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Albanian Medical Journal Albanian Medical Journal AALBANIAN mMedical journalJJ Number 3 - 2016 AALLBBAANNIIAANN MMEEDDIICCAALL JJOOUURRNNAALL R E P U B L I C O F A L B A N I A MINISTRY OF HEALTH INSTITUTE OF PUBLIC HEALTH ALBANIAN MEDICAL JOURNAL 3-2016 ALBANIAN medical journal 3-2016 ALBANIANAMJ medical journal Editors in Chief Genc Burazeri (Albania) Eduard Kakarriqi (Albania) Editorial Board (in alphabetical order) Alban Dibra (Albania) Alban Ylli (Albania) Ariel Ahart (USA) Arjan Bregu (Albania) Arjan Harxhi (Albania) Arnold D. Kaluzny (USA) Bajram Hysa (Albania) Bledar Kraja (Albania) Charles Hardy (USA) Doncho Donev (Macedonia) Enver Roshi (Albania) Ervin Toçi (Albania) Gazmend Bejtja (Albania) Gentiana Qirjako (Albania) Greg Evans (USA) Helmut Brand (The Netherlands) Ilir Alimehmetiˆ (Albania) Izet Masic (Bosnia and Herzegovina) Jera Kruja (Albania) Jolanda Hyska (Albania) Katarzyna Czabanowska (The Netherlands) Kenneth A. Rethmeier (USA) Kliti Hoti (Albania) Klodian Dhana (Albania) Klodian Rjepaj (Albania) Kreshnik Petrela (Albania) Llukan Rrumbullaku (Albania) Malcolm Whitfield (United Kingdom) Mariana Dyakova (United Kingdom) Mark Avery (Australia) Mindaugas Stankunas (Lithuania) Naim Jerliu (Kosovo) Naser Ramadani (Kosovo) Nevzat Elezi (Macedonia) Peter Schröder-Bäck (The Netherlands) Silva Bino (Albania) Suela Këlliçi (Albania) Suzanne Havala Hobbs (USA) Theodhore Tulchinsky (Israel) Tomasz Brzostek (Poland) Tony Smith (United Kingdom) Ulrich Laaser (Germany) Wlodzimierz Cezary Wlodarczyk (Poland) Zejdush Tahiri (Kosovo) Design & Layout Albanian Medical Journal Editorial Office: Genc Musa Institute of Public Health Aleksandër Moisiu Street 80, Tirana, Albania Technical Editors Tel/Fax ++3554370058 Florida Beluli and Kleopatra Sava E-mail: [email protected] Web: http://albanianmedicaljournal.com ALBANIAN MEDICAL JOURNAL 3 - 2016 TABLE OF CONTENTS ALBANIAN MEDICAL JOURNAL: 2016;3 ORIGINAL RESEARCH Feyzi Gokosmanoglu, Ceyhun Varim, Hakan Cinemre, Yasemin Kaya, Gulsah Baycelebi The relationship between spirometric parameters and hemodialysis adequacy in hemodialysis patients ...................................................................................................... 5 Damir Suljevic, Lejla Mehinovic, Andi Alijagic Hepatitis and biochemical markers in correlation with alpha-fetoprotein as a diagnostic indicator for the HBV and HCV differentiation .................................................................. 13 Adriana Babameto, Bledar Kraja, Skerdi Prifti, Bashkim Resuli Alcohol use among adolescents and young adults in Albania ............................................... 21 Teona Bushati, Leart Berdica, Mehdi Alimehmeti, Gentian Kaloshi, Arsen Seferi, Ridvan Alimehmeti, Ermira Pajaj, Mentor Petrela Use of molecular markers immunoreactivity can help stratify glioma s patients into groups within the same grade and histological entity ........................................................... 27 Epaminonda Fype, Ornela Nuredini, Mimoza Goga, Armela Cuko, Rinard Kertoci, Ilir Skenduli, Ilir Ohri Improvement of biochemical parameters due to non-invasive ventilation in patients with chronic obstructive pulmonary disease and acute respiratory failure ............................ 35 Erjona Shehu, Esmeralda Meta, Arsilda Gjataj, Ermira Vasili, Dhimiter Kraja, Arjan Harxhi A clinical study of Kaposi Sarcoma among HIV/AIDS patients in Albania ......................... 39 Ersela Alikaj, Xhina Mulo, Alda Gjoni Traumas on dentition during childhood and their consequences ........................................... 46 Enton Bollano, Krenar Lilaj, Dariel Thereska, Arben Gjata Is the left lateral sphincterotomy a necessity during the Milligan-Morgan hemorrhoidectomy in patients with hemorrhoids prolapse? .................................................. 53 ALBANIAN MEDICAL JOURNAL 3 - 2016 3 ALBANIAN MEDICAL JOURNAL Alketa Ymeri (Pere), Silvana Celiku, Ibrahim Avdiu The adjuvant treatment of breast cancer human epidermal growth factor receptor (HER2) positive in Albania ............................................................................................... 61 Eftiola Pojani, Erida Nelaj, Artan Simaku, Alban Ylli Effectiveness of combined Measles, Mumps and Rubella vaccine in Albania: An analysis based on health impact surveillance ................................................................ 67 Krenar Lilaj, Enton Bollano, Dariel Thereska, Arben Gjata Effects of blood transfusion in patients with upper gastrointestinal bleeding ........................ 75 Teuta Haveri Treating keratoconus disease with the cross-linking method ............................................... 82 REVIEWS Anne Wiebke Ohlrogge Harmonised health indicators in the European Union: A brief introduction .......................... 90 Laerta Kakariqi, Sonila Vito Prescription patterns of drugs used for peptic ulcer disease in primary health care in Albania during 2004-2014: International comparisons ......................................................... 96 SHORT REPORTS Hasan Ergenç, Serdar Olt, Özlem Uysal Sönmez, Selçuk Yaylaci, Aysel Gürkan Toçoglu, Sümeyye Korkmaz, Ali Tamer Comparison of two different methods used in the assay of Her 2/Neu (C-erb B2) in breast cancer .................................................................................................................. 103 Serdar Olt, Mustafa Erhan Altunöz, Selçuk Yaylaci Helicobacter pylori eradication experience with sequential treatment consisting of antibiotics which are used in conventional triple therapy .................................................... 108 INSTRUCTIONS TO AUTHORS http://albanianmedicaljournal.com/index.php/instructions-to-authors ......................................... 111 4 ALBANIAN MEDICAL JOURNAL 3 - 2016 ALBANOIARN IMGEIDNICAAL JORUERNSAEL ARCH The relationship between spirometric parameters and hemodialysis adequacy in hemodialysis patients Feyzi Gokosmanoglu1, Ceyhun Varim1, Hakan Cinemre1, Yasemin Kaya2, Gulsah Baycelebi3 1Department of Internal Medicine, Faculty of Medicine, Sakarya University, Turkey; 2Department of Internal Medicine, Faculty of Medicine, Ordu University, Turkey; 3Department of Internal Medicine, Ordu Unye State Hospital, Ordu, Tukey. Corresponding author: Ceyhun Varim, MD; Address: Adnan Menderes caddesi, Saglik Sokak, No. 195-54000, Adapazari/Sakarya, Turkey; Telephone: +902642552106; E-mail: [email protected] Abstract Aim: In our study we aimed to investigate the relationship between spirometric parameters and Kt/V, which is an indicator of dialysis adequacy. Methods: The study was conducted at four centers in Turkey using Kt/V values in evaluating hemodialysis adequacy. Subjects included 71 patients 18 years old and above who had been receiving hemodialysis treatment for at least six months. Patients Kt/V values were calculated. Spirometric parameters of FEV1, FVC, FEV1/FVC, PE, and FEF25-75 were measured in all patients. Relationships between these parameters and URR, serum electrolytes, serum creatinine, blood urea nitrogen, and hemoglobin were assessed. Results: Factors potentially affecting patients spirometric parameters of FEV1, FVC, FEV1/ FVC, PEF, and FEF25-75 were examined by using cascading multiple linear regression analysis method. The highest variance (R2) model for FVC was determined as having two components, age and Kt/V. For the FEV1, a three-factored model was formed, and age and Kt/V were determined to be independent predictor indicators. Regarding the PEF value, Kt/V and age were found to be independent predictors for the four-component model. Conclusion: Our findings indicate that age and dialysis adequacy (Kt/V) constitute statistically significant independent predictors for spirometric parameters in hemodialysis patients. Keywords: dialysis adequacy, hemodialysis, spirometric parameters. ALBANIAN MEDICAL JOURNAL 3 - 2016 5 ALBANIAN MEDICAL JOURNAL Introduction and mortality rates significantly decrease (3). Chronic renal failure (CRF) is a chronic and Nowadays, after clinical inspection and lung graphics progressive disease. A decrease in glomerular (X-ray), spirometric tests become one of the basic filtration rate (GFR) continues with deterioration of investigation methods in diagnosis, treatment and kidneys metabolic-endocrine functions and impair- monitoring of diseases. With these tests, we can ment of fluid-solid balance regulation.When creatinine evaluate pulmonary functions in an objective and clearance falls below 5-10 ml/minute/1.73 m2, end quantitative manner. There are few studies stage renal failure is indicated and patients require investigating the relationship between Kt/V adequacy renal replacement treatments, such as hemodialysis, and respiratory functions in hemodialysis patients. In peritoneal dialysis and renal transplantation. The most our study we aimed to investigate the relationship used renal replacement treatment is hemodialysis between spirometric tests and Kt/V value, which is (HD). Studies have found that effective hemodialysis an indicator of dialysis adequacy. decreases morbidity and mortality. Pulmonary complications are frequently seen in these patients Methods due to inadequate dialysis or because patients do not The study was conducted at four centers in Turkey obey fluid restrictions. Pulmonary edema, pleural using Kt/V values in evaluating hemodialysis effusion, fibrosis, calcification, pulmonary hyper- adequacy. Subjects included 71 patients who were tension, and/or hemosiderosis may occur in patients 18 years old and above and who had been diagnosed with CRF (1). Also,
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