-aza-8-oxabicyclo[4.3.0.]inonan-9-one. -
Composite Carbon Foams As an Alternative to the Conventional Biomass-Derived Activated Carbon in Catalytic Application
materials Article Composite Carbon Foams as an Alternative to the Conventional Biomass-Derived Activated Carbon in Catalytic Application Mahitha Udayakumar 1,2 , Renáta Zsanett Boros 3,László Farkas 3 , Andrea Simon 4 , Tamás Koós 5, Máté Leskó 6, Anett Katalin Leskó 5, Klara Hernadi 7,8 and Zoltán Németh 1,* 1 Advanced Materials and Intelligent Technologies Higher Education and Industrial Cooperation Centre, University of Miskolc, H-3515 Miskolc, Hungary; [email protected] 2 Institute of Chemistry, University of Miskolc, H-3515 Miskolc, Hungary 3 Wanhua-Borsod Chem Zrt, Bolyai tér 1, H-3700 Kazincbarcika, Hungary; [email protected] (R.Z.B.); [email protected] (L.F.) 4 Institute of Ceramic and Polymer Engineering, University of Miskolc, H-3515 Miskolc, Hungary; [email protected] 5 Institute of Energy and Quality Affairs, University of Miskolc, H-3515 Miskolc, Hungary; [email protected] (T.K.); [email protected] (A.K.L.) 6 Institute of Mineralogy and Geology, University of Miskolc, H-3515 Miskolc, Hungary; [email protected] 7 Institute of Physical Metallurgy, Metal Forming and Nanotechnology, University of Miskolc, H-3515 Miskolc, Hungary; [email protected] 8 Department of Applied and Environmental Chemistry, University of Szeged, H-6720 Szeged, Hungary * Correspondence: [email protected]; Tel.: +36-46-565-111/1380 Citation: Udayakumar, M.; Boros, R.Z.; Farkas, L.; Simon, A.; Koós, T.; Abstract: The suitability of a new type of polyurethane-based composite carbon foam for several Leskó, M.; Leskó, A.K.; Hernadi, K.; possible usages is evaluated and reported. A comparison of the properties of the as-prepared carbon Németh, Z. -
Acetylcholinesterase: the “Hub” for Neurodegenerative Diseases And
Review biomolecules Acetylcholinesterase: The “Hub” for NeurodegenerativeReview Diseases and Chemical Weapons Acetylcholinesterase: The “Hub” for Convention Neurodegenerative Diseases and Chemical WeaponsSamir F. de A. Cavalcante Convention 1,2,3,*, Alessandro B. C. Simas 2,*, Marcos C. Barcellos 1, Victor G. M. de Oliveira 1, Roberto B. Sousa 1, Paulo A. de M. Cabral 1 and Kamil Kuča 3,*and Tanos C. C. França 3,4,* Samir F. de A. Cavalcante 1,2,3,* , Alessandro B. C. Simas 2,*, Marcos C. Barcellos 1, Victor1 Institute G. M. ofde Chemical, Oliveira Biological,1, Roberto Radiological B. Sousa and1, Paulo Nuclear A. Defense de M. Cabral (IDQBRN),1, Kamil Brazilian Kuˇca Army3,* and TanosTechnological C. C. França Center3,4,* (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil; [email protected] (M.C.B.); [email protected] (V.G.M.d.O.); [email protected] 1 Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN), Brazilian Army (R.B.S.); [email protected] (P.A.d.M.C.) Technological Center (CTEx), Avenida das Américas 28705, Rio de Janeiro 23020-470, Brazil; 2 [email protected] Mors Institute of Research (M.C.B.); on Natural [email protected] Products (IPPN), Federal (V.G.M.d.O.); University of Rio de Janeiro (UFRJ), CCS,[email protected] Bloco H, Rio de Janeiro (R.B.S.); 21941-902, [email protected] Brazil (P.A.d.M.C.) 32 DepartmentWalter Mors of Institute Chemistry, of Research Faculty of on Science, Natural Un Productsiversity (IPPN), -
Chemical Weapons Convention Inventory Report - 2017
University of British Columbia Risk Management Services CHEMICAL WEAPONS CONVENTION INVENTORY REPORT - 2017 Department: Name of Building: Room No. Principal Investigator: SCHEDULE 1 CHEMICALS Location Quantity Obtained /Stored / Used A.Toxic Chemicals 1 O-Alkyl (<=C10, incl. cycloalkyl) alkyl (Me, Et, n-Pr or i-Pr) – phosphonofluoridates, Sarin: O-Isopropyl methylphosphonofluoridate (CAS 107-44-8) Soman: O-Pinacolyl methylphosphonofluoridate (CAS 96-64-0) 2 O-Alkyl (H or <=C10, incl. cycloalkyl) S-2-dialkyl (Me, Et, n- Pr or i-Pr) -aminoethyl alkyl (Me, Et, n-Pr or i-Pr) phosphonothiolates, and corresponding alkylated or protonated salts VX: O-Ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate (CAS 50782-69-9) 3 O-Alkyl (H or <=C10, incl. cycloalkyl) S-2-dialkyl (Me, Et, n- Pr or i-Pr) -aminoethyl alkyl (Me, Et, n-Pr or i-Pr) phosphonothiolates, and corresponding alkylated or protonated salts VX: O-Ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate (CAS 50782-69-9) 4 Sulphur Mustards: 2-Chloroethylchloromethylsulfide (CAS 2625-76-5) Mustard gas: Bis (2-chloroethyl) sulfide (CAS 505-60-2) Bis (2-chloroethylthio)methane (CAS 63869-13-6) Sesquimustard: 1, 2-Bis (2-chloroethylthio) ethane (CAS 3563-36-8) 1, 3-Bis (2-chloroethylthio) -n-propane (CAS 63905-10-2) 1, 4-Bis (2-chloroethylthio) -n-butane (CAS 142868-93-7) 1, 5-Bis (2-chloroethylthio) -n-pentane (CAS 142868-94-8) Bis (2-chloroethylthiomethyl) ether (CAS 63918-90-1) O-Mustard: Bis (2-chloroethylthioethyl) ether (CAS 63918-89-8) 5 Lewisites: Lewisite 1: 2-Chlorovinyldichloroarsine (CAS 541-25-3) Lewisite 2: Bis (2-chlorovinyl) chloroarsine (CAS 40334-69-8) Lewisite 3: Tris (2-chlorovinyl) arsine (CAS 40334-70-1) 6 Nitrogen Mustards: HN1: Bis (2-chloroethyl) ethylamine (CAS 538-07-08) HN2: Bis (2-chloroethyl) methylamine (CAS 51-75-2) HN3: Tris (2-chloroethyl) amine (CAS 555-77-1) University of British Columbia Risk Management Services CHEMICAL WEAPONS CONVENTION INVENTORY REPORT - 2017 Department: Name of Building: Room No. -
UAH Chemical Hygiene Plan
UAH CHEMICAL HYGIENE Effective Date: Feb. 2014 PLAN The Campus Chemical Hygiene Plan (Campus CHP) was developed to ensure the safety of laboratory employees and maintain compliance with the OSHA Laboratory Standard. In addition to OSHA regulations, this document also presents key information on the practices and procedures that must be implemented to maintain compliance with other state, federal, and local regulations required for the use and storage of hazardous chemicals. Prepared by: The Office of Environmental Health & Safety Contents 1. Introduction .............................................................................................................................. 1 1.1 Purpose .................................................................................................................................................. 1 1.2 Background on Regulatory Compliance .................................................................................... 1 1.3 Chemical Hygiene Plan Overview ................................................................................................. 2 1.4 Scope and Applicability .................................................................................................................... 3 1.5 Implementation of the Plan ............................................................................................................ 4 1.6 Availability of the Plan ..................................................................................................................... 4 1.7 Annual -
1 S1ab13 29211900 29211900 Mc
Product HS Code Product S/N Code AHTN 2007 AHTN 2012 UOM Product Description 1 S1AB13 29211900 29211900 MC - HN1: BIS(2-CHLOROETHYL)ETHYLAMINE 2 S1AB14 29211900 29211900 MC - HN2: BIS(2-CHLOROETHYL)METHYLAMINE 3 S1AB15 29211900 29211900 MC - HN3: TRIS(2-CHLOROETHYL)AMINE O-ALKYL (H OR <= C10, INCL. CYCLOALKYL) S-2-DIALKYL (ME, ET, N-PR OR I-PR)-AMINOETHYL ALKYL (ME, ET, N-PR OR I-PR) PHOSPHONOTHIOLATES AND CORRESPONDING ALKYLATED OR PROTONATED SALTS E.G. - VX: O-ETHYL S-2- 4 S1AN03 29309000 29309090 MC DIISOPROPYLAMINOETHYL METHYL PHOSPHONOTHIOLATE 5 S1AB01 29309000 29309090 MC - 2- CHLOROETHYLCHLOROMETHYLSULFIDE 6 S1AB02 29309000 29309090 MC - MUSTARD GAS: BIS(2-CHLOROETHYL)SULFIDE 7 S1AB03 29309000 29309090 MC - BIS(2-CHLOROETHYLTHIO)METHANE 8 S1AB04 29309000 29309090 MC - SESQUIMUSTARD: 1,2-BIS(2-CHLOROETHYLTHIO)ETHANE 9 S1AB05 29309000 29309090 MC - 1,3-BIS(2-CHLOROETHYLTHIO)-N-PROPANE 10 S1AB06 29309000 29309090 MC - 1,4-BIS(2-CHLOROETHYLTHIO)-N-BUTANE 11 S1AB07 29309000 29309090 MC - 1,5-BIS(2-CHLOROETHYLTHIO)-N-PENTANE 12 S1AB08 29309000 29309090 MC - BIS(2-CHLOROETHYLTHIOMETHYL)ETHER 13 S1AB09 29309000 29309090 MC - O-MUSTARD: BIS(2-CHLOROETHYLTHIOETHYL)ETHER O-ALKYL (<= C10, INCL. CYCLOALKYL) ALKYL (ME, ET, N-PR OR I-PR)- PHOSPHONOFLUORIDATES E.G. - SARIN: O-ISOPROPYL METHYLPHOSPHONOFLUORIDATE, - SOMAN: O-PINACOLYL 14 S1AN01 29310090 29319090 MC METHYLPHOSPHONOFLUORIDATE O-ALKYL (<= C10, INCL. CYCLOALKYL) N,N-DIALKYL (ME, ET, N-PR OR I- PR) PHOSPHORAMIDOCYANIDATES E.G. - TABUN: O-ETHYL N,N- 15 S1AN02 29310090 29319090 MC DIMETHYL PHOSPHORAMIDOCYANIDATE 29319041 (For liquid forms) or 29319049 (For other 16 S1AB10 29310040 forms) MC - LEWISITE 1: 2-CHLOROVINYLDICHLOROARSINE 29319041 (For liquid forms) or 29319049 (For other 17 S1AB11 29310040 forms) MC - LEWISITE 2: BIS(2-CHLOROVINYL)CHLOROARSINE 29319041 (For liquid forms) or 29319049 (For other 18 S1AB12 29310040 forms) MC - LEWISITE 3: TRIS(2-CHLOROVINYL)ARSINE 19 S1AT01 30029000 30029000 MC SAXITOXIN 20 S1AT02 30029000 30029000 MC RICIN ALKYL (ME, ET, N-PR OR I-PR) PHOSPHONYLDIFLUORIDES E.G.